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Search Results: 1 - 10 of 714129 matches for " Hanan M. Elnahas* and Ayman A. Mowafy "
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LIPOSOMAL GEL AS OCULAR DELIVERY SYSTEM FOR DICLOFENAC SODIUM: IN- VITRO AND IN-VIVO STUDIES
O. A. Sammour , Md. A. Mahdy , Hanan M. Elnahas* and Ayman A. Mowafy
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: The aim of this work is to formulate topically effective controlled release ophthalmic liposomal gel for targeting diclofenac sodium to the eye in an attempt to heal the inflamed tissue of ocular ulcerative area. Large unilamellar vesicles (LUVs) and multilamellar vesicles (MLVs) gel formulations composing of phosphatidylcholine (PC) and cholesterol (CH) in the molar ratios of (7:2; 7:4 and 7:7) with or without stearylamine (SA) or dicetylphosphate (DP) were prepared using reversed-phase evaporation and lipid film hydration methods respectively. The prepared liposomal systems were evaluated for their entrapment efficiency, morphological characters, physical stability, particle size and drug release rate .LUVs entrapped greater amount of drug than MLVs. Drug loading was increased by increasing CH content as well as by inclusion of SA into the lipid bilayer. Drug release rate showed an order of negatively > neutral > positively charged liposomes, which is the reverse of results of drug loading efficiency. Physical stability study indicated that 92.56%, 84.11%, 76.41% and 91.1%, 82.19% and 75.54% of diclofenac sodium was retained in positive, negative, and neutral MLVs and LUVs respectively after storing for 120 days at refrigeration temperature. The in vivo anti-inflammatory activity was evaluated using a thermal technique , results showed that the percentage of healed ulcers were 12.5%, 35%, 67.5%, 82.5%, 85%, 87.5% and 95% for negative control, positive control, 0.5% carbopol 934 gel, LUVs liposomes suspension, MLVs liposomes suspension, LUVs and MLVs gels, respectively.
Letrozole versus Gonadotropin in Unexplained Infertile Couples Failed to Conceive with Clomiphene Citrate  [PDF]
Moustafa Abbas Ibrahaiem, Sherin A. Shazly, Khaled F. Helal, Hala Mowafy, Manal M. El Behery
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.410088
Abstract:

Background: Unexplained infertility represents about 15% - 20% of infertile couples. Usually, these cases need assistance. Clomiphene citrate is the most used drug for this problem but sometimes pregnancy failed to achieve it, so other options for assistance are gonadotrophin or letrezole. The objective of our study was to compare the pregnancy rate for letrezole and gonadotropin inunexplained infertile women’s who failed to conceive with clomiphene citrate. Methods: This prospective quasi-randomized trial was carried out in cytogenetic unite at obstetrics and gynecology department, Zagazig University Hospital. 140 infertile females were included, induction of ovulation by letrozole for half of them and by gonadotrophin for the other half. Results: There was statistically highly significant decrease in duration of stimulation, E2 levels and endometrial thickness at day of HCG in letrezole group, no significant difference between two groups as regard number of follicles and pregnancy rate per cycle, while the cumulative pregnancy rate and the cost of stimulation are significantly higher in gonadotrophin group. Conclusion: In patient with unexplained infertility who failed to conceive with clomiphene citrate, gonadotrophins have a higher pregnancy rate than letrezole. However, pregnancy rate was high enough with lower cost with letrezole to be acceptable and justified its use in this group of patients.

Genetic and Metabolic Variability between Two Subspecies of Chamaeleo chamaeleon (Reptilia: Chamaeleonidae) in Egypt  [PDF]
Mohamed A. M. Kadry, Hanan R. H. Mohamad
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.58083
Abstract:

The degree of variability between two subspecies of Chamaeleo chamaeleon; C. chamaeleon chamaeleon inhabiting El-Dabaa (MarsaMatrouh) and C. chamaeleon musae inhabiting El-Arish (North Sinai) of Egypt was investigated in this study using polyacrylamide gel electrophoreses for Lactate dehydrogenase (Ldh) and Alfa-esterase (α-Est) isoenzymes. Total lipids and proteins of liver and muscle tissues in both species were analyzed. Three Ldh isoforms were recorded for both subspecies and the activity. Rate of flow (RF) of Ldh-1 seemed to be higher in C. chamaeleon chamaeleon than in C. chamaeleon musae. This high activity could be supported by the significant increase in the total lipids and proteins in liver and muscle tissues of this species. It may thus be reasonable to suppose that C. chamaeleon chamaeleon is more active, energetic and adaptable in its habitat than C. chamaeleon musae. The α-Est showed four fractions in both subspecies. The null

Enhancement in Mechanical Properties of Polystyrene Filled with Carbon Nano-Particulates (CNPS)  [PDF]
Ayman A. Aly, Moustafa M. Mahmoud, Adel A. Omar
World Journal of Nano Science and Engineering (WJNSE) , 2012, DOI: 10.4236/wjnse.2012.22013
Abstract: The idea of adding reinforcing materials, or fillers, to polymers has been around for many decades. The reason for the creation of polymer composite materials came about due of the need for materials with specific properties for specific applications. For example, composite materials are unique in their ability to allow brittle and ductile materials to become softer and stronger. It is expected that good tribological properties can be obtained for polymers filled with nano-scale fillers. A soft plastic can become harder and stronger by the addition of a light weight high stiffness material. In the present work, the effect of adding different percentages of carbon nano-particulates to polystyrene (PS) on the mechanical properties of nano-composites produced was investigated. Based on the experimental observations, it was found that as the percentage of the carbon nano-particulates (CNPS) increased hardness increased and consequently friction coefficient remarkably decreased.
The Prevalence of Metabolic Syndrome in an Apparently Healthy, Normotensive and Non-Diabetic Population in Saudi Arabia by Two Definitions: Implications for Local Practice  [PDF]
Suhad M. Bahijri, Rajaa M. Al Raddadi, Hanan Jambi, Mohammad-Nabeel A. Alaama, Gordon Ferns
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2013, DOI: 10.4236/ojemd.2013.31003
Abstract:

Objectives: We aimed to 1) investigate the prevalence of MS in apparently healthy, non-hypertensive non-diabetic individuals living in Jeddah using the IDF and the NCEP-ATP III criteria to test for agreement in classification, and to determine the characteristics of subjects identified by either definition, and 2) examine the significance of family medical history and life style habits. Methods: 557 apparently healthy individuals aged 18 - 50 y were randomly approached in Jeddah health centres. 412 agreed to participate, while 55 were excluded because they were found to be frankly hypertensive and/or diabetic. Finally, 357 apparently healthy subjects with no hypertension or diabetes were fully studied. Anthropometric and demographic information were collected. Insulin, glucose, and lipid profile were obtained in fasting blood samples. Individuals were identified using the two definitions of metabolic syndrome, and their characteristics were compared statistically to the rest of the population. Results: Of the 233 subjects fulfilling the inclusion criteria, 44 and 39 (18.9% and 16.7%) were identified as having MS by the IDF or ATPIII definitions, respectively. The most common characteristic was central obesity using the IDF definition, and low HDL-cholesterol using the NCEP-ATP III definition. As expected from our exclusion criteria, the least common feature was high blood pressure in both cases. There was no significant difference between subgroups with and without MS with regard to smoking, exercise, and family history of disease. Regression analysis indicated the strongest predictors of MS were: blood glucose, LDL-C/HDL-C ratio and plasma insulin using the NCEP-ATPIII definition, and blood glucose, Waist /Hip ratio and plasma atherogenic index (PAI) using the IDF definition. Conclusions: In the absence of local cut-off thresholds for waist circumference, subjects might escape diagnosis using the IDF definition. The use of waist/Hip ratio, LDL-C: HDL-C, PAI and circulating insulin help with the diagnosis.

Reliability of Plasma Von Willebrand Factor Antigen in Prediction of Esophageal Varices in Patients with Liver Cirrhosis  [PDF]
Hasan Sedeek Mahmoud, Ali A. Ghweil, Shamardan E. Bazeed, Hanan M. Fayed, Mona M. Abdel Meguid
Open Journal of Gastroenterology (OJGas) , 2015, DOI: 10.4236/ojgas.2015.56010
Abstract: Background: Bleeding esophageal varices (OVs) due to portal hypertension are one of the major complications with high mortality in liver cirrhosis. So, early detection and management are mandatory. Aim: To evaluate the role of Von Willebrand factor (VWF) in predicting the presence of OVs. Patients and Methods: 62 patients with liver cirrhosis representing different Child-Pugh classes were included. The diagnosis of liver cirrhosis was based on the combination of clinical, laboratory and US examinations. All included patients underwent the following investigations: complete blood count, liver function tests (ALT, AST, serum bilirubin, albumin and total protein, prothrombin time (PT) and concentration (PC), INR and serum alkaline phosphatase), serum creatinine, Von Willebrand factor antigen (VWF-Ag) measurement and abdominal US. Upper endoscopic evaluation was done to detect presence or absence of varices (esophageal or gastric) and/or PHG. Results: 38 males and 24 females with their mean age (46 ± 12 years old) were included. Plasma Von Willebrand factor-Ag level was significantly higher in patients with OVs than those without varices (P value = 0.000). Also, its level was significantly higher in patients with higher grade of OVs, G3 than those with G1 or G2 (P value = 0.000). Patients with large OVs including those with G2 and G3 showed significantly higher values of VWF than those with small OVs (NO and G1) (P value = 0.000). VWF was independent predictor for detecting the presence of OVs with good sensitivity (90), specificity (77.3) and accuracy (85.5) at a cutoff value of 1.74 U/ml. Also it was an independent predictor for detecting the presence of large OVs with good sensitivity (91.2), specificity (85.7) and accuracy (88.7) at a cutoff value of 2.16 U/ml. Conclusion: VWF-Ag could be used as a non invasive laboratory independent predictor for the detection of OVs.
Ultraviolet Protection, Flame Retardancy and Antibacterial Properties of Treated Polyester Fabric Using Plasma-Nano Technology  [PDF]
Wafaa M. Raslan, Usama S. Rashed, Hanan El-Sayad, Azza A. El-Halwagy
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.210194
Abstract: Nanotechnology provides the ability to engineer the properties of materials. The possibility of using dielectric barrier discharge (DBD) air plasma treatment for fibre surface activation to facilitate deposition of aluminum oxide (Al2O3), nano-silver (Ag) and nano-titanium dioxide (TiO2) onto polyester fabric is investigated. It is aimed to study the possibility of engineering the multifunctional of polyester fabric. The treated fabric is evaluated through measuring the whiteness index (WI), wettability, surface roughness, surface morphology, flame retardancy, ultraviolet protection factor (UPF), thermo-gravimetric analysis (TGA), antibacterial activity, mechanical properties, and coloration behavior as well as fastness properties. Scan electron microscopy (SEM) and transmission electron microscopy (TEM) graphs show deposition of Al2O3 and nano particles (NPs) of TiO2 and Ag onto the fibre after washing several times. Air plasma-Al2O3 treatment improves the flame retarding, UPF, the thermal stability and whiteness of polyester fabric; whereas air plasma-nano Ag treatment affects positively the antibacterial activity of the fibre and air plasma-nano TiO2 enhances the fibre protection against ultraviolet rays. The colouration behaviour of the treated samples is unchanged or slightly improved.
Survival and Prognostic Factors in Patients with Carcinoma of Cervical Stump  [PDF]
Hanan Ahmed Wahba, Hend Ahmed El-Hadaad, Waleed Nabeel Abozeed, Waleed Elnahas, Sameh Roshdy, Anas Gamal
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.611109
Abstract: Purpose: To evaluate patients with carcinoma of cervical stump (CCS) and analyse different clinico-pathologic factors affect prognosis. Patients and Methods: This study was carried out through review of clinical records of patients. Recorded data included information on age, tumor stage, presenting symptoms, size of tumor, histopathology, grade, type, cause of subtotal hysterectomy (STH), treatment and follow-up results. Staging according to International Federation of Gynecology and Obstetrics (FIGO) staging system was done through: PHYSICAL examination, pelvic examination under anaesthesia, chest X-ray, magnetic resonance imaging (MRI) of the abdomen and pelvis, cystoscopy, rectosigmoidoscopy and intravenous pyelography. Prognostic factors as age, size of tumor, stage, lymph node (LN) involvement, pathological type, grade and type of CCS either true or coincidental were analysed through multivariate analysis. Results: 62% of patients are above 50 years with stage II in 48.7%. Squamous cell carcinoma was more common but 54% are of GIII. 89% were true CCS. Positive lymph nodes were reported in 27%. The predominant reason for STH was abnormal bleeding (73%). In about 95% of cases, women seeked medical attention because of symptoms and the most common presenting symptom was bleeding (54%). According to the stage and performance status of patients, treatment consisted of radiotherapy either external or interstitial, chemotherapy and chemoradiotherapy. Through multivariate analysis, the following was found to have adverse impact on survival: Coincidental type (P = 0.04), high grade (P = 0.03), advanced stage (P = 0.01), larger tumor size (P = 0.02), lymph node involvement (P = 0.029) and older age (P = 0.035). While pathological type was not (P = 0.52). After median follow-up of 52 months; 5-year overall survival was 65%. Conclusion: CCS has a low morbidity. Adverse survival outcomes can be anticipated in those patients with: high grade lesions, advanced stages, large tumor size, coincidental type, older age and positive lymph node involvement.
A Survey of MANET Survivability Routing Techniques  [PDF]
Malik N. Ahmed, Abdul Hanan Abdullah, Ayman El-Sayed
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2013, DOI: 10.4236/ijcns.2013.64021
Abstract:

Mobile ad hoc networks have a wide range of application usage today, due to its great services, easy installation and configuration, and its other distinctive characteristics. In contrast, the attackers also have developed their own way to disrupt MANET normal operations. Many techniques, approaches and protocols have proposed to support Mobile Ad hoc Network (MANET) survivability in adversarial environment. Survivable of routing operations is the key aspects of the challenge in MANETs because most of destructive attacks classified as active attacks and all are intent to attack MANET routing operation to prevent it from providing it services in a right time. In this paper, we will discuss the most effective and practical initiatives have designed to keep MANET survive in an adversarial environment and how it supporting MANET availability.

Low-Level Laser Therapy versus Four Layers Compression Technique in the Treatment of Venous Ulcers  [PDF]
Medhat El-Laboudy, Ayman M. Samir, Ahmad M. Tawfik, Waleed A. Sorour, Adel M. Tolba
Surgical Science (SS) , 2014, DOI: 10.4236/ss.2014.59065
Abstract: Objective: The aim of the study is to evaluate the effect of low-level laser therapy in comparison to compression bandage therapy in the treatment of venous ulcers. Subjects & Methods: This study was carried out in the period from March 2013 to March 2014. The study included 40 adult patients with a diagnosis of venous ulcer classified as C6 according to the clinical classification of CEAP classification. The patients were divided into 2 groups: the first one included 20 patients treated by low-level laser therapy at the Rheumatology and Rehabilitation department, and the second group included 20 patients in whom we use four layers compression bandaging at the vascular surgery department. Results: 32 ulcers were treated in group I and 35 ulcers were treated in group II. The patients of group I were 7 (35%) females and 13 (65%) males, their age range were (24 - 56) years. The patients of group II were 11 (55%) males and 9 (45%) females; their age ranges were (32 - 50) years. Measurements of the ulcers size by (cm2) were taken at the beginning of therapy, at 1 month, at 2 months and at 3 months later on. The calculation of the area of the ulcer was done by using the graph papers to document the ulcer’s perpendicular linear dimensions. According to the size of the ulcer, some ulcers heal within 1 month (15.6%) ulcers in group I, and (28.5%) in group II. Some ulcers heal within 2 months (28%) in group I, and (37%) in group II. The remaining ulcers heal within 3 months or more which are (56%) ulcers in group I, and (34.2%) ulcers in group II. The recurrence rate of chronic venous leg ulcer in compression bandage technique used in group II was the least one as the total number of recurrent cases were 5 (25%), followed by laser therapy used in group I. Conclusion: There was no significant efficacy of the low-level laser therapy over the four layers compression technique in the management of chronic venous ulcers.
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