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A role for spleen monocytes in post-ischemic brain inflammation and injury
Yi Bao, Eunhee Kim, Sangram Bhosle, Heeral Mehta, Sunghee Cho
Journal of Neuroinflammation , 2010, DOI: 10.1186/1742-2094-7-92
Abstract: Ischemia-reperfusion causes inflammation that attracts monocyte/macrophage cells to infarct [1-3]. Monocytes are circulating antigen-presenting leukocytes that play an important role in inflammation, T-cell differentiation, phagocytosis, and innate immunity [4,5]. It has been shown that circulating and spleen monocytes are similar in their morphology, phagocytic capability, and gene expression profiles [6]. The study also identified the spleen as a monocyte reservoir and their numbers in the spleen are several folds higher than in circulation [6]. In addition, the number of monocytes that migrate to the infarct area after a myocardial infarction well exceeds the number in circulation under homeostatic conditions [4]. These studies suggest a potential role of the spleen in deploying monocytes upon cerebral ischemia.Human and mouse monocytes exhibit distinct subsets that are reminiscent of macrophage phenotypes [5,7,8]. In mice, the subset that expresses a high level of the hematopoietic cell differentiation antigen Ly-6C (Ly-6Chi) also expresses the G-protein linked membrane protein, CCR2. The Ly-6Chi/CCR2+ monocyte subset is specifically recruited to an injury site by monocyte chemoattractant protein-1 (MCP-1), which is produced by the inflamed tissue, and become classically activated M1 macrophages. In contrast, the Ly-6Clow monocyte subset expresses CX3CR1, a receptor for the chemokine CX3CL1 (fractalkine), but is devoid of CCR2 expression. This anti-inflammatory Ly-6Clow/CCR2-/CX3CR1+ subset is recruited to normal tissue and develops into resident M2 macrophages that function in host defense and repair after injury [9,10]. Recruitment of the pro-inflammatory Ly-6Chi/CCR2+ subset to inflammatory sites is believed to be CCR2-dependent, since monocytes from CCR2-null mice do not traffic as efficiently into a myocardial infarct as CCR2+ monocytes [6]. Furthermore, CCR2-null mice were protective against cerebral inflammation following ischemia [11], suggesting that CC
Antifungal activity of some medicinal plants against Fusarium oxysporum f.sp. Iycopersici
Indian Phytopathology , 2011,
Abstract: The antifungal activity of ethanolic extracts of medicinal plants were evaluated against Fusarium oxysporum f.sp. Iycopersici involved in wilt disease of tomato. On screening the ethanolic extracts of different plant parts of 45
The Effects of Interferential Stimulation on Pain and Motion after Shoulder Surgery: A Prospective Randomized Study  [PDF]
Vishal Mehta
Surgical Science (SS) , 2015, DOI: 10.4236/ss.2015.610067
Abstract: Purpose: The purpose of this study is to determine the effects of interferential stimulation on pain and motion after shoulder surgery. Study Design: Randomized Controlled Trial. Methods: 102 patients undergoing arthroscopic rotator cuff repair or labral repair were prospectively randomized to receive either an interferential stimulation unit immediately after surgery (STIM) or not to receive the unit (NO-STIM). Each patient was measured for the range of motion (ROM) in forward flexion (FF), abduction (ABD), internal rotation (IR) and external rotation (ER). These measurements were taken prior to surgery and at the 6 weeks post-operative time point. Visual Analogue Scale (VAS) scores (0 - 10) and the amount of narcotic taken (standardized to 10 mg equivalents of hydrocodone) were measured and compared between the two groups at 2 days and 4 weeks post-operatively. 51 patients were excluded due to failure to document VAS scores and medication usage, lack of follow-up at the 6 weeks post-operative time point or hospitalization after surgery. This left 27 patients in the STIM group and 24 patients in the NO-STIM group. Results: No difference was found in the amount of narcotic taken after 2 days (STIM 14.37 ± 1.02, NO-STIM 15.88 ± 1.22, p = 0.34) or after 4 weeks (STIM 45.32 ± 4.36, NO-STIM 48.96 ± 5.50, p = 0.60). No difference in mean VAS scores were found at 2 days (STIM 5.56 ± 0.53, NO-STIM 4.63 ± 0.57, p = 0.24) or 4 weeks (STIM 1.68 ± 0.39, NO-STIM 1.38 ± 0.34, p = 0.57). At 6 weeks post-operatively, a difference was found in ER (STIM 62.5 ± 4.09, NO-STIM 50.4 ± 4.09, p = 0.04), and no differences found in FF (STIM 134.2 ± 5.29, NO-STIM 133.3 ± 4.85, p = 0.60), ABD (STIM 124.8 ± 6.22, NO-STIM 119.6 ± 5.42, p = 0.53) or IR (STIM 60.0 ± 3.69, NO-STIM 55.9 ± 3.03, p = 0.39). A post-hoc power analysis performed using an á = 0.05 revealed the study to be 90% powered to identify a difference of one narcotic equivalent between groups and 90% powered to identify a 0.3 difference in VAS scores. Conclusions: The use of an interferential stimulator in the immediate post-operative period had no effect on pain or narcotic usage following arthroscopic rotator cuff repair or labral repair. External rotation was significantly greater in the interferential stimulator group while no differences were found in other motion parameters.
Investigation of Crystallization Kinetics in Glassy Se and Binary Se98M2 (M=Ag, Cd, Zn) Alloys Using DSC Technique in Non-Isothermal Mode  [PDF]
Chandrabhan Dohare, Neeraj Mehta
Journal of Crystallization Process and Technology (JCPT) , 2012, DOI: 10.4236/jcpt.2012.24025
Abstract: The crystallization kinetics of glassy Se and binary Se98M2 (M=Ag, Cd, Zn) alloys have been studied at different heating rates (5, 10, 15, 20 Kmin-1) using Differential Scanning Calorimetric (DSC) technique. The crystallization temperature (Tc) is determined from exothermic peak obtained in DSC scans of present samples. The variation in peak crystallization temperature (Tc) with the heating rate (β) has been used to investigate the growth kinetics using Kissinger, Augis-Bennet and Matusita-Sakka models. The activation energy of crystallization (Ec) has been found to increase with Ag additive and to decrease with Zn and Cd additive. The value of various kinetic parameters such as rate constant (Kp), Avrami index (n), thermal stability (S) and Hruby number (Hr) have been calculated under non-isothermal mode. The maximum change in different kinetic parameters has been found after the incorporation of Ag additive.
Day surgery for cataracts and iris-clip implant insertions
Mehta Hemant,Mehta Mrinalini
Indian Journal of Ophthalmology , 1983,
Titanasilsesquioxane-Alkylaluminum Catalyst System for Ethylene Polymerization  [PDF]
Akshay Mehta, Gopal Tembe, Parimal Parikh, Girish Mehta
Modern Research in Catalysis (MRC) , 2012, DOI: 10.4236/mrc.2012.13005
Abstract: Homogeneous Ti(IV) complexes covalently anchored to Polyhedral Oligomeric Silsesquioxane (POSS) have been synthesized by the stoichiometric reaction between titanium(IV)alkoxide and (iso-Octyl)7Si7O9(OH)3. These catalyst precursors formulated as [Ti(OR)(iso-Octyl)7Si7O12] were characterized by physicochemical and spectroscopic methods. These supported catalysts are found to be active in polymerization of ethylene at high temperatures in presence of ethylaluminum sesquichloride (Et3Al2Cl3, EASC) as co-catalyst. The polyethylene obtained are generally linear, crystalline and display low molecular weight distribution. The microstructure of the polymer was analyzed by NMR and FT-IR spectroscopic methods which indicated a chain transfer reaction to aluminum. The unique molecular properties of PE formed has been compared with commercial micronized PE wax which find industrial applications in surface coating and ink formulations. The effect of reaction conditions on catalytic behaviour is described.
Thermo-Mechanical Processing of Iron-Phosphorous-Carbon Alloys  [PDF]
Yashwant Mehta, P. S. Mishra
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.101006
Abstract: Phosphorous is widely considered as an impurity in steels. Consequently, its role as an important alloying element in iron could never be established. The present paper deals with the exploitation of phosphorous as a useful alloying element in iron in conjunction with carbon by way of improved thermo-mechanical processing leading to a tough steel equivalent to high strength low alloy steels. It was observed that phosphorous is pushed towards ferrite grains by carbon which in turn forms pearlite along ferrite grains. Suitable adjustment in the amounts of carbon and phosphorous yields an attractive set of mechanical properties after appropriate processing. Typical chemistry and processing combinations yields UTS: 700 MPa and % El: 25% Area under the stress-strain curve: 60 Joules.
Numerical Polynomial Homotopy Continuation Method and String Vacua
Dhagash Mehta
Advances in High Energy Physics , 2011, DOI: 10.1155/2011/263937
Abstract: Finding vacua for the four-dimensional effective theories for supergravity which descend from flux compactifications and analyzing them according to their stability is one of the central problems in string phenomenology. Except for some simple toy models, it is, however, difficult to find all the vacua analytically. Recently developed algorithmic methods based on symbolic computer algebra can be of great help in the more realistic models. However, they suffer from serious algorithmic complexities and are limited to small system sizes. In this paper, we review a numerical method called the numerical polynomial homotopy continuation (NPHC) method, first used in the areas of lattice field theories, which by construction finds all of the vacua of a given potential that is known to have only isolated solutions. The NPHC method is known to suffer from no major algorithmic complexities and is embarrassingly parallelizable, and hence its applicability goes way beyond the existing symbolic methods. We first solve a simple toy model as a warm-up example to demonstrate the NPHC method at work. We then show that all the vacua of a more complicated model of a compactified M theory model, which has an structure, can be obtained by using a desktop machine in just about an hour, a feat which was reported to be prohibitively difficult by the existing symbolic methods. Finally, we compare the various technicalities between the two methods. 1. Introduction A lot of current research in string phenomenology is focused on developing methods to find and analyze vacua of four-dimensional effective theories for supergravity descended from flux compactifications. Stated in explicit terms, one is interested in finding all the vacua (usually, isolated stationary points) of the scalar potential of such a theory. In particular, given a K?hler potential and a superpotential , for uncharged moduli fields, the scalar potential is given by where is the K?hler derivative and is the inverse of . Once the vacua are found, one can then classify them by either using the eigenvalues of the Hessian matrix of or by introducing further constraints such as . Finding all the stationary points of a given potential , amounts to solving the stationary equations, that is, solving the system of equations consisting of the first derivatives of , with respect to all the fields, equated to zero. The stationary equations for arising in the string phenomenological models are usually nonlinear. In the perturbative limit, usually has a polynomial form. This is an important observation since we can then use
Pharmacovigilance: the devastating consequences of not thinking about adverse drug reactions: The burden of adverse drug reactions (ADRs) on patient care has been found to be high globally and is particularly high in South Africa
UC Mehta
Continuing Medical Education , 2011,
Order extension of order monomorphisms on a preordered topological space
Ghanshyam Mehta
International Journal of Mathematics and Mathematical Sciences , 1993, DOI: 10.1155/s0161171293000821
Abstract: This paper proves Nachbin-type extension theorems for infinitely many functions on a topological space equipped with a preorder.
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