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Search Results: 1 - 10 of 2838 matches for " Helen Cramp "
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Symmetries of Spin Calogero Models
Vincent Caudrelier,Nicolas Crampé
Symmetry, Integrability and Geometry : Methods and Applications , 2008,
Abstract: We investigate the symmetry algebras of integrable spin Calogero systems constructed from Dunkl operators associated to finite Coxeter groups. Based on two explicit examples, we show that the common view of associating one symmetry algebra to a given Coxeter group $W$ is wrong. More precisely, the symmetry algebra heavily depends on the representation of $W$ on the spins. We prove this by identifying two different symmetry algebras for a $B_L$ spin Calogero model and three for $G_2$ spin Calogero model. They are all related to the half-loop algebra and its twisted versions. Some of the result are extended to any finite Coxeter group.
Heisenberg XXX Model with General Boundaries: Eigenvectors from Algebraic Bethe Ansatz
Samuel Belliard,Nicolas Crampé
Physics , 2013, DOI: 10.3842/SIGMA.2013.072
Abstract: We propose a generalization of the algebraic Bethe ansatz to obtain the eigenvectors of the Heisenberg spin chain with general boundaries associated to the eigenvalues and the Bethe equations found recently by Cao et al. The ansatz takes the usual form of a product of operators acting on a particular vector except that the number of operators is equal to the length of the chain. We prove this result for the chains with small length. We obtain also an off-shell equation (i.e. satisfied without the Bethe equations) formally similar to the ones obtained in the periodic case or with diagonal boundaries.
Associations of ATR and CHEK1 Single Nucleotide Polymorphisms with Breast Cancer
Wei-Yu Lin, Ian W. Brock, Dan Connley, Helen Cramp, Rachel Tucker, Jon Slate, Malcolm W. R. Reed, Sabapathy P. Balasubramanian, Lisa A. Cannon-Albright, Nicola J. Camp, Angela Cox
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068578
Abstract: DNA damage and replication checkpoints mediated by the ATR-CHEK1 pathway are key to the maintenance of genome stability, and both ATR and CHEK1 have been proposed as potential breast cancer susceptibility genes. Many novel variants recently identified by the large resequencing projects have not yet been thoroughly tested in genome-wide association studies for breast cancer susceptibility. We therefore used a tagging SNP (tagSNP) approach based on recent SNP data available from the 1000 genomes projects, to investigate the roles of ATR and CHEK1 in breast cancer risk and survival. ATR and CHEK1 tagSNPs were genotyped in the Sheffield Breast Cancer Study (SBCS; 1011 cases and 1024 controls) using Illumina GoldenGate assays. Untyped SNPs were imputed using IMPUTE2, and associations between genotype and breast cancer risk and survival were evaluated using logistic and Cox proportional hazard regression models respectively on a per allele basis. Significant associations were further examined in a meta-analysis of published data or confirmed in the Utah Breast Cancer Study (UBCS). The most significant associations for breast cancer risk in SBCS came from rs6805118 in ATR (p=7.6x10-5) and rs2155388 in CHEK1 (p=3.1x10-6), but neither remained significant after meta-analysis with other studies. However, meta-analysis of published data revealed a weak association between the ATR SNP rs1802904 (minor allele frequency is 12%) and breast cancer risk, with a summary odds ratio (confidence interval) of 0.90 (0.83-0.98) [p=0.0185] for the minor allele. Further replication of this SNP in larger studies is warranted since it is located in the target region of 2 microRNAs. No evidence of any survival effects of ATR or CHEK1 SNPs were identified. We conclude that common alleles of ATR and CHEK1 are not implicated in breast cancer risk or survival, but we cannot exclude effects of rare alleles and of common alleles with very small effect sizes.
Moms in motion: a group-mediated cognitive-behavioral physical activity intervention
Anita G Cramp, Lawrence R Brawley
International Journal of Behavioral Nutrition and Physical Activity , 2006, DOI: 10.1186/1479-5868-3-23
Abstract: A randomized, two-arm intervention design was used. Fifty-seven post natal women were randomized to one of two conditions: (1) a standard exercise treatment (SE) and (2) a standard exercise treatment plus group-mediated cognitive behavioral intervention (GMCB). Participants in both conditions participated in a four-week intensive phase where participants received standard exercise training. In addition, GMCB participants received self-regulatory behavioral skills training via six group-mediated counseling sessions. Following the intensive phase, participants engaged in a four-week home-based phase of self-structured exercise. Measures of physical activity, barrier efficacy, and proximal outcome expectations were administered and data were analyzed using ANCOVA procedures.ANCOVA of change scores for frequency, minutes, and volume of physical activity revealed significant treatment effects over the intensive and home-based phases (p's < 0.01). In addition, ANCOVA of change in mean barrier efficacy and proximal outcome expectations at the conclusion of the intensive phase demonstrated that GMCB participants increased their initial level of barrier efficacy and outcome expectations while SE participants decreased (p < 0.05).While both exercise programs resulted in improvements to exercise participation, the GMCB intervention produced greater improvement in overall physical activity, barrier efficacy and proximal outcome expectations.When examining the prevalence of physical inactivity by gender and age, women over the age of 25 are at an increased risk for sedentary behavior [1-3]. While current research identifies a number of possible barriers to regular physical activity, one particular barrier that occurs for women between the age of 25 and 35 is childbearing and the early years of raising children. These factors have been explored as one possible explanation for the sedentary behavior of young mothers [4]. The post natal period, defined as occurring immediately afte
Coordinate Bethe Ansatz for Spin s XXX Model
Nicolas Crampé,Eric Ragoucy,Ludovic Alonzi
Symmetry, Integrability and Geometry : Methods and Applications , 2011,
Abstract: We compute the eigenfunctions and eigenvalues of the periodic integrable spin s XXX model using the coordinate Bethe ansatz. To do so, we compute explicitly the Hamiltonian of the model. These results generalize what has been obtained for spin 1/2 and spin 1 chains.
Coordinate Bethe Ansatz for Spin s XXX Model
Nicolas Crampé,Eric Ragoucy,Ludovic Alonzi
Physics , 2010, DOI: 10.3842/SIGMA.2011.006
Abstract: We compute the eigenfunctions and eigenvalues of the periodic integrable spin s XXX model using the coordinate Bethe ansatz. To do so, we compute explicitly the Hamiltonian of the model. These results generalize what has been obtained for spin 1/2 and spin 1 chains.
Integrable Boundary for Quad-Graph Systems: Three-Dimensional Boundary Consistency
Vincent Caudrelier,Nicolas Crampé,Qi Cheng Zhang
Physics , 2013, DOI: 10.3842/SIGMA.2014.014
Abstract: We propose the notion of integrable boundary in the context of discrete integrable systems on quad-graphs. The equation characterizing the boundary must satisfy a compatibility equation with the one characterizing the bulk that we called the three-dimensional (3D) boundary consistency. In comparison to the usual 3D consistency condition which is linked to a cube, our 3D boundary consistency condition lives on a half of a rhombic dodecahedron. The We provide a list of integrable boundaries associated to each quad-graph equation of the classification obtained by Adler, Bobenko and Suris. Then, the use of the term "integrable boundary" is justified by the facts that there are B\"acklund transformations and a zero curvature representation for systems with boundary satisfying our condition. We discuss the three-leg form of boundary equations, obtain associated discrete Toda-type models with boundary and recover previous results as particular cases. Finally, the connection between the 3D boundary consistency and the set-theoretical reflection equation is established.
Eigenvectors of open XXZ and ASEP models for a class of non-diagonal boundary conditions
Nicolas Crampé,Eric Ragoucy,Damien Simon
Statistics , 2010, DOI: 10.1088/1742-5468/2010/11/P11038
Abstract: We present a generalization of the coordinate Bethe ansatz that allows us to solve integrable open XXZ and ASEP models with non-diagonal boundary matrices, provided their parameters obey some relations. These relations extend the ones already known in the literature in the context of algebraic or functional Bethe ansatz. The eigenvectors are represented as sums over cosets of the $BC_n$ Weyl group.
Osteoprotegerin Secretion by Mevastatin via p38MAPK and NF-kB  [PDF]
Helen Smith
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2012, DOI: 10.4236/ojra.2012.22006
Abstract: Osteoprotegerin (OPG) is a protein produced by many cell types that has the remarkable property of inhibiting bone loss. It does this by binding to the key bone resorptive cytokine, receptor activator of NF-kB ligand (RANKL). This cytokine is produced mainly by osteoblastic cells and is instrumental in osteoclast differentiation. If the ratio of RANKL:OPG increases, bone resorption increases and results in bone loss in diseases such osteoporosis, rheumatoid arthritis and hypercalcaemia of malignancy. Hence, if drugs can be found that increase OPG, this will decrease the activity of osteoclasts and therefore bone resorption. Statins are cholesterol lowering drugs that have recently been shown to increase bone formation in rodents. It was hypothesised from this finding that this could be due to an increase in OPG production. If these commonly prescribed drugs could be used to prevent bone loss or to increase bone formation then this may prove a useful means of reducing fracture risk in patients. Treating Saos-2 osteoblast-like cells in vitro with mevastatin increased OPG production and secretion through the mevalonate pathway. A failure of geranylgeranylation of Rho and/or farnesylation of Ras proteins leads to an increase in PI-3K activation then AKT activation leading to several different signaling pathways such as MAPK’s and NF-kB. NF-kB and p38MAPK inhibitors prevented the statin stimulation of OPG but not the decrease in cell number, suggesting that statins regulate OPG secretion via PI-3K, p38MAPK and NF-kB.
Religious Wear (Uniforms) in Psychiatry  [PDF]
Helen Bright
Open Journal of Psychiatry (OJPsych) , 2014, DOI: 10.4236/ojpsych.2014.42015
Abstract:

Uniforms represent more than just a body cover. There could be symbols of status, power, authority, values, beliefs, identity, wealth representation, self-protection, health and safety, suppression of individuality and identification on one hand by the wearer. The observers may perceive uniforms differently based on their experiences, expectations, education, perceptual ability, conformity, status, power, self-confidence, and need for trust and communication without barrier or judgment. Forty five adult mentally ill patients (21 female and 24 male) were administered questionnaires with Linkert Scale regarding how approachable or off-putting they find casual and religious wear in social worker. Significantly more patients preferred casual wear to religious. Chi squared test equals 28.689 with p value of less than 0.0001 for four degrees of freedom.

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