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Search Results: 1 - 10 of 801 matches for " Hiromi Kataoka "
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Simulation Program to Determine Sample Size and Power for a Multiple Logistic Regression Model with Unspecified Covariate Distributions  [PDF]
Naoko Kumagai, Kohei Akazawa, Hiromi Kataoka, Yutaka Hatakeyama, Yoshiyasu Okuhara
Health (Health) , 2014, DOI: 10.4236/health.2014.621336
Abstract: Binary logistic regression models are commonly used to assess the association between outcomes and covariates. Many covariates are inherently continuous, and have a variety of distributions, including those that are heavily skewed to the left or right. Existing theoretical formulas, criteria, and simulation programs cannot accurately estimate the sample size and power of non-standard distributions. Therefore, we have developed a simulation program that uses Monte Carlo methods to estimate the exact power of a binary logistic regression model. This power calculation can be used for distributions of any shape and covariates of any type (continuous, ordinal, and nominal), and can account for nonlinear relationships between covariates and outcomes. For illustrative purposes, this simulation program is applied to real data obtained from a study on the influence of smoking on 90-day outcomes after acute atherothrombotic stroke. Our program is applicable to all effect sizes and makes it possible to apply various statistical methods, logistic regression and related simulations such as Bayesian inference with some modifications.
Potential of new anti-cancer agents targeting the nuclear translocation signaling of HB-EGF C-terminal fragments during the development of colitis-associated cancer  [PDF]
Satoshi Tanida, Keiji Ozeki, Tsutomu Mizoshita, Hironobu Tsukamoto, Hiromi Kataoka, Takashi Joh
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.48A2004
Abstract:

In inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn’s disease (CD), the duration and severity of inflammation are responsible for the development of colorectal cancer. Inflammatory cytokines such as interleukin (IL)-8 and tumor necrotic factor (TNF)-a, which are released by epithelial and immune cells, are involved in the pathogenesis of colitis-associated cancer. Current treatments for advanced colorectal cancers focus primarily on targeting epidermal growth factor receptor (EGFR) signaling. IL-8 (a G-protein coupled receptor (GPCR) agonist), which is involved in neutrophil recruitment and activation in persistent active colitis, also promotes cleavage of theproheparin-binding epidermal growth factor—like growth factor (proHB-EGF) through a disintegrin and metalloproteinase (ADAM), so that the resulting soluble HB-EGF activates EGFR. In parallel, the carboxy-terminal fragment of proHB-EGF (HB-EGF-CTF) translocates into the inner nuclear membrane, where HB-EGF-CTF binds the nuclear promyelocytic leukemia zinc finger (PLZF) protein, resulting in the nuclear export of the PLZF transcriptional repressor and thereby affecting cell proliferation. Screening for potent chemical inhibitors of the interactions between HB-EGF-CTF and PLZF identified telmisartan (and related compounds in corporating a biphenyl tetrazole moiety) as inhibitors of cell proliferation. Here we focus on the inhibitory effects of these compounds on cell proliferation, demonstrating the potential for targeting the nuclear translocation of HB-EGF-CTF in the treatment of colitis-associated cancer.

Self-administered questionnaire versus interview as a screening method for intimate partner violence in the prenatal setting in Japan: A randomised controlled trial
Yaeko Kataoka, Yukari Yaju, Hiromi Eto, Shigeko Horiuchi
BMC Pregnancy and Childbirth , 2010, DOI: 10.1186/1471-2393-10-84
Abstract: We conducted a randomised controlled trial to screen participants at three points in time in a prenatal clinic in Tokyo, Japan. There were 328 consenting women between 14 and 25 weeks of pregnancy who were consecutively selected and randomly assigned to either the interview or self-administered questionnaire group. Both groups completed the same screening instrument three times during their pregnancy. The primary outcome was the total number of women identified by each screening method and the secondary outcome was the effect of the screening as measured by the women's comfort level and their expressed need to consult with the nurse.For all three screenings, the identification rate in the interview group was significantly lower than that for the self-administered questionnaire group (relative risk 0.66, 95% CI 0.46 to 0.97), even after controlling for smoking (adjusted odds ratio 0.59, 95% CI 0.35 to 0.98). The two groups did not differ for secondary outcomes.The self-administered questionnaire identified more IPV than the face-to-face interview when screening pregnant women in a Japanese prenatal clinic.UMIN-CTRC000000353Intimate partner violence (IPV) is a serious social issue in Japan. A national survey conducted in 2008 revealed that approximately 25% of adult women, an estimated eight million women, reported being subjected to physical violence by a male partner, over their lifetime: approximately 16% reported sexual violence, and approximately 17% reported psychological abuse [1]. This survey revealed that the 5-year prevalence of IPV was 14% among women. Furthermore the number of women experiencing physical, sexual or psychological violence from a partner has increased gradually, approximately 19% to 33%, over the ten-year period of 1998-2008 [1,2].The law for the prevention of spousal violence and the protection of victims, enacted in Japan in 2001, called for the identification of abused women and for providing adequate resources such as support centres or
Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis
Satoshi Tanida,Tsutomu Mizoshita,Takashi Mizushima,Takaya Shimura,Takeshi Kamiya,Hiromi Kataoka,Takashi Joh
Ulcers , 2011, DOI: 10.1155/2011/457637
Abstract: In ulcerative colitis (UC), the duration and severity of inflammation are responsible for the development of colorectal cancer. Reactive oxygen species (ROS), reactive nitric metabolites (RNMs) and interleukin (IL)-8, released by epithelial and immune cells, are involved in the pathogenesis of colitis-associated cancer. Nitric oxide and peroxynitrite activate epidermal growth factor receptor (EGFR), and therapeutic agents targeted towards EGFR are currently used to treat advanced colorectal cancer. IL-8 (a G-protein coupled receptor (GPCR) agonist), which is involved in neutrophil recruitment and activation in persistent active colitis, also promotes cleavage of the proheparin-binding epidermal growth factor-like growth factor (proHB-EGF) through a disintegrin and metalloproteinase (ADAM). The cleaved HB-EGF and C-terminal fragments (intracellular CTF) regulate proliferation via EGFR activation and nuclear export of promyelocytic leukemia zinc finger, transcription repressor, respectively. Here, we focus on the mechanisms by which RNM- and IL-8-induced EGF signaling regulate cell proliferation during the development of colitis-associated cancer.
Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment
Satoshi Tanida,Tsutomu Mizoshita,Keiji Ozeki,Hironobu Tsukamoto,Takeshi Kamiya,Hiromi Kataoka,Daitoku Sakamuro,Takashi Joh
International Journal of Surgical Oncology , 2012, DOI: 10.1155/2012/862879
Abstract: Cisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts and its cytotoxicity is mediated by propagation of DNA damage recognition signals to downstream pathways involving ATR, p53, p73, and mitogen-activated protein kinases, ultimately resulting in apoptosis. Cisplatin resistance arises through a multifactorial mechanism involving reduced drug uptake, increased drug inactivation, increased DNA damage repair, and inhibition of transmission of DNA damage recognition signals to the apoptotic pathway. In addition, a new mechanism has recently been revealed, in which the oncoprotein c-Myc suppresses bridging integrator 1 (BIN1), thereby releasing poly(ADP-ribose)polymerase 1, which results in increased DNA repair activity and allows cancer cells to acquire cisplatin resistance. The present paper focuses on the molecular mechanisms of cisplatin-induced apoptosis and of cisplatin resistance, in particular on the involvement of BIN1 in the maintenance of cisplatin sensitivity. 1. Introduction Gastric cancer is one of the most prevalent malignancies in Japan and East Asian countries [1], This cancer represents the major cause of mortality in these countries, despite great advances in diagnosis and multimodal treatments [2]. Cisplatin (cis-Diamminedichloroplatinum (II): CDDP) is an important chemotherapeutic agent in the treatment of advanced gastric cancer. Some trials of combination chemotherapy with S-1 and cisplatin as the first-line or second-line treatment for advanced and recurrent gastric cancer have yielded good responses and this treatment is well tolerated [3, 4]. However, there is diversity in the efficacy of cisplatin and in patient response to anti-cancer drugs including cisplatin, which can be of importance in terms of therapeutic outcome. Molecules and factors that are capable of predicting patient responses and resistance to anticancer agents are therefore of great interest and have been extensively studied. A recent study of the potent predictor of cisplatin sensitization Bridging integrator 1 (BIN1, also known as box-dependent MYC-interacting protein 1) demonstrated that BIN1 plays an important role in sensitization to cisplatin [5]. BIN1 is a nucleocytoplasmic adaptor protein that is involved in pleiotropic cellular functions such as suppression of oncogenic transformation. Here, we provide an overview of the molecular mechanism of cisplatin-induced apoptosis and of cisplatin resistance as well as of the mechanisms by
Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis
Satoshi Tanida,Tsutomu Mizoshita,Takashi Mizushima,Takaya Shimura,Takeshi Kamiya,Hiromi Kataoka,Takashi Joh
Ulcers , 2011, DOI: 10.1155/2011/457637
Abstract: In ulcerative colitis (UC), the duration and severity of inflammation are responsible for the development of colorectal cancer. Reactive oxygen species (ROS), reactive nitric metabolites (RNMs) and interleukin (IL)-8, released by epithelial and immune cells, are involved in the pathogenesis of colitis-associated cancer. Nitric oxide and peroxynitrite activate epidermal growth factor receptor (EGFR), and therapeutic agents targeted towards EGFR are currently used to treat advanced colorectal cancer. IL-8 (a G-protein coupled receptor (GPCR) agonist), which is involved in neutrophil recruitment and activation in persistent active colitis, also promotes cleavage of the proheparin-binding epidermal growth factor-like growth factor (proHB-EGF) through a disintegrin and metalloproteinase (ADAM). The cleaved HB-EGF and C-terminal fragments (intracellular CTF) regulate proliferation via EGFR activation and nuclear export of promyelocytic leukemia zinc finger, transcription repressor, respectively. Here, we focus on the mechanisms by which RNM- and IL-8-induced EGF signaling regulate cell proliferation during the development of colitis-associated cancer. 1. Introduction The incidence of inflammatory bowel diseases such as UC has been increasing on an annual basis. Uncontrolled and excessive host immune responses, during which oxidative stress-like reactive oxygen species (ROS), reactive nitrogen metabolites (RNMs), and free radicals are produced from inflammatory cell infiltrates in the gut mucosa, are known to trigger mucosal injury and induce inflammation. Long-term high disease activity has been established as a potential risk factor for the development of colitis-associated cancer [1, 2]. Colorectal cancer represents the major cause of excess morbidity and mortality due to malignancy associated with UC. The cumulative incidence of such a malignancy is below 1% in the first 8–10 years of UC, but then rises in annual increments of 0.5–1.0% thereafter to reach 5–10% after 20 years and 15–20% after 30 years [3]. In addition to ROS and RNM, the perpetuation of active inflammation in the mucosa of patients with UC, which is mediated by inflammatory cytokines such as interleukin (IL)-8 and tumor necrotic factor- (TNF-) α, is also believed to increase the risk of colitis-associated cancer. Thus, ROS, RNM, and inflammatory cytokines play important roles in the perpetuation of inflammation in UC leading to the development of colorectal cancer. There has been recent, widespread application of therapeutic treatments targeting key molecules that are involved in cell
Two cases of juvenile hypertrophic cardiomyopathy presenting with marked bi-atrial enlargement on standard 12-lead electrocardiogram  [PDF]
Hajime Kataoka
Open Journal of Internal Medicine (OJIM) , 2012, DOI: 10.4236/ojim.2012.21007
Abstract: This report describes two cases of juvenile hypertrophic cardiomyopathy (HCM) in which prominent bi-atrial enlargement was observed on standard 12-lead electrocardiogram, suggesting inherent predis-position to extreme enlargement and/or hypertrophy may exist in atrial myocardium in juvenile HCM. Comparative study between juvenile and adult HCM patients using a large sample size is required to confirm this hypothesis.
An Empirical Analysis of Women’s Promotion in Japanese Companies: Comparison with Chinese and Korean Cases  [PDF]
Hiromi Ishizuka
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.63063
Abstract: The purpose of this study is to contribute to the economic revitalization of Japan by learning from other countries through a consideration of diversity. From Chinese urban areas, we study an example of a fluid labor market, and a firmly rooted movement of women into the workplace. From Korea, even though the male-female disparities are greater than those in Japan, we study a concrete case in terms of the rapid speed of the changing workplace. The framework includes not only promotion at the company level, but also lifestyle at the household level. The study uses the numerical values and analysis is through the Negative Binominal Regression Model. Findings include: 1) in Japan, there is “slow promotion” in the both case of men and women and a “glass ceiling” for women; 2) in China, the decisive male-female disparity is the difference in the “age of fixed retirement”. Gender gaps in working conditions are uncommon. Home factors slightly disturb promotions. Tenure is short and there is a fluid labor market. There is a “sticky floor” for women; 3) in Korea, the gender gap of graduate’s with more than a bachelor’s degree is small. Men with no official title are concentrated in the low rank, and have long tenures. There is a “sticky floor” for men. There are two years of compulsory military service for young men. Despite this, many men are promoted to higher managerial positions in their lifetimes.
An Empirical Analysis of Substitution and Complementarity of Gender Labor Demand of Enterprises in Japan, Korea, and China: With a Factor Decomposition of Gender Wage Differentials  [PDF]
Hiromi Ishizuka
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.810125
Abstract: The purpose of this study is the effect of expansion of female labor demand on male labor demand for labor market reform to facilitate Japanese economic development. Firstly, the estimates using Hicks’ (1970) partial elasticity of complementarity and Allen’s (1938) partial elasticity of substitution revealed an increase in male labor demand when female labor demand increased in all three countries. The results were a relationship of complementarity in labor demand between male and female regular employees in the order of China, South Korea, Japan. However, a push factor or a pull factor is assumed to make up a complementarity relationship. Therefore secondly, the factor decomposition analysis of wage gap is used to investigate which factors are applicable. The gender wage gap consists of economic rationality and economic irrational discriminatory [Neumark (1988); Oaxaca and Ransom (1994)]. The gap was confirmed in all three countries. Although the actual gender average wage difference was small in China, “discriminatory preference theory” was suggested that there is underpayment of women in Japan and Korea. In Japan, as women have a high potential labor force participation rate, expansion of female labor demand seems promising as an economic policy, not least because of the declining population. Labor-related economic policies are needed, such as the creation of a fluid labor market in China, or the implementation of effective
Colon Mucosa Exhibits Loss of Ectopic MUC5AC Expression in Patients with Ulcerative Colitis Treated with Oral Tacrolimus
Tsutomu Mizoshita,Satoshi Tanida,Hironobu Tsukamoto,Keiji Ozeki,Takahito Katano,Masahide Ebi,Yoshinori Mori,Hiromi Kataoka,Takeshi Kamiya,Takashi Joh
ISRN Gastroenterology , 2013, DOI: 10.1155/2013/304894
Abstract: Background. Tacrolimus (FK506) is effective for patients with ulcerative colitis (UC). However, there are few reports on tacrolimus therapy (TT) with respect to the relationship with endoscopic and clinicopathologic findings. Methods. Thirty patients with moderate/severe active UC refractory to or dependent on corticosteroid were treated with oral tacrolimus. The expression of ectopic MUC5AC in the colon was pathologically analyzed before and at 12 weeks after TT, evaluating the Mayo score and steroid-sparing effects. Results. Both mean disease and endoscopic activity index scores were reduced at levels of statistical significance in 26 UC patients receiving more than one month of TT ( ). The dose of prednisolone was reduced by a statistically significant amount ( ), and 14 of the 26 patients (53.8%) had steroid-free status 12 weeks after TT. The decrease in ectopic MUC5AC expression in the mucous cells of the colon was significantly associated with endoscopic improvement of inflammation in the UC patients with TT ( ). Loss of ectopic MUC5AC expression was detected in all patients who had complete response. Conclusions. Tacrolimus appears to be effective for the treatment of moderate/severe UC patients. Loss of ectopic MUC5AC expression may be important for pathologic remission in the colon of UC patients. 1. Introduction Ulcerative colitis (UC) is an idiopathic, chronic, and inflammatory disorder characterized by diarrhea, rectal bleeding, abdominal pain, fever, anemia, and body weight loss [1, 2]. Corticosteroid (CS) therapy is administered to patients with UC when flare-ups occur [1, 3]. Most patients with UC initially respond to CS therapy, but about 20% of patients become steroid dependent within 1 year after CS therapy starts [4]. Steroid-free status is important for patients with UC because CSs often induce undesirable side effects such as diabetes mellitus, osteoporosis, and opportunistic infections [2, 5]. Tacrolimus (FK506) is effective for patients with UC refractory to or dependent on CS and is usually used as a rescue and bridging therapy before initiating azathioprine (AZA) or 6-mercaptopurine (6-MP) therapy [6–12]. Tacrolimus therapy is useful as an alternative therapy for steroid-refractory UC [13]. Tacrolimus induces inhibition of the transcription of the early activation genes encoding interleukin- (IL-) 2, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) that are responsible for the development of inflammation [6, 14]. A higher initial dose of tacrolimus has been observed to ensure achievement of target levels [15]. In a
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