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Search Results: 1 - 10 of 26749 matches for " Hanjun Jin "
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The promise and reality of personal genomics
Bryndis Yngvadottir, Daniel G MacArthur, Hanjun Jin, Chris Tyler-Smith
Genome Biology , 2009, DOI: 10.1186/gb-2009-10-9-237
Abstract: Which country has published the largest per-capita number of personal genomes? The United States, the United Kingdom? Actually, it is Korea. A recent article in Nature by Kim et al. [1] presents the genome sequence of a Korean male, AK1 - the seventh published sequence of an individual human genome and the second from Korea. The rapid progress in personal genome sequencing is possible because so-called 'next-generation' sequencing technology has decreased costs by orders of magnitude and increased throughput. But those advantages come at a price: short, error-prone reads derived from single molecules that have to be stitched back together to make a best-guess at the starting sequence. We are still at the stage of working out how to apply the available technologies to coax out biological information: the goal of a US$1,000 genome providing life-changing personal medical insights is still some way off.The first aim of a genome-sequencing project is to assemble around 6 billion As, Cs, Gs and Ts, comprising the diploid genome of the individual, in the right order. This is a challenge both of scale and because of sequence complexities such as repeated elements. By a series of frankly heroic measures, Kim et al. [1] have succeeded in generating a sequence that is likely to be substantially more complete and accurate than any other individual human genome derived so far using the new sequencing technology. Nonetheless, the effort invested in producing such a high-quality sequence, including the cloning and high-coverage sequencing of large segments of the genome from bacterial artificial chromosomes (BACs), is not routinely feasible and the final product is still far from complete. The clear message is that sequencing technology still has a long way to go before we enter the era of cheap, complete and reliable individual genome sequencing.The high depth of coverage for the AK1 sequence (most parts of the genome were sequenced around 28 times (28×)) meant that most variant
Success Factors in Western and Chinese Born Global Companies  [PDF]
Svante Andersson, Mike Danilovic, Hanjun Huang
iBusiness (IB) , 2015, DOI: 10.4236/ib.2015.71004
Abstract: Born Global firms are becoming increasingly more important in terms of internationalization, innovation, ability to grow and providing employment. Most of the previous research about Born Globals is done in North America, Europe or Australia, all these being developed industrialized countries but not developing countries or emerging markets. However, the emerging markets in general, and the Chinese in particular, have become very important for the world economy. Our aim is to investigate the differences between Western literature and literature from emerging markets, regarding internationalization process of Born Global firms. We also aim to discuss the various success factors, which underlie Born Globals’ internationalization process, particularly focusing on Born Globals firms in the China. Our methodology in this research has been literature review and interviews with Chinese CEOs of Born Global firms. However, this paper is only based on the litterateur part of our research. Our analysis shows that most of the Chinese Born Globals publications about the internationalization success factors are based on the Western literature and use them as the theoretical platform in the design of their own research strategy and research questions design. The consequence of this observation is important as it indicates that Chinese researchers are reproducing research under different contextual and situational conditions that might lead to unclear conclusions or maybe even wrong conclusions. Furthermore, compared to most Western Born Global companies, which treat innovation as core competence, the innovation culture becomes one of the biggest weaknesses of Chinese manufacturing Born Globals’ internationalization. China has special economic environment. Chinese manufacturing Born Globals not only need to follow the market but also the government policies, since the government greatly influences the industries and the whole economy. To foreign investors who want to exploit Chinese market, they also should take Chinese economic background and government policies into consideration. One important aspect of Chinese born Globals, neglected in previous research on Born Globals, that has been identified in our research, is the critical success factor of Chinese manufacturing Born Globals—the political and economic background and the role of the Chinese Government in the transformation process of Chinese business life, and the Guanxi network.
Quasi-Stationary Distributions in Linear Birth and Death Processes
Wenbo Liu,Hanjun Zhang
Journal of Mathematics Research , 2011, DOI: 10.5539/jmr.v3n1p27
Abstract: The quasi-stationary distributions {aj} for a linear birth and death process is determined by two methods. The first method obtains our desired results by computing directly while the second method bases on the relationship between {aj} and its limiting of probability generating function. In addition, we also obtain the stationary distribution for a linear birth, death and immigration process with the second method.
Domain of attraction of the quasi-stationary distribution for one-dimensional diffusions
Hanjun Zhang,Guoman He
Mathematics , 2014,
Abstract: In this paper, we study quasi-stationarity for one-dimensional diffusions killed at 0, when 0 is a regular boundary and $+\infty$ is an entrance boundary. We give a necessary and sufficient condition for the existence of exactly one quasi-stationary distribution, and that this distribution attracts all initial distributions.
On quasi-ergodic distribution for one-dimensional diffusions
Guoman He,Hanjun Zhang
Mathematics , 2014,
Abstract: In this paper, we study quasi-ergodicity for one-dimensional diffusion $X$ killed at 0, when 0 is an exit boundary and $+\infty$ is an entrance boundary. Using the spectral theory tool, we show that if the killed semigroup is intrinsically ultracontractive, then there exists a unique quasi-ergodic distribution for $X$. An example is given to illustrate the result.
Existence and construction of quasi-stationary distributions for one-dimensional diffusions
Hanjun Zhang,Guoman He
Mathematics , 2014,
Abstract: In this paper, we study quasi-stationary distributions (QSDs) for one-dimensional diffusions killed at 0, when 0 is a regular boundary and $+\infty$ is a natural boundary. More precisely, we not only give a necessary and sufficient condition for the existence of a QSD, but we also construct all QSDs for one-dimensional diffusions. Moreover, we give a sufficient condition for $R$-positivity of the process killed at the origin. This condition is only based on the drift, which is easy to check.
Aminopeptidases do not directly degrade tau protein
K Chow, Hanjun Guan, Louis B Hersh
Molecular Neurodegeneration , 2010, DOI: 10.1186/1750-1326-5-48
Abstract: An N-terminally His tagged-PSA was expressed and purified from Sf9 insect cells. Although this PSA preparation cleaved Tau, product analysis with N and C terminal Tau antibodies coupled with mass spectrometry showed an endoproteolytic cleavage atypical for an aminopeptidase. Furthermore, the reaction was not blocked by the general aminopeptidase inhibitor bestatin or the specific PSA inhibitor puromycin. In order to test whether Tau hydrolysis might be caused by a protease contaminant the enzyme was expressed in E. coli as glutathione S-transferase and maltose binding protein fusion proteins or in Sf9 cells as a C-terminally His-tagged protein. After purification to near homogeneity none of these other recombinant forms of PSA cleaved Tau. Further, Tau-cleaving activity and aminopeptidase activities derived from the Sf9 cell expression system were separable by molecular sieve chromatography. When tested in a cellular context we again failed to see a PSA dependent cleavage of Tau. A commercial preparation of a related aminopeptidase, aminopeptidase N, also exhibited Tau cleaving activity, but this activity could also be separated from aminopeptidase activity.It is concluded that PSA does not directly cleave Tau.The microtubule-associated protein tau (Tau) is located primarily in the central nervous system (CNS) and regulates the stability of microtubules. Tau is normally phosphorylated in cells with its state of phosphorylation related to developmental state [1]. Under abnormal conditions Tau becomes hyperphosphorylated, dissociates from microtubules and forms aggregates [2,3]. There are a number of neurodegenerative diseases caused by Tau aggregation collectively termed tauopathies. Among these is Alzheimer's disease in which intracellular Tau aggregates known as tangles are found in the brain and are believed to contribute to the etiology of the disease [4-6].Like other microtubule-associated proteins (MAPs), a tandem microtubule-binding motif GSxxNxxHxPGGG is foun
PIEZOELECTRIC CERAMICS WITH kp=0.15
kp值为15%的压电陶瓷的研制

Zhang Hanjun,
张汉君

电子与信息学报 , 1985,
Abstract: 陶瓷滤波器材料的k_p值需要从15%到75%形成系列。而低k_p值材料的Q_M值必须在3500以上,频率稳定度(△f/f)必须优于0.01%才有使用价值。为此,我们在k_p值为20%的材料基础上,进行了k_p值为15%的材料的研制。 k_p值为20%的材料的配方可以写作:
Asymptotical Mean Square Stability of Cohen-Grossberg Neural Networks with Random Delay
Zhu Enwen,Zhang Hanjun,Zou Jiezhong
Journal of Inequalities and Applications , 2010,
Abstract: The asymptotical mean-square stability analysis problem is considered for a class of Cohen-Grossberg neural networks (CGNNs) with random delay. The evolution of the delay is modeled by a continuous-time homogeneous Markov process with a finite number of states. The main purpose of this paper is to establish easily verifiable conditions under which the random delayed Cohen-Grossberg neural network is asymptotical mean-square stability. By employing Lyapunov-Krasovskii functionals and conducting stochastic analysis, a linear matrix inequality (LMI) approach is developed to derive the criteria for the asymptotical mean-square stability, which can be readily checked by using some standard numerical packages such as the Matlab LMI Toolbox. A numerical example is exploited to show the usefulness of the derived LMI-based stability conditions.
Asymptotical Mean Square Stability of Cohen-Grossberg Neural Networks with Random Delay
Enwen Zhu,Hanjun Zhang,Jiezhong Zou
Journal of Inequalities and Applications , 2010, DOI: 10.1155/2010/247587
Abstract: The asymptotical mean-square stability analysis problem is considered for a class of Cohen-Grossberg neural networks (CGNNs) with random delay. The evolution of the delay is modeled by a continuous-time homogeneous Markov process with a finite number of states. The main purpose of this paper is to establish easily verifiable conditions under which the random delayed Cohen-Grossberg neural network is asymptotical mean-square stability. By employing Lyapunov-Krasovskii functionals and conducting stochastic analysis, a linear matrix inequality (LMI) approach is developed to derive the criteria for the asymptotical mean-square stability, which can be readily checked by using some standard numerical packages such as the Matlab LMI Toolbox. A numerical example is exploited to show the usefulness of the derived LMI-based stability conditions.
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