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Search Results: 1 - 10 of 461691 matches for " Hamzaoui A "
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Levels of soluble VCAM-1, soluble ICAM-1, and soluble E-selectin in patients with tuberculous pleuritis
A. Hamzaoui,K. Hamzaoui,A. Kahan,A. Chabbou
Mediators of Inflammation , 1996, DOI: 10.1155/s0962935196000403
Abstract:
Expression of Bcl-2 in Inflammatory Sites from Patients with Active Beh et's Disease
K. Hamzaoui,A. Hamzaoui,L. Zakraoui,A. Chabbou
Mediators of Inflammation , 1999, DOI: 10.1080/09629359990595
Abstract:
Interleukin-6 in peripheral blood and inflammatory sites in Beh et's disease
K. Hamzaoui,A. Hamzaoui,A. Kahan,M. Hamza
Mediators of Inflammation , 1992, DOI: 10.1155/s0962935192000437
Abstract:
Levels of soluble Fas/APO-1 in patients with Beh et's disease
K. Hamzaoui,A. Hamzaoui,L. Zakraoui,A. Chabbou
Mediators of Inflammation , 1998, DOI: 10.1080/09629359891261
Abstract:
Circulating intercellular adhesion molecules in blood and bronchoalveolar lavage in Beh et's disease
A. Hamzaoui,K. Hamzaoui,A. Chabbou,K. Ayed
Mediators of Inflammation , 1995, DOI: 10.1155/s0962935195000573
Abstract:
Intrinsic Defects in UV-irradiated MgO Single Crystal Detected by Thermoluminescence
D. Kadri,A. Mokeddem,S. Hamzaoui
Journal of Applied Sciences , 2005,
Abstract: The Thermoluminescence (TL) properties of an MgO single crystal sample were studied from 170 to 500°K after UV-irradiation (4.8 eV for 10 min). The aim of this study was to determine the MgO intrinsic defects centers and in particular the F, F+, F2 and Fcat centers, these defects are localized in the 270-570 nm region, their TL signal was characterized by four emission bands detected at wavelengths 540, 380, 350 and 290 nm, respectively.
Inflammatory response in induced sputum mononuclear cells from patients with acute exacerbation of asthma
A. Hamzaoui,M. Ben Brahim,A. Zhioua,Kh. Ayed,K. Hamzaoui
Mediators of Inflammation , 2000, DOI: 10.1080/09629350020002886
Abstract: Examination of sputum provides a direct method to investigate airway inflam mation non-invasively in particular Th1 (IL-2, IFN–γ) and Th2 (IL–4, IL–10) cytokine production.
The impact of vitamin D deficiency on immune T cells in asthmatic children: a case-control study
Maalmi H, Berra es A, Tangour E, Ammar J, Abid H, Hamzaoui K, Hamzaoui A
Journal of Asthma and Allergy , 2012, DOI: http://dx.doi.org/10.2147/JAA.S29566
Abstract: ct of vitamin D deficiency on immune T cells in asthmatic children: a case-control study Original Research (4185) Total Article Views Authors: Maalmi H, Berra es A, Tangour E, Ammar J, Abid H, Hamzaoui K, Hamzaoui A Published Date May 2012 Volume 2012:5 Pages 11 - 19 DOI: http://dx.doi.org/10.2147/JAA.S29566 Received: 29 December 2011 Accepted: 14 February 2012 Published: 09 May 2012 Ha fa Maalmi,1,2 Anissa Berra es,1,2,3 Eya Tangour,1,2,3 Jamel Ammar,1,2,3 Hanadi Abid,1,2,3 Kamel Hamzaoui,1,2 Agnes Hamzaoui1,2,3 1Department of Basic Sciences, Medicine School of Tunis, University Tunis El Manar, Tunis; 2Unit Research, Homeostasis and Cell Dysfunction, Ariana; 3Department of Pneumopediatry, A Mami Hospital, Ariana, Tunisia Background: Vitamin D exerts profound effects on both adaptive and innate immune functions involved in the development and course of autoimmune and inflammatory diseases. As the incidence of vitamin D insufficiency is surprisingly high in the general population, experimental studies have started to investigate whether vitamin D levels (measured as serum 25 hydroxy vitamin D-25[OH]D) are correlated with immune cells and clinical parameters. Purpose: The aim of the present research was to investigate serum vitamin D status in a case-control study in children with asthma and to study associations between vitamin D levels and certain immunological parameters. Materials and methods: A case control study of thirty-nine children with clinically controlled asthma was enrolled to assess the relationship between serum vitamin D concentrations and disease activity. Vitamin D was assayed with a radioimmunoassay kit. We evaluated the relationship between vitamin D concentrations and forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and the FEV1/FVC ratio. Correlations between inflammatory mediators, Th1, Th2, Th17, and regulatory T cells (Treg) and vitamin D were investigated. Results: Only 15.38% of our asthmatic children had a sufficient serum 25(OH)D (≥30 ng/mL) whereas 80% of healthy children expressed sufficient levels. Deficient values of vitamin D (<20 ng/mL) were observed in 17 (43.59%) asthmatic patients (14.40 ± 3.30 ng/mL; P = 0.0001). Deficiency was not observed in controls. Th1/Th2 ratio was significantly correlated to 25(OH)D level (r = 0.698; P = 0.0001). A significant negative correlation was observed between serum interleukin-17 and vitamin D levels in young asthmatics (r = -0.617; P = 0.001). A significant correlation was observed between CD25+Foxp3+ Treg cells and vitamin D values in asthmatics (r = 0.368; P = 0.021). Conclusion: Even in a southern Mediterranean country, hypovitaminosis D is frequent in children with asthma. Our findings suggest that vitamin D is an important promoter of T cell regulation in vivo in young asthmatics.
Transcriptional characteristics of CD4+ T cells in young asthmatic children: RORC and FOXP3 axis
Hamzaoui A, Maalmi H, Berra es A, Abid H, Ammar J, Hamzaoui K
Journal of Inflammation Research , 2011, DOI: http://dx.doi.org/10.2147/JIR.S25314
Abstract: anscriptional characteristics of CD4+ T cells in young asthmatic children: RORC and FOXP3 axis Original Research (2969) Total Article Views Authors: Hamzaoui A, Maalmi H, Berra es A, Abid H, Ammar J, Hamzaoui K Published Date November 2011 Volume 2011:4 Pages 139 - 146 DOI: http://dx.doi.org/10.2147/JIR.S25314 Agnes Hamzaoui1,2,*, Ha fa Maalmi1,*, Anissa Berra es1,2, Hanadi Abid1,2, Jamel Ammar1,2, Kamel Hamzaoui1 1Department of Pediatrics and Respiratory Disease, Homeostasis and Cell Dysfunction Unit Research, Abderrahman Mami Hospital, Ariana, Tunisia; 2Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia *These authors contributed to this work equally Background: Asthma is a chronic inflammatory disorder, hypothetically caused by autoreactive Th2 cells, whereas Th1 and regulatory T cells may confer protection. The development of Th subpopulations is dependent on the expression of lineage-specific transcription factors. Purpose: This study aimed to assess the balance of CD4+ T cell populations in asthmatic children. Methods: Peripheral blood mononuclear cells (PBMC) mRNA expression was assessed in 30 asthmatic children (18 patients with mild asthma and 12 with moderate asthma). Real-time polymerase chain reaction (RT-PCR) quantified TBX21, GATA-3, RORC, FOXP3, and EBI3 mRNA expression. Intracellular cytokine expression of IL-2, IL-4, IL-10, and IFN-γ in CD4+ T cells in asthmatic children was measured by flow cytometry. IL-6 and IL-17 cytokines were assessed in serum by enzyme-linked immunosorbent assay (ELISA). Results: A significant increase was found in the percentage of CD4+ and CD8+ T cell-producing IL-4, IL-6, and IL-17. A decreased percentage of CD4+ producing IFN-γ in asthmatic children was found. Expression of GATA-3 (Th2), retinoid-related orphan receptor C (RORC) (Th17), and EBI3 were increased in asthmatic patients compared to healthy controls. Expression of FOXP3 (Treg) and TBX21 (Th1) were decreased (P < 0.0001 and P < 0.0001) in asthmatic children. Analysis of transcription factor ratios revealed an increase in the RORC/FOXP3 (P = 0.0001), and a significant decrease of TBX21/GATA-3 (P = 0.0001) ratios in patients with asthma. Conclusion: Young asthmatics were characterized by increased IL-4 production and low IFN-γ synthesis. The increased serum IL-17 and IL-6 levels sustained an inflammatory environment in young asthmatics. The results indicate that FOXP3 and RORC mRNA expression could be associated with the sustained inflammatory process, transduced by low immune tolerance by Treg cells. The TBX21/GATA-3 and RORC/FOXP3 ratios dysregulation in asthmatics is consistent with the plasticity existing between Th1, Th17, and Treg cells during inflammation.
Pulmonary Embolism Revealing Idiopathic Membranous Glomerulonephritis
A. Hamzaoui,O. Harzallah,R. Klii,L. Njim,S. Mahjoub
Case Reports in Medicine , 2010, DOI: 10.1155/2010/683652
Abstract: We describe a case of a 55-year-old man who presented with pulmonary embolism and who was found to have nephrotic syndrome due to idiopathic membranous nephropathy. There are no other signs of nephrotic syndrome such as edema.
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