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Search Results: 1 - 10 of 108157 matches for " Hao-Cheng Chen "
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An Open-label, Randomized Comparison of Levofloxacin and Amoxicillin/ Clavulanate plus Clarithromycin for the Treatment of Hospitalized Patients with Community-acquired Pneumonia
Ting-Yu Lin,Shu-Min Lin,Hao-Cheng Chen,Chih-Jan Wang
Chang Gung Medical Journal , 2007,
Abstract: Background: Anti-pneumococcal fluoroquinolone has been used to treat communityacquiredpneumonia (CAP) frequently because of its broad antimicrobialspectrum.Methods: This randomized, open-label study was conducted in a tertiary teaching hospital.Eligible patients were randomized to levofloxacin 500 mg IV q24h followedby 500 mg orally q24h or a combination of amoxicillin/clavulanate500 mg/100 mg IV q8h with oral clarithromycin 500 mg q12h and then oralamoxicillin/clavulanate 250 mg/125 mg q8h with oral clarithromycin 500 mgq12h for 7-14 days.Results: From July 2004 to February 2006, 50 patients were enrolled (levofloxacin, n= 26; combination therapy, n = 24). The clinical response rate in the clinicallyevaluable population was similar for both groups (78.3% vs. 77.3%; p =1.000). Levofloxacin had a higher microbiological response rate overall, andfor Gram-negative and non-pseudomonas Gram-negative pathogens than thecombination therapy but the difference was not statistically significant(60.0% vs. 38.9%, 55.0% vs. 21.0% and 75.0% vs. 25.0%, respectively). Thelength of hospital stay was similar for both groups (7.4 3.1 vs. 6.8 2.1days; p = 1.000).Conclusion: Patients who were admitted to our hospital for CAP were older and had morecomorbidities with a much higher incidence of Gram-negative pathogensthan in a previous study. Levofloxacin was at least as effective as amoxicillin/clavulanate plus clarithromycin in clinical and microbiologicalresponses. Levofloxacin had a higher microbiological eradication rate thanthe combination therapy but the difference was not statistically significant.This deserves further study with a larer sample size.
Complications of airway self-expandable metallic stent in benign airway diseases  [PDF]
Fu-Tsai Chung, Shu-Min Lin, Chun-Liang Chou, Hao-Cheng Chen, Chih-Hsi Kuo, Horng-Chyuan Lin, Chien-Ying Liu, Chun-Hua Wang, Han-Pin Kuo, Chih-Teng Yu
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.41A016

Objectives: To present the complications of Ultraflex Self-Expandable Metallic Stents (SEMSs) applied in patients with benign tracheobronchial diseases. Methods: Eighty patients received 124 SEMSs were retrospectively reviewed in a tertiary hospital. Results: The baseline characteristics of patients received SEMS implantation including age (mean + standard deviation: 62.5 + 14.8 years), gender (male, 60.5%), smoking (46.8%), forced expiratory volume in first one second (FEV1) (mean + standard deviation, 0.92 +0.41 L/s), follow-up days after SEMS implantation (median (interquartile range); 457 (131 - 897)) and covered SEMS (33.9%) were listed. Symptoms improved after SEMS implantation among 95 patients (76.6%). Time to complications developed was 236 (median; interquartile range, 59 - 672) days. The overall complication rate was 41.9% after SEMS implantation. The complications included SEMS migration (6.5%), granuloma (19.3%) and SEMS fracture (16.1%). Successful management rates of SEMS migration, granuloma and SEMS fracture were up to 100%, 83.3%, and 85% respectively. Conclusions: Patients received SEMS implantation due to benign conditions had poor lung function and were old. The complication rate in patients with benign conditions was high after longer follow-up period, however, successful management achieved in most patients with complications.

An outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort study
Fu-Tsai Chung, Hao-Cheng Chen, Chun-Liang Chou, Chih-Teng Yu, Chih-Hsi Kuo, Han-Pin Kuo, Shu-Min Lin
Journal of Cardiothoracic Surgery , 2011, DOI: 10.1186/1749-8090-6-46
Abstract: Of 149 patients, 72 with benign and 77 with malignant tracheobronchial disease received 211 SEMSs (benign, 116; malignant, 95) and were retrospectively reviewed in a tertiary hospital.The baseline characteristics of patients who received SEMS implantation for benign conditions and those who underwent implantation for malignant conditions were significantly different. These characteristics included age (mean, 63.9 vs. 58; p < 0.01), gender (male, 62% vs. 90%; p < 0.0001), smoking (47% vs. 85%; p < 0.0001), forced expiratory volume in 1 second (mean, 0.9 vs. 1.47 L/s; p < 0.0001), follow-up days after SEMS implantation (median; 429 vs. 57; p < 0.0001), and use of covered SEMS (36.2% vs. 94.7%; p < 0.0001). Symptoms improved more after SEMS implantation in patients with benign conditions than in those with malignant conditions (76.7% vs. 51.6%; p < 0.0001). The overall complication rate after SEMS implantation in patients with benign conditions was higher than that in patients with malignancy (42.2% vs. 21.1%; p = 0.001). Successful management of SEMS migration, granulation tissue formation, and SEMS fracture occurred in 100%, 81.25%, and 85% of patients, respectively.Patients who received SEMS implantation owing to benign conditions had worse lung function and were older than those who received SEMS for malignancies. There was higher complication rate in patients with benign conditions after a longer follow-up period owing to the nature of the underlying diseases.Patients with symptomatic central airway lesions can be treated with surgery or endoscopic intervention [1-3]. Owing to advances in endobronchial stents and insertion techniques, interventional bronchoscopic procedures have been widely used in patients with benign and malignant lesions [4-7]. Rigid and flexible bronchoscopies are the most common methods of stent implantation in these patients. Some patients are not candidates for surgical intervention or rigid bronchoscopy with a general anaesthetic, however,
Diagnostic Value of EBUS-TBNA for Lung Cancer with Non-Enlarged Lymph Nodes: A Study in a Tuberculosis-Endemic Country
Chih-Hsi Kuo,Hao-Cheng Chen,Fu-Tsai Chung,Yu-Lun Lo,Kang-Yun Lee,Chih-Wei Wang,Wen-Han Kuo,Tzu-Chen Yen,Han-Pin Kuo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016877
Abstract: In tuberculosis (TB)-endemic areas, contrast-enhanced computed tomography (CT) and positron emission tomography (PET) findings of lung cancer patients with non-enlarged lymph nodes are frequently discrepant. Endobronchial ultrasound-guided transbronchial aspiration (EBUS-TBNA) enables real-time nodal sampling, and thereby improves nodal diagnosis accuracy. This study aimed to compare the accuracy of nodal diagnosis by using EBUS-TBNA, and PET.
Concomitant Active Tuberculosis Prolongs Survival in Non-Small Cell Lung Cancer: A Study in a Tuberculosis-Endemic Country
Chih-Hsi Kuo, Chun-Yu Lo, Fu-Tsai Chung, Kang-Yun Lee, Shu-Min Lin, Chun-Hua Wang, Chih-Chen Heh, Hao-Cheng Chen, Han-Pin Kuo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033226
Abstract: Background Adjuvant tumor cell vaccine with chemotherapy against non-small cell lung cancer (NSCLC) shows limited clinical response. Whether it provokes effective cellular immunity in tumor microenvironment is questionable. Concomitant active tuberculosis in NSCLC (TBLC) resembles locoregional immunotherapy of tumor cell vaccine; thus, maximally enriches effective anti-tumor immunity. This study compares the survival and immunological cell profile in TBLC over NSCLC alone. Methods Retrospective review of NSCLC patients within 1-year-period of 2007 and follow-up till 2010. Results A total 276 NSCLC patients were included. The median survival of TBLC is longer than those of NSCLC alone (11.6 vs. 8.8 month, p<0.01). Active tuberculosis is an independent predictor of better survival with HR of 0.68 (95% CI, 0.48~0.97). Squamous cell carcinoma (SCC) (55.8 vs. 31.7%, p<0.01) is a significant risk factor for NSCLC with active TB. The median survival of SCC with active tuberculosis is significantly longer than adenocarcinoma or undetermined NSCLC with TB (14.2 vs. 6.6 and 2.8 months, p<0.05). Active tuberculosis in SCC increases the expression of CD3 (46.4±24.8 vs. 24.0±16.0, p<0.05), CXCR3 (35.1±16.4 vs. 19.2±13.3, p<0.01) and IP-10 (63.5±21.9 vs. 35.5±21.0, p<0.01), while expression of FOXP3 is decreased (3.5±0.5 vs. 13.3±3.7 p<0.05, p<0.05). Survival of SCC with high expression of CD3 (12.1 vs. 3.6 month, p<0.05) and CXCR3 (12.1 vs. 4.4 month, p<0.05) is longer than that with low expression. Conclusions Active tuberculosis in NSCLC shows better survival outcome. The effective T lymphocyte infiltration in tumor possibly underlies the mechanism. Locoregional immunotherapy of tumor cell vaccine may deserve further researches.
Endobronchial Mucosa Invasion Predicts Survival in Patients with Small Cell Lung Cancer
Pai-Chien Chou, Shu-Min Lin, Chun-Yu Lo, Hao-Cheng Chen, Chih-Wei Wang, Chun-Liang Chou, Chih-Teng Yu, Horng-Chyuan Lin, Chun-Hua Wang, Han-Pin Kuo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047613
Abstract: Background Current staging system for small cell lung cancer (SCLC) categorizes patients into limited- or extensive-stage disease groups according to anatomical localizations. Even so, a wide-range of survival times has been observed among patients in the same staging system. This study aimed to identify whether endobronchial mucosa invasion is an independent predictor for poor survival in patients with SCLC, and to compare the survival time between patients with and without endobronchial mucosa invasion. Methods We studied 432 consecutive patients with SCLC based on histological examination of biopsy specimens or on fine-needle aspiration cytology, and received computed tomography and bone scan for staging. All the enrolled patients were assessed for endobronchial mucosa invasion by bronchoscopic and histological examination. Survival days were compared between patients with or without endobronchial mucosa invasion and the predictors of decreased survival days were investigated. Results 84% (364/432) of SCLC patients had endobronchial mucosal invasion by cancer cells at initial diagnosis. Endobronchial mucosal involvement (Hazard ratio [HR], 2.01; 95% Confidence Interval [CI], 1.30–3.10), age (HR, 1.04; 95% CI, 1.03–1.06), and extensive stage (HR, 1.39; 95% CI, 1.06–1.84) were independent contributing factors for shorter survival time, while received chemotherapy (HR, 0.32; 95% CI, 0.25–0.42) was an independent contributing factor better outcome. The survival days of SCLC patients with endobronchial involvement were markedly decreased compared with patients without (median 145 vs. 290, p<0.0001). Among SCLC patients of either limited (median 180 vs. 460, p<0.0001) or extensive (median 125 vs. 207, p<0.0001) stages, the median survival duration for patients with endobronchial mucosal invasion was shorter than those with intact endobronchial mucosa, respectively. Conclusion Endobronchial mucosal involvement is an independent prognostic factor for SCLC patients and associated with decreased survival days.
Feasibility of Bispectral Index-Guided Propofol Infusion for Flexible Bronchoscopy Sedation: A Randomized Controlled Trial
Yu-Lun Lo, Ting-Yu Lin, Yueh-Fu Fang, Tsai-Yu Wang, Hao-Cheng Chen, Chun-Liang Chou, Fu-Tsai Chung, Chih-Hsi Kuo, Po-Hao Feng, Chien-Ying Liu, Han-Pin Kuo
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027769
Abstract: Objectives There are safety issues associated with propofol use for flexible bronchoscopy (FB). The bispectral index (BIS) correlates well with the level of consciousness. The aim of this study was to show that BIS-guided propofol infusion is safe and may provide better sedation, benefiting the patients and bronchoscopists. Methods After administering alfentanil bolus, 500 patients were randomized to either propofol infusion titrated to a BIS level of 65-75 (study group) or incremental midazolam bolus based on clinical judgment to achieve moderate sedation. The primary endpoint was safety, while the secondary endpoints were recovery time, patient tolerance, and cooperation. Results The proportion of patients with hypoxemia or hypotensive events were not different in the 2 groups (study vs. control groups: 39.9% vs. 35.7%, p = 0.340; 7.4% vs. 4.4%, p = 0.159, respectively). The mean lowest blood pressure was lower in the study group. Logistic regression revealed male gender, higher American Society of Anesthesiologists physical status, and electrocautery were associated with hypoxemia, whereas lower propofol dose for induction was associated with hypotension in the study group. The study group had better global tolerance (p<0.001), less procedural interference by movement or cough (13.6% vs. 36.1%, p<0.001; 30.0% vs. 44.2%, p = 0.001, respectively), and shorter time to orientation and ambulation (11.7±10.2 min vs. 29.7±26.8 min, p<0.001; 30.0±18.2 min vs. 55.7±40.6 min, p<0.001, respectively) compared to the control group. Conclusions BIS-guided propofol infusion combined with alfentanil for FB sedation provides excellent patient tolerance, with fast recovery and less procedure interference. Trial Registration ClinicalTrials. gov NCT00789815
Hepatoid Microcarcinoma of the Pancreas: A Case Report and Review of the Literature
Shih-Chiang Huang,Hao-Cheng Chang,Ta-Sen Yeh,Kwai-Fong Ng
Chang Gung Medical Journal , 2012,
Abstract: Hepatoid differentiation in pancreatic carcinoma is a rare phenomenon. It occurs either as a pure form or as a component with other subtypes. Herein, we report a 52-year-old man with an ampullary large cell neuroendocrine carcinoma presenting with obstructive jaundice for 2 months. A 0.5-cm nodule was found in the pancreatic head. Morphologically, the nodule was composed of exclusively hepatocytic tumor cells and sinusoids with dysplastic cytology and capsular invasion. The patient did not have a hepatic mass or ectopic normal liver tissue. This is the first reported case of ampullary large cell neuroendocrine carcinoma coinciding with a pancreatic hepatoid microcarcinoma. The clinicopathological features of pancreatic hepatoid carcinomas and their histogenesis are discussed.
Preparation of Porous F-WO3/TiO2 Films with Visible-Light Photocatalytic Activity by Microarc Oxidation
Chung-Wei Yeh,Kee-Rong Wu,Chung-Hsuang Hung,Hao-Cheng Chang,Chuan-Jen Hsu
International Journal of Photoenergy , 2012, DOI: 10.1155/2012/285129
Abstract: Porous F-WO3/TiO2 (mTiO2) films are prepared on titanium sheet substrates using microarc oxidation (MAO) technique. The X-ray diffraction patterns show that visible-light (Vis) enabling mTiO2 films with a very high content of anatase TiO2 and high loading of WO3 are successfully synthesized at a low applied voltage of 300 V using electrolyte contenting NaF and Na2WO4 without subsequent heat treatment. The cross-sectional transmission electron microscopy micrograph reveals that the mTiO2 films feature porous networks connected by many micron pores. The diffused reflection spectrum displays broad absorbance across the UV-Vis regions and a significant red shift in the band gap energy (∼2.23 eV) for the mTiO2 film. Owing to the high specific surface area from the porous microstructure, the mTiO2 film shows a 61% and 50% rate increase in the photocatalytic dye degradation, as compared with the N,C-codoped TiO2 films under UV and Vis irradiation, respectively.
A Pilot Clinical Study to Investigate the Human Whole Blood Spectrum Characteristics in the Sub-THz Region
Tzu-Fang Tseng,Borwen You,Hao-Cheng Gao,Tzung-Dau Wang,Chi-Kuang Sun
Physics , 2014, DOI: 10.1364/OE.23.009440
Abstract: We have conducted a pilot clinical study to not only investigate the THz spectra of ex-vivo fresh human whole blood of 28 patients following 8-hours fasting guideline, but also to find out the critical blood ingredients of which the concentration dominantly affects those THz spectra. A great difference between the THz absorption properties of human blood among different people was observed, while the difference can be up to ~15% of the averaged absorption coefficient of the 28 samples. Our pilot clinical study indicates that triglyceride and red blood cell were two dominant factors to have significant clinically defined negative correlation to the sub-THz absorption coefficients.
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