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Search Results: 1 - 10 of 468 matches for " Hannes Kiesewetter "
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Sodium channels and mammalian sensory mechanotransduction
Ramin Raouf, Francois Rugiero, Hannes Kiesewetter, Rachel Hatch, Edith Hummler, Mohammed A Nassar, Fan Wang, John N Wood
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-21
Abstract: Here we show that deleting β and γENaC sodium channels in sensory neurons does not result in mechanosensory behavioural deficits. We had shown previously that Nav1.7/Nav1.8 double knockout mice have major deficits in behavioural responses to noxious mechanical pressure. However, all classes of mechanically activated currents in DRG neurons are unaffected by deletion of the two sodium channels. In contrast, the ability of Nav1.7/Nav1.8 knockout DRG neurons to generate action potentials is compromised with 50% of the small diameter sensory neurons unable to respond to electrical stimulation in vitro.Behavioural deficits in Nav1.7/Nav1.8 knockout mice reflects a failure of action potential propagation in a mechanosensitive set of sensory neurons rather than a loss of primary transduction currents. DEG/ENaC sodium channels are not mechanosensors in mouse sensory neurons.The identity of the noxious mechanotransduction channels in sensory neurons remains elusive but increasing evidence, particularly from knockout mice, indicates that transduction of noxious stimuli are carried out by more than one channel [1]. Many candidates have been proposed, however none has fulfilled the requirements of a bona fide noxious mechanotransducer that is expressed in mechanosensitive neurons, is activated by high threshold mechanical stimulation, and can be modulated by inflammatory mediators [2]. The list of potential mechanotransducers include TRP channels, potassium channels (see [1] for review), and the novel channel family Fam38a and b (Piezo1 and 2) transmembrane proteins [3]Some invertebrate sodium channels of the ENaC/DEG superfamily are mechanosensors [4-6] but it is still unknown if any mammalian epithelial or voltage gated sodium channels participate in noxious mechanotransduction. Evidence from knockout mice suggests that ASICs are not involved in sensory transduction [7]. Epithelial Na+ channels (ENaC) are voltage-independent, Na+-selective ion channels composed of α, β and γ
Who has really paid for the Reconstruction of East Germany? Expected and Realized Returns on Real Estate Investments in East and West Germany in the 1990s
Dirk Kiesewetter,Tina Bensemann,Kristin Sch?nemann
BuR : Business Research , 2009,
Abstract: We evaluate the profitability of investments in residential property in Germany after unification with a focus on the comparison of East and West Germany. Calculations are carried out for (1) the after-tax return an investor might have expected at the beginning of the 1990s, and (2) the after-tax return that has been realized ten years after. We compare a set of statistical data for investments in fifty major cities by using complete financial budgeting. The results show that tax subsidies could not always protect investors from losing money, but they have boosted realized returns after tax considerably. Therefore, it was indeed the taxpayers, not the investors, who have borne the cost of reconstructing East Germany.
Parallel optimized sampling for stochastic equations
Bogdan Opanchuk,Simon Kiesewetter,Peter D. Drummond
Mathematics , 2015,
Abstract: Stochastic equations play an important role in computational science, due to their ability to treat a wide variety of complex statistical problems. However, current algorithms are strongly limited by their sampling error, which scales inversely to the square root of the sample size. In this paper, we obtain a new class of parallel optimized sampling methods for treating stochastic equations. The objective of parallel optimized sampling is to reduce the sampling error in the observables of an ensemble of stochastic trajectories. This is achieved through calculating a finite set of observables, typically statistical moments, in parallel, and minimizing the errors compared to known target values. The algorithm is both numerically efficient and unbiased, in the sense that it converges for large sample number. Importantly, it does not increase the errors in higher order moments, and generally reduces such errors as well. The same procedure is applied both to initial ensembles and to changes in a finite time-step. Results of these methods show that errors in initially optimized moments can be reduced to the machine precision level, typically around sixteen decimals precision in current hardware. For nonlinear stochastic equations, sampled moment errors during time-evolution are larger than this, due to error propagation effects. Even so, we provide evidence for error reductions of up to two orders of magnitude in a nonlinear equation example, for low order moments, which is a large practical benefit. The sampling error reduction scales inversely as the square root of the sample size for non-optimized moments, as expected, but with the advantage of a very much smaller prefactor than for standard, non-optimized methods.
Mit Nachdruck gegen den Verleger. Alte Allianzen und neue Positionen am literarischen Markt
Hannes Fischer
Libreas : Library Ideas , 2012,
Abstract:
Wolfgang Wüst, Die lokale Policey. Normensetzung und Ordnungspolitik auf dem Lande.
Hannes Ludyga
Forum Historiae Iuris , 2008,
Abstract:
Ursula Niedermeier, Lippisches Judenrecht und der Schutz der Juden in den Zivilprozessen der lippischen Obergerichte im 19. Jahrhundert.
Hannes Ludyga
Forum Historiae Iuris , 2008,
Abstract:
Satu Lidman, Zum Spektakel und Abscheu
Hannes Ludyga
Forum Historiae Iuris , 2008,
Abstract:
Südosteurop ische Geschichte als global verflochtene Regionalwissenschaft: aktuelle Perspektiven des Berliner Wissenschaftsstandortes
Hannes Grandits
Südosteurop?ische Hefte , 2012,
Abstract:
Virtual Environments for Mathematics and Geometry Education
Hannes Kaufmann
Themes in Science and Technology Education , 2009,
Abstract: Since ancient times mathematicians and geometricians have used visualisations to describe, discuss, study and teach mathematics. In mathematics education, visualisations are still usedwhenever possible to support teaching, to inspire students and feed their need to actually see abstract mathematical facts. In our times, virtual reality presents a fascinating, extremely motivatingnew tool in teachers’ hands which allows students to see mathematics in three dimensions. This article gives an overview of various, mainly immersive, virtual environments that have been developed in the previous 10 years to support mathematics and geometry education. The focus lies on one advanced application for geometry education that has been usedand evaluated with over 500 students throughout the years. Findings and teaching experiences are described and discussed.
Ist sicheres Cloud Computing m glich?
Lubich Hannes
IMVS Fokus Report , 2012,
Abstract: Die Auslagerung der Erbringung von ICT-Diensten ist im Zuge der Globalisierung und des stetigen Kostensenkungs-, Optimierungs- und Innovationsdrucks weit fortgeschritten. W hrend bei bis herigen Outsourcing-Modellen jedoch eher die übergabe oder die Migration bereits vorhande ner Entwicklungs-, Betriebs- und Wartungsleistungen inklusive Personal und ICT-Infrastrukturen an externe Diensterbringer im Zentrum des Servicemodells standen, entsteht durch das Angebot von cloudbasierten Dienstleistungen ein neues Auslagerungsmodell. Dieses neue Modell basiert auf der Nutzung einer technologisch wesentlich st rker standardisierten, dafür jedoch weitgehend dynamischen, orts- und umgebungsunabh ngigen Infrastruktur und Diensterbringung
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