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Search Results: 1 - 10 of 758 matches for " Harshad Thakur "
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Knowledge, Practices and Restrictions related to Menstruation among young Women from Low Socioeconomic Community in Mumbai, India
Harshad Thakur,Elisabeth Faxelid
Frontiers in Public Health , 2014, DOI: 10.3389/fpubh.2014.00072
Abstract: The main objective was to assess knowledge, practices and restrictions faced by young women regarding their menstrual hygiene. The views of adult women having young daughters were also included and both views were compared. In addition, the factors influencing the menstrual hygiene practices were also studied. The study was carried out during 2008 in Mumbai, India. The mixed methods approach was followed for the data collection. Both qualitative and quantitative methods were used to collect the data. For quantitative survey, totally 192 respondents (96 adult and 96 younger women) were selected. While young women were asked about questions related to their menstruation, adult women were asked questions to find out how much they know about menstrual history of their daughters. The qualitative data helped to supplement the findings from the quantitative survey and to study the factors affecting menstrual practices in young women. The mean age at menarche reported was 13.4 years and 30-40% of young girls did not receive any information about menstruation before menarche. It is thus seen that very few young girls between the age group 15-24 years did receive any information before the onset of menstruation. Among those who received some information, it was not adequate enough. The source of information was also not authentic. Both young and adult women agreed on this. Due to the inadequate knowledge, there were certain unhygienic practices followed by the young girls resulting in poor menstrual hygiene. It also leads to many unnecessary restrictions on young girls and they faced many health problems and complaints which were either ignored or managed inappropriately. The role of health sector was almost negligible from giving information to the management of health problems of these young girls. This paper reemphasizes the important, urgent and neglected need of providing correct knowledge to the community including adolescent girls.
Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]
Komal Mehta, Jayesh Gala, Surendra Bhasale, Sattayasheel Naik, Millind Modak, Harshad Thakur, Nivedita Deo, Mark JS Miller
BMC Complementary and Alternative Medicine , 2007, DOI: 10.1186/1472-6882-7-34
Abstract: Subjects (n = 95) were screened and randomized to receive glucosamine sulfate (n = 47, 1500 mg/day) or reparagen (n = 48, 1800 mg/day), a polyherbal consisting of 300 mg of vincaria (Uncaria guianensis) and 1500 mg of RNI 249 (Lepidium meyenii) administered orally, twice daily. Primary efficacy variable was response rate based on a 20% improvement in WOMAC pain scores. Additional outcomes were WOMAC scores for pain, stiffness and function, visual analog score (VAS) for pain, with assessments at 1, 2, 4, 6 and 8 weeks. Tolerability, investigator and subject global assessments and rescue medication consumption (paracetamol) were measured together with safety assessments including vital signs and laboratory based assays.Subject randomization was effective: age, gender and disease status distribution was similar in both groups. The response rates (20% reduction in WOMAC pain) were substantial for both glucosamine (89%) and reparagen (94%) and supported by investigator and subject assessments. Using related criteria response rates to reparagen were favorable when compared to glucosamine. Compared to baseline both treatments showed significant benefits in WOMAC and VAS outcomes within one week (P < 0.05), with a similar, progressive improvement over the course of the 8 week treatment protocol (45–62% reduction in WOMAC or VAS scores). Tolerability was excellent, no serious adverse events were noted and safety parameters were unchanged. Rescue medication use was significantly lower in the reparagen group (p < 0.01) at each assessment period. Serum IGF-1 levels were unaltered by treatments.Both reparagen and glucosamine sulfate produced substantial improvements in pain, stiffness and function in subjects with osteoarthritis. Response rates were high and the safety profile was excellent, with significantly less rescue medication use with reparagen. Reparagen represents a new natural productive alternative in the management of joint health.Current Controlled Trials ISRCTN2543
Immunomodulatory role of Tinospora cordifolia as an adjuvant in surgical treatment of diabetic foot ulcers: A prospective randomized controlled study
Purandare Harshad,Supe Avinash
Indian Journal of Medical Sciences , 2007,
Abstract: Background : Chronic diabetic patients with wounds have deficient growth factors and impaired local and systemic cellular immunity. Treatment with growth factors is expensive with risk of infection transmission, and these factors may not achieve optimum wound concentration. We evaluated the role of generalized immunomodulation in diabetic ulcers by using Tinospora cordifolia as an adjuvant therapy and studied its influence on parameters/determinants of healing, on bacterial eradication and on polymorphonuclear phagocytosis. Materials and Methods :A prospective double-blind randomized controlled study lasting for over 18 months in 50 patients. The ulcer was classified by wound morphology and severity with Wound Severity Score (Pecoraro-Reiber system). Mean ulcer area, depth and perimeter were measured and swabs taken for culture. Blood was collected to assess polymorphonuclear % phagocytosis (PMN function by Lehrer-Cline C. albicans method). Medical therapy, glycemic control, debridement, wound care were optimized. At 4 weeks, parameters were reassessed. PMN function was reviewed at 3 months. Results and Analysis : Forty-five patients completed the trial: study group - 23 (M:F = 17:1; mean age = 56.3 years; mean ulcer duration = 21.1 days); control group 22 (M:F = 19:3; mean age = 56.3 years; mean ulcer duration = 30.4 days). Net improvement was seen in 17 patients (73.9%) in the study group; while in the control group, in 13 patients (59.1%); P = 0.292. Specific parameters included rate of change of ulcer area - cm 2 /day (study - 0.15; control - 0.07; P = 0.145); rate of change of ulcer perimeter - mm/day (study - 0.09; control = - 0.07; P = 0.089); change of depth - mm (study - 2.2; control - 1.4; P = 0.096); change of wound score (study - 14.4; control - 10.6; P = 0.149); total number of debridements (study - 1.9; control - 2.5; P = 0.03) and change in % phagocytosis (study - 3.9; control - 2.3; P = 0.048). Conclusion : Diabetic patients with foot ulcers on T. cordifolia as an adjuvant therapy showed significantly better final outcome with improvement in wound healing. Reduced debridements and improved phagocytosis were statistically significant, indicating beneficial effects of immunomodulation for ulcer healing.
Effect of Micro Size Cenosphere Particles Reinforcement on Tribological Characteristics of Vinylester Composites under Dry Sliding Conditions  [PDF]
Santram Chauhan, Sunil Thakur
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2012, DOI: 10.4236/jmmce.2012.1110092
Abstract: In this paper the friction and wear characteristics of vinylester and cenosphere reinforced vinylester composites have been investigated under dry sliding conditions, under different applied normal load and sliding speed. Wear tests were carried using pin on a rotating disc under ambient conditions. Tests were conducted at normal loads 10, 30, 50 and 70 N and under sliding velocity of 1.88, 3.14, 4.39 and 5.65 m/s. The results showed that the coefficient of friction decreases with the increase in applied normal load values under dry conditions. On the other hand for pure vinylester specific wear rate increases with increase in applied normal load. However the specific wear rate for 2%, 6%, 10% and 15% cenosphere reinforced vinylester composite decreases with the increase in applied normal load under dry conditions. The results showed that with increase in the applied normal load and sliding speed the coefficient of friction and spe- cific wear rate decreases under dry sliding conditions. It is also found that a thin film formed on the counterface seems to be effective in improving the tribological characteristics. The specific wear rates for pure vinylester and vinylester composite under dry sliding condition were in the order of 10-6 mm3/Nm. The results showed that the inclusion of cenosphere as filler materials in vinylester composites will increase the wear resistance of the composite significantly. SEM analysis has been carried to identify the wear mechanism.
Biological Management of Damping-Off, Buckeye Rot and Fusarial Wilt of Tomato (cv. Solan Lalima) under Mid-Hill Conditions of Himachal Pradesh  [PDF]
Nitika Thakur, Astha Tripathi
Agricultural Sciences (AS) , 2015, DOI: 10.4236/as.2015.65053
Abstract: Disease management is often complicated by the presence of multiple types of pathogens; in an organic system, it is appropriate to develop disease control strategies. The available literature so far reflects that the management of important disease of tomato is through the integrated approaches and very few organic approaches have been tried with various degree of success. Boiopriming of seeds with biocontrol agents (Trichoderma viridae, Trichoderma harzianum and Pseudomonas fluorescens) in combination with different biofertilizers (Azotobacter, Azospirillum and PSB) and organic manures (FYM and vermi-compost) were tested against disease incidence and health management of tomato seedling under nursery as well as field conditions. The studies were conducted during two successive years (2012-2013) at farmer’s field with the objective to combat with the increasing disease incidence of three major disease damping-off, fusarium wilt and buckeye rot from nursery stage to the final harvesting. The study focused on the use of biocontrol agents as the suitable alternative to chemical pesticides with sustainable disease management without pesticide residues in foodstuff. The bio priming of seeds with fungal antagonist Trichoderma viridae and harzianum and bacterial antagonist Pseudomonas fluorescens significantly improved the germination behavior of tomato seeds as compared to untreated control. Highest mean germination (93.1%) and seedling vigour (953.33) was recorded in Treatment 3 (FYM @ 200 q/ ha + Azospirillum + PSB + Trichoderma herzianum (4 kg/ha each) and lowest in control (60.3%) and (304.83), thus indicating a significant per cent increase in seedling emergence (54.4%) and seedling vigour (95.23%). A considerable reduction in disease incidence (pre and post) of damping off was observed in treatment T? and T? (VC @ 50 q/ha + Azospirillum + PSB + Trichoderma herzianum @ (4 kg/ha) with 45.6% and 35.4% respectively). Treatment T? proved highest in terms of yield (665 Kg/Ha), Hence these diseases can be managed by successful application of Biocontrol agents.

Modulation of cell death pathways in cancer stem cells: Targeting histone demethylases  [PDF]
Ravi Thakur, Durga Prasad Mishra
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.326093
Abstract: Cancer stem cells (CSCs) are tumor initiating cells within the tumor mass; that play a critical role in cancer pathogenesis. CSCs regulate cancer cell survival, metastatic potential, resistance to conventional radio-chemotherapy, disease relapse and poor prognosis. Recent studies have established that the drug resistant cancers and cancer cell lines possess high stem cell like traits compared to their drug sensitive counterparts. Histone demethylases are recently been linked to drug induced reversible tolerant state in cancers. Lysine histone demethylases are enzymes those demethylate lysines in histones and can act as transcriptional repressors or activators. Apart from histones other cellular proteins like E2F1, Rb, STAT3 and p53 are also regulated by methylation and demethylation cycles. In cancer cells these enzymes regulate cell survival, migration, invasion, and proliferation. This review summarizes the current progress of research on the role of histone demethylases in supporting drug tolerant cancer stem cell state and their potential as a drug target.
Theoretical Estimation of Stability of Dielectric Elastomers  [PDF]
Asha Dahiya, O. P. Thakur
World Journal of Condensed Matter Physics (WJCMP) , 2012, DOI: 10.4236/wjcmp.2012.24036
Abstract: When dielectric elastomers sandwiched between compliant electrodes and high electric voltage is applied to the dielectric elastomers. Then due to the electrostatic force between the electrodes the elastomers expands in plane and contract out of plane so that it becomes thinner. As the thickness decreases we observe the increase in the applied electric voltage with the positive feedback effect. This positive feedback leads the electrical as well as mechanical breakdown of elastomer. By applying a mechanical pre-stretch the mechanical stability of dielectric elastomers gets also increased. In this paper, a new generalized set of strain/stretch variables qrN has been introduced to get the expression for second order elastic moduli for the ideal electro elastic material deformed to orthorhombic structure. The strength of a loaded crystal determined from the new moduli has been compared with the strength of classical (Green, Stretch) moduli. It has been observed that the use of incorrect formula by ignoring shear strain leads to incorrect estimation of stability. This problem has been resolved by considering stretch variable in tensor form as generally observed in the process of electrostriction in the elastomers.
A Heuristic Reputation Based System to Detect Spam Activities in a Social Networking Platform, HRSSSNP  [PDF]
Manoj Rameshchandra Thakur, Sugata Sanyal
Social Networking (SN) , 2013, DOI: 10.4236/sn.2013.21005
Abstract: The introduction of the social networking platform has drastically affected the way individuals interact. Even though most of the effects have been positive, there exist some serious threats associated with the interactions on a social networking website. A considerable proportion of the crimes that occur are initiated through a social networking platform [1]. Almost 33% of the crimes on the internet are initiated through a social networking website [1]. Moreover activities like spam messages create unnecessary traffic and might affect the user base of a social networking platform. As a result preventing interactions with malicious intent and spam activities becomes crucial. This work attempts to detect the same in a social networking platform by considering a social network as a weighted graph wherein each node, which represents an individual in the social network, stores activities of other nodes with respect to itself in an optimized format which is referred to as localized data set. The weights associated with the edges in the graph represent the trust relationship between profiles. The weights of the edges along with the localized data set are used to infer whether nodes in the social network are compromised and are performing spam or malicious activities.
ERβ interacting protein ERAP 140 shows age dependent alteration in its interaction and expression in male mouse brain  [PDF]
Vijay Paramanik, Mahendra Kumar Thakur
World Journal of Neuroscience (WJNS) , 2013, DOI: 10.4236/wjns.2013.31001

Estrogen mediates multiple functions in the brain through the interaction of estrogen receptor (ER)α and ERβ with a host of nuclear proteins that regulate specific gene transcription. We have identified ERAP 140, AIB 1, Trk A, Src, pCREB and CREB as ERβ interacting proteins in the mouse brain. Earlier we showed that the interaction of ERβ with ERAP 140 decreased whereas its expression increased with aging in the brain of female mice. Here we report that the pattern of interaction and expression is different in male mice as compared to females. The interaction of ERAP 140 with ERβ decreased in adult male mouse brain as compared to young and remained almost similar in old whereas its expression was higher in adult than young and old, which were almost similar. Further in silico secondary structure analysis by self-optimized prediction method alignment (SOPMA) and PSIPRED revealed that ERβ interacting proteins were rich in alpha helices and coils. Such findings might help to design ER modulators which can regulate specific functions of estrogen in the brain during aging and degenerative diseases.

RNA interference revolution
Electronic Journal of Biotechnology , 2003,
Abstract: rna interference (rnai) is a potent method using only a few double stranded rna (dsrna) molecule per cell to silence the expression which has made it one of the hottest topics in molecular biology in last two years. not long ago scientists conducted gene knock out using antisense, dominant negative or knockout techniques which were ineffective, but the discovery of rnai has enabled to knock out gene in any organism efficiently. rna silencing was first discovered in transgenic plants, where it was termed co-suppression or post transcriptional gene silencing (ptgs). five years ago the evidence for rna silencing emerged from experimental observation on caenorhabditis elegans, this new approach for achieving efficient, targeted gene silencing is now making its way beyond laboratory notebooks into biotech strategic plans. it?s a phenomenon of gene silencing which offers a quick and easy way to determine the function of a gene. it?s a natural catalytic process and an intrinsic property of every cell of every multicellular organism. reported to be 1,000-fold more effective than antisense. the new field of rnai based genomics is increasingly being qualified as a fundamental paradigm shift for biomedical research and development and quite possibly the start of a veritable revolution for the development of modern therapeutics.
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