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Search Results: 1 - 10 of 616 matches for " Hilary Humphreys "
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Susceptibility of Staphylococcus aureus Isolates Causing Bloodstream Infection to the Antimicrobial Peptide LL-37  [PDF]
Sinead McNicholaswhj, Hilary Humphreys, Deirdre Fitzgerald Hughes
Open Journal of Medical Microbiology (OJMM) , 2013, DOI: 10.4236/ojmm.2013.31012

Both bacterial and host factors contribute to complicated bloodstream infection (BSI) caused by Staphylococcus aureus including methicillin-resistant S. aureus (MRSA). One bacterial factor that may affect the persistence of S. aureus in complicated BSI is reduced susceptibility to the innate immune defence peptide LL-37. LL-37 susceptibility among S. aureus isolates causing uncomplicated and complicated BSI was investigated. Following incubation with 2.5 μg/ml LL-37 for 1 h, the mean percentage survival was 67.6% and 74.9% for isolates causing uncomplicated and complicated BSI, respectively. Reduced LL-37 susceptibility may contribute to the persistence of S. aureus in complicated BSI.

Comparison of the antimicrobial activity of Ulmo honey from Chile and Manuka honey against methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.
Orla Sherlock, Anthony Dolan, Rahma Athman, Alice Power, Georgina Gethin, Seamus Cowman, Hilary Humphreys
BMC Complementary and Alternative Medicine , 2010, DOI: 10.1186/1472-6882-10-47
Abstract: Ulmo 90 honey was compared with manuka UMF? 25+ (Comvita?) honey and a laboratory synthesised (artificial) honey. An agar well diffusion assay and a 96 well minimum inhibitory concentration (MIC) spectrophotometric-based assay were used to assess antimicrobial activity against five strains of methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa.Initial screening with the agar diffusion assay demonstrated that Ulmo 90 honey had greater antibacterial activity against all MRSA isolates tested than manuka honey and similar activity against E. coli and P. aeruginosa. The MIC assay, showed that a lower MIC was observed with Ulmo 90 honey (3.1% - 6.3% v/v) than with manuka honey (12.5% v/v) for all five MRSA isolates. For the E. coli and Pseudomonas strains equivalent MICs were observed (12.5% v/v). The MIC for artificial honey was 50% v/v. The minimum bactericidal concentration for all isolates tested for Ulmo 90 honey was identical to the MIC. Unlike manuka honey, Ulmo 90 honey activity is largely due to hydrogen peroxide production.Due to its high antimicrobial activity, Ulmo 90 may warrant further investigation as a possible alternative therapy for wound healing.The use of honey as a traditional remedy for microbial infections dates back to ancient times [1]. The difference in antimicrobial potency among the different honeys can be more than 100-fold, depending on its geographical, seasonal and botanical source as well as through harvesting, processing and storage conditions [2]. The antimicrobial activity of honey is attributed largely to osmolarity, pH, hydrogen peroxide production and the presence of other phytochemical components e.g. methylglyoxal (MGO) [3]. In vivo, such activity may occur due to a synergistic relationship between any of these components rather than a single entity.Manuka honey which originates from the manuka tree (Leptospermum scoparium) is sold as a therapeutic agent world wide. The presence of MGO in
Developing an educational framework for the teaching of simulation within nurse education  [PDF]
Melanie Humphreys
Open Journal of Nursing (OJN) , 2013, DOI: 10.4236/ojn.2013.34049

The use of simulations as a teaching and learning tool within health care has increasing importance; simulations are seen as the major teaching method for practicing and assessing developing skills, knowledge, attitudes and meaningful decision-making within the field of nursing. Certainly the utilisations of simulations feature widely within many aspects of health care; a greater understanding of the key conceptual notions will serve to benefit all of those engaged within their application. This literature review has enabled the construction of a conceptual model for the teaching of simulation and can serve to promote the continued positive development of simulations within education. Through a consistent and insightful approach to teaching, dynamic learning will be assured within this very important aspect of engaging the nursing student within the learning process.

Andrew Humphreys
Kajian Malaysia , 2010,
Abstract: Since the Emergency, the Malaysian government has maintained a security policy which somewhat paradoxically combines the use ofcoercive, repressive legislation with a "hearts and minds" ideology.Following 9/11, I argue that the government has adapted this "heartsand minds" approach to the so-called War on Terror. The BarisanNasional governments of Mahathir Mohamad and Abdullah Badawi bothformulated ideological strategies designed to undermine the ideological strength of al-Qaeda and establish Malaysia as a leader of the Muslim world. Mahathir and Abdullah hinged their ideological approach on a state-constructed form of Islam and sought to portray Malaysia as a tolerant and moderate Muslim country. However, it will be shown that the use of ideology in Malaysia is often calibrated to ensure regime security rather than national security. The Malaysian government has used its ideology to promote elite interests and limit the discursive space for alternative and opposing viewpoints. Significantly, ideology has been used to justify crackdowns against genuine political opponents and to legitimise the political status quo.
Continuity in a Changing World: Malaysia’s Coercive Security Apparatus in the Age of Terror and Beyond
Andrew Humphreys
ASEAS : ?sterreichische Zeitschrift für Südostasienwissenschaften , 2009,
Abstract: The Malaysian government’s use of its repressive security legislation has had a significant impact on Malaysia’s modern political history. The focus of the present article is on the government’s use of its coercive security apparatus since the terrorist attacks of 9/11. My argument is that the apparatus is largely unchanged by the current global climate of the "War on Terror." Notably, Malaysia’s use of coercion has become increasingly less criticized by other governments, notably those in the West. Perhaps as a consequence, the government has become increasingly bold in its crackdowns against opposition elements. Following the political upheaval of the 2008 election, however, the future of the security apparatus is in question. --- Der Einsatz repressiver Sicherheitsgesetze durch die malaysische Regierung beeinflusste die moderne politische Geschichte Malaysias in nicht unerheblicher Weise. Dieser Beitrag analysiert den Einsatz des Sicherheitsapparates durch die malaysische Regierung seit den Terroranschla gen des 11. September 2001. Ich argumentiere, dass dieser Apparat im gegenwa rtigen weltweiten Klima des "Kriegs gegen den Terrorismus" gro tenteils unvera ndert blieb, dass jedoch gleichzeitig Malaysias Einsatz von Gewalt von anderen (vor allem westlichen) Regierungen weniger kritisiert wird als fru her. Eine mo gliche Konsequenz dessen ist die zunehmend ru cksichtslosere Vorgehensweise der Regierung gegen oppositionelle Stro mungen. Als Folge des politischen Umschwungs nach der Wahl 2008 steht die Zukunft des Sicherheitsapparates jedoch in den Sternen.
Elizabeth Humphreys
Physics , 2011,
Abstract: An astrophysical MASER (Microwave Amplification by Stimulated Emission of Radiation) is a source of stimulated spectral line emission. Maser emission is observed from the circumstellar envelopes of evolved stars, molecular clouds/star-forming regions, active galactic nuclei, supernova remnants, comets, and the Saturnian moons. It arises from molecules such as water (H2O), hydroxyl radicals (OH), methanol (CH3OH), formaldehyde (CH2O), silicon monoxide (SiO), ammonia (NH3), silicon sulphide (SiS), hydrogen cyanide (HCN), and from atomic hydrogen recombination lines. Masers are compact, of high brightness temperature, and often display narrow spectral line widths, polarized emission and variability. Free electron-cyclotron astrophysical masers additionally exist.
Probability theory and its models
Paul Humphreys
Mathematics , 2008, DOI: 10.1214/193940307000000347
Abstract: This paper argues for the status of formal probability theory as a mathematical, rather than a scientific, theory. David Freedman and Philip Stark's concept of model based probabilities is examined and is used as a bridge between the formal theory and applications.
Sustainability: A Platform for Debate
Hilary Tovey
Sustainability , 2009, DOI: 10.3390/su1010014
Abstract: Sustainability, as a new platform for debating sustainable development, drawing on a range of disciplinary perspectives and knowledges, provides an opportunity to ask some searching questions about this concept. This short paper seeks to remind ourselves of some of the questions we might ask (recognizing that there are also many others). It asks, in particular, about the organisation of work in contemporary societies and the sorts of relations to nature to which this gives rise; the sorts of knowledges which may help us to become more sustainable in our use of natural resources; the most useful modes of knowledge organization, transfer and dissemination for sustainability; and whether ‘sustainability’ is only or primarily about sustaining nature, or whether it must also include trying to create and sustain a certain kind of society.
Review of "Insect Pathogens Molecular Approaches and techniques" by S. P. Stock, J. Vandenberg, I. Glazer and N. Boemare
Hilary Hurd
Parasites & Vectors , 2009, DOI: 10.1186/1756-3305-2-28
Abstract: The multi authored book, consisting of sixteen chapters, is broken down into four themes; identification and diagnostics, evolutionary relationships and population genetics, host-pathogen interactions and genomics and genetic engineering. The chapters follow a standard format and consist of several short sections covering a wide range of topics related to the chapter heading. In some cases this results in a superficial overview, but all chapters contain a comprehensive list of references so that readers can follow up areas of specific interest. Most chapters deal with particular taxa of entomopathogenic organisms thus the reader may wish to focus upon chapters pertaining to their particular study group or take a comparative approach. Emphasis throughout is on molecular techniques, often discussed and evaluated from the point of view of the authors' personal experience. Although a useful glossary is provided the extensive use of acronyms warrants, in addition, a list of abbreviations.In the first section of the book authors of all the chapters emphasise the importance of molecular techniques to the revision of taxonomy and classification on a phylogenetic basis. Likewise in the second section authors emphasise the significant changes made to hypothesis concerning the evolutionary biology of insect pathogens following the application of DNA sequencing and analytical methods. Chapters on host-pathogen interactions cover an eclectic range of topics including the development of a baculovirus expression vector, tsetse fly immune responses and gene expression in tripartite nematode-bacterium-insect symbiosis. In the last chapter in this section and those in the final section on genomics and genetic engineering, detailed overviews of molecular strategies are given, a case study approach is frequently taken and future prospects and pitfalls discussed.As someone not directly involved with the fields of work presented in this book I found aspects of all chapters interesting. T
Interactions between parasites and insects vectors
Hurd, Hilary;
Memórias do Instituto Oswaldo Cruz , 1994, DOI: 10.1590/S0074-02761994000600007
Abstract: this review stresses the importance of studies that will provide a basic understanding of the pathology of parasite-infected vector insects. this knowledge should be a vital component of the very focussed initiatives currently being funded in the areas of vector control. vector fecundity reduction is discussed as an example of such pathology. underlying mechanisms are being investigated in a model system, hymenolepis diminuta-infected tenebrio molitor and in onchocerca-infected blackflies and plasmodium-infected anopheles stephensi. in all cases, host vitellogenesis is disrupted by the parasite and, in the tapeworm/beetle model, interaction between the parasite and the endocrine control of the insect's reproductive physiology has been demonstrated.
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