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Search Results: 1 - 10 of 529 matches for " Hirofumi Kawakubo "
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Laparoscopic Submucosal Dissection for Gastrointestinal Stromal Tumor of the Stomach: A Novel Technique for Local Excision with a Minimal Curative Margin  [PDF]
Norihito Wada, Yoshiro Saikawa, Hiroya Takeuchi, Tsunehiro Takahashi, Rieko Nakamura, Hirofumi Kawakubo, Kaori Kameyama, Makio Mukai, Yuko Kitagawa
Surgical Science (SS) , 2012, DOI: 10.4236/ss.2012.310098
Abstract: Background: Laparoscopic wedge resection is accepted as a curative treatment for small- and mediumsized gastroin-testinal stromal tumors (GISTs) of the stomach. Conventional methods involving surgical staplers require relatively large lateral margins, which may cause deformity and postoperative dysfunction of the gastric remnant. In this study, we introduce a novel technique called laparoscopic submucosal dissection (LSD) in which the defects of the stomach are minimized and a microscopic negative margin is secured. Methods: The normal seromuscular layer of the gastric wall was dissected with a 5 mm lateral margin. Then, the submucosal tissue was divided carefully using a monopolar electrosurgical device with a curved spatula tip. Results: The operation time was 170 min, and the amount of bleeding was very small. We confirmed an intact pseudo-capsule and marginal subserosal or submucosal tissue of the tumor by histological analysis. The postoperative course was uneventful with no complications. Endoscopy showed minimal deformity of the gastric remnant. Conclusions: We think that LSD is a curative and less invasive treatment for GIST of the stomach. Further investigations are necessary to evaluate the oncological and functional outcomes of this procedure.
Mucosal hyperplasia in an uncovered portion of partially covered metal stent
Kazumichi Kawakubo,Hiroyuki Isayama,Naoki Sasahira,Hirofumi Kogure
World Journal of Gastrointestinal Endoscopy , 2012, DOI: 10.4253/wjge.v4.i9.432
Abstract: Covered self-expandable metal stents were developed to overcome tumor in-growth through the metal mesh. Stent migration is one of their malfunctions. Recently, the partially covered wallflex stent (PCWS) was developed with flared ends to prevent migration However, difficulty has been reported in its removal. We describe the removal of a PCWS embedded in mucosal hyperplasia at the uncovered proximal flared end, visualized by using SpyGlass cholangioscopy.
Clinical analysis of high serum IgE in autoimmune pancreatitis
Kenji Hirano, Minoru Tada, Hiroyuki Isayama, Kazumichi Kawakubo, Hiroshi Yagioka, Takashi Sasaki, Hirofumi Kogure, Yousuke Nakai, Naoki Sasahira, Takeshi Tsujino, Nobuo Toda, Kazuhiko Koike
World Journal of Gastroenterology , 2010,
Abstract: AIM: To clarify the clinical significance of high serum IgE in autoimmune pancreatitis (AIP).METHODS: Forty-two AIP patients, whose IgE was measured before steroid treatment, were analyzed. To evaluate the relationship between IgE levels and the disease activity of AIP, we examined (1) Frequency of high IgE (> 170 IU/mL) and concomitant allergic diseases requiring treatment; (2) Correlations between IgG, IgG4, and IgE; (3) Relationship between the presence of extrapancreatic lesions and IgE; (4) Relationship between clinical relapse and IgE in patients treated with steroids, and (5) Transition of IgE before and after steroid treatment.RESULTS: IgE was elevated in 36/42 (86%) patients. Concomitant allergic disease was observed in seven patients (allergic rhinitis in three, bronchial asthma in three, and urticaria in one). There were no significant correlations between IgG, IgG4, and IgE (r = -0.168 for IgG, and r = -0.188 for IgG4). There was no significant difference in IgE in the patients with and without extrapancreatic lesions (526 ± 531 IU/mL vs 819 ± 768 IU/mL, P = 0.163), with and without clinical relapse (457 ± 346 IU/mL vs 784 ± 786 IU/mL, P = 0.374). There was no significant difference in IgE between before and after steroid treatment (723 ± 744 IU/mL vs 673 ± 660 IU/mL, P = 0.633).CONCLUSION: Although IgE does not necessarily reflect the disease activity, IgE might be useful for the diagnosis of AIP in an inactive stage.
Recent progress and limitations of chemotherapy for pancreatic and biliary tract cancers
Minoru Tada, Yousuke Nakai, Takashi Sasaki, Tsuyoshi Hamada, Rie Nagano, Dai Mohri, Koji Miyabayashi, Keisuke Yamamoto, Hirofumi Kogure, Kazumichi Kawakubo, Yukiko Ito, Natsuyo Yamamoto, Naoki Sasahira, Kenji Hirano, Hideaki Ijichi, Keishuke Tateishi, Hi
World Journal of Clinical Oncology , 2011,
Abstract: Gemcitabine chemotherapy has been the standard for advanced pancreatic cancer for more than a decade. New oral fluoropyrimidines such as S-1 and capecitabine are other key drugs. Gemcitabine plus erlotinib was the only combination therapy that significantly prolonged survival, although the effect was minimal. Little or no improvement in survival with recent molecular-targeted drugs might be attributed to the very high incidence of K-ras gene mutation in pancreatic cancer. Recently, the non-gemcitabine-based-regimen of FOLFIRINOX showed significantly greater overall survival compared with gemcitabine for the first time. For biliary tract cancer, gemcitabine plus cisplatin combination chemotherapy has been proved to significantly prolong survival and will become the standard therapy. Further improvement in survival is expected by the addition of cetuximab.
Avalia??o das mudan?as na linha de costa na foz do rio Ribeira de Iguape/desembocaura lagunar da Barra do Icapara (litoral sul de S?o Paulo - Brasil) utilizando dados do Landsat MSS, TM e ETM+
Shinji Kawakubo, Fernando;
Investigaciones geográficas , 2009,
Abstract: multitemporal landsat mss, tm e etm+ data were used to assess the morphological coastline changes at ribeira de iguape river outlet and barra do icapara lagoonal mouth, southern coastal region of the state of s?o paulo, brazil. fraction images of soil, shadow/water and vegetation were created through a spectral linear mixture modeling (slmm) and related with erosive and depositional features. after that, the fraction images were classified using a región growing segmentation and a supervised classification by región. comparing the classifications generated (1976, 1980, 1993 and 2000) was possible to assess the dynamic actions which occur in the área. the results show that erosive and depositional processes are extremely fast and the geomorphic features can be changed in a short period of time
Avalia o das mudan as na linha de costa na foz do rio Ribeira de Iguape/desembocaura lagunar da Barra do Icapara (litoral sul de S o Paulo - Brasil) utilizando dados do Landsat MSS, TM e ETM+
Fernando Shinji Kawakubo
Investigaciones geográficas , 2009,
Abstract: Se utilizaron imágenes multitemporales generadas por los sensores MSS, TM e ETM+ para la evaluación de los cambios morfológicos relacionados con la línea de costa en la desembocadura del río Ribeira de Iguape/desembocadura lagunar de la Barra do Icapara, litoral sur del Estado de S o Paulo (Brasil). Se crearon imágenes fracción representando las proporciones del suelo, sombra/agua limpia y vegetación para cada conjunto de datos por medio de un modelo linear de mezcla espectral (MLME) relacionándolas con las formas erosivas y de deposición. Las imágenes fracción fueron clasificadas usando una técnica de segmentación por crecimiento de regiones y clasificación supervisada por regiones. La comparación de las clasificaciones (1976, 1980, 1993 y 2000) posibilitó evaluar la dinámica de los procesos que actúan en esa región. Los resultados mostraron que los procesos erosivos y de deposición son extremamente dinámicos y las entidades geomórficas son susceptibles a los cambios en un cuarto intervalo de tiempo.
A standard Hamiltonian formulation for the dynamical Casimir effect
Toru Kawakubo,Katsuji Yamamoto
Physics , 2008,
Abstract: We present a quantum description of photon creation via dynamical Casimir effect based on the standard Hamiltonian formulation. The particle representation is constructed in the expansion of field operators fixed with the initial modes. The Hamiltonian is presented in terms of the creation and annihilation operators with the time-varying couplings which originate from the external properties such as an oscillating boundary or a plasma mirror of a semiconductor slab. Some consideration is also made for the experimental realization with a semiconductor plasma mirror.
Optical homodyne detection in view of joint probability distribution
Toru Kawakubo,Katsuji Yamamoto
Physics , 2010, DOI: 10.1103/PhysRevA.82.032102
Abstract: Optical homodyne detection is examined in view of joint probability distribution. It is usually discussed that the relative phase between independent laser fields are localized by photon-number measurements in interference experiments such as homodyne detection. This provides reasoning to use operationally coherent states for laser fields in the description of homodyne detection and optical quantum-state tomography. Here, we elucidate these situations by considering the joint probability distribution and the invariance of homodyne detection under the phase transformation of optical fields.
Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations
Hirofumi Noguchi
Journal of Transplantation , 2011, DOI: 10.1155/2011/783168
Abstract: Pancreatic islet transplantation is a promising option for the treatment of type 1 diabetic patients. After the successful demonstration of the Edmonton protocol, islet transplantation has advanced significantly on several fronts, including improved pancreas procurement and preservation systems. Since we frequently use pancreata from donors after cardiac death in Japan,we have applied the in situ regional organ cooling system for pancreas procurement to reduce the warm ischemic time. To reduce the apoptosis of pancreatic tissue during cold preservation, we have applied the ductal injection of preservation solution. For pancreas preservation, we use modified Kyoto solution, which is advantageous at trypsin inhibition and less collagenase inhibition. In this paper, we show pancreas procurement and preservation in our group for islet transplantation.
Tribochemistry of Ionic Liquid Lubricant on Magnetic Media
Hirofumi Kondo
Advances in Tribology , 2012, DOI: 10.1155/2012/526726
Abstract: The newly synthesized perfluoropolyether (PFPE) ionic liquid whose terminal group is an ammonium salt with a carboxylic acid has better frictional properties when compared to the conventional PFPEs. Stick-slip motion was not observed even for the smooth surface for the modified PFPE tape. The friction is almost independent of the PFPE structure, but depends on the amine structures. The ammonium salt being tightly anchored to the rubbing surface covers uniformly, which leads to better lubricity. The higher dispersive interaction of the hydrophobic group of the amine is endowed with a compensating friction reduction. Steric hindrance of the hydrophilic group causes a high friction. Based on these findings, a saturated long chain ammonium salt is the best selection. Moreover, the modified PFPEs are dissolved in alcohol and hexane, which makes practical use convenient without any environmental problems. These ionic lubricants invented around 1987 have been used for magnetic tapes for about a quarter century because of their good lubricity and are reviewed in this paper. 1. Introduction Magnetic recording systems have been responsible for the widespread and inexpensive recording of sound, video, and information processing. Despite the availability of other means of storing data, such as optical recordings and semiconductor devices, magnetic recording media have the advantages of low cost, stable storage, a relatively higher data transfer rate, a relatively short seek time, and high volumetric storage capacity [1]. 2. Hard Disk Drive Systems (HDDs) In current hard disk drive (HDD) systems, a rigid disk is rotated by a spindle motor at a speed of 10000 revolutions per minute (rpm). Information is written and read by a magnetic head with a tiny electric current attached to the end of the slider. The physical spacing between the magnetic sensors and the disk is down to almost 10?nm in recent systems, and it will be necessary to be within 5–7?nm for areal densities in the Tbin?2 range [2]. The read/write magnetic heads are mounted in the slider and travel across the data zone during the reading and writing operations. However, when the drive stops, this head assembled device rests in the landing zone which is typically textured in order to reduce wear during contact-start-stop (CSS) operations. Most drives require that the static and kinetic friction forces at the head-media-interface (HMI) remain low under extreme environmental conditions and after the required number of CSS that is usually 10,000 or greater [3]. The rigid disk consists of an Al-Mg alloy or
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