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Search Results: 1 - 10 of 7861 matches for " Hans Sandbrink "
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In silico identification of putative promoter motifs of White Spot Syndrome Virus
Hendrik Marks, Xin-Ying Ren, Hans Sandbrink, Mari?lle CW van Hulten, Just M Vlak
BMC Bioinformatics , 2006, DOI: 10.1186/1471-2105-7-309
Abstract: The collective information shows that the upstream region of early WSSV genes, containing a TATA box and an initiator, is similar to Drosophila RNA polymerase II core promoter sequences, suggesting utilization of the cellular transcription machinery for generating early transcripts. The alignment of the 5' ends of known well-established late genes, including all major structural protein genes, identified a degenerate motif (ATNAC) which could be involved in WSSV late transcription. For these genes, only one contained a functional TATA box. However, almost half of the WSSV late genes, as previously assigned by microarray analysis, did contain a TATA box in their upstream region.The data may suggest the presence of two separate classes of late WSSV genes, one exploiting the cellular RNA polymerase II system for mRNA synthesis and the other generating messengers by a new virus-induced transcription mechanism.White Spot Syndrome Virus (WSSV), type species of the virus family Nimaviridae (genus whispovirus), is a pathogen of major economic importance in cultured penaeid shrimp [1,2]. Histopathological studies on WSSV infected shrimp have shown that the virus mainly infects tissues of ectodermal and mesodermal origin, such as the stomach, gills, heart, gut, muscle tissue and hematopoietic tissue [3-5]. Infected cells within these tissues are characterized by the appearance of homogeneous hypertrophied nuclei and chromatin margination [1,5,6]. WSSV particles have been mainly detected in the nuclei of infected cells, indicating that transcription, replication and virion assembly probably occur in the nucleus [5-8]. It is not clear how the virions are released from the nucleus of an infected cell, but this most likely occurs by budding or by rupture of the nuclear envelope and/or the cell membrane.The circular ds DNA genome of three WSSV isolates, originating from Taiwan (WSSV-TW), China (WSSV-CN) and Thailand (WSSV-TH), have been completely sequenced [9-11]. The genome of W
Variability in detection and quantification of interferon β-1b–induced neutralizing antibodies
Hans-Peter Hartung, Bernd Kieseier, Douglas Goodin, Barry Arnason, Giancarlo Comi, Massimo Filippi, Douglas R Jeffery, Ludwig Kappos, Timon Bogumil, Brigitte Stemper, Rupert Sandbrink, Yukiko Nakada, Haruhiko Nakajima, Susanne Schwenke, Stephan Lehr, Juergen Heubach, Christoph Pohl, Joachim Reischl
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-129
Abstract: Blood samples from 125 IFNB-1b–treated patients, which were tested NAb negative or NAb positive after conclusion of a clinical study, were retested three years after first being assessed in four different laboratories that offer routine NAb testing to practicing neurologists. The myxovirus protein A (MxA) induction assay, the cytopathic effect (CPE) assay (two laboratories), or the luciferase assay were used. Intra- and inter-laboratory agreement between assays with respect to NAb detection and NAb titer quantification were evaluated.High agreement for NAb detection (kappa coefficient, 0.86) and for titer levels was observed for the intra-laboratory comparison in the laboratory using the MxA induction assay performed three years ago and now. A similarly high agreement for NAb detection (kappa coefficient, 0.87) and for titer quantification was noted for the MxA assay of this laboratory with one of two laboratories using the CPE assay. All other inter-laboratory comparisons showed kappa values between 0.57 and 0.68 and remarkable differences in individual titer levels.There are considerable differences in the detection and quantification of IFNB-induced NAbs among laboratories offering NAb testing for clinical practice using different assay methods. It is important that these differences are considered when interpreting NAb results for clinical decision-making and when developing general recommendations for potentially clinically meaningful NAb titer levels.
Network Economies for the Internet-Application Models  [PDF]
Hans Gottinger
iBusiness (IB) , 2011, DOI: 10.4236/ib.2011.34042
Abstract: We propose a decentralized model of network and server economies, where we show efficient QoS (Quality of Service) provisioning and Pareto allocation of resources (network and server resources) among agents and suppliers, which are either network routers or servers (content providers). Specifically, it is shown 1) how prices for resources are set at the suppliers based on the QoS demands from the agents and 2) how dynamic routing algorithms and admission control mechanisms based on QoS preferences emerge from the user classes for the network economy.
Fatal Complications and Early Death after Surgical Treatment of Lung Cancer in 2000 and 2010. A Population Based Study  [PDF]
Hans Rostad
Surgical Science (SS) , 2013, DOI: 10.4236/ss.2013.41019
Abstract:

In the year 2000 lung cancer was operated in 349 patients in Norway, in 2010 the number was 461. In the first period fatal surgical hemorrhage occurred in eight patients, in four of them peroperatively. Postoperative hemorrhage occurred in four patients in the year 2000 and in two in 2010. Ten patients died intra- or postoperatively in the two periods which is a mortality rate within 30 days after surgery of 4.3% in the first and 1.1% in the second period. Pneumonectomy was performed in 34 patients in 2000 and eight in 2010, respectively. Altogether 19 patients died within six months after surgery without having experienced surgical complications. Pneumonectomy should not be performed in elderly and debilitated persons.

On the Foundations of Guidelines for Health Economic Assessment  [PDF]
Hans Keiding
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.45004
Abstract:

In recent years, increased attention has been given to guidelines for cost-effectiveness analysis of medical interventions, and some of these guidelines (such as NICE [1]) have become rather influential. In the paper, we present a model of retrieving and processing information to be used for the study of guidelines and their use. Our main result, which relies on a version of the theorem of Blackwell [2], shows that in cases where there are sufficiently many decisions to be made on the basis of the information obtained, there can be no other objective ranking of methods than the trivial one ranking more information is higher than less information. In our context, this means that guidelines may have administrative advantages but cannot be considered as a scientifically based approach to better decision making.

Supersymmetric Yang-Mills theory: a step towards the continuum
Georg Bergner,Istvan Montvay,Gernot Münster,Dirk Sandbrink,Umut D. ?zugurel
Physics , 2011,
Abstract: The spectrum of supersymmetric Yang-Mills theory presented so far shows an unexpected gap between the bosonic and fermionic masses. This finding was in contradiction with the basic requirements of supersymmetry. In this work we will present new results indicating that the mass gap is reduced at a smaller lattice spacing. Hence lattice artifacts are the most likely explanation for it. These new results have been obtained at a larger beta value and on a larger lattice.
First studies of the phase diagram of N=1 supersymmetric Yang-Mills theory
G. Bergner,P. Giudice,G. Münster,S. Piemonte,D. Sandbrink
Physics , 2015,
Abstract: The behavior of supersymmetric theories at finite temperatures differs from that of other theories in certain aspects. Due to the different thermal statistics of bosons and fermions, supersymmetry is explicitly broken for any non-zero value of the temperature. We study N=1 supersymmetric Yang-Mills theory on the lattice at finite temperatures. This model is the simplest supersymmetric extension of the pure gauge sector of QCD, describing the interactions between gluons and their fermionic superpartners, the gluinos. At zero temperature the theory confines like QCD, and chiral symmetry is spontaneously broken. At high temperatures, deconfinement and chiral symmetry restoration are expected to take place, but it is not known whether these two phase transitions coincide or not. First results on this topic, obtained in numerical simulations on the lattice, will be presented and discussed.
Phase structure of the N=1 supersymmetric Yang-Mills theory at finite temperature
G. Bergner,P. Giudice,G. Münster,S. Piemonte,D. Sandbrink
Physics , 2014, DOI: 10.1007/JHEP11(2014)049
Abstract: Supersymmetry (SUSY) has been proposed to be a central concept for the physics beyond the standard model and for a description of the strong interactions in the context of the AdS/CFT correspondence. A deeper understanding of these developments requires the knowledge of the properties of supersymmetric models at finite temperatures. We present a Monte Carlo investigation of the finite temperature phase diagram of the N=1 supersymmetric Yang-Mills theory (SYM) regularised on a space-time lattice. The model is in many aspects similar to QCD: quark confinement and fermion condensation occur in the low temperature regime of both theories. A comparison to QCD is therefore possible. The simulations show that for N=1 SYM the deconfinement temperature has a mild dependence on the fermion mass. The analysis of the chiral condensate susceptibility supports the possibility that chiral symmetry is restored near the deconfinement phase transition.
The gluino-glue particle and finite size effects in supersymmetric Yang-Mills theory
Georg Bergner,Tobias Berheide,Istvan Montvay,Gernot Münster,Umut D. ?zugurel,Dirk Sandbrink
Physics , 2012, DOI: 10.1007/JHEP09(2012)108
Abstract: The spectrum of particles in supersymmetric Yang-Mills theory is expected to contain a spin 1/2 bound state of gluons and gluinos, the gluino-glue particle. We study the mass of this particle in softly broken supersymmetric Yang-Mills theory on a lattice by means of numerical simulations. The main focus is the estimation of finite size effects. We extrapolate the mass first to the infinite volume and then to the limit of a vanishing gluino mass. The results indicate that finite size effects are tolerable on lattices of moderate size, and that remaining deviations from supersymmetry are probably due to finite lattice spacing effects.
N=1 supersymmetric Yang-Mills theory on the lattice
Georg Bergner,Istvan Montvay,Gernot Münster,Dirk Sandbrink,Umut D. ?zugurel
Physics , 2013,
Abstract: Numerical simulations of supersymmetric theories on the lattice are intricate and challenging with respect to their theoretical foundations and algorithmic realisation. Nevertheless, the simulations of a four-dimensional supersymmetric gauge theory have made considerable improvements over the recent years. In this contribution we summarise the results of our collaboration concerning the mass spectrum of this theory. The investigation of systematic errors allows now a more precise estimate concerning the expected formation of supersymmetric multiplets of the lightest particles. These multiplets contain flavour singlet mesons, glueballs, and an additional fermionic state.
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