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Search Results: 1 - 10 of 3273 matches for " Hirachan Mangal Prasad "
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Percutaneous Endoscopic Lumbar Spine Surgery for Lumbar Disc Herniation and Lumbar Spine Stenosis: Emphasizing on Clinical Outcomes of Transforaminal Technique  [PDF]
Singh Ratish, Zeng-Xin Gao, Hirachan Mangal Prasad, Zhang Pei, Dangol Bijendra
Surgical Science (SS) , 2018, DOI: 10.4236/ss.2018.92007
Abstract: Lumbar Disc Herniation and Lumbar Spine Stenosis are the most common spine diseases which are mainly due to age related Spine degeneration. Diagnosis of both Lumbar Disc Herniation and Lumbar Spine Stenosis depends on clinical findings as well as radiological investigations. Treatment of choice of these conditions is on the basis of the patient conditions. Surgical treatment is the option only when the conservative treatment does not improve the patient’s clinical condition. Advancement and improvement of the technology have resulted in the traditional open surgical treatment into minimal invasive surgery. Intervention of the different surgical instruments with expert spinal surgeons had made percutaneous endoscopic lumbar Spine surgery as one of the preferred choices of surgery for treating Lumbar Disc Herniation and Lumbar Spine Stenosis. The concept of percutaneous endoscopic surgery for lumbar region is to provide surgical options without producing iatrogenic morbidity associated with the open surgical procedures. Conventionally, there are different approaches/techniques for Percutaneous Endoscopic Lumbar Spine Surgery, but in this review we are mainly focusing on the Transforaminal Technique. Regarding the Lumbar Disc Herniation treatment with transforaminal approach, a number of articles have been published due to which we mainly focused on those articles which were published after 2009 onwards. While fewer articles related to Lumbar Spine Stenosis treatment with Transforaminal approach were found, we tried to brief out all those articles. On the basis of comparative study of different surgeries done for Lumbar Disc Herniation and Lumbar Spine Stenosis, Percutaneous Transforaminal endoscopic Lumbar Surgery provides a substantial benefit. Transforaminal approach for treating Lumbar Disc Herniation and Lumbar Spine Stenosis is safe and effective. The Percutaneous Transforaminal Endoscopic Lumbar Surgery has advantage as it is performed under local anesthesia with shorter length of hospitalization and early return to normal life. The clinical outcome of the patient that underwent Percutaneous Transforaminal Endoscopic Lumbar Surgery for Lumbar Disc Herniation and Lumbar Spine Stenosis is quite good in regard of its fewer complication and more benefits.
Clinical Outcome of Percutaneous Endoscopic Lumbar Surgery (PELS) in Treatment of Lumbar Disc Herniation  [PDF]
Mangal P. Hirachan, Zengxin Gao, Yucheng Lin, Ratish Singh
Open Journal of Orthopedics (OJO) , 2017, DOI: 10.4236/ojo.2017.74012
Abstract: Lumbar disc herniation is a spinal problem seen in both young and old people causing pain in the back with pain and numbness in lower extremity leading to disability limiting daily activities. When conservative treatments are ineffective, then it is treated by surgeries, more recently with minimal invasive percutaneous endoscopic lumbar surgery (PELS). One of the mostly accepted PELS by spinal surgeons is percutaneous transforaminal endoscopic lumbar discectomy, which can be performed for any age. The main aim of this review was to evaluate clinical outcome and safety based on the Oswestry Disable Index (ODI), Visual Analog Scale (VAS) and MacNab criteria and complications of PELS surgery and its advantages in clinical basis.
Inventory Control in Supply Chain Through Lateral Transshipment – A Case Study in Indian Industry
Dharamvir Mangal,Pankaj Chandna
International Journal of Engineering , 2009,
Abstract: Supply chain management emphasizes collaborative relationships between supply chain members. The purpose of this work is to examine the antecedents of retailer - retailer partnership and to explore its impact on the supply chain performance. We consider coordination among stocking locations through replenishment strategies that take explicitly into consideration transshipments, transfer of a product among locations at the same echelon level. A continuous review inventory system has been adopted, in which lateral transshipments are allowed. In general, if a demand occurs at a location and there is no stock on hand, the demand is assumed to be backordered or lost. Lateral transshipments serve as an emergency supply in case of stock out and the rule for lateral transshipments is to always transship when there is a shortage at one location and stock on hand at the other. The aim is to explore the role of lateral transshipment to control inventory and associated cost within supply chain and, from this, to develop an exploratory framework that assists understanding in the area. A simple and intuitive model is presented that enables us to characterize optimal inventory and transshipment policies for ‘n’ locations. The research is based on a case study of a bi-wheeler company in India by using its data and to strengthen its supply chain. This paper represents such an effort in that it integrates both inventory and transshipment components in the study of multi-location inventory systems. This work will enable the managers to overcome the uncertainties of demand and lead-time resulting into customer satisfaction and cost reduction.
Prevalence and risk factors for bronchial asthma in adults in Jaipur district of Rajasthan (India)
Gupta P,Mangal D
Lung India , 2006,
Abstract: No information is available on epidemiology of bronchial asthma in Rajasthan. A field study was therefore, undertaken to estimate prevalence of bronchial asthma and to define the risk factors influencing the disease prevalence in Jaipur district of the state using a previously validated questionnaire. Besides demographic data, information on smoking habits, domestic cooking fuel used, atopic symptoms, and family history suggestive of asthma was also collected. Multivariate logistic regression analysis was performed to calculate odds ratio of various potential risk factors. Data from 8863 respondents (5010 men, 3853 women) were analyzed after excluding children below 15 years of age. One or more respiratory symptoms were present in 5.3% of the subjects. Asthma was diagnosed in 1.86%, 1.44%, 0.51 and 0.38% of the rural male, rural female, urban male and urban female respondents respectively, with an overall prevalence of 0.96%. History of atopy in self and/or history of atopy/asthma in the first-degree relative were found to be the most important risk factor. Advancing age, usual residence in rural area and tobacco smoking, especially hookah smoking, were also associated with significantly higher odds of having asthma.
Development and evaluation of artemether parenteral microemulsion
Tayade N,Nagarsenker Mangal
Indian Journal of Pharmaceutical Sciences , 2010,
Abstract: The objective of the present investigation was to develop a parenteral microemulsion delivering artemether, a hydrophobic antimalarial drug and to evaluate antimalarial activity of the microemulsion in comparison to the marketed oily injection of artemether (Larither ). The microemulsion was evaluated for various parameters such as globule size, ability to withstand centrifugation and freeze-thaw cycling and effect of sterilization method on the drug content and globule size. The in vivo antimalarial activity of the microemulsion was evaluated in P. berghei infected mice in comparison to the Larither . The stability of the microemulsion was evaluated at 5o for 1 month. The microemulsion exhibited globule size of 113 nm and it could successfully withstand centrifugation and freeze-thaw cycling. The method of sterilization did not have any significant effect on the artemether content and globule size of the microemulsion. The microemulsion showed around 1.5-fold higher antimalarial activity and higher survival as compared to that of marketed artemether injection Larither and it showed a good stability at the end of 1 month.
Characterization of gelatin-sodium alginate complex coacervation system
Shinde Ujwala,Nagarsenker Mangal
Indian Journal of Pharmaceutical Sciences , 2009,
Abstract: A gelatin and sodium alginate complex coacervation system was studied and an effect of pH and colloid mixing ratios on coacervation was investigated. A colloid mixing ratio at which optimum coacervation occurred varied with the coacervation pH. Viscometric, turbidity and coacervate dry yield investigations were used to investigate optimum conditions for complex coacervation. Optimum coacervation occurred at pH 3.5 at a gelatin sodium alginate ratio 4:1. Coacervate and equilibrium fluid was analyzed for gelatin and sodium alginate contents and yields calculated on the basis of chemical analysis showed that optimum coacervation occurred at 25% sodium alginate fraction at pH 3.5.
A study on improvement of solubility of rofecoxib and its effect on permeation of drug from topical formulations
Kulkarni Madhur,Nagarsenkar Mangal
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: Rofecoxib, a practically insoluble cox-2 selective nonsteroidal antiinflammatory agent was subjected to improvement in solubility by preparing its binary mixtures with β cyclodextrin using various methods such as physical mixing, co-grinding, kneading with aqueous methanol and co-evaporation from methanol-water mixture. Characterization of the resulting binary mixtures by differential scanning calorimetry and X-ray diffraction studies indicated partial amorphization of the drug in its binary mixtures. In vitro dissolution studies exhibited remarkable increase in rate and extent of dissolution of the drug from its complexes with β -cyclodextrin. Pure rofecoxib as well as its co-ground binary mixture were formulated as aqueous gels for topical application. In vitro skin permeation of rofecoxib from formulation containing rofecoxib-cyclodextrin complex was significantly higher (p< 0.05) at 1, 2, 12, 18 and 24 hr as compared to formulation containing pure rofecoxib. This could be attributed to better solubility of binary mixture in the aqueous gel vehicle leading to greater concentration gradient between the vehicle and skin and hence higher flux of the drug.
ECG-guided central venous catheterization - can it truly detect internal jugular venous malpositioning of subclavian catheter
Jain Amit,Mangal Kishore
Annals of Cardiac Anaesthesia , 2011,
Relationship between Parental Involvement and Academic Achievement of Higher Secondary Students
Mangal Singh,vinod devgun
Review of Research , 2012,
Abstract: The present study aims to find out extent of relationship between academic achievement and parental encouragement representative sample of 400 higher secondary school students 200 male students and 200 female students were taken by using simple random sampling technique. the tools used were Parental Encouragement Scale by Kusum Agarwal (1998),Personal Data Form ( english version ). The study revealed a significant positive relationship between academic achievement and parental encouragement.
Novel LanT Associated Lantibiotic Clusters Identified by Genome Database Mining
Mangal Singh, Dipti Sareen
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091352
Abstract: Background Frequent use of antibiotics has led to the emergence of antibiotic resistance in bacteria. Lantibiotic compounds are ribosomally synthesized antimicrobial peptides against which bacteria are not able to produce resistance, hence making them a good alternative to antibiotics. Nisin is the oldest and the most widely used lantibiotic, in food preservation, without having developed any significant resistance against it. Having their antimicrobial potential and a limited number, there is a need to identify novel lantibiotics. Methodology/Findings Identification of novel lantibiotic biosynthetic clusters from an ever increasing database of bacterial genomes, can provide a major lead in this direction. In order to achieve this, a strategy was adopted to identify novel lantibiotic biosynthetic clusters by screening the sequenced genomes for LanT homolog, which is a conserved lantibiotic transporter specific to type IB clusters. This strategy resulted in identification of 54 bacterial strains containing the LanT homologs, which are not the known lantibiotic producers. Of these, 24 strains were subjected to a detailed bioinformatic analysis to identify genes encoding for precursor peptides, modification enzyme, immunity and quorum sensing proteins. Eight clusters having two LanM determinants, similar to haloduracin and lichenicidin were identified, along with 13 clusters having a single LanM determinant as in mersacidin biosynthetic cluster. Besides these, orphan LanT homologs were also identified which might be associated with novel bacteriocins, encoded somewhere else in the genome. Three identified gene clusters had a C39 domain containing LanT transporter, associated with the LanBC proteins and double glycine type precursor peptides, the only known example of such a cluster is that of salivaricin. Conclusion This study led to the identification of 8 novel putative two-component lantibiotic clusters along with 13 having a single LanM and 3 with LanBC genes. Putative lantibiotic clusters identified here hold the potential for the discovery of novel lantibiotic(s).
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