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Search Results: 1 - 10 of 3597 matches for " Harrell Gill-King "
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Response to: Use of prior odds for missing persons identifications - authors' reply
Bruce Budowle, Jianye Ge, Ranajit Chakraborty, Harrell Gill-King
Investigative Genetics , 2012, DOI: 10.1186/2041-2223-3-3
Abstract: We are concerned that statisticians, such as Biedermann et al. [1], advocate the position that data may not be needed to support assumptions 'as long as probability is properly considered as an expression of personal belief'. At a time when the National Academy of Sciences [2] has urged the need for the forensic science community to provide reliable results based on 'objective' data, these authors' position cannot be reconciled. The Report noted (on its page 8), 'The simple reality is that the interpretation of forensic evidence is not always based on scientific studies to determine its validity ... A body of research is required to establish the limits and measures of performance and to address the impact of sources of variability and potential bias. Such research is sorely needed, but it seems to be lacking in most of the forensic disciplines that rely on subjective assessments of matching characteristics. These disciplines need to develop rigorous protocols to guide these subjective interpretations and pursue equally rigorous research and evaluation programs'. It is this approach that distinguishes science from other epistemologies. Then the Report called for research in its Recommendation 3 (page 23), 'Research is needed to address issues of accuracy, reliability, and validity in the forensic science disciplines ... [and in section c of Recommendation 3] the development of quantifiable measures of uncertainty in the conclusions of forensic analyses'.Foremost, none should abide the inclusion of overstated evidence in reports or legal proceedings as it can impinge on the presumption of innocence. The tenet of this presumption should be held dearly by all, and we as scientists should strive to reduce practices that cannot be supported. Biedermann et al. [1] appear to argue that, because there is 'subjectivity in science', one does not necessarily have to be held to a standard of justifying assumptions. It is well accepted that there is subjectivity in science. Inde
Use of prior odds for missing persons identifications
Bruce Budowle, Jianye Ge, Ranajit Chakraborty, Harrell Gill-King
Investigative Genetics , 2011, DOI: 10.1186/2041-2223-2-15
Abstract: Mass disasters can result from natural, accidental and intentional causes. One of the tragedies of such events is loss of lives. Many jurisdictions seek to identify the victims so they can be returned to their respective families, for investigative purposes and/or for legal reasons (for example, resolution of estates, probate and criminal investigations). As in other forensic applications, identification is a matter of evaluating variables to reduce the pool of candidates with the intent of approaching individualization. Various characteristics or traits are used to assist in the identification of the human remains, including but not limited to skeletal features (for example, sex, age, stature and ancestry), dental comparisons, fingerprints, distinguishing marks (for example, tattoos and scars), medical devices and implants, other unique features, DNA profiles and, to a much lesser extent, eyewitness accounts and sometimes personal items. However, the frequency of the observed value of each variable needs to be assessed appropriately to effectively reduce the candidate pool.For the past two decades, DNA typing has played a more prominent role in the identification of human remains, and particularly so for highly decomposed and fragmented remains [1-12]. DNA profiles from recovered unidentified human remains may be compared with direct reference samples (for example, toothbrush, razor and hairbrush) and/or profiles from relatives (that is, an indirect comparison or kinship analysis) to identify possible associations. The strength of the genetic associations is often quantified by calculating a likelihood ratio (LR). The LR is used to evaluate whether there is evidence to support a specified biological relationship or direct identification. The literature is replete with approaches to calculating the LRs for direct and kinship analyses [5,13-23] and therefore need not be discussed further herein.The genetic evidence (that is, LR) can be combined with nongenetic eviden
A Research on Eurozone Bond Market and Determinants of Sovereign Bond Yields  [PDF]
Navjeet Gill
Journal of Financial Risk Management (JFRM) , 2018, DOI: 10.4236/jfrm.2018.72012
Abstract: This empirical research uses an OLS regression framework to examine the effect of the overall debt crisis on European sovereign bonds by conducting an overview of the bond market. It identifies the determinants which affect the generation of the indebtedness of sovereign bonds and play a major role in the determination of their solvency and hence, the spreads. These results reveal that Interest Rate, Inflation, Debt to GDP, Deficit to GDP, Gross Domestic Product rate of growth, and VSTOXX index are the most significant determinants of the sovereign bond spreads in the 6 sample countries, i.e. France, Germany, United Kingdom, Greece, Italy and Spain. To summarize, the main factors which affected bond spreads before the crisis, were not the country-specific fundamentals but rather the convergence of bond yields in the euro-zone countries due to and following the launch of the monetary union but during the crisis, increased risk aversion and lack of lender of last resort, shifted the focus to country specific factors and the bond spreads began to diverge according to the determinants highlighted in this study.
Modified hyper-Ramsey methods for the elimination of probe shifts in optical clocks
R. Hobson,W. Bowden,S. A. King,P. E. G. Baird,I. R. Hill,P. Gill
Physics , 2015,
Abstract: We develop a method of modified hyper-Ramsey spectroscopy in optical clocks, achieving complete immunity to the frequency shifts induced by the probing fields themselves. Using particular pulse sequences with tailored phases, frequencies, and durations, we can derive an error signal centered exactly at the unperturbed atomic resonance with a steep discriminant which is robust against variations in the probe shift. We experimentally investigate the scheme using the magnetically-induced $^1$S$_0- ^3$P$_0$ transition in $^{88}$Sr, demonstrating automatic suppression of a sizeable \num{2e-13} probe Stark shift to below \num{1e-16} even with very large errors in shift compensation.
Cultural Roots for Computing:The Case of African Diasporic Orature and Computational Narrative in the GRIOT System
D. Fox Harrell
Fibreculture Journal , 2008,
Abstract: Cultural practices and values are implicitly built into all computational systems. However, it is not common to develop systems with explicit critical engagement with, and foundations in, cultural practices and values aside from those traditionally privileged in discourse surrounding computing practices. I assert that engaging commonly excluded cultural values and practices can potentially spur computational innovation, and can invigorate expressive computational production. In particular, diverse ways of representing and manipulating semantic content and distinctive relationships between humans and our (digital) artifacts can form the basis for new technical and expressive computing practices. This idea is developed using the example of the GRIOT system. GRIOT is a platform for implementing interactive and generative computational narratives. Its underlying theoretical bases are in algebraic semantics from computer science, cognitive linguistics, and semiotics. Initial systems built in GRIOT enable generation of poetry in response to user input. GRIOT is deeply informed by African diasporic traditions of orature and socio-cultural engagement.
Autologous fat grafting: use of closed syringe microcannula system for enhanced autologous structural grafting
Alexander RW,Harrell DB
Clinical, Cosmetic and Investigational Dermatology , 2013,
Abstract: Robert W Alexander,1 David Harrell2 1Department of Surgery, School of Medicine and Dentistry, University of Washington, Seattle, WA, USA; 2Harvest-Terumo Inc, Plymouth, MA, USA Objectives: Provide background for use of acquiring autologous adipose tissue as a tissue graft and source of adult progenitor cells for use in cosmetic plastic surgery. Discuss the background and mechanisms of action of closed syringe vacuum lipoaspiration, with emphasis on accessing adipose-derived mesenchymal/stromal cells and the stromal vascular fraction (SVF) for use in aesthetic, structural reconstruction and regenerative applications. Explain a proven protocol for acquiring high-quality autologous fat grafts (AFG) with use of disposable, microcannula systems. Design: Explain the components and advantage of use of the patented super luer-lock and microcannulas system for use with the closed-syringe system. A sequential explanation of equipment selection for minimally traumatic lipoaspiration in small volumes is presented, including use of blunt injection cannulas to reduce risk of embolism. Results: Thousands of AFG have proven safe and efficacious for lipoaspiration techniques for large and small structural fat grafting procedures. The importance and advantages of gentle harvesting of the adipose tissue complex has become very clear in the past 5 years. The closed-syringe system offers a minimally invasive, gentle system with which to mobilize subdermal fat tissues in a suspension form. Resulting total nuclear counting of undifferentiated cells of the adipose-derived -SVF suggests that the yield achieved is better than use of always-on, constant mechanical pump applied vacuum systems. Conclusion: Use of a closed-syringe lipoaspiration system featuring disposable microcannulas offers a safe and effective means of harvesting small volumes of nonmanipulated adipose tissues and its accompanying progenitor cells within the SVF. Closed syringes and microcannulas are available as safe, sterile, disposable, compact systems for acquiring high-quality AFG. Presented is a detailed, step-by-step, proven protocol for performing quality autologous structural adipose transplantation. Keywords: autologous fat grafting, closed syringe lipoaspiration, adipose-derived adult stem-stromal cell, bioscaffolds, lipoaspiration/liposuction, stromal vascular fraction (SVF)
Commutators, eigenvalue gaps, and mean curvature in the theory of Schr?dinger operators
Evans M. Harrell II
Mathematics , 2003,
Abstract: Commutator relations are used to investigate the spectra of Schr\"odinger Hamiltonians, $H = -\Delta + V({x}),$ acting on functions of a smooth, compact $d$-dimensional manifold $M$ immersed in $\bbr^{\nu}, \nu \geq d+1$. Here $\Delta$ denotes the Laplace-Beltrami operator, and the real-valued potential--energy function $V(x)$ acts by multiplication. The manifold $M$ may be complete or it may have a boundary, in which case Dirichlet boundary conditions are imposed. It is found that the mean curvature of a manifold poses tight constraints on the spectrum of $H$. Further, a special algebraic r\^ole is found to be played by a Schr\"odinger operator with potential proportional to the square of the mean curvature: $$H_{g} := -\Delta + g h^2,$$ where $\nu = d+1$, $g$ is a real parameter, and $$h := \sum\limits_{j = 1}^{d} {\kappa_j},$$ with $\{\kappa_j\}$, $j = 1, ..., d$ denoting the principal curvatures of $M$. For instance, by Theorem \ref{thm3.1} and Corollary \ref{cor4.5}, each eigenvalue gap of an arbitrary Schr\"odinger operator is bounded above by an expression using $H_{1/4}$. The "isoperimetric" parts of these theorems state that these bounds are sharp for the fundamental eigenvalue gap and for infinitely many other eigenvalue gaps.
Geometric lower bounds for the spectrum of elliptic PDEs with Dirichlet conditions in part
Evans M. Harrell
Mathematics , 2004,
Abstract: An extension of the lower-bound lemma of Boggio is given for the weak forms of certain elliptic operators, which have partially Dirichlet and partially Neumann boundary conditions, and are in general nonlinear. Its consequences and those of an adapted Hardy inequality for the location of the bottom of the spectrum are explored in corollaries wherein a variety of assumptions are placed on the shape of the Dirichlet and Neumann boundaries.
Quandles and Linking Number
Natasha Harrell,Sam Nelson
Mathematics , 2006,
Abstract: We study the quandle counting invariant for a certain family of finite quandles with trivial orbit subquandles. We show how these invariants determine the linking number of classical two-component links up to sign.
Non-classicality and quandle difference invariants
Natasha Harrell,Sam Nelson
Mathematics , 2006,
Abstract: Non-classical virtual knots may have non-isomorphic upper and lower quandles. We exploit this property to define the quandle difference invariant, which can detect non-classicality by comparing the numbers of homomorphisms into a finite quandle from a virtual knot's upper and lower quandles. The invariants for small-order finite quandles detect non-classicality in several interesting virtual knots. We compute the difference invariant with the six smallest connected quandles for all non-evenly intersticed Gauss codes with 3 and 4 crossings. For non-evenly intersticed Gauss codes with 4 crossings, the difference invariant detects non-classicality in 86% of codes which have non-trivial upper or lower counting invariant values.
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