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Search Results: 1 - 10 of 439 matches for " Hemant Tupalli "
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Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: A randomized controlled trial [ISRCTN38432711]
Mark JS Miller, Komal Mehta, Sameer Kunte, Vidyanand Raut, Jayesh Gala, Ramesh Dhumale, Anil Shukla, Hemant Tupalli, Himanshu Parikh, Paul Bobrowski, Jayesh Chaudhary
Journal of Inflammation , 2005, DOI: 10.1186/1476-9255-2-11
Abstract: Patients (n = 107) with mild to moderate osteoarthritis of the knee were randomly assigned to one of 4 groups; high dose sierrasil (3 g/day), low dose sierrasil (2 g/day), low dose sierrasil (2 g/day) + cat's claw extract (100 mg/day) or placebo, administered for 8 weeks. Treatment was double blinded. Primary efficacy variables were WOMAC scores (A, B, C and total). Visual analog score (VAS) for pain, consumption of rescue medication (paracetamol), and tolerability were secondary variables. Safety measures included vital signs and laboratory-based assays.Ninety-one of the 107 patients successfully completed the protocol. All four groups showed improvement in WOMAC and VAS scores after 8 weeks (p < 0.001), in all 3 groups receiving sierrasil the magnitude of benefits were greater vs. placebo (WOMAC Total 38–43% vs. 27%) but this was not statistically significant. In reference to baseline values sierrasil treated groups had a considerably faster onset of benefits. Placebo-treated individuals failed to show significant benefits at 4 weeks (11% reduction in total WOMAC). In contrast, after 1 or 2 weeks of therapy all the sierrasil groups displayed significant reductions in WOMAC scores (p < 0.05) and at week 4 displayed a 38–43% improvement. VAS was significantly improved at 4 weeks in all groups (p < 0.001) but was significantly greater in all sierrasil groups compared to placebo (p < 0.05). Rescue medication use was 28-23% lower in the herbomineral combination and high dose sierrasil groups although not statistically different from placebo (P = 0.101 and P = 0.193, respectively). Tolerability was good for all groups, no serious adverse events were noted and safety parameters remained unchanged.The natural mineral supplement, sierrasil alone and in combination with a cat's claw extract, improved joint health and function within 1–2 weeks of treatment but significant benefits over placebo were not sustained, possibly due to rescue medication masking. Sierrasil may offer
Towards more effective strategies for management of diabetes in Mauritius  [PDF]
Hemant Kassean
Open Journal of Preventive Medicine (OJPM) , 2012, DOI: 10.4236/ojpm.2012.22037
Abstract: Over the past 2 decades, the prevalence of diabetes in Mauritius has remained one of the highest in the world with no recent significant improvement. Mauritius ranked 2nd in 2002 and 4th in the world in 2009 with nearly one in five of its adult population above the age of 30 years being affected. Nearly half of those affected do not know that they have the disease and this adversely influences quality of life, risks of complications as well as morbidity and mortality. Despite the availability of free health services, over 50% of diabetes patients are poorly controlled and the risk of complications from diabetes such as cardiovascular diseases, renal failure, blindness, peripheral vascular and neurological diseases leading to lower limb amputations, remain very high. Despite continued efforts from the Ministry of Health and Quality of Life (MOH & QOL) to provide easily accessible diabetes care to all patients, the outcome remains poor. Most of the outpatients and primary health care centres are overcrowded and the set-up does not provide optimal care and attention. Diabetes care is very much medical-orientated and the health promotion campaigns have had little impact so far. Prevention and control of diabetes must become a priority. There is an urgent need for enhanced heath promotion and education, as evidence suggests that a change in diet and lifestyle can bring about significant improvement in the incidence and prevalence of diabetes. This paper examines some of the key actions/ proposals with respect to: evaluation of actions taken, health promotion campaigns, attitude and behavioural change, focused leadership and commitment, marketing strategies, effective segmentation and targeting.
A Note on Convergence of a Sequence and Its Applications to Geometry of Banach Spaces  [PDF]
Hemant Kumar Pathak
Advances in Pure Mathematics (APM) , 2011, DOI: 10.4236/apm.2011.13009
Abstract: The purpose of this note is to point out several obscure places in the results of Ahmed and Zeyada [J. Math. Anal. Appl. 274 (2002) 458-465]. In order to rectify and improve the results of Ahmed and Zeyada, we introduce the concepts of locally quasi-nonexpansive, biased quasi-nonexpansive and conditionally biased quasi-nonexpansive of a mapping w.r.t. a sequence in metric spaces. In the sequel, we establish some theorems on convergence of a sequence in complete metric spaces. As consequences of our main result, we obtain some results of Ghosh and Debnath [J. Math. Anal. Appl. 207 (1997) 96-103], Kirk [Ann. Univ. Mariae Curie-Sklodowska Sec. A LI.2, 15 (1997) 167-178] and Petryshyn and Williamson [J. Math. Anal. Appl. 43 (1973) 459-497]. Some applications of our main results to geometry of Banach spaces are also discussed.
A New Bandwidth Interval Based Forecasting Method for Enrollments Using Fuzzy Time Series  [PDF]
Hemant Kumar Pathak, Prachi Singh
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.24065
Abstract: In this paper, we introduce the concept of (4/3)? bandwidth interval based forecasting. The historical enrollments of the university of Alabama are used to illustrate the proposed method. In this paper we use the new simplified technique to find the fuzzy logical relations.
A Classification Algorithm to Improve the Design of Websites  [PDF]
Hemant Kumar Singh, Brijendra Singh
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.57057
Abstract: In very short time today web has become an enormously important tool for communicating ideas, conducting business and entertainment. At the time of navigation, web users leave various records of their action. This vast amount of data can be a useful source of knowledge for predicting user behavior. A refined method is required to carry out this task. Web usages mining (WUM) is the tool designed to do this task. WUM system is used to extract the knowledge based on user behavior during the web navigation. The extracted knowledge can be used for predicting the users’ future request when user is browsing the web. In this paper we advanced the online recommender system by using a Longest Common Subsequence (LCS) classification algorithm to classify users’ navigation pattern. Classification using the proposed method can improve the accuracy of recommendation and also proposed an algorithm that uses LCS method to know the user behavior for improvement of design of a website.
Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors
Hemant Sarin
Journal of Translational Medicine , 2009, DOI: 10.1186/1479-5876-7-77
Abstract: Malignant brain tumors consist of high-grade primary brain tumors such as malignant gliomas[1], and metastatic lesions to the brain from peripheral cancers such as lung, breast, renal, gastrointestinal tract, and melanoma[2,3]. Glioblastoma, the highest grade of malignant glioma, is the most common high-grade primary brain tumor in adults[4,5]. Overall, metastatic brain tumors are the most common brain tumors in adults, as 10% to 20% of patients with a malignant peripheral tumor develop brain metastases[2,3,6]. Even though malignant gliomas are generally treated with a combination of surgery, radiotherapy and systemic chemotherapy[7,8], and metastatic brain tumors with a combination of surgery and radiotherapy [9-11], the overall long-term prognosis of patients with these tumors, whether primary or metastatic, remains poor. Patient median survival times typically range between 3 and 16 months [12-16], and the percentage of patients alive at 5 years ranges between 3% and 10%[12,13,16,17]. In the treatment of both malignant gliomas and metastatic brain tumors, surgery and radiotherapy are more effective when used in combination[7-11,18-20]. In the treatment of malignant gliomas, there some minimal additional benefit of systemic chemotherapy[8,15,20-27]; and in the treatment of metastatic brain tumors, it remains unclear as to if there is any additional benefit of systemic chemotherapy[9,10,28-31].Systemic chemotherapy consists of small molecule chemotherapy drugs[8,32] that are drugs of molecular weights (MW) less than 1 kDa and diameters less than 1 to 2 nm. These small molecule chemotherapy drugs include traditional drugs that target the cell cycle, for example, DNA alkylating drugs, and newer investigational drugs that target cell surface receptors and associated pathways, for example, tyrosine kinase inhibitors[8,32]. The ineffectiveness of these chemotherapy drugs in treating malignant brain tumors has been attributed to the blood-brain barrier (BBB) being a sign
Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability
Hemant Sarin
Vascular Cell , 2010, DOI: 10.1186/2040-2384-2-14
Abstract: The findings and published data of studies on capillary wall ultrastructure and capillary microvascular permeability to lipid-insoluble endogenous and non-endogenous molecules from the 1950s to date were reviewed. In this study, the blood capillary types in different tissues and organs were classified on the basis of the physiologic upper limits of pore size to the transvascular flow of lipid-insoluble molecules. Blood capillaries were classified as non-sinusoidal or sinusoidal on the basis of capillary wall basement membrane layer continuity or lack thereof. Non-sinusoidal blood capillaries were further sub-classified as non-fenestrated or fenestrated based on the absence or presence of endothelial cells with fenestrations. The sinusoidal blood capillaries of the liver, myeloid (red) bone marrow, and spleen were sub-classified as reticuloendothelial or non-reticuloendothelial based on the phago-endocytic capacity of the endothelial cells.The physiologic upper limit of pore size for transvascular flow across capillary walls of non-sinusoidal non-fenestrated blood capillaries is less than 1 nm for those with interendothelial cell clefts lined with zona occludens junctions (i.e. brain and spinal cord), and approximately 5 nm for those with clefts lined with macula occludens junctions (i.e. skeletal muscle). The physiologic upper limit of pore size for transvascular flow across the capillary walls of non-sinusoidal fenestrated blood capillaries with diaphragmed fenestrae ranges between 6 and 12 nm (i.e. exocrine and endocrine glands); whereas, the physiologic upper limit of pore size for transvascular flow across the capillary walls of non-sinusoidal fenestrated capillaries with open 'non-diaphragmed' fenestrae is approximately 15 nm (kidney glomerulus). In the case of the sinusoidal reticuloendothelial blood capillaries of myeloid bone marrow, the transvascular transport of non-endogenous macromolecules larger than 5 nm into the bone marrow interstitial space takes pl
Influence of Variables in Drug Absorption and Their Implications
Hemant Joshi
Pharmaceutical Reviews , 2006,
Abstract: Prediction of drug absorption has become a powerful tool for the developmentof medicinal drugs and several attempts have focused on predicting drug absorptionfrom structure. However, there seem to exist several misperceptions towardsnature of absorption. Among those are intestinal absorption,permeability, fraction absorbed, and bioavailability, to some extent. In factthe these terms can neither be regarded as equivalents nor can be usedinterchangeably.Further the terms absorption; permeability, etc. are specific, discrete,fundamental properties of a drug molecule which cannot be solely predicted fromits structural representation but in real status, drug absorptionis a very complex process and depends upon various propertiesof molecule such as solubility and permeability,formulation aspects,physiological variables, including regional permeability differences(absorption window), pH, lumenal and mucosal enzymatic activity, intestinalmotility, etc. An attempt is been made in order to explore and understand the influence of the above said variables on drug absorption andtheir implications in developing predictive absorption algorithms.
For the Voyeur within Us
Hemant Shah
University of Toronto Medical Journal , 2001, DOI: 10.5015/utmj.v78i2.1032
Use of Foley catheter as a flap retainer
Saraiya Hemant
Indian Journal of Plastic Surgery , 2008,
Abstract: Keeping skin graft or a flap adherent to the underlying surface can sometimes be a difficult job, particularly inside a cavity. Different methods have been used for this function with varying success but the search is still on for an ideal pressure dressing.
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