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Search Results: 1 - 10 of 606 matches for " Heiko Golpon "
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Endobronchial ultrasound guided fine needle aspiration versus transcervical mediastinoscopy in nodal staging of non small cell lung cancer: a prospective comparison study
Ruoyu Zhang, Christina Mietchen, Marcus Krüger, Bettina Wiegmann, Heiko Golpon, Sabine Dettmer, Axel Haverich, Patrick Zardo
Journal of Cardiothoracic Surgery , 2012, DOI: 10.1186/1749-8090-7-51
Abstract: From April 2008 to December 2009, 36 patients with mediastinal lymphadenopathy underwent simultaneous EBUS-FNA/ TM at our institution. Among them were 26 patients with confirmed or suspected NSCLC.A total of 133 samples were obtained by EBUS-FNA and 157 samples by TM. EBUS-FNA achieved significantly less conclusive, but more indeterminate pathological results in comparison to TM (78.7% vs. 98.6%, p?<?0.001; 14.9% vs. 1.4%, p?=?0.007). Less paratracheal nodes were sampled by EBUS-FNA (right: 46.2% vs. 88.5%, p?=?0.003; left: 23.1% vs. 65.4%, p?=?0.005), while sampling rates in the subcarinal localisation were comparable (96.2% vs. 80.8%, p?=?NS). Among patients with confirmed NSCLC and conclusive EBUS-FNA/ TM findings (n?=?18), the prevalence of N2/N3 disease was 66.7% (n?=?12) according to TM findings. Diverging nodal stages were found in five patients (27.8%). Three patients who were N2 negative in EBUS-FNA were upstaged to N2 or N3 by TM, two patients with N2 status in EBUS-FNA were upstaged to N3 by TM.Compared to TM, EBUS-FNA had a lower diagnostic yield and resulted in systematic mediastinal nodal understaging. At this point we suggest corroborating negative EBUS-FNA results by transcervical mediastinoscopy.
Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency
Rembert Koczulla, Danny Jonigk, Thomas Wolf, Christian Herr, Sarah Noeske, Walter Klepetko, Claus Vogelmeier, Nils von Neuhoff, Johanna Rische, Sabine Wrenger, Heiko Golpon, Robert Voswinckel, Maurizio Luisetti, Ilaria Ferrarotti, Tobias Welte, Sabina Janciauskiene
Orphanet Journal of Rare Diseases , 2012, DOI: 10.1186/1750-1172-7-29
Abstract: Explanted lungs of end-stage ZZ AATD-related (treated and non-treated with AAT augmentation therapy) and “normal” MM COPD, and liver biopsies from patients suffering from liver cirrhosis with and without ZZ AATD were used for gene expression analysis by Affymetrix microarrays or RT-PCR.A total of 162 genes were found to be differentially expressed (p-value?≤?0.05 and |FC|?≥?2) between MM and ZZ COPD patients. Of those, 134 gene sets were up-regulated and 28 were down-regulated in ZZ relative to MM lung tissue. A subgroup of genes, zinc finger protein 165, snail homolog 1 (Drosophila) (SNAI1), and Krüppel-like transcription factors (KLFs) 4 (gut), 9 and 10, perfectly segregated ZZ and MM COPD patients. The higher expression of KLF 9 and KLF10 has been verified in the replication cohort with AATD-related end-stage lung emphysema and liver cirrhosis. Furthermore, higher expression of KLF9, SNAI1 and DEFA1 was found in ZZ COPD lungs without augmentation therapy relative to MM COPD or ZZ COPD with augmentation therapy.These results reveal the involvement of transcriptional regulators of the zinc-finger family in COPD pathogenesis and provide deeper insight into the pathophysiological mechanisms of COPD with and without AATD.
GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells
Nils Nickel, Danny Jonigk, Tibor Kempf, Clemens L Bockmeyer, Lavinia Maegel, Johanna Rische, Florian Laenger, Ulrich Lehmann, Clemens Sauer, Mark Greer, Tobias Welte, Marius M Hoeper, Heiko A Golpon
Respiratory Research , 2011, DOI: 10.1186/1465-9921-12-62
Abstract: GDF-15 expression in normal lungs and lung specimens of PAH patients were studied by real-time RT-PCR and immunohistochemistry. Using laser-assisted micro-dissection, GDF-15 expression was further analyzed within vascular compartments of PAH lungs. To elucidate the role of GDF-15 on endothelial cells, human pulmonary microvascular endothelial cells (HPMEC) were exposed to hypoxia and laminar shear stress. The effects of GDF-15 on the proliferation and cell death of HPMEC were studied using recombinant GDF-15 protein.GDF-15 expression was found to be increased in lung specimens from PAH patients, com-pared to normal lungs. GDF-15 was abundantly expressed in pulmonary vascular endothelial cells with a strong signal in the core of plexiform lesions. HPMEC responded with marked upregulation of GDF-15 to hypoxia and laminar shear stress. Apoptotic cell death of HPMEC was diminished, whereas HPMEC proliferation was either increased or decreased depending of the concentration of recombinant GDF-15 protein.GDF-15 expression is increased in PAH lungs and appears predominantly located in vascular endothelial cells. The expression pattern as well as the observed effects on proliferation and apoptosis of pulmonary endothelial cells suggest a role of GDF-15 in the homeostasis of endothelial cells in PAH patients.GDF-15 is a protein belonging to the TGF-beta family, which includes several proteins involved in tissue homeostasis, differentiation, remodeling and repair [1]. As a pleiotropic cytokine it is involved in the stress response program of different cell types after cellular injury. Under normal conditions, GDF-15 is only weakly expressed in most tissues [2]. However GDF-15 is strongly upregulated in disease states such as acute injury, tissue hypoxia, inflammation and oxidative stress [3-6].In the cardiovascular system, GDF-15 is expressed in cardiomyocytes and other cell types including macrophages, endothelial cells, vascular smooth muscle cells, and adipocytes [1,7,8].
Where Do We Stand on Locating the Self?  [PDF]
Jakub Limanowski, Heiko Hecht
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.24049
Abstract: The subjective location of the Self in the body is a traditionally problematic question, and it can only be addressed from the first-person perspective. However, this does not preclude an empirical approach to the question. In the present study, we examined whether a large sample of participants would be willing and able to determine the perceived location of their Self. The main goal was to assess current beliefs about the nature of the Self and its assumed relation to specific bodily organs. Eighty-seven participants indicated the center of their Self by placing crosshairs on human silhouettes and abstract, non-human silhouettes with varying anatomy. Results show a clearly dominant role of the brain and the heart for Self-location in humans, but only of the brain for Self-location in abstract creatures. Moreover, results reveal that people believe there is one single point inside the human body where their Self is located.
A High-Performance Cellular Automaton Model of Tumor Growth with Dynamically Growing Domains  [PDF]
Jan Poleszczuk, Heiko Enderling
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.51017
Abstract:

Tumor growth from a single transformed cancer cell up to a clinically apparent mass spans many spatial and temporal orders of magnitude. Implementation of cellular automata simulations of such tumor growth can be straightforward but computing performance often counterbalances simplicity. Computationally convenient simulation times can be achieved by choosing appropriate data structures, memory and cell handling as well as domain setup. We propose a cellular automaton model of tumor growth with a domain that expands dynamically as the tumor population increases. We discuss memory access, data structures and implementation techniques that yield high-performance multi-scale Monte Carlo simulations of tumor growth. We discuss tumor properties that favor the proposed high-performance design and present simulation results of the tumor growth model. We estimate to which parameters the model is the most sensitive, and show that tumor volume depends on a number of parameters in a non-monotonic manner.

Towards Interoperability in Genome Databases: The MAtDB (MIPS Arabidopsis thaliana Database) Experience
Heiko Schoof
Comparative and Functional Genomics , 2003, DOI: 10.1002/cfg.278
Abstract: Increasing numbers of whole-genome sequences are available, but to interpret them fully requires more than listing all genes. Genome databases are faced with the challenges of integrating heterogenous data and enabling data mining. In comparison to a data warehousing approach, where integration is achieved through replication of all relevant data in a unified schema, distributed approaches provide greater flexibility and maintainability. These are important in a field where new data is generated rapidly and our understanding of the data changes. Interoperability between distributed data sources allows data maintenance to be separated from integration and analysis. Simple ways to access the data can facilitate the development of new data mining tools and the transition from model genome analysis to comparative genomics. With the MIPS Arabidopsis thaliana genome database (MAtDB, http://mips.gsf.de/proj/thal/db) our aim is to go beyond a data repository towards creating an integrated knowledge resource. To this end, the Arabidopsis genome has been a backbone against which to structure and integrate heterogenous data. The challenges to be met are continuous updating of data, the design of flexible data models that can evolve with new data, the integration of heterogenous data, e.g. through the use of ontologies, comprehensive views and visualization of complex information, simple interfaces for application access locally or via the Internet, and knowledge transfer across species.
Probing fusion dynamics with scattering experiments
Timmers, Heiko;
Brazilian Journal of Physics , 2003, DOI: 10.1590/S0103-97332003000200002
Abstract: the fusion of heavy nuclei at energies spanning the coulomb barrier involves the coupling of their relative motion to the internal degrees of freedom of the binary system formed by them. the fusion process is thus a realisation of the fundamental problem of surmounting a potential barrier in an environment of many other degrees of freedom. in the nuclear binary system the number, strength, and nature of the coupling interactions can be widely varied by selecting specific projectile-target combinations. strong coupling interactions result in a distribution of fusion barriers. these strong couplings can often be clearly identified by extracting representations of this fusion barrier distribution from precision measurements of the excitation function. alternative representations of the fusion barrier distribution can be obtained from scattering experiments, which generally involve less experimental effort. since they are not sensitive to the fusion barrier distribution at energies above the average fusion barrier, these alternative representations can only reveal coupling interactions with signatures in the low energy part of the distribution, such as coupling to positive q-value neutron transfer channels.
Knitting the kNet - Towards a Global Net of Knowledge
Heiko Haller
Open Journal of Knowledge Management , 2010,
Abstract: kNet is the vision of a future knowledge-sharing platform. In a fictitious scenario, this article describes how certain semantic Internet services could support scientific knowledge sharing and leverage knowledge transfer. In the following discussion, the core features of this platform are discussed and compared with existing state of the art systems.
Review: Jo Reichertz (2003). Die Abduktion in der qualitativen Sozialforschung Review: Jo Reichertz (2003). Die Abduktion in der qualitativen Sozialforschung [Abduction in Qualitative Social Research] Rese a: Jo Reichertz (2003). Die Abduktion in der qualitativen Sozialforschung [La abducción en la investigación social cualitativa]
Heiko Grunenberg
Forum : Qualitative Social Research , 2005,
Abstract: Jo REICHERTZ bietet mit seinem Buch "Die Abduktion in der qualitativen Sozialforschung" einen umfangreichen Einblick in das Ph nomen der Abduktion und geht dabei zum Teil über die der Publikationsreihe zugedachten Stellung als Grundlagenwerk hinaus. Er arbeitet den Begriff aus den überlegungen Charles Sanders PEIRCE' heraus und unterzieht ihn einer ausgiebigen Prüfung. Schlie lich leitet er daraus konkrete Implikationen für die Praxis qualitativer Sozialforschung ab. REICHERTZ bringt dabei zahlreiche Mythen und Hoffnungen ins Wanken, die nicht selten mit abduktivem Vorgehen hineingelegt worden sind. Dadurch ist das Buch ebenso aufschlussreich wie ernüchternd. Aus eben diesen Gründen ist die Lektüre zwar sehr empfehlenswert für alle, die an methodologisch gut untermauerter empirischer Forschung interessiert sind, denn es werden Anknüpfungspunkte für methodische Laien, wie auch für sehr fortgeschrittene Lesende geboten. Den Spielraum für abduktive Vorgehensweisen schr nkt es allerdings in berechtigter Weise ein. Das Buch ist ein gelungenes Beispiel dafür, das die Auseinandersetzung mit oftmals knochentrockenen aufbereiteten methodologischen Themen auch auf eine heitere und Interesse weckende Art geschehen kann. URN: urn:nbn:de:0114-fqs0502170 Jo REICHERTZ' study, "Abduction in Qualitative Social Research," delivers a detailed insight into the phenomenon of "abduction," by which he exceeds the introductory nature of this on-going series of publications. Focusing of Charles Sanders PEIRCE's perception of abduction, REICHERTZ extensively reevaluates the concept, conclusively deriving concrete implications for its practical application in qualitative social research. The author criticizes and dashes hopes and myths connected with the abductive procedure and, because of this, readers will find his study both instructive and disillusioning. The book is highly recommended for all those who are interested in well-founded empirical research because it offers points of interest for newcomers as well as experts in the field of empirical methods. The book rightly restricts the possibilities for abductive procedures. "Abduction in Qualitative Social Research" is an excellent example of how austere methodology can arouse interest in a cheerful manner. URN: urn:nbn:de:0114-fqs0502170 El estudio de Jo REICHERTZ "La abducción en la investigación social cualitativa" presenta una detallada interpretación del fenómeno de la "abducción", la cual excede el carácter introductorio de esta serie de publicaciones. Centrándose en la percepción de Charles Sanders PEIRCE sobre la abd
Review: Cornelia Müller (1998). Redebegleitende Gesten. Kulturgeschichte – Theorie – Sprachvergleich Review: Cornelia Müller (1998). Redebegleitende Gesten. Kulturgeschichte – Theorie – Sprachvergleich [Gestures with Speech. Cultural History, Theory, Comparison] Rese a: Cornelia Müller (1998). Redebegleitende Gesten. Kulturgeschichte – Theorie – Sprachvergleich [Gestos que acompa an el habla. Historia cultural – Teoría – Comparación de idiomas]
Heiko Droste
Forum : Qualitative Social Research , 2001,
Abstract: URN: urn:nbn:de:0114-fqs010268 URN: urn:nbn:de:0114-fqs010268 URN: urn:nbn:de:0114-fqs010268
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