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Search Results: 1 - 10 of 3135 matches for " Hamid Khorram-Khorshid "
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Effects of IMOD? and Angipars? on mouse D-galactose-induced model of aging
Samane Ghanbari, Mahsa Yonessi, Azadeh Mohammadirad, Mahdi Gholami, Maryam Baeeri, Hamid Khorram-Khorshid, Farhad Gharibdoost, Mohammad Abdollahi
DARU Journal of Pharmaceutical Sciences , 2012, DOI: 10.1186/2008-2231-20-68
Abstract: Results showed that D-Galactose induces a significant oxidative stress and proinflammatory cascade of aging while both IMOD and Angipars recovered all of them. Interestingly, IMOD and Angipars were better than Vitamin E in improving male sex hormones in aged mice. This effect is so important and should be considered as an advantage although it cannot be explained with current knowledge. The conclusion is that IMOD and Angipars have marked anti-aging effect on D-galactose-induced model of aging.Use of natural medicines was increased in the world because of their lower adverse effects, price and good efficacy in most human illnesses [1-3]. Recent experimental and clinical studies have confirmed anti-aging effects of some traditionally-used herbs [4]. In the recent years, the novel registered drug named (IMOD) has shown positive effects on reduction of oxidative stress and pro-inflammatory status in various studies [5]. IMOD is a combination of ethanolic extracts of Rosa canina, Tanacetum vulgare and Urtica dioica that are combined with selenium and urea and then exposed to a pulsed electromagnetic field [6]. Angipars is also a registered drug derived from a plant named Melilotus officinalis under electromagnetic processes which has marked antioxidant effects and is used as a drug of choice for management of human diabetic foot [7,8]. Both IMOD and Angipars have been approved by Iranian Food and Drug Organisation for their main effects including human immunodeficiency syndrome and diabetic foot, respectively.Aging as an extremely complex biological phenomenon is demonstrated by accumulation of deleterious changes during the time with an increase in the chance of disease and death. The free radical and oxidative stress theory of aging is recognized as one of the most plausible and promising explanations for the process of aging [9]. Aging is associated with dysregulated immune system, weakened sex hormones and increased amount of oxidative stress markers or inflammatory
Association Between Alzheimer’s Disease and Apolipoprotein E Polymorphisms
E Gozalpour,K Kamali,K Mohammd,HR Khorram Khorshid
Iranian Journal of Public Health , 2010,
Abstract: Background: Alzheimers disease as a neurodegenerative disorder is the commonest type of dementia. A growing number of genes have been reported as the risk factors, which increase the susceptibility to Alzheimer's disease. Apolipoprotein E (APOE), which its ε4 allele has been reported as a risk factor in late onset Alzheimers disease (AD), is the main cholesterol carrier in the brain. The main goal of this study was to assess the role of APOE genotypes and alleles in AD in Iranian population.Methods: This study was performed in Tehran, Iran from 2007 to 2008. Totally, 154 AD cases and 162 control subjects from Iranian population were genotyped for APOE using PCR method. Genotype and alleles frequencies for APOE were calculated and compared between AD case and control subjects by χ2 or Fishers exact test. Type one error assumed less than 0.05.Results: The frequency of ε2ε3 genotype was significantly higher in control subjects than AD patients was (13.5% versus 5.2%, P< 0.05) and ε3ε4 genotype frequency was significantly higher in AD cases compared with control subjects. APOE -ε2 allele frequency in cases was lower than that of control subjects but this difference was not significant (4.2% versus 7.7%).Conclusion: It seems that individuals carrying ε4 allele, develop AD 6.5 times more than non-carriers do (OR= 6.566, 95% CI= 2.89-14.92). It has been reported that ε4 allele acts in dose- age-dependent manner but we have shown that the risk of developing AD in male APOE -ε4 allele carriers is higher than that of female ε4 carriers.
Evaluation of acute and sub-chronic toxicity of Semelil (ANGIPARSTM), a new phytotherapeutic drug for wound healing in rodents
Abdollahi M,Farzamfar B,Salari P,Khorram Khorshid HR
DARU : Journal of Pharmaceutical Sciences , 2008,
Abstract: Semelil (ANGIPARSTM), an herbal formulation containing Melilotus officinalis extract, is a novel compound being developed for treatment of chronic wounds, particularly diabetic foot ulcers. The purpose of this study was to investigate toxicological, pharmacological, and pathomorphological effects of I.M. and I.P. administration of Semelil in animals."nThe acute toxicity parameters of Semelil diluted in normal saline (1:10 or 1:5) were determined after a single injection into BALB/c mice and Wistar rats in two steps. First, the LD50 was approximately assessed and then the precise lethal dose indices were estimated by the probit-analysis method. Specific single-dose effects of Semelil were monitored for clinical signs of toxicity, including general state of the animals, changes in their behavior, hematological and biochemical parameters for 14 days after drug administration. Then, subacute-chronic toxicity was evaluated in rats treated with Semelil for 3 months. "nIn acute toxicity study, the calculated LD50 for drug diluted at 1:5 was in the range of 44-52 ml/kg. The adverse effects at drug doses close to the LD50 included depressed mood, narcosis, and sleep. No adverse pharmacological or toxicological effects of the drug diluted at 1:10 and administered in the single-dose (25-50 ml/kg body wt.) or chronically (daily doses of 0.07 and 0.21 ml/kg body wt.) were noted. Thus, the animal studies demonstrated a favorable safety profile for the phytotherapeutic Semelil.
Protective Effects of Setarud (IMODTM) on Development of Diet-Induced Hypercholesterolemia in Rabbits
JA Azonov,HR Khorram Khorshid,YA Novitsky,M Farhadi
DARU : Journal of Pharmaceutical Sciences , 2008,
Abstract: Background: A new herbal drug setarud (IMODTM) containing selenium, carotene, and flavonoids, was expected to have positive effects on lipid metabolism and liver functions, due to the nature of its primary components. This study was designed to determine effectiveness of the drug in reducing the risk of development of diet-induced hypercholesterolemia in laboratory animals. Methods: Two groups of male rabbits (n=10 per group) as: intact and control groups on regular chow, were fed a high-cholesterol diet, and two experimental groups were maintained on the same diet and treated with different daily doses (0.02 g/kg and 0.04 g/kg) of setarud (brand name IMOD , Pars Roos, Iran). The treatment groups were then compared with the intact and control groups and with one another for the effects of the drug which was determined by changes in blood sugar, serum lipid levels, and liver function tests. Results: Results showed that drug had important benefits in alleviating the impact of high-cholesterol diet on serum lipids and liver function markers in drug-treated groups relative to hyperlipidemic controls (p < 0.001). A more favorable modification of total cholesterol and triglyceride levels and the atherogenic index was found in animals, which received 0.04 g/kg drug, as compared to the 0.02 g/kg dose group (p < 0.05). Assessment of serum total protein, albumin, transaminases, and bilirubin levels showed that no changes in liver function of control and drug-treated animals during the period of the study. Conclusion: From the results of this study it may concluded that setarud has dose-dependent positive effects on liver and lipid metabolism and may acts as an effective anti-hyperglycemic agent.
In vivo and in vitro genotoxicity studies of Semelil (ANGIPARSTM)
Khorram Khorshid HR,Sadeghi B,Heshmat R,Abdollahi M
DARU : Journal of Pharmaceutical Sciences , 2008,
Abstract: Semelil is a novel herbal-based compound formulated for treatment of bed sore and diabetic foot ulcer. The objective of the present preclinical study was to assess the mutagenicity and genotoxicity of Semelil in full compliance with the standard guidelines for testing chemicals. "nThe potential genotoxicity of Semelil, as part of the safety evaluation process was assessed in three different in vitro and in vivo tests, including bacterial reverse mutation (Ames test), mammalian bone marrow chromosomal aberration, and rodent dominant lethal assays. "nEffects of Semelil was clearly negative at different doses in the Ames test. No statistically significant differences were observed between the levels of chromosomal aberrations in bone marrow cells of mice from the experimental and control groups. The rate of post-implantation losses and thus, the number of lethal mutations in germ cells at different stages of spermatogenesis in male mice treated with a single dose of Semelil did not statistically exceed the control rate. While on the basis of these observations, Semelil can be considered genotoxically safe, further investigations using other bio-assays for mutagenicity studies are warranted.
Studies on Potential Mutagenic and Genotoxic Activity of Setarud
HR Khorram Khorshid,Y.A Novitsky,M Abdollahi,M.H Shahhosseiny
DARU : Journal of Pharmaceutical Sciences , 2008,
Abstract: Background: Setarud (IMODTM) is a new herbal drug that has demonstrated immune modulating activity in preliminary investigations. The aim of this study was to evaluate the potential of mutagenicity and genotoxic properties of Setarud following the guidelines of the Organization for Economic Co-operation and Development (OECD) for the Testing of Chemicals. Methods: Ames Salmonella/mammalian microsome mutagenesis assay was used to evaluate the ability of the drug and its metabolites to induce mutation in Salmonella tester strains. Setarud was applied in concentrations of 0.1-1000 μg/dish. The effect of the drug metabolites which were formed in the presence of rat liver microsomal fraction S9 was investigated using complete and incomplete microsomal activation mixtures, separately. Induction of dominant lethal mutations in spermatogenic stem cells of male mice was also assessed. Results: In the Ames test, the drug preparation did not cause a significant increase in the number of revertant bacterial colonies as compared with negative control meaning that Setarud within the tested range did not exhibit mutagenic activity. The level of post-implantation losses and as a result the number of lethal mutations in germ cells at different stages of spermatogenesis in mice treated with Setarud was not statistically higher than that of control. Conclusion: Under experimental conditions which were employed, the drug was not mutagenic or genotoxic.
Effects of Semelil (ANGIPARS ) on focal cerebral ischemia in male rats
M Asadi-Shekaari,H Eftekhar Vaghefi,A Talakoub,HR Khorram Khorshid
DARU : Journal of Pharmaceutical Sciences , 2010,
Abstract: "n Background and the purpose of the study: Cerebral ischemia is one of the main causes of long term disability and death in aged populations. Many herbal drugs and extracts have been used for the treatment of cerebral ischemia induced insults. This study was designed to investigate the protective effect of Semelil (ANGIPARSTM), a new herbal drug, on focal cerebral ischemia in male rats. Material and methods: Male rats were divided into five groups: sham-operated, ischemic animals treated with distilled water as vehicle, ischemic animals treated with 1, 10 and 100 mg/kg of Semilil respectively. Middle cerebral artery occlusion (MCAO) model was used in NMRI rats and neuronal injury analyzed in hippocampal CA1 sector after 48 hrs of Middle Cerebral Artery (MCAO). Results: Results of this study showed that treatment with semelil attenuated ischemic damages and has positive effects on focal cerebral ischemia.
Propensity Score Matching in a Case-Control Study
K Kamali,K Mohammad,H.R Khorram Khorshid,A Mirabzadeh A
Journal of School of Public Health and Institute of Public Health Research , 2008,
Abstract: Background and Aim: Case-Control studies provide evidence in the area of health. Validity and accuracy of such studies depend to a large extent on the similarity (similar distributions) of the case and control groups according to confounding variables. Matching is a method for controlling or eliminating the effects of important confounders. Matching using propensity score has recently been introduced to control the effect of confounders, especially when there are many of them in a study. Materials and Methods:Matching according to propensity score was used in a genetic association study-a case-control study involving 300 subjects-to assess the effect of candidate genes on Alzheimer's disease in the Iranian population. Propensity score was calculated using STATA.8 software; age, sex, education level, job and genetic background were included in the model to calculate the score. Results: A total of 385 blood samples were taken from the participants. We managed to extract DNA in 155 of the 173 case subjects and in 161 of the 212 control subjects. The model for propensity score was statistically significant. Of the total of 316 DNA samples, 302 were matched based on their calculated propensity scores, while the individual matching method could only deliver 28 pairs.Conclusion: The propensity-score matching method results in selection of a larger number of pairs, as compared with the conventional individual matching method. We propose to use this method, which also ensures a similar distribution of confounders between the case and control groups, particularly when there are limitations in the number of subjects available for matching.
Preclinical Evaluation of PM 701 in Experimental Animals
F. Khorshid
International Journal of Pharmacology , 2008,
Abstract: In this study, we addressed the toxicological effect of PM 701 on various animal species. Results showed that there was no mortality recorded to doses up to 10 g kg-1 body weights during the 4 weeks of observation. Function tests for Liver (SGOT-SGPT-Alk.Phos) and kidney (urea and creatinine) revealed that PM 701 have no hepatotoxic or nephrotoxic effects. No hematological toxicity was detected. Histological studies, showed no effect on gastric mucosa, no alteration in liver or kidney parenchyamatous architecture. Hepatocytes showed preserved cellular outline with no signs of necrosis. Few renal tubules showed degenerative changes. Splenic tissue showed activation and enlargement of germinal centers of white pulp lymph nodules indicating activation of immune defense without any effect on vital body organs. Therefore, compared to toxicity induced by well known chemotherapeutic agent, PM 701 could be considered safe as potentially anticancer agent with minimal or even negligible effects on vital organs such as liver and kidney and recommended to be subjected to clinical trial in human volunteers. PM 701 was categorized as practically non toxic.
Evaluation Forage Clipping Stages and Different Levels of Nitrogen on Grain and Forage Yields of TRITICALE (× TRITICOSECALE WITTMACK)  [PDF]
Mohsen Niazkhani, Abdolmajid Khorshid, Alireza Eivazi
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.515233
Abstract:

In order to reach suitable forage clipping and estimate nitrogen fertilizer to most economical proficiency, an experiment was carried out at Saatlo Station in 2008-2009 seasons. A factorial experiment was done based on the randomized complete blocks design with 4 replications. The first factor was three levels of clipping stages including non-clipping, clipping at tillering and booting stages. Different levels of nitrogen fertilizer including 0, 40, 80, 120 and 160 kg/ha were arranged at the second factor. Results showed that non-clipping and clipping at booting stage with 610.5 and 203.1 g/m2 had the most and the lowest grain yield, respectively. The highest economical proficiency (3743.06 $/ha) resulted with using 80 kg/ha nitrogen fertilizer and non-clipping. With considering both forage and grain yield, it is necessary that the clipping should be done at tillering stage with using of 120 kg/ha nitrogen fertilizer (3336.56 $/ha). At regression of economical proficiency traits of grain yield, straw and total dry matter remained at the final model. Economical proficiency had the significant positive correlation with spike per square meter (0.87**), grain yield (0.64

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