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Search Results: 1 - 10 of 139406 matches for " Hemant K. Vyas "
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Vaccines and Antibodies for Therapeutic Use in Cancers  [PDF]
G. P. Talwar, Jagdish C. Gupta, M. Diwan, J. Frick, S. K. Sharma, S. N. Wadhwa, R. M. Gupta, S. K. Gupta, Shilpi Purswani, Hemant K. Vyas
Journal of Cancer Therapy (JCT) , 2016, DOI: 10.4236/jct.2016.76040
Abstract: This review describes briefly the beneficial use of two vaccines developed by us for treatment of cancers. The vaccine against Luteinizing Hormone Releasing Hormone (LHRH) is effective in carcinoma of prostate as well as in breast cancers dependent on androgens and estrogens respectively. LHRH being identical in both males and females, the same vaccine is usable in both Prostate and Breast steroid hormones-dependent-cancers. Monoclonal antibodies are finding therapeutic utility in several cancers, and many have received Drugs Regulatory approval. The monoclonals developed by us against hCG and against epitopes present on androgen-independent castration resistant prostate cancers are briefly recapitulated. Anti-hCG antibodies kill several cancers expressing hCG. An example is given of A549 lung carcinoma. MoAb730 and MoAb7B2G10 kill DU-145 and PC-3 androgen-independent castration resistant prostate cancer cells. Some cancers such as MOLT-4, a T-lymphoblastic leukemia, though expressing hCG are not killed by PiPP, the high affinity anti-hCG antibody. Linking the antibody to curcumin however works like a “Magic Bullet”. All MOLT-4 cells are killed by this conjugate, the antibody homes selectively to cancer cells expressing hCG to deliver curcumin which exercises the killing effect. A recombinant vaccine, hCGβ-LTB (human chorionic gonadotropin subunit β linked to B subunit of heat-labile enterotoxin of E. coli) has been made, which induces high titre bioeffective antibodies not only in BalbC, but also in other genetic strains of mice. The vaccine employs autoclaved Mycobacterium indicus pranii (MiP) as adjuvant. MiP invigorates both humoral and cell mediated immune responses against Human chorionic gonadotropin (hCG). Besides being a potent adjuvant, MiP used alone heals anogenital warts in humans and has the property of preventing and curing SP2/O Myelomas in mice.
Time to detoxify medical literature from guideline overdose
Dinesh Vyas,Arpita K Vyas
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i26.3331
Abstract: The current financial turmoil in the United States has been attributed to multiple reasons including healthcare expenditure. Health care spending has increased from 5.7 percent of the gross domestic product (GDP) in 1965 to 16 percent of the GDP in 2004. Healthcare is driven with a goal to provide best possible care available at that period of time. Guidelines are generally assumed to have the high level of certainty and security as conclusions generated by the conventional scientific method leading many clinicians to use guidelines as the final arbiters of care. To provide the standard of care, physicians follow guidelines, proposed by either groups of physicians or various medical societies or government organizations like National Comprehensive Cancer Network. This has lead to multiple tests for the patient and has not survived the test of time. This independence leads to lacunae in the standardization of guidelines, hence flooding of literature with multiple guidelines and confusion to patients and physicians and eventually overtreatment, inefficiency, and patient inconvenience. There is an urgent need to restrict articles with Guidelines and develop some strategy like have an intermediate stage of pre-guidelines and after 5-10 years of trials, a systematic launch of the Guidelines. There can be better ways than this for putting together guidelines as has been suggested by multiple authors and researchers.
Isolation of Monoclonal Antibodies with Predetermined Conformational Epitope Specificity
Anton M. Sholukh, Muhammad M. Mukhtar, Michael Humbert, Sosthène S. Essono, Jennifer D. Watkins, Hemant K. Vyas, Vivekanandan Shanmuganathan, Girish Hemashettar, Maria Kahn, Shiu-Lok Hu, David C. Montefiori, Victoria R. Polonis, Peter H. Schur, Ruth M. Ruprecht
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038943
Abstract: Existing technologies allow isolating antigen-specific monoclonal antibodies (mAbs) from B cells. We devised a direct approach to isolate mAbs with predetermined conformational epitope specificity, using epitope mimetics (mimotopes) that reflect the three-dimensional structure of given antigen subdomains. We performed differential biopanning using bacteriophages encoding random peptide libraries and polyclonal antibodies (Abs) that had been affinity-purified with either native or denatured antigen. This strategy yielded conformational mimotopes. We then generated mimotope-fluorescent protein fusions, which were used as baits to isolate single memory B cells from rhesus monkeys (RMs). To amplify RM immunoglobulin variable regions, we developed RM-specific PCR primers and generated chimeric simian-human mAbs with predicted epitope specificity. We established proof-of-concept of our strategy by isolating mAbs targeting the conformational V3 loop crown of HIV Env; the new mAbs cross-neutralized viruses of different clades. The novel technology allows isolating mAbs from RMs or other hosts given experimental immunogens or infectious agents.
A cost analysis of deliveries conducted in various health care settings in a city of India
Sheetal Vyas,Gneyaa S Bhatt,Kinnari I Gupta,Hemant Tiwari
Healthline , 2011,
Abstract: Background: Health is associated with various socio-economical issues which affects accessibility of a common man to the health care delivery systems. Cost analysis can be an important element in setting levels of user fees and can help sort out important economical issues. The present study was carried out to study the total cost borne in case of normal delivery and caesarean section in various health care settings and to compare them. Material & Methods: Personal interviews of 101 women delivered either by normal (ND) or by caesarean section (CS) in Government, Corporation or Private Hospital or in Home were taken. Information was collected regarding the direct medical cost, direct non medical cost and the indirect cost was analyzed by using appropriate statistical software. Results: Mean of Total cost in case of normal delivery was Rs. 575.13 (+ 172.04), Rs. 1839.73 (+ 887.07), Rs. 3035.56 (+ 1538.32), and Rs. 812.27 (+ 658.21) in Government, Corporation and Private Hospitals and in Home respectively. Mean of total cost in case of CS delivery was Rs 1823.67 (+ 801.13), Rs. 4232.87 (+ 1135.94), & Rs. 9754.67 (+ 2450.28) in respective institutions. Significant difference (p < 0.001) was found in total cost among above mentioned settings both for ND & CS. However after Post hoc analysis, no significant difference was found between total cost of normal delivery at home and at government hospital. Conclusions: The above analysis helped us to explore the cost of delivery care in above settings. As there was no significant difference found between total costs of normal delivery at home and at government hospital, people should be motivated for the Government hospital deliveries instead of home deliveries. Further research on long term outcome needs to be done.
Animal Bite Management Practices: Study at Three Municipal Corporation Hospitals of Ahmedabad
Vyas Sheetal, Gupta Kinnari, Bhatt Gneyaa, Tiwari Hemant
National Journal of Community Medicine , 2010,
Abstract: Context: Rabies is a deadly Zoonotic disease most often transmitted to humans through a dog bite. Most of these deaths could be prevented through post-exposure prophylaxis (PEP), including immediate wound washing, rabies immunoglobulin administration and vaccination. Aims: To study attitude and pre-treatment practices among the study population. Methods: Cross sectional study was carried out by conducting exit interview of 100 cases of animal bite each from three hospitals run by Ahmedabad Municipal Corporation. Observations: Total 300 cases of animal bites were studied in the present study. Most common biting animal was dog as 97.33% cases gave history of dog bite. Almost half of the cases belonged to age group less than 20 years with mean age of 19+ 20.2 years and male to female ratio was 3:1. Right lower limb was the most common (45.7%) biting site and majority (59%) had category III bites. Immediate pre-treatment of wound was practiced by 72% of cases before visiting hospitals however only 5.7% had gone for immediate washing of wound with soap and water. The local applications at the site of bite were tobacco snuff, red chilli, turmeric, and miscellaneous things like Garlic, Jaggery, Kerosene, Lime, Bandage, Soframycine, Ghee, Wheat flour etc. which were practiced by 66% of cases. The average time interval between bite and visiting the hospital was 32 hours. Conclusions: With the availability of safe and effective tissue culture vaccines prevention of rabies is virtually assured by immediate and appropriate post exposure treatment. There is need for creating awareness in public and medical community about proper wound management, judicious use of anti-rabies serum and use of modern tissue culture vaccine after animal bite.
Brain Enhancing Ingredients from āyurvedic Medicine: Quintessential Example of Bacopa monniera, a Narrative Review
Hemant K. Singh
Nutrients , 2013, DOI: 10.3390/nu5020478
Abstract: āyurveda, the science ( ved) of life ( ayu), owing its origin to Veda, the oldest recorded wisdom of human civilization written in 3500 BCE, contains extensive knowledge of various diseases and their therapeutic approaches. It essentially relied on nature and the immune system of an individual, and therapeutic interventions were introduced only to augment the immune system. āyurveda had eight specialties, including psycho-neuroscience (a combination of psychology, clinical psychology and psychiatry) and a unique promotive therapy encompassing nutrition, rejuvenation and geriatrics. The symptoms of various brain disorders, including memory disorder, were well defined. The goal of āyurveda was to help an individual to achieve his cherished goal of leading a healthy life of 100 years. To achieve this, great emphasis was laid on nutrition, diet and a good conduct by the two great exponents of āyurveda viz. Carak and Su?ruta. By following these regimens, an individual could lead a less stressful life free from emotional disturbances. Both Carak and Su?ruta had believed that these in combination with rasayana (rejuvenating) plants could enable an individual to lead a healthy life of 100?years.
An Exploratory Study of Experimental Tools for Wireless Sensor Networks  [PDF]
A.K. Dwivedi, O.P. Vyas
Wireless Sensor Network (WSN) , 2011, DOI: 10.4236/wsn.2011.37025
Abstract: The objective of this contribution is to present expositive review content on currently available experimental tools/services/concepts used for most emerging field Wireless Sensor Network that has capability to change many of the Information Communication aspects in the upcoming era. Currently due to high cost of large number of sensor nodes most researches in wireless sensor networks area is performed by using these experimental tools in various universities, institutes, and research centers before implementing real one. Also the statistics gathered from these experimental tools can be realistic and convenient. These experimental tools provide the better option for studying the behavior of WSNs before and after implementing the physical one. In this contribution 63 simulators/simulation frameworks, 14 emulators, 19 data visualization tools, 46 testbeds, 26 debugging tools/services/concepts, 10 code-updation/reprogramming tools and 8 network monitors has been presented that are used worldwide for WSN researches.
Distribution of Trichoderma spp. in cumin rhizosphere and their potential in suppression of wilt
Indian Phytopathology , 2012,
Abstract: In a sample survey of 15 conventional cumin fields of western Rajasthan the wilt caused by Fusarium oxysporum f. sp. cumini (Foe) was severe (20 - 35%) in five, moderate 15%) in six, and absent in four fields. Wilt incidence was high in fields where pearl millet was the rainy season crop, and less in those with summer fallow or summer ploughing. In the fields where the disease was either absent or low, high population density of Trichoderma spp. and low of Fusarium spp including Foe were recorded. Trichoderma spp. effectively inhibited the growth and I or sporulation of Foe in vitro through production of volatile and non-volatile antibiotics. In a pot trial T. aureoviride and T. harzianum as seed plus soil application resulted in significantly higher germination and lower disease. High densities of Trichoderma spp, and considerably low of Foe (over the untreated controls) were recorded in cumin rhizosphere at 30, 60 and 90 days of sowing. Combination of both the SCAs was more effective than the individual for wilt suppression.
Performance forecasting of common effluent treatment plant parameter by artificial neural network
Monika Vyas,Bharat Modhera,Vivek Vyas,A. K. Sharma
Journal of Engineering and Applied Sciences , 2011,
Abstract: Use of Artificial Neural Network (ANN) models is progressively increasingly to predict waste water treatment plant variables. This forecasting helps the operators to take corrective action and manage the process accordingly as per the norms. It is a proved useful device to surmount a few of the limitations of usual mathematical models for wastewater treatment plants for the reason that of their complex mechanisms, changing aspects-dynamics and inconsistency. This analysis considers the relevance of ANN techniques to predict influent and effluent biochemical oxygen demand (BOD) for effluent treatment process. Here, a three-layered feed forward ANN, using a back propagation learning algorithm, has been applied for predicting effluent BOD. After collecting historical plant data of BOD from common effluent treatment plant at Govindpura, Bhopal (India), Efficiency of plant for removal of BOD is found to be around 80%. (3 years data collected from the influent and effluent streams of the station.) Two ANN-based models for prediction of BOD concentrations at influent and effluent points were formed. The suitable architecture of the neural network models was ascertained after several steps of training and testing of the models. The ANN-based models were established to offer an efficient and a robust tool in prediction and modeling.
Impact of VAM and bacterial inoculants on wheat genotype C-306
Indian Phytopathology , 2012,
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