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Search Results: 1 - 4 of 4 matches for " Hermance Moussambi "
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Impact of Quantum Fluctuations on the Modulational Instability of a Modified Gross-Pitaevskii Equation with Two-Body Interaction  [PDF]
Camus Gaston Latchio Tiofack, Thierry Blanchard Ekogo, Hermance Moussambi, Alidou Mohamadou, Timoleon C. Kofane
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.38125
Abstract: Modulational instability conditions for the generation of localized structures in the context of matter waves in Bose-Einstein condensates are investigated analytically and numerically. The model is based on a modified Gross-Pitaevskii equation, which account for the energy dependence of the two-body scattering amplitude. It is shown that the modified term due to the quantum fluctuations modify significantly the modulational instability gain. Direct numerical simulations of the full modified Gross-Pitaevskii equation are performed, and it is found that the modulated plane wave evolves into a train of pulses, which is destroyed at longer times due to the effects of quantum fluctuations.
NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro
Matthew J Simmons, Ryan Serra, Nicole Hermance, Michelle A Kelliher
Breast Cancer Research , 2012, DOI: 10.1186/bcr3321
Abstract: Mammary gland development was analyzed by using whole-mount analysis and by flow cytometry in nulliparous transgenic mice maintained in the presence/absence of doxycycline (or intracellular NOTCH1). Mammary tumors were examined histologically and immunophenotyped by staining with antibodies followed by flow cytometry. Tumors were transplanted into mammary fat pads under limiting dilution conditions, and tumor-initiating cell frequency was calculated. Mammary tumor cells were also plated in vitro in a tumorsphere assay in the presence/absence of doxycycline. RNA was isolated from mammary tumor cell lines cultured in the presence/absence of doxycycline and used for gene-expression profiling with Affymetrix mouse arrays. NOTCH1-regulated genes were identified and validated by using quantitative real-time polymerase chain reaction (PCR). Mammary tumor-bearing mice were treated with doxycycline to suppress NOTCH1 expression, and disease recurrence was monitored.Similar to published studies, we show that constitutive expression of human intracellular NOTCH1 in the developing mouse mammary gland inhibits side branching and promotes luminal cell fate. These mice develop mammary adenocarcinomas that express cytokeratin (CK) 8/18. In vivo limiting-dilution analyses revealed that these mammary tumors exhibit functional heterogeneity and harbor a rare (1/2,978) mammary tumor-initiating cell population. With this dox-regulated NOTCH1 mammary tumor model, we demonstrate that NOTCH1 inhibition results in mammary tumor regression in vivo and prevents disease recurrence in four of six tumors tested. Consistent with the in vivo data, NOTCH1 inhibition reduces mammary tumorsphere activity in vitro. We also identify the embryonic stem cell transcription factor Nanog as a novel NOTCH1-regulated gene in tumorspheres and in mouse and human breast cancer cell lines.These data indicate that NOTCH1 inhibition results in mammary tumor regression in vivo and interferes with disease recurrence.
Omega-3 fatty acids plus rosuvastatin improves endothelial function in South Asians with dyslipidemia
Catalin Mindrescu,Rakesh P Gupta,Eileen V Hermance,Mary C DeVoe
Vascular Health and Risk Management , 2008,
Abstract: Catalin Mindrescu1,2,3, Rakesh P Gupta1,3, Eileen V Hermance1, Mary C DeVoe1, Vikas R Soma1, John T Coppola1,2, Cezar S Staniloae1,21Comprehensive Cardiovascular Center, Saint Vincent’s Hospital Manhattan, New York, NY, USA; 2New York Medical College, Valhalla, NY, USA; 3Rakesh P Gupta and Catalin Mindrescu contributed equally to this article.Background: The present study was undertaken to investigate the effect of statins plus omega-3 polyunsaturated fatty acids (PUFAs) on endothelial function and lipid profile in South Asians with dyslipidemia and endothelial dysfunction, a population at high risk for premature coronary artery disease.Methods: Thirty subjects were randomized to rosuvastatin 10 mg and omega-3-PUFAs 4 g or rosuvastatin 10 mg. After 4 weeks, omega-3-PUFAs were removed from the first group and added to subjects in the second group. All subjects underwent baseline, 4-, and 8-week assessment of endothelial function and lipid profile.Results: Compared to baseline, omega-3-PUFAs plus rosuvastatin improved endothelial-dependent vasodilation (EDV: 1.42% to 11.36%, p = 0.001), and endothelial-independent vasodilation (EIV: 3.4% to 17.37%, p = 0.002). These effects were lost when omega-3-PUFAs were removed (EDV: 11.36% to 0.59%, p = 0.003). In the second group, rosuvastatin alone failed to improve both EDV and EIV compared to baseline. However, adding omega-3-PUFAs to rosuvastatin, significantly improved EDV ( 0.66% to 14.73%, p = 0.001) and EIV (11.02% to 24.5%, p = 0.001). Addition of omega-3-PUFAs further improved the lipid profile (triglycerides 139 to 91 mg/dl, p = 0.006, low-density lipoprotein cholesterol 116 to 88 mg/dl, p = 0.014).Conclusions: Combined therapy with omega-3-PUFAs and rosuvastatin improves endothelial function in South Asian subjects with dyslipidemia and endothelial dysfunction.Keywords: omega-3 fatty acids, endothelial function, South Asians, dyslipidemia, rosuvastatin
A Novel Live-Attenuated Vaccine Candidate for Mayaro Fever
William J. Weise,Meghan E. Hermance,Naomi Forrester,A. Paige Adams,Rose Langsjoen,Rodion Gorchakov,Eryu Wang,Maria D. H. Alcorn,Konstantin Tsetsarkin,Scott C. Weaver
PLOS Neglected Tropical Diseases , 2014, DOI: 10.1371/journal.pntd.0002969
Abstract: Mayaro virus (MAYV) is an emerging, mosquito-borne alphavirus that causes a dengue-like illness in many regions of South America, and which has the potential to urbanize. Because no specific treatment or vaccine is available for MAYV infection, we capitalized on an IRES-based approach to develop a live-attenuated MAYV vaccine candidate. Testing in infant, immunocompetent as well as interferon receptor-deficient mice demonstrated a high degree of attenuation, strong induction of neutralizing antibodies, and efficacy against lethal challenge. This vaccine strain was also unable to infect mosquito cells, a major safety feature for a live vaccine derived from a mosquito-borne virus. Further preclinical development of this vaccine candidate is warranted to protect against this important emerging disease.
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