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Search Results: 1 - 10 of 21869 matches for " Han-Pin Kuo "
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Asthma Control in Asthmatic Patients Treated for Lung Cancer
Chung-Hsing Hsieh,Chun-Hua Wang,Han-Pin Kuo,Kang-Yun Lee
Chang Gung Medical Journal , 2011,
Abstract: Background: The balance of the Th1 and Th2 immune response plays an important role inthe regulation of the immune system and in general health. Tumor bearinghosts are supposed to have a balance shifting to the Th2 pathway, while afavorable Th1 anti-tumor pathway is induced in tumor-resected hosts. Theclinical impacts of a tumor-related Th2 environment have not been clearlystudied. The present study was conducted to test the hypothesis that nonsmallcell lung cancer (NSCLC) has an impact on control of asthma, a wellknownTh2-predominant inflammatory disease.Method: Thirty-eight patients with the diagnoses of both asthma and lung cancer wereretrospectively enrolled. Patients were divided into two groups according totheir response to lung cancer treatment, the responder group (completeregression, partial regression and stable disease) and non-responder group(progression of disease). Asthma control test (ACT) scores were analyzedone year before diagnosis, at the time of diagnosis of lung cancer, and at thetime of re-staging after cancer treatment.Results: All the asthmatics with lung cancer had worsening of their symptomsaccording to their ACT scores at the time of diagnosis of lung cancer comparedto scores in the preceding year (21.6
Cross-talk between Bradykinin and Epidermal Growth Factor in Regulating IL-6 Production in Human Airway Smooth Muscle Cells
Po-Hao Feng,Te-Chih Hsiung,Han-Pin Kuo,Chien-Da Huang
Chang Gung Medical Journal , 2010,
Abstract: Background: Bradykinin (BK), a G-protein-coupled-receptor (GPCR) agonist via the B2receptor induces interleukin (IL)-6 expression in airway smooth muscle(ASM) cells by involving the extracellular signal-regulated kinase 1/2(ERK1/2) signaling pathway. In some cell species, GPCR agonists have beenshown to activate the ERK 1/2 pathway via transactivation of epidermalgrowth factor (EGF) receptor (EGFR). In this study, we tested whether thereis cross-talk between BK and EGF in the regulation of IL-6 gene expressionin ASM cells.Methods: ASM cells were treated with BK, EGF, AG-1478 and genistein. IL-6 productionwas analyzed by enzyme-linked immunosorbent assay (ELISA).Immunoblot study was used for detection of ERK1/2 activation.Transactivation of EGFR phosphorylation was detected by immunoprecipitation.Results: ELISA showed that EGF (10 ng/ml, 18 hr) increased IL-6 secretion (from234
Complications of airway self-expandable metallic stent in benign airway diseases  [PDF]
Fu-Tsai Chung, Shu-Min Lin, Chun-Liang Chou, Hao-Cheng Chen, Chih-Hsi Kuo, Horng-Chyuan Lin, Chien-Ying Liu, Chun-Hua Wang, Han-Pin Kuo, Chih-Teng Yu
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.41A016

Objectives: To present the complications of Ultraflex Self-Expandable Metallic Stents (SEMSs) applied in patients with benign tracheobronchial diseases. Methods: Eighty patients received 124 SEMSs were retrospectively reviewed in a tertiary hospital. Results: The baseline characteristics of patients received SEMS implantation including age (mean + standard deviation: 62.5 + 14.8 years), gender (male, 60.5%), smoking (46.8%), forced expiratory volume in first one second (FEV1) (mean + standard deviation, 0.92 +0.41 L/s), follow-up days after SEMS implantation (median (interquartile range); 457 (131 - 897)) and covered SEMS (33.9%) were listed. Symptoms improved after SEMS implantation among 95 patients (76.6%). Time to complications developed was 236 (median; interquartile range, 59 - 672) days. The overall complication rate was 41.9% after SEMS implantation. The complications included SEMS migration (6.5%), granuloma (19.3%) and SEMS fracture (16.1%). Successful management rates of SEMS migration, granuloma and SEMS fracture were up to 100%, 83.3%, and 85% respectively. Conclusions: Patients received SEMS implantation due to benign conditions had poor lung function and were old. The complication rate in patients with benign conditions was high after longer follow-up period, however, successful management achieved in most patients with complications.

An outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort study
Fu-Tsai Chung, Hao-Cheng Chen, Chun-Liang Chou, Chih-Teng Yu, Chih-Hsi Kuo, Han-Pin Kuo, Shu-Min Lin
Journal of Cardiothoracic Surgery , 2011, DOI: 10.1186/1749-8090-6-46
Abstract: Of 149 patients, 72 with benign and 77 with malignant tracheobronchial disease received 211 SEMSs (benign, 116; malignant, 95) and were retrospectively reviewed in a tertiary hospital.The baseline characteristics of patients who received SEMS implantation for benign conditions and those who underwent implantation for malignant conditions were significantly different. These characteristics included age (mean, 63.9 vs. 58; p < 0.01), gender (male, 62% vs. 90%; p < 0.0001), smoking (47% vs. 85%; p < 0.0001), forced expiratory volume in 1 second (mean, 0.9 vs. 1.47 L/s; p < 0.0001), follow-up days after SEMS implantation (median; 429 vs. 57; p < 0.0001), and use of covered SEMS (36.2% vs. 94.7%; p < 0.0001). Symptoms improved more after SEMS implantation in patients with benign conditions than in those with malignant conditions (76.7% vs. 51.6%; p < 0.0001). The overall complication rate after SEMS implantation in patients with benign conditions was higher than that in patients with malignancy (42.2% vs. 21.1%; p = 0.001). Successful management of SEMS migration, granulation tissue formation, and SEMS fracture occurred in 100%, 81.25%, and 85% of patients, respectively.Patients who received SEMS implantation owing to benign conditions had worse lung function and were older than those who received SEMS for malignancies. There was higher complication rate in patients with benign conditions after a longer follow-up period owing to the nature of the underlying diseases.Patients with symptomatic central airway lesions can be treated with surgery or endoscopic intervention [1-3]. Owing to advances in endobronchial stents and insertion techniques, interventional bronchoscopic procedures have been widely used in patients with benign and malignant lesions [4-7]. Rigid and flexible bronchoscopies are the most common methods of stent implantation in these patients. Some patients are not candidates for surgical intervention or rigid bronchoscopy with a general anaesthetic, however,
NF-κB Repressing Factor Inhibits Chemokine Synthesis by Peripheral Blood Mononuclear Cells and Alveolar Macrophages in Active Pulmonary Tuberculosis
Kuo-Hsiung Huang, Chun-Hua Wang, Kang-Yun Lee, Shu-Min Lin, Chien-Huang Lin, Han-Pin Kuo
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077789
Abstract: NF-κB repressing factor (NRF) is a transcriptional silencer implicated in the basal silencing of specific NF-κB targeting genes, including iNOS, IFN-β and IL-8/CXCL8. IP-10/CXCL10 and IL-8/CXCL8 are involved in neutrophil and lymphocyte recruitment against M. tuberculosis (MTb) and disease progression of pulmonary tuberculosis (TB). Alveolar macrophages (AM) and peripheral blood mononuclear cells (PBMC) were used to study the regulatory role of NRF in pulmonary TB. AM and PBMC were purified from 19 TB patients and 15 normal subjects. To study the underlying mechanism, PBMC were exposed to heated TB bacilli. The regulation role of NRF in IP-10/CXCL10 and IL-8/CXCL8 was determined by NRF knock-down or over-expression. NRF binding capabilities in promoter sites were measured by chromatin immunoprecipitation (ChIP) assay. The levels of IP-10/CXCL10, IL-8/CXCL8 and NRF were significantly higher in AM and PBMC in patients with active TB. NRF played an inhibitory role in IP-10/CXCL10 and IL-8/CXCL8 inductions. We delineate the role of NRF in pulmonary TB, which inhibits the expressions of IP-10/CXCL10 and IL-8/CXCL8 in AM and PBMC of patients with high bacterial load. NRF may serve as an endogenous repressor to prevent robust increase in IP-10/CXCL10 and IL-8/CXCL8 when TB bacterial load is high.
The Relationship among Teaching Beliefs, Student-Centred Teaching Concept and the Instructional Innovation  [PDF]
Mei-Hui Lin, Tsai-Fu Chuang, Han-Pin Hsu
Journal of Service Science and Management (JSSM) , 2014, DOI: 10.4236/jssm.2014.73017

The objective of this study is to investigate the relationship among teachers’ teaching beliefs, student-centred teaching concept and instructional innovation in Taiwan. The study was conducted with the participation of 538 teachers of elementary schools. A questionnaire of the “teaching beliefs and instructional innovation” designed by the authors was used as the data collection instruments. The descriptive statistics, Pearson product-moment correlation and multiple regression analysis were used in this study. Analysis results showed that: 1) There is a positive relationship between the teaching beliefs and the instructional innovation. 2) Teacher with a high degree of student-centred teaching concept would exhibit a higher level style of instructional innovation. 3) Multiple regression analysis can be used to infer causal relationships between the teachers’ teaching beliefs and instructional innovation.

Diagnostic Value of EBUS-TBNA for Lung Cancer with Non-Enlarged Lymph Nodes: A Study in a Tuberculosis-Endemic Country
Chih-Hsi Kuo,Hao-Cheng Chen,Fu-Tsai Chung,Yu-Lun Lo,Kang-Yun Lee,Chih-Wei Wang,Wen-Han Kuo,Tzu-Chen Yen,Han-Pin Kuo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016877
Abstract: In tuberculosis (TB)-endemic areas, contrast-enhanced computed tomography (CT) and positron emission tomography (PET) findings of lung cancer patients with non-enlarged lymph nodes are frequently discrepant. Endobronchial ultrasound-guided transbronchial aspiration (EBUS-TBNA) enables real-time nodal sampling, and thereby improves nodal diagnosis accuracy. This study aimed to compare the accuracy of nodal diagnosis by using EBUS-TBNA, and PET.
Extravascular Lung Water Correlates Multiorgan Dysfunction Syndrome and Mortality in Sepsis
Fu-Tsai Chung,Horng-Chyuan Lin,Chih-Hsi Kuo,Chih-Teng Yu,Chun-Liang Chou,Kang-Yun Lee,Han-Pin Kuo,Shu-Min Lin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015265
Abstract: This study was designated to investigate whether increased extravascular lung water index (EVLWI) may correlate multiple organ dysfunction syndrome (MODS) and mortality in sepsis.
Amplified Mycobacterium Tuberculosis Direct Test for Diagnosing Tuberculous Pleurisy—A Diagnostic Accuracy Study
Chieh-Mo Lin, Shu-Min Lin, Fu-Tsai Chung, Horng-Chyuan Lin, Kang-Yun Lee, Chien-Da Huang, Chih-Hsi Kuo, Chien-Ying Liu, Chun-Hua Wang, Han-Pin Kuo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044842
Abstract: Background The study was designed to investigate the clinical usefulness of Amplified Mycobacterium Tuberculosis Direct (AMTD) tests for diagnosing TB pleurisy. Methods One hundred and fifty-two patients for whom the exclusion of tuberculous pleural effusion was necessary were retrospectively analyzed. Results The sensitivity of AMTD in diagnosing pleural TB was 36.4% (20 of 55). Combining sputum and pleural effusion AFB smear, pleural biopsy, and AMTD test of pleural effusion increased sensitivity to 82.5% (33/40). There were significantly higher percentages of neutrophils in the pleural effusion in the positive than in the negative AMTD group (38.0±6.7% vs. 11.1±3.7%, p<0.001). Patients with symptom duration <18 days prior to pleural effusion studies had more positive AMTD tests than those with symptom >18 days (70% vs. 31.4%; OR 5.09; 95% CI 1.54–16.79; p = 0.011). Conclusions Combining AMTD tests with conventional diagnostic methods offer good sensitivity for pleural TB diagnosis. Patients in the early course of the disease are better candidates for AMTD tests.
Concomitant Active Tuberculosis Prolongs Survival in Non-Small Cell Lung Cancer: A Study in a Tuberculosis-Endemic Country
Chih-Hsi Kuo, Chun-Yu Lo, Fu-Tsai Chung, Kang-Yun Lee, Shu-Min Lin, Chun-Hua Wang, Chih-Chen Heh, Hao-Cheng Chen, Han-Pin Kuo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033226
Abstract: Background Adjuvant tumor cell vaccine with chemotherapy against non-small cell lung cancer (NSCLC) shows limited clinical response. Whether it provokes effective cellular immunity in tumor microenvironment is questionable. Concomitant active tuberculosis in NSCLC (TBLC) resembles locoregional immunotherapy of tumor cell vaccine; thus, maximally enriches effective anti-tumor immunity. This study compares the survival and immunological cell profile in TBLC over NSCLC alone. Methods Retrospective review of NSCLC patients within 1-year-period of 2007 and follow-up till 2010. Results A total 276 NSCLC patients were included. The median survival of TBLC is longer than those of NSCLC alone (11.6 vs. 8.8 month, p<0.01). Active tuberculosis is an independent predictor of better survival with HR of 0.68 (95% CI, 0.48~0.97). Squamous cell carcinoma (SCC) (55.8 vs. 31.7%, p<0.01) is a significant risk factor for NSCLC with active TB. The median survival of SCC with active tuberculosis is significantly longer than adenocarcinoma or undetermined NSCLC with TB (14.2 vs. 6.6 and 2.8 months, p<0.05). Active tuberculosis in SCC increases the expression of CD3 (46.4±24.8 vs. 24.0±16.0, p<0.05), CXCR3 (35.1±16.4 vs. 19.2±13.3, p<0.01) and IP-10 (63.5±21.9 vs. 35.5±21.0, p<0.01), while expression of FOXP3 is decreased (3.5±0.5 vs. 13.3±3.7 p<0.05, p<0.05). Survival of SCC with high expression of CD3 (12.1 vs. 3.6 month, p<0.05) and CXCR3 (12.1 vs. 4.4 month, p<0.05) is longer than that with low expression. Conclusions Active tuberculosis in NSCLC shows better survival outcome. The effective T lymphocyte infiltration in tumor possibly underlies the mechanism. Locoregional immunotherapy of tumor cell vaccine may deserve further researches.
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