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Search Results: 1 - 10 of 1158 matches for " Hector Lantigua "
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Nutritional support and brain tissue glucose metabolism in poor-grade SAH: a retrospective observational study
J Michael Schmidt, Jan Claassen, Sang-Bae Ko, Hector Lantigua, Mary Presciutti, Kiwon Lee, E Sander Connolly, Stephan A Mayer, David S Seres, Neeraj Badjatia
Critical Care , 2012, DOI: 10.1186/cc11160
Abstract: We used a retrospective observational cohort study of 50 mechanically ventilated poor-grade (Hunt-Hess 4 or 5) aneurysmal SAH patients who underwent brain microdialysis monitoring for an average of 109 hours. Enteral nutrition was started within 72 hours of admission whenever feasible. Intensive insulin therapy was used to maintain serum glucose levels between 5.5 and 7.8 mmol/l. Serum glucose, insulin and caloric intake from enteral tube feeds, dextrose and propofol were recorded hourly. Cerebral metabolic distress was defined as a lactate to pyruvate ratio (LPR) > 40. Time-series data were analyzed using a general linear model extended by generalized estimation equations (GEE).Daily mean caloric intake received was 13.8 ± 6.9 cal/kg and mean serum glucose was 7.9 ± 1 mmol/l. A total of 32% of hourly recordings indicated a state of metabolic distress and < 1% indicated a state of critical brain hypoglycemia (< 0.2 mmol/l). Calories received from enteral tube feeds were associated with higher serum glucose concentrations (Wald = 6.07, P = 0.048), more insulin administered (Wald = 108, P < 0.001), higher body mass index (Wald = 213.47, P < 0.001), and lower body temperature (Wald = 4.1, P = 0.043). Enteral feeding (Wald = 1.743, P = 0.418) was not related to brain glucose concentrations after accounting for serum glucose concentrations (Wald = 67.41, P < 0.001). In the presence of metabolic distress, increased insulin administration was associated with a relative reduction of interstitial brain glucose concentrations (Wald = 8.26, P = 0.017), independent of serum glucose levels.In the presence of metabolic distress, insulin administration is associated with reductions in brain glucose concentration that are independent of serum glucose levels. Further study is needed to understand how nutritional support and insulin administration can be optimized to minimize secondary injury after subarachnoid hemorrhage.Hyperglycemia, defined as serum glucose > 11 mmol/l after suba
Tonic-Clonic Activity at Subarachnoid Hemorrhage Onset: Impact on Complications and Outcome
Gian Marco De Marchis, Deborah Pugin, Hector Lantigua, Christopher Zammit, Prasanna Tadi, J. Michael Schmidt, M. Cristina Falo, Sachin Agarwal, Stephan A. Mayer, Jan Claassen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071405
Abstract: Objective Tonic-clonic activity (TCA) at onset complicates 3% to 21% of cases of subarachnoid hemorrhage (SAH). The impact of onset TCA on in-hospital complications, including seizures, remains unclear. One study associated onset TCA with poor clinical outcome at 6 weeks after SAH, but to our knowledge no other studies have confirmed this relationship. This study aims to assess the impact of onset TCA on in-hospital complications, poor functional outcome, mortality, and epilepsy at 3 months. Methods Analysis of a prospective study cohort of 1479 SAH patients admitted to Columbia University Medical Center between 1996 and 2012. TCA within 6 hours of hemorrhage onset was identified based on accounts of emergency care providers or family witnesses. Results TCA at onset was described in 170 patients (11%). Patients with onset TCA were younger (P = 0.002), presented more often with poor clinical grade (55% vs. 26%, P<0.001) and had larger amounts of cisternal, intraventricular, and intracerebral blood than those without onset TCA (all, P<0.001). After adjusting for known confounders, onset TCA was significantly associated with in-hospital seizures (OR 3.80, 95%-CI: 2.43–5.96, P<0.001), in-hospital pneumonia (OR 1.56, 95%-CI: 1.06–2.31, p = 0.02), and delayed cerebral ischemia (OR 1.77, 95%-CI: 1.21–2.58, P = 0.003). At 3 months, however, onset TCA was not associated with poor functional outcome, mortality, and epilepsy after adjusting for age, admission clinical grade, and cisternal blood volume. Conclusions Onset TCA is not a rare event as it complicates 11% of cases of SAH. New and clinically relevant findings are the association of onset TCA with in-hospital seizures, pneumonia and delayed cerebral ischemia. Despite the increased risk of in-hospital complications, onset TCA is not associated with disability, mortality, and epilepsy at 3 months.
Síndrome frágil X: Mutaciones dinámicas y su repercusión en otras enfermedades genéticas
Lantigua Cruz,Aracely;
Revista Cubana de Pediatr?-a , 1997,
Abstract: in this article, it is presented an updated review of the fragile x syndrome, both of their clinical and genetics aspects. it also refers to the impact the mechanisms of this peculiar mutation have had on the explanation of genetic phenomena such as the anticipation, which are characteristic of various diseases, mainly neuromuscular and neurodegenerative diseases. finally, it deals with the present approach not only of the clinical diagnosis of the fragile x syndrome, but also of the cytogenetic and mollecular one and with its repercussion on the prenatal diagnosis.
Síndrome frágil X: Mutaciones dinámicas y su repercusión en otras enfermedades genéticas
Aracely Lantigua Cruz
Revista Cubana de Pediatr?-a , 1997,
Abstract: En este artículo se presenta una revisión actualizada del síndrome frágil X, tanto en sus aspectos clínicos como genéticos. Se hace referencia al impacto que los mecanismos de esta peculiar mutación, han tenido en la explicación de fenómenos genéticos como la anticipación, característicos de varias enfermedades fundamentalmente neuromusculares y neurodegenerativas. Finalmente, se hace referencia al enfoque actual del diagnóstico del síndrome frágil X tanto clínico como citogenético y molecular, y a su repercusión en el diagnóstico prenatal. In this article, it is presented an updated review of the fragile X syndrome, both of their clinical and genetics aspects. It also refers to the impact the mechanisms of this peculiar mutation have had on the explanation of genetic phenomena such as the anticipation, which are characteristic of various diseases, mainly neuromuscular and neurodegenerative diseases. Finally, it deals with the present approach not only of the clinical diagnosis of the fragile X syndrome, but also of the cytogenetic and mollecular one and with its repercussion on the prenatal diagnosis.
Resultados energéticos de la remotorización de los ómnibus Girón VI con motores Yuchai
Raúl Ramos Lantigua
Avanzada Científica , 2011,
Abstract: En el trabajo se muestran los resultados energéticos obtenidos en el segundo semestre del a o 2009 por los ómnibus Girón VI, remotorizados con motores Yuchai. Para el desarrollo del mismo se tomó la base de datos disponibles de la explotación, y los aportados por el estudio total eficiente de la energía, en el que se obtuvieron los indicadores en la explotación de dicho transporte en los a os 2008 y 2009, para este último a o se incluyeron además los indicadores físicos en los ya remotorizados. El análisis de la intensidad energética entregada por estos ómnibus remotorizados, permitió demostrar que el motor Yuchai es más eficiente, alcanzando ahorros significativos de combustible. Demostrándose además la correlación existente entre el consumo y el tráfico, obteniéndose la ecuación característica y su coeficiente de correlación, indicando la existencia de relación estadísticamente significativa. Se corroboró que la propuesta de sustituir los motores de gasolina por motores Yuchai de combustible diesel, es factible técnica y económicamente.
Improving the Reliability of Unmanned Aircraft System Wireless Communications through Cognitive Radio Technology  [PDF]
Hector Reyes, Naima Kaabouch
Communications and Network (CN) , 2013, DOI: 10.4236/cn.2013.53027

Unmanned Aircraft System networks are a special type of networks where high speeds of the nodes, long distances and radio spectrum scarcity pose a number of challenges. In these networks, the strength of the transmitted/received signals varies due to jamming, multipath propagation, and the changing distance among nodes. High speeds cause another problem, Doppler Effect, which produces a shifting of the central frequency of the signal at the receiver. In this paper we discuss a modular system based on cognitive to enhance the reliability of UAS networks.

Chiral Dirac Equation Derived From Quaternionic Maxwell’s Systems  [PDF]
Hector Torres-Silva
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2013, DOI: 10.4236/jemaa.2013.53017

In the present article we propose a simple equality involving the Dirac operator and the Maxwell operators under chiral approach. This equality establishes a direct connection between solutions of the two systems and moreover, we show that it is valid when the natural relation between the frequency of the electromagnetic wave and the energy of the Dirac particle is fulfilled if the electric field E is parallel to the magnetic field H. Our analysis is based on the quaternionic form of the Dirac equation and on the quaternionic form of the Maxwell equations. In both cases these reformulations are completely equivalent to the traditional form of the Dirac and Maxwell systems. This theory is a new quantum mechanics (QM) interpretation. The below research proves that the QM represents the electrodynamics of the curvilinear closed chiral waves. It is entirely according to the modern interpretation and explains the particularities and the results of the quantum field theory. Also this work may help to clarify the controversial relation between Maxwell and Dirac equations while presenting an original way to derive the Dirac equation from the chiral electrodynamics, leading, perhaps, to novel conception in interactions between matter and electromagnetic fields. This approach may give a reinterpretation of Majorana equation, neutrino mass, violation of Heinsenberg’s measurement-disturbation relationship and mass generation in systems like graphene devices.

N-Body Simulations of Small Galaxy Groups
Hector Aceves,Hector Velazquez
Physics , 2002,
Abstract: A series of N-body simulations aimed to study the dynamics of small groups of galaxies are presented. The properties of small galaxy groups are very well reproduced, and those of Hickson's compact groups are well reproduced by the most advanced stage of collapsing groups. We find no overmerging problem in our simulations. An important fraction of groups (~40%) initially in virial equilibrium can last for ~10 Gyr without complete merging. These results provide an alternative solution to the overmerging expected in Hicksons's compact groups.
Compiling Uncertainty Away in Conformant Planning Problems with Bounded Width
Hector Palacios,Hector Geffner
Computer Science , 2014, DOI: 10.1613/jair.2708
Abstract: Conformant planning is the problem of finding a sequence of actions for achieving a goal in the presence of uncertainty in the initial state or action effects. The problem has been approached as a path-finding problem in belief space where good belief representations and heuristics are critical for scaling up. In this work, a different formulation is introduced for conformant problems with deterministic actions where they are automatically converted into classical ones and solved by an off-the-shelf classical planner. The translation maps literals L and sets of assumptions t about the initial situation, into new literals KL/t that represent that L must be true if t is initially true. We lay out a general translation scheme that is sound and establish the conditions under which the translation is also complete. We show that the complexity of the complete translation is exponential in a parameter of the problem called the conformant width, which for most benchmarks is bounded. The planner based on this translation exhibits good performance in comparison with existing planners, and is the basis for T0, the best performing planner in the Conformant Track of the 2006 International Planning Competition.
Information Theory and Computational Thermodynamics: Lessons for Biology from Physics
Hector Zenil
Information , 2012, DOI: 10.3390/info3040739
Abstract: We survey a few aspects of the thermodynamics of computation, connecting information, thermodynamics, computability and physics. We suggest some lines of research into how information theory and computational thermodynamics can help us arrive at a better understanding of biological processes. We argue that while a similar connection between information theory and evolutionary biology seems to be growing stronger and stronger, biologists tend to use information simply as a metaphor. While biologists have for the most part been influenced and inspired by information theory as developed by Claude Shannon, we think the introduction of algorithmic complexity into biology will turn out to be a much deeper and more fruitful cross-pollination.
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