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Search Results: 1 - 10 of 462411 matches for " Haruhito A Uchida "
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Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-long-evans-Tokushima Fatty rats
Kaihara,Masanobu,Nakamura,Yoshio,Sugimoto,Taro,Uchida,Haruhito A.
Acta Medica Okayama , 2009,
Abstract: We investigated the impact of olmesartan and temocapril on pancreatic islet beta-cells during the development of diabetes mellitus using Otsuka-Long-Evans-Tokushima Fatty (OLETF) rats. Four-week-old male OLETF rats were fed standard chow (untreated:n5), or chow containing either 0.005% olmesartan(n5) or 0.01% temocapril (n5) until being sacrificed at 35 weeks of age. Pancreas sections were double-stained with anti-insulin and anti-glucagon antibodies. The percent areas of beta-cells, alpha-cells and non-alpha-non-beta-cells were compared among groups. In untreated OLETF rats, the fasting plasma glucose (FPG) level was elevated at the 18th week and remained elevated until the 35th week. On the other hand, no significant elevation in FPG levels was observed in olmesartan- or temocapril-treated rats. Pancreatic islets from olmesartan-treated rats were significantly smaller in size as compared with those from untreated OLETF rats. Furthermore, the average area occupied by beta-cells as a fraction of the total area of an individual islet was significantly higher in olmesartan- or temocapril-treated rats than that in untreated OLETF rats. Olmesartan and temocapril both prevented the development of hyperglycemia, possibly through the prevention of islet beta-cell loss in spontaneously diabetic OLETF rats.
Calpain-2 Compensation Promotes Angiotensin II-Induced Ascending and Abdominal Aortic Aneurysms in Calpain-1 Deficient Mice
Venkateswaran Subramanian, Jessica J. Moorleghen, Anju Balakrishnan, Deborah A. Howatt, Athar H. Chishti, Haruhito A. Uchida
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072214
Abstract: Background and Objective Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine proteases, in mice. In addition, pharmacological inhibition of calpain attenuated AngII-induced abdominal aortic aneurysm (AA) in mice. Recent studies have shown that AngII infusion into mice leads to aneurysmal formation localized to the ascending aorta. However, the precise functional contribution of calpain isoforms (-1 or -2) in AngII-induced abdominal AA formation is not known. Similarly, a functional role of calpain in AngII-induced ascending AA remains to be defined. Using BDA-410, an inhibitor of calpains, and calpain-1 genetic deficient mice, we examined the relative contribution of calpain isoforms in AngII-induced ascending and abdominal AA development. Methodology/Results To investigate the relative contribution of calpain-1 and -2 in development of AngII-induced AAs, male LDLr ?/? mice that were either calpain-1 +/+ or ?/? were fed a saturated fat-enriched diet and infused with AngII (1,000 ng/kg/min) for 4 weeks. Calpain-1 deficiency had no significant effect on body weight or blood pressure during AngII infusion. Moreover, calpain-1 deficiency showed no discernible effects on AngII-induced ascending and abdominal AAs. Interestingly, AngII infusion induced increased expression of calpain-2 protein, thus compensating for total calpain activity in aortas of calpain-1 deficient mice. Oral administration of BDA-410, a calpain inhibitor, along with AngII-infusion significantly attenuated AngII-induced ascending and abdominal AA formation in both calpain-1 +/+ and ?/? mice as compared to vehicle administered mice. Furthermore, BDA-410 administration attenuated AngII-induced aortic medial hypertrophy and macrophage accumulation. Western blot and immunostaining analyses revealed BDA-410 administration attenuated AngII-induced C-terminal fragmentation of filamin A, an actin binding cytoskeletal protein in aorta. Conclusion Calpain-2 compensates for loss of calpain-1, and both calpain isoforms are involved in AngII-induced aortic aneurysm formation in mice.
A case of focal segmental glomerulosclerosis in an adult patient with hypogammaglobulinemia superimposed on membranoproliferative glomerulonephritis in childhood
Kenji Tsuji, Haruhito A Uchida, Tetsuichiro Ono, Tasuyuki Inoue, Katsuji Shinagawa, Shinji Kitamura, Yohei Maeshima, Hitoshi Sugiyama, Hirofumi Makino
BMC Nephrology , 2012, DOI: 10.1186/1471-2369-13-46
Abstract: We report a 36-year-old man who had suffered membranoproliferative glomerulonephritis (MPGN) in his childhood, later diagnosed with CVID at 35?years of age. He presented at our hospital with signs of proteinuria. A renal biopsy revealed he suffered from focal segmental glomerulosclerosis (FSGS), possibly due to obesity and hypertension, not CVID - associated MPGN.This is the first case report of FSGS in a CVID patient. In this case, we have to pay attention not only to the treatment of obesity and hypertension for FSGS but also to the recurrence of immune-complex glomerulonephritis such as MPGN, in case of the restoration of hypogammaglobulinemia.
Advances in Angioscopic Imaging of Vascular Disease  [PDF]
Yasumi Uchida, Yasuto Uchida
World Journal of Cardiovascular Surgery (WJCS) , 2012, DOI: 10.4236/wjcs.2012.24021

Percutaneous angioscopy, using high resolution fiberoptic imaging, allows direct and two-dimensional visualization of the vascular interior, thereby enabling macroscopic pathological diagnosis. Percutaneous angioscopy has revealed that the vascular luminal surface exhibits various colors and morphologies characteristic of different vascular diseases. This imaging technique is used for evaluation of the severity of vascular diseases, staging of atherosclerosis, analysis of thrombus composition, evaluation of interventional and surgical therapies, and for guidance of intravascular interventions such as angioplasty, venous valvuloplasty and aortic stentgrafting. Recently, dye-image angioscopy has been used clinically for analyses of thrombus composition, endothelial damage and plaque composition. Intravascular microscopy was also developed for cellular imaging of vascular disease. Furthermore, fluorescent angioscopy was developed for molecular imaging of substances comprising atherosclerotic plaques. In this article, we describe the history of the development of angioscopy, angioscopic systems and techniques, angioscopic changes associated with vascular diseases, angioscope-guided intravascular therapies, and evaluation of intravascular and surgical therapies. Angioscopic pictures, except those of the coronary arteries, have rarely been published in the literature, so we have included many representative angioscopic pictures obtained by the authors in this article.

Immunotherapy of Genitourinary Malignancies
Teruo Inamoto,Haruhito Azuma
Journal of Oncology , 2012, DOI: 10.1155/2012/397267
Abstract: Most cancer patients are treated with some combination of surgery, radiation, and chemotherapy. Despite recent advances in local therapy with curative intent, chemotherapeutic treatments for metastatic disease often remain unsatisfying due to severe side effects and incomplete long-term remission. Therefore, the evaluation of novel therapeutic options is of great interest. Conventional, along with newer treatment strategies target the immune system that suppresses genitourinary (GU) malignancies. Metastatic renal cell carcinoma and non-muscle-invasive bladder caner represent the most immune-responsive types of all human cancer. This review examines the rationale and emerging evidence supporting the anticancer activity of immunotherapy, against GU malignancies.
Fairness Norms and the Incidence of Environmental Subsidy  [PDF]
Toshihiro Uchida
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.36100
Abstract: Although fairness concerns are frequently discussed in the real world environmental politics, their effects are relatively neglected in the environmental economics literature. Using a survey method, this paper attempts to reveal how fairness norms affect the incidence of subsidy both in the short-run and long-run. The results indicate that statutory incidence (legal right to receive subsidy) affects people’s fairness norms on who should receive subsidy. In particular it is considered unfair for a firm to receive a part of the subsidy when it is legally granted to the consumer side. If firms avoid behaviors that are considered unfair, the tax and subsidy equivalence theorem may not hold under this situation. The survey results also reveal that fairness norms affect the incidence of subsidy in the long-run, in a sense that the allocation of gains that are generated due to subsidy is affected. People find it fair if allocation is made in proportion to firms’ own effort. Therefore, if an increase in profit is achieved by activities directly supported by subsidy, people find it less justifiable for firms to keep all the gains by themselves and thus firms may be forced to share the gains with consumers.
High-Quality Three-Dimensional Computed Tomography Angiography of Abdominal Viscera with Small Focal Spot, Low Tube Voltage, and Iterative Model Reconstruction Technique  [PDF]
Masafumi Uchida
Open Journal of Radiology (OJRad) , 2015, DOI: 10.4236/ojrad.2015.51002
Abstract: Purpose: To evaluate the quality of three-dimensional (3D) CT angiography images of the abdominal viscera with small focal spot, low tube voltage, and iterative model reconstruction technique (IMR). Materials and Methods: Seven patients with suspected disease of the pancreatobiliary system had undergone CT with high-quality CTA protocol in the present study. There were 5 men and 2 women, ranging in age from 52 to 80 years (mean: 64 years). Results: Depiction of abdominal small artery, small portal vein was possible in all cases. In two cases that we were able to compare, it was superior to standard CTA in small vascular depiction in CTA made clearly in high quality protocol. Conclusions: Although the use of small focal spot, low tube voltage, and IMR can produce higher-quality images of abdominal vessels than standard CTA, this improvement is not significant at elevated radiation doses.
High-Resolution Micro-Siting Technique for Large Scale Wind Farm Outside of Japan Using LES Turbulence Model  [PDF]
Takanori Uchida
Energy and Power Engineering (EPE) , 2017, DOI: 10.4236/epe.2017.912050
Abstract: The spatial distribution of wind speed varies greatly over steep complex terrain, thus the selection of an optimal site in such terrain for wind turbine construction requires great care. We have developed a numerical model for simulating unsteady flows called RIAM-COMPACT (Research Institute for Applied Mechanics, Kyushu University, COM putational Prediction of Airflow over Complex Terrain), which is based on the LES (Large-Eddy Simulation) technique. The computational domain of RIAM-COMPACT can be varied from several meters to several kilometers, and the model is able to predict airflow over complex terrain with high accuracy. The present paper discusses the application of RIAM-COMPACT to the micro-siting of wind turbines at sites outside Japan. The results from two case studies will be presented.
High-Resolution LES of Terrain-Induced Turbulence around Wind Turbine Generators by Using Turbulent Inflow Boundary Conditions  [PDF]
Takanori Uchida
Open Journal of Fluid Dynamics (OJFD) , 2017, DOI: 10.4236/ojfd.2017.74035
We have developed an LES (Large-Eddy Simulation) code called RIAM-COMPACT (Research Institute for Applied Mechanics, Kyushu University, Computational Prediction of Airflow over Complex Terrain). The analysis do-main of this numerical model extends from several meters to several kilometers. The model is able to predict airflow over complex terrain with high accuracy and is also now able to estimate the annual power output of wind turbine generators with the use of field observation data. In the present study, a numerical simulation of turbulent airflow over an existing wind farm was performed using RIAM-COMPACT and high-resolution elevation data. Based on the simulation results, suitable and unsuitable locations for the operation of WTGs (Wind Turbine Generators) were identified. The latter location was subject to the influence of turbulence induced by small topographical variations just upwind of the WTG location.
CFD Prediction of the Airflow at a Large-Scale Wind Farm above a Steep, Three-Dimensional Escarpment  [PDF]
Takanori Uchida
Energy and Power Engineering (EPE) , 2017, DOI: 10.4236/epe.2017.913052
Abstract: The Duogu Wind Farm, China Huadian Group Corporation’s first wind project in Yunnan, China, has been approved by the Provincial Development and Reform Commission. The acquired site is in Mengzi, in the south-east of Yunnan Province. The developer has deployed thirty-three 1.5 MW turbines in this wind farm (49.5 MW), and the total cost of construction has been estimated to be CNY449.7 million ($69.61 million). The present study compared the prediction accuracy of two CFD software packages for simulating flow over an escarpment with a steep slope. The two software packages were: 1) Open FOAM (Turbulence model: SST k-ω RANS), which is a free, open source CFD software package developed by Open CFD Ltd at the ESI Group and distributed by the Open FOAM Foundation and 2) RIAM-COMPACT (Turbulence model: Standard Smagorinsky LES), which has been developed by the lead author of the present paper. Generally good agreement was obtained between the results from the simulations with Open FOAM and RIAM-COMPACT.
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