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Search Results: 1 - 10 of 182 matches for " Hiromasa Nakayasu "
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Effects of Direct Switching Dual Bronchodilators between Dry Powder and Soft Mist Inhalers in COPD Patients  [PDF]
Taisuke Akamatsu, Toshihiro Shirai, Hiromasa Nakayasu, Kanami Tamura, Toshihiro Masuda, Shingo Takahashi, Yuko Tanaka, Hirofumi Watanabe, Yutaro Kishimoto, Kyohei Oishi, Mika Saigusa, Akito Yamamoto, Satoru Morita, Kazuhiro Asada
Open Journal of Respiratory Diseases (OJRD) , 2020, DOI: 10.4236/ojrd.2020.101002
Abstract: Objective: Dual bronchodilation with long-acting muscarinic antagonist and long-acting β2-agonist combinations are available worldwide in COPD patients. However, the choice of agents remains under debate. We hypothesized that switching devices between dry powder and soft mist inhalers without a wash-out period to mimic clinical practice would improve clinical symptoms and lung function. The aim of this study was to examine the effects of switching between once-daily glycopyrronium/indacaterol (GLY/IND) or umeclidinium/vilanterol (UMEC/VI), dry powder inhalers, and tiotropium/olodaterol (TIO/OLO), a soft mist inhaler, in COPD patients. Methods: This was a prospective, open-label, 8-week, observational study with follow-up. Subjects included 57 COPD patients, who attended outpatient clinics at Shizuoka General Hospital for routine check-ups between February and December 2015, receiving GLY/IND (50/110 μg) or UMEC/VI (62.5/25 μg). After an 8-week run-in period, medications were switched to TIO/OLO (5/5 μg). Study outcomes included patient’s global rating (PGR), modified MRC (mMRC), COPD assessment test (CAT), and spirometric and forced oscillatory parameters after 8 weeks. PGR used in this study was a 7-point scale ranging from 1 to 7, with 4 in the middle. Patients who consented to switch from TIO/OLO to GLY/IND or UMEC/VI were followed-up thereafter. Results: In total, 53 patients completed the study (mean age, 75 years; 48 males and 5 females; GOLD 1/2/3/4 = 19/27/6/1; mMRC 0/1/2/3/4 = 14/22/12/4/1; UMEC/VI 26, GLY/IND 27). PGR, mMRC, and CAT improved in 20 (38%), 9 (17%), and 15 patients (28%), respectively. Respiratory system resistance at 5 Hz (R5), 20 Hz (R20), and the difference between R5 and R20 (R5 - R20) significantly improved. In a follow-up of 16 patients after switching from TIO/OLO to UMEC/VI (9) or GLY/IND (7), PGR, mMRC, and CAT improved in 5 (31%), 3 (12%), and 4 patients (25%), respectively, and R20 significantly improved (p = 0.011). Conclusions: Switching dual bronchodilators between dry powder and soft mist inhalers improves symptoms and airway narrowing in some COPD patients.
On metric viscosity solutions for Hamilton-Jacobi equations of evolution type
Atsushi Nakayasu
Mathematics , 2014,
Abstract: This paper studies Hamilton-Jacobi equations of evolution type defined in a general metric space. We give a notion of a solution through optimal principles and establish a unique existence theorem of the solution for initial value problems. We also note a relationship between the notion of a solution and another notion based on characterization of the modulus of the gradient in the sense of [13].
Two approaches to minimax formula of the additive eigenvalue for quasiconvex Hamiltonians
Atsushi Nakayasu
Mathematics , 2014,
Abstract: Two different proofs for an inf-sup type representation formula (minimax formula) of the additive eigenvalues corresponding to first-order Hamilton-Jacobi equations are given for quasiconvex (level-set convex) Hamiltonians not necessarily convex. The first proof, which is similar to known proofs for convex Hamiltonians, invokes a Jensen-like inequality for quasiconvex functions instead of the standard Jensen's inequality. The second proof is completely different with elementary calculations. It is based on convergence of derivatives of mollified Lipschitz continuous functions whose proof is also given. These methods also relate to an approximation problem of viscosity solutions.
Preparation and Properties of Polyaniline in the Presence of Trehalose  [PDF]
Hirotsugu Kawashima, Hiromasa Goto
Soft Nanoscience Letters (SNL) , 2011, DOI: 10.4236/snl.2011.13013
Abstract: Oxidative polymerization of aniline in aqueous solution in the presence of trehalose was conducted. Fourier transform infrared spectroscopy confirmed successful preparation of polyaniline containing a trace amount of trehalose. Electron spin resonance spectroscopy revealed that electron spin concentration of the polyaniline increases with aniline/trehalose ratio in the polymerization. Scanning electron microscopy revealed that the polyaniline shows granular and porous morphology. Electrical conductivity of these polyanilines was in the order of 10-4 S/cm.
Preparation of Polyaniline/ZnO Films by Electrochemical Polymerization  [PDF]
Yuki Kaitsuka, Hiromasa Goto
Open Journal of Polymer Chemistry (OJPChem) , 2016, DOI: 10.4236/ojpchem.2016.61001
Abstract: A series of polyaniline (PANI)/zinc oxide (ZnO) nano-particle (diameter 70 nm) composite films were prepared by electrochemical polymerization in the presence of ZnO nanoparticle. Furthermore, PANI-ZnO/PVA (PVA = polyvinyl alcohol) double-layer system was prepared. We first report preparations of a photocatalyst/conducting polymer light absorber by using ZnO nano-particles.
Carbon Material with Fibonacci Parastichy Structure  [PDF]
Aohan Wang, Hiromasa Goto
Soft (Soft) , 2017, DOI: 10.4236/soft.2017.51001
Abstract: The curd of Romanesco broccoli was carbonized at 900°C under argon atmosphere in a gold furnace chamber. The carbonization afforded a carbon material with a fine logarithmic spiral on the surface, resembling the Fibonacci parastichy structure of the Romanesco broccoli flower bud. The carbonized “flower bud” structure was observed under scanning electron microscopy. Infrared absorption spectra and X-ray photoelectron spectroscopy measurements confirmed the chemical structure and component of the carbon material.
Lyotropic Liquid Crystal Electrochemical Polymerization of Thiophene-Based Monomers: Polymerization in Cholesteric Liquid Crystal and Columnar Phase  [PDF]
Naoto Eguchi, Hiromasa Goto
Soft (Soft) , 2017, DOI: 10.4236/soft.2017.52002
Abstract: Synthesis of conductive polymer poly([thiophene]-[benzo[1,2,3]thiadiazole] [thiophene]) (abbreviated as P(T-Btdaz-T)) was achieved by electrochemical polymerization in hydroxypropyl cellulose (HPC)/N,N-dimethylformamide (DMF) in liquid crystal state. The polymer thus obtained shows fingerprint texture, which is derived from helical structure of the HPC in cholesteric liquid crystal state. Fourier transform infrared spectroscopy measurements revealed that the polymer film is P(T-Btdaz-T)/HPC composite. Circular dichroism optical absorption spectroscopy measurements show that the polymer has the optical activity. Next, electrochemical polymerization of 3,4-ethylene-dioxythiophene (EDOT) was carried out in columnar phase liquid crystal. The polymer transcribes the columnar structure and shows optical structure resembling columnar liquid crystal electrolyte solution.
Supply Management Options for Tea Producing Countries: A Case Study on Indonesian Tea Product and its Competitors
Henry Yuliando,Nakayasu Akira
Journal of Applied Sciences , 2006,
Abstract: This study identified the factors and further discussed the supply management policies to improve the tea prices. The empirical analysis in present study was based on the concept of demand response or elasticity and export quota scheme. The simulation results from 1999-2003 indicated that with a reduction in the export volume, the prices and export earnings go up and vice versa. Similarly, appropriate measures for export selling prices and earnings are necessary in keeping the current situation of the Indonesian tea industry in view.
Study on the Factors Influencing the Consumption of Safe Vegetables in Hochiminh City, Vietnam
Hai Hoang,Akira Nakayasu
Journal of Applied Sciences , 2006,
Abstract: The aim of this study is to determine why consumption of safe vegetables1) remains low despite Vietnamese consumers` wish to consume safe vegetables for the sake of good health. Multiple regression analysis was applied to analyze socio-economic factors that may influence the consumption of safe vegetables. Results showed that price, income, education, age and the number of presence children in a family significantly affected the consumers` decision to use safe vegetables. This study also revealed that there are many issues involved in the consumption of safe vegetables such as: consumers did not know well or trust the quality of safe vegetables; the price of safe vegetables is too high. Therefore, lowering the price; controlling the quality of safe vegetables; educating both producers and consumers about food poisoning and its effects would help to promote the consumption of safe vegetables.
Regioselective Direct Carboxylation of 2-Naphthol with Supercritical CO2 in the Presence of K2CO3  [PDF]
Shigeki Furukawa, Kensuke Otokawa, Osamu Sasaki, Ken Nakayasu, Tatsuaki Yamaguchi
International Journal of Organic Chemistry (IJOC) , 2013, DOI: 10.4236/ijoc.2013.33028
Abstract: A direct regioselective preparation of 2-hydroxynaphthalene-6-carboxylic acid, a useful industrial intermediate of aro-matic polyester from 2-naphthol was conducted by use of excess amount of K2CO3 (10-fold molar to 2-naphthol) under supercritical CO2 at 10 MPa and 473 K. The obtained yield under this condition was ca. 20 mol% to 2-naphthol. The further investigations may provide an alternative process to the conventional Kolbe-Schmitt reaction, because of no use of strong alkali and recoverability of K2CO3. Theoretical explanation about the regioselectivity was achieved by means of DFT calculations.
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