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Search Results: 1 - 10 of 401400 matches for " Hebat Allah M. Bakri "
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Multiple Primary Malignancies: Metastatic Renal with Early Breast and Endometrial Cancers: A Case Report  [PDF]
Amal Rayan, Abbas Ahmed M. Ashraf, Hebat Allah M. Bakri
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.911075
Abstract: Double primary malignancies could be divided into two categories, depending on the interval between tumor diagnoses. A secondary malignancy could be defined as a new cancer that has occurred as a result of previous treatment with radiation or chemotherapy. Second primary malignancy can occur at any age but its commonly at old age. A 46 premenopausal female patient presented to our outpatient clinic complaining from a mass in her right breast, routine metastatic work-up for distant metastasis declared multiple hepatic metastases, RT renal mass, and bone metastases. Palliative radiotherapy to tender and weight bearing sites followed by 4 cycles of systemic chemotherapy FEC regimen were received. Tru-cut needle biopsy from renal mass detected renal cell carcinoma of clear cell type, the patient started sunitinib and tamoxifen with bisphosphonate (Zoledronic acid), assessment of the response revealed reduction of the size and number of HFLs, and the size of renal mass, so the patient was decided to do cytoreductive nephrectomy and then continued on TAM and sunitinib. Collectively, due to the rising incidence of multiple primary malignancies, further studies should be done not only for better clinical evaluation and treatments but also for accurate determination of possible causes, pathogenesis, effective managements and screening programs.
Antibodies to Mutated Citrullinated Vimentin in Rheumatoid Arthritis: Diagnostic Value, Association with Radiological Damage and Axial Skeleton Affection
Howaida E. Mansour,Khaled M. Metwaly,Iman A. Hassan,Hebat-Allah A. Elshamy
Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders , 2010,
Abstract: Background: Early definitive diagnosis and effective treatment are mandatory in rheumatoid arthritis (RA) as it can halt the disease progression and subsequent joints destruction. Objective: To investigate the diagnostic and prognostic value of anti-mutated citrullinated vimentin (anti-MCV) and its correlation with disease activity, peripheral and axial skeleton affection in RA patients. Patients and methods: A total of 123 patients with different rheumatic diseases were enrolled in a prospective-two year study at Ain Shams University hospital: 64 patients with RA and 59 patients with other rheumatic diseases as controls. RA patients were fulfilling the traditional and the new ACR/EULAR diagnostic criteria for RA. They have been followed up for two years. At baseline, all RA patients were subjected to: Clinical assessment of disease activity by taking full histories, general and local examination, measurement of 28 joint count of tender and swollen joints with calculation of disease activity score (DAS-28) for each patient. Complete blood count, erythrocytes sedimentation rate, C-reactive protein and rheumatoid factor titers were performed. Anti-MCV IgG immunoglobulins’ assay was performed at the study endpoint by ELISA. RA patients were then classified into; anti-MCV positive and anti-MCV negative groups for statistical comparison. Plain X-ray was performed on the peripheral joints and scored by the Simple Erosion Narrowing score (SEN-score). Magnetic Resonance Imaging (MRI) scans were carried out to 22 RA patients on cervical and lumbosacral regions. Results: Anti-MCV antibodies were found to be of high sensitivity (79.6%) and specificity (96.6%) in diagnosing RA. The area under the curve was 0.893 at 95% confidence interval (CI), confers an odds ratio of 23.5. Anti-MCV positive RA patients had significantly higher DAS-28 and SEN-scores than anti-MCV negative patients; who were found to have more benign disease with lower incidence of erosions (P , 0.05). MRI scans revealed that; 17/22 (77%) had cervical joints involvement while, 8 (36%) had lumbo-sacral joint lesions (P , 0.05), both were correlated significantly with aggressive peripheral joint disease. Conclusion: Anti-MCV antibodies are promising diagnostic and prognostic marker in RA, with high sensitivity and specificity. They may identify a subset of RA patients with aggressive early erosive disease. The axial skeleton—especially the cervical spine—could be affected in RA and this was correlated with aggressive peripheral joints’ disease. MRI scanning is a sensitive method for detectin
Antibodies to Mutated Citrullinated Vimentin in Rheumatoid Arthritis: Diagnostic Value, Association with Radiological Damage and Axial Skeleton Affection
Howaida E. Mansour, Khaled M. Metwaly, Iman A. Hassan, Hebat-Allah A. Elshamy and Moataz M.S. Elbeblawy
Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders , 2012, DOI: 10.4137/CMAMD.S4827
Abstract: Abstract Background: Early definitive diagnosis and effective treatment are mandatory in rheumatoid arthritis (RA) as it can halt the disease progression and subsequent joints destruction. Objective: To investigate the diagnostic and prognostic value of anti-mutated citrullinated vimentin (anti-MCV) and its correlation with disease activity, peripheral and axial skeleton affection in RA patients. Patients and methods: A total of 123 patients with different rheumatic diseases were enrolled in a prospective-two year study at Ain Shams University hospital: 64 patients with RA and 59 patients with other rheumatic diseases as controls. RA patients were fulfilling the traditional and the new ACR/EULAR diagnostic criteria for RA. They have been followed up for two years. At baseline, all RA patients were subjected to: Clinical assessment of disease activity by taking full histories, general and local examination, measurement of 28 joint count of tender and swollen joints with calculation of disease activity score (DAS-28) for each patient. Complete blood count, erythrocytes sedimentation rate, C-reactive protein and rheumatoid factor titers were performed. Anti-MCV IgG immunoglobulins’ assay was performed at the study endpoint by ELISA. RA patients were then classified into; anti-MCV positive and anti-MCV negative groups for statistical comparison. Plain X-ray was performed on the peripheral joints and scored by the Simple Erosion Narrowing score (SEN-score). Magnetic Resonance Imaging (MRI) scans were carried out to 22 RA patients on cervical and lumbosacral regions. Results: Anti-MCV antibodies were found to be of high sensitivity (79.6%) and specificity (96.6%) in diagnosing RA. The area under the curve was 0.893 at 95% confidence interval (CI), confers an odds ratio of 23.5. Anti-MCV positive RA patients had significantly higher DAS-28 and SEN-scores than anti-MCV negative patients; who were found to have more benign disease with lower incidence of erosions (P , 0.05). MRI scans revealed that; 17/22 (77%) had cervical joints involvement while, 8 (36%) had lumbo-sacral joint lesions (P , 0.05), both were correlated significantly with aggressive peripheral joint disease. Conclusion: Anti-MCV antibodies are promising diagnostic and prognostic marker in RA, with high sensitivity and specificity. They may identify a subset of RA patients with aggressive early erosive disease. The axial skeleton—especially the cervical spine—could be affected in RA and this was correlated with aggressive peripheral joints’ disease. MRI scanning is a sensitive method for detecting axial skeleton involvement in RA, in attempt for better disease control and outcomes.
Diagnostic performance and predictive value of rheumatoid factor, anti-cyclic-citrullinated peptide antibodies and HLA-DRB1 locus genes in rheumatoid arthritis
Nihal A Fathi, Azza M Ezz-Eldin, Eman Mosad, Rania M Bakry, Hosny B Hamed, Sahar Ahmed, Marwa Mahmoud, Hebat-Allah G Rashed, Fatma Abdullah
International Archives of Medicine , 2008, DOI: 10.1186/1755-7682-1-20
Abstract: Sixty patients with RA were examined. Radiographic changes were evaluated by (Larsen score) and disease activity was measured by disease activity score 28 (DAS28). The markers analyzed were: erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptides (anti-CCP2) and HLA-DRB1 alleles typed by PCR.In this study, anti-CCP antibodies, CRP, RF and AKA were detected in 83.3%, 56.7%, 71.7% and 52% of patients respectively. HLA-DRB1*01 was found in 45% of patients and 35% of them had one or two HLA-DRB1*04 alleles. According to DRB1*04 subtypes, (DRB1* 0405) was present in of 80% them. For prediction of grade of activity, the independent predictors were anti-CCP (OR 19.6), and DRB1*04 positive allele (OR 5.1). The combination of DRB1*04 + anti-CCP antibodies gave increase in the specificity and positive predictive value to 92% and 90 respectively. As regards to the prediction of radiological joint damage, the independent predictors were HLA-DRB1*04, HLA-DRB1*01, RF, and CRP > 18 (OR 5.5, 4.5, 2.5, 2.0 respectively).Our findings suggest that anti-CCP2 is superior to RF for the detection of RA and provided predictive information on joint destruction and disease activity. The presence of RA associated antibodies (ACCP or RF) and/or the SE genes are indicative for a poorer radiological outcome and higher grade of activity.Rheumatoid arthritis (RA) is an inflammatory disease of unknown cause. The course of rheumatoid arthritis is ranging from mild to aggressive forms, the latter being very difficult to cope with. It has been shown that early diagnosis and treatment reduce joint destruction, and improve survival [1]. Risk factors have been identified in groups of patients with different outcomes such as baseline radiographic joint changes, presence of rheumatoid factor (RF), specific human leukocyte antigens (HLA); HLA-DRB1 genotypes, high disease activity, high disability scores, and high levels of acute phase protei
Carboxymethyl Cellulose Acetate Butyrate: A Review of the Preparations, Properties, and Applications
Mohamed El-Sakhawy,Samir Kamel,Ahmed Salama,Hebat-Allah Sarhan
Journal of Drug Delivery , 2014, DOI: 10.1155/2014/575969
Abstract: Carboxymethyl cellulose acetate butyrate (CMCAB) has gained increasing importance in several fields, particularly in coating technologies and pharmaceutical research. CMCAB is synthesized by esterification of CMC sodium salt with acetic and butyric anhydrides. CMCAB mixed esters are relatively high molecular weight (MW) thermoplastic polymers with high glass transition temperatures (Tg). CMCAB ester is dispersible in water and soluble in a wide range of organic solvents, allowing varied opportunity to the solvent choice. It makes application of coatings more consistent and defect-free. Its ability to slow down the release rate of highly water-soluble compounds and to increase the dissolution of poorly soluble compounds makes CMCAB a unique and potentially valuable tool in pharmaceutical and amorphous solid dispersions (ASD) formulations. 1. Introduction Cellulose is the most abundant regenerated biopolymer in the planet, with annual production of about 5 × 1011 metric tons. Most of the cellulose is utilized in industry as a raw material in paper production. Only about 4 from 108 million tons of annually produced pulp are used for chemical production [1]. Hydroxyl groups of cellulose can be reacted to form esters or ethers of different physical and chemical properties suitable for various applications [2]. Cellulose derivatives have significant roles in industry; they represent a main source for fibers, textiles, coatings, thermoplastic films, food additives [1], and pharmaceutical technologies [3]. Cellulose derivatives are usually classified as two main classes, esters and ethers, according to the reactant nature. Cellulose derivatives usually contain free hydroxyl groups available for additional treatments to yield mixed esters. The mixed esters have several improved properties over all neat esters. Cellulose acetate propionate (CAP) and cellulose acetate butyrate (CAB) are the most commercially important mixed esters [4]. Mixed cellulose derivatives with both ester and ether groups could be also attained. Due to their low degree of substitution and high hydrolytic stability, carboxymethyl cellulose can be further esterified with organic acid anhydrides to add either single or mixed ester groups [5]. Cellulose esters in coating compositions improved many properties as hardness, aluminum flake orientation, flow and leveling, redissolving resistance, clarity, and gloss while it reduced dry-to-touch time, cratering, and blocking [6–9]. Mixed cellulose derivatives afford the benefits of conventional cellulose esters with a moderate increase in viscosity
RELATIONSHIPS BETWEEN HAEMOGLOBIN (Hb) TYPE AND PRODUCTIVE AND REPRODUCTIVE PERFORMANCE OF RAHMANI EWES LAMBS
M. ABD-ALLAH
Online Journal of Animal and Feed Research , 2012,
Abstract: Two hundred Rahmani ewes and seventy-one lambs used to study the relationship between the type of haemoglobin and some productive and reproductive traits. Distribution of Hb types and allelic frequencies were higher for type AA of ewes, while for lamb's type BB was higher than type AA. Fertility rate was higher in ewes with the type of haemoglobin AA than ewes with type AB or BB. Hemoglobin type, year of mating and breed of sire were not significant effects on fertility, while, age of dam and season of mating had a significant (P<0.01 or P<0.05) effect on fertility. Autumn season was the best season in fertility (84%) compared to (60%) in summer and (64%) in winter season. Ewes sired by Rahmani rams had the highest fertility (73%) compared to those sired by Chios rams (66%). All factors (Haemoglobin type, age of dam, year of lambing, season of mating, and breed of sire) had no significant effect on litter size at birth. However, ewes with Hb BB produced more lambs than either ewes with HB AB or ewes with Hb AA. Also, ewes aged 4 years had the highest litter size at birth. Ewes mating during autumn season produced more lambs than those mating during summer. Haemoglobin type was not significant effect on body weights of Rahmani lambs and F1 cross C R at all ages studied. Rahmani lambs with Hb AA had the lowest value of birth weight (4.05 kg vs. 4.14; 4.3 kg) compared lambs with Hb AB or BB, while lambs with Hb BB had highest weight at weaning , 6, 9 and 12 months of ages. F1 ( C R) lambs with Hb AA had the highest weight at birth, 6, 9 and 12 months of age, while lambs with Hb BB had the highest weight at weaning age. Haemoglobin type was not significant effect on daily gain at all periods studied for both Rahmani and F1 ( C R) lambs. Generally, Rahmani and ( C R) lambs with
CeO2掺杂的Mn/Al催化剂的物化、表面及催化性能
Nasr Allah M. DERAZ
催化学报 , 2008,
Abstract: ?PureandCeO2-dopedMn/Almixedoxideswerepreparedbythewetimpregnationmethodusingfinelypowderedalumina,manganese,andceriumnitrates.Thephysicochemical,surface,andcatalyticpropertiesofthethermallytreatedsolids(at500,800,and900℃)wereinvestigatedusingXRD,nitrogenadsorptionat-196℃,andhydrogenperoxidedecompositioninanaqueoussolutionat30~50℃.TheMnoxidationstatechangedfromMn4+toMn2+onincreasingthecalcinationtemperature.ThereweretwouniquefeaturesassociatedwithCeO2thatareofinterest.Thefirstwasthatitfavoredthedispersionofmanganeseoxidesdepositedontheγ-Al2O3catalystcalcinedat500℃.ThesecondwasthatitenhancedtheformationofMn3O4speciesfromMn2O3depositedinitiallyonthealuminasupportcalcinedat800and900℃.Consequently,thespecificsurfaceareaoftheMn/Almixedoxidescalcinedat500℃wasincreasedbyincreasingtheamountofdopantadded.Anoppositeeffectwasobservedbyincreasingthecalcinationtemperaturefrom500to900℃.Thedopingfollowedbycalcinationatdifferenttemperaturesbroughtaboutanincreaseinthecatalyticactivityofmixedoxides.Pretreatmentsdidnotmodifythemechanismofthecatalyzedreactionbutchangedthenumberofcatalyticallyactivesiteswithoutchangingthenatureofthesesites.
Evaluation of Safety and Health Performance on Construction Sites (Kuala Lumpur)
D. M. Yakubu,I. M. Bakri
Journal of Management and Sustainability , 2013, DOI: 10.5539/jms.v3n2p100
Abstract: Occupational safety and health Act (Act 514) obligate each employer to provide and maintain a safe and healthful workplace for all his employees. Construction is a risky business with a lot of injuries and illness, due to poor safety performances. The aim of the study is to investigate the safety and health performance of contractors on construction sites. A comparative and sensitivity analysis conducted reveal that as allocation to the construction increases so also the rate of accidents increases and that fatal accidents contribute more to the total accidents rates, as such there is need to assess the performance of contractors as regard to safety and health operation. The result of the SHASSIC score reveal that the sites consider for the study were 3 – star in ranking, were its risks/hazards activities are well managed and documented, but still there are other risks/hazards activities that are not taken care off due to negligent on the side of the contractors. The finding affirm the importance of safety program in construction site, as such to ensure successful implementation of the safety program, the following condition must be made; management commitment, safe work condition and safe work habit.
Intravitreal triamcinolone for intraocular inflammation and associated macular edema
Steven M Couch, Sophie J Bakri
Clinical Ophthalmology , 2009, DOI: http://dx.doi.org/10.2147/OPTH.S4477
Abstract: travitreal triamcinolone for intraocular inflammation and associated macular edema Review (5304) Total Article Views Authors: Steven M Couch, Sophie J Bakri Published Date November 2008 Volume 2009:3 Pages 41 - 47 DOI: http://dx.doi.org/10.2147/OPTH.S4477 Steven M Couch, Sophie J Bakri Mayo Clinic Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA Abstract: Triamcinolone acetonide (TA) is a corticosteroid that has many uses in the treatment of ocular diseases because of its potent anti-inflammatory and anti-permeability actions. Intraocular inflammation broadly referred to as uveitis can result from several causes, including the immune system and after ophthalmic surgery. One of the most common reasons for vision loss with uveitis is macular edema. TA has been used for many years as an intravitreal injection for the treatment of ocular diseases. Several case control studies have been reported showing the efficacy of TA in the treatment of intraocular inflammation and associated macular edema caused by Behcet’s disease, Vogt-Koyanagi-Harada syndrome, sympathetic ophthalmia and white dot syndromes. It has also been shown efficacious in cases of pars planitis and idiopathic posterior uveitis. Some authors have reported its use in postoperative cystoid macular edema. Many of the studies on the use of TA in controlling intraocular inflammation and concomitant macular edema showed its effect to be transient in many patients requiring reinjection. Complications can arise from intravitreal injection of TA including elevated intraocular pressure and cataract. Rarely, it can be associated with infectious and non-infectious endophthalmitis. TA may be useful as an adjuvant in the treatment of uveitis and its associated macular edema, especially in patients resistant or intolerant to standard treatment.
Use of triamcinolone during vitrectomy surgery to visualize membranes and vitreous
Steven M Couch,Sophie J Bakri
Clinical Ophthalmology , 2008,
Abstract: Steven M Couch, Sophie J BakriMayo Clinic Department of Ophthalmology, Mayo Clinic, Rochester, MN, USAAbstract: Triamcinolone is a corticosteroid that is used to treat many ophthalmic diseases. Recently, its use has been advocated to aid in visualization of transparent tissue in ophthalmic surgery. It can be used in anterior segment surgery to help manage vitreous loss during complicated cataract surgery. It has been used to visualize the posterior cortical vitreous during pars plana vitrectomy. In addition, it can be useful in the visualization and peeling of the internal limiting membrane. Triamcinolone has been advocated in surgical repair of proliferative vitreoretinopathy both for its visualizing properties and its anti-inflammatory properties. Overall, triamcinolone use in surgery is safe with low incidence of complications including elevated intraocular pressure, cataract and endophthalmitis.Keywords: cataract surgery, chromovitrectomy, epiretinal membrane, internal limiting membrane, triamcinolone acetonide, vitrectomy
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