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Search Results: 1 - 10 of 34555 matches for " Haixia Lu "
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Strategies of polyhydroxyalkanoates modification for the medical application in neural regeneration/nerve tissue engineering  [PDF]
Xiaoyun Lu, Leilei Wang, Zhiqian Yang, Haixia Lu
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.46097
Abstract:

Neural regeneration was once considered to be impossible, especially in the central nervous system where neural regeneration comprise the generation of new neurons, glia, axons, myelin, and synapses. Until recently, neural stem cells/neural progenitor cells (NSCs/NPCs) were identified from various areas of brain and brought hopes to the neural repair and regeneration. Tissue engineering has revolutionized the current neural regeneration technology and it has become a pioneering interdisciplinary field in the areas of biomedical research. Polyhydoxyalkanoate (PHA) as one of biodegradable material has been successfully used as tissue engineering materials. It has also been applied in nerve tissue engineering due to the high biocompatibility and low cytotoxicity. Over the past 10 years, different kinds of modification strategies have been undertaken to improve the properties of PHA to fit the requirements from various fields. Several members of PHA family have been attempted for neural regeneration. This article reviewed the recent modification strategies for improving the properties of PHA and highlighted the pioneer applications in neural regeneration.

On Kalman Smoothing for Wireless Sensor Networks Systems with Multiplicative Noises
Xiao Lu,Haixia Wang,Xi Wang
Journal of Applied Mathematics , 2012, DOI: 10.1155/2012/717504
Abstract: The paper deals with Kalman (or H2) smoothing problem for wireless sensor networks (WSNs) with multiplicative noises. Packet loss occurs in the observation equations, and multiplicative noises occur both in the system state equation and the observation equations. The Kalman smoothers which include Kalman fixed-interval smoother, Kalman fixedlag smoother, and Kalman fixed-point smoother are given by solving Riccati equations and Lyapunov equations based on the projection theorem and innovation analysis. An example is also presented to ensure the efficiency of the approach. Furthermore, the proposed three Kalman smoothers are compared.
SYNTHESIS OF POLY (BIBENZIMIDAZOLE-P-PHENYL- BENZOBISOXAZOLE)
YANHUA,LU; JIANMIN,CHEN; HAIXIA,CUI; HUIDI,ZHOU;
Journal of the Chilean Chemical Society , 2009, DOI: 10.4067/S0717-97072009000400001
Abstract: a diacid monomer of benzobisoxazole 2, 6-di(p-phenylene-carboxylic) acid (bbodpa) was synthesized in a simple procedure, and characterized by means of ftir, 1h nmr and 13c nmr. the resulting bbodpa was polymerized with 3, 3'-diaminobenzidine tetrahydrochloride (dab) to prepare poly (bibenzimidazole-p-phenyl-benzobisoxazole) (pbbibbo) in polyphosphonc acid. the inherent viscosities values of pbbibbo indicated that it was a kind of high molecular weight polymer. the structure of pbbibbo was confirmed by 1h nmr, 13c nmr and ftir. thermal properties and dissolubility of pbbibbo were also investigated. these results showed that pbbibbo exhibited good thermal stability.
Encumbering the intramolecular π donation by using a bridge: A strategy for designing metal-free compounds to hydrogen activation
ZhiXiang Wang,Gang Lu,HaiXia Li,LiLi Zhao
Chinese Science Bulletin , 2010, DOI: 10.1007/s11434-010-0005-x
Abstract: On the basis of the FLP (frustrated Lewis pair) principle, a new strategy has been proposed to construct the “frustration” in designing metal-free hydrogen activation compounds, by using FMO (frontier molecular orbital) analyses and quantum mechanics calculations. Unlike the known FLPs which use bulky substituents to prevent them from forming stable Lewis acid/base complexes, the new approach encumbers the intramolecular π donation from the electron donor to the acceptor (e.g. in BH2NH2) by using a CH2 bridge (giving BH2CH2NH2). The strategy is simple and effective. Its effectiveness is demonstrated by the small hydrogen activation energy (12.0 kcal/mol) of the model molecule (BH2CH2NH2), which is significantly less than the 42.7 kcal/mol of BH2NH2 and also less than the 18.5 kcal/mol of BH2PH2 whose derivative, R2PB(C6F5)2, has been experimentally shown to be able to activate hydrogen. We also exemplified how to use the strategy to design experimentally more realizable molecules. The example shows promises as a hydrogen activation agent. The strategy can be used to design metal-free catalysts for direct hydrogenation.
Encumbering the intramolecular π donation by using a bridge: A strategy for designing metal-free compounds to hydrogen activation

ZhiXiang Wang,Gang Lu,HaiXia Li,LiLi Zhao,

科学通报(英文版) , 2010,
Abstract: On the basis of the FLP (frustrated Lewis pair) principle, a new strategy has been proposed to construct the “frustration” in designing metal-free hydrogen activation compounds, by using FMO (frontier molecular orbital) analyses and quantum mechanics calculations. Unlike the known FLPs which use bulky substituents to prevent them from forming stable Lewis acid/base complexes, the new approach encumbers the intramolecular π donation from the electron donor to the acceptor (e.g. in BH2NH2) by using a CH2 bridge (giving BH2CH2NH2). The strategy is simple and effective. Its effectiveness is demonstrated by the small hydrogen activation energy (12.0 kcal/mol) of the model molecule (BH2CH2NH2), which is significantly less than the 42.7 kcal/mol of BH2NH2 and also less than the 18.5 kcal/mol of BH2PH2 whose derivative, R2PB(C6F5)2, has been experimentally shown to be able to activate hydrogen. We also exemplified how to use the strategy to design experimentally more realizable molecules. The example shows promises as a hydrogen activation agent. The strategy can be used to design metal-free catalysts for direct hydrogenation.
SYNTHESIS OF POLY (BIBENZIMIDAZOLE-P-PHENYL- BENZOBISOXAZOLE)
LU YANHUA,CHEN JIANMIN,CUI HAIXIA,ZHOU HUIDI
Journal of the Chilean Chemical Society , 2009,
Abstract: A diacid monomer of benzobisoxazole 2, 6-di(p-phenylene-carboxylic) acid (BBODPA) was synthesized in a simple procedure, and characterized by means of FTIR, 1H NMR and 13C NMR. The resulting BBODPA was polymerized with 3, 3'-diaminobenzidine tetrahydrochloride (DAB) to prepare poly (bibenzimidazole-p-phenyl-benzobisoxazole) (PBBIBBO) in polyphosphonc acid. The inherent viscosities values of PBBIBBO indicated that it was a kind of high molecular weight polymer. The structure of PBBIBBO was confirmed by 1H NMR, 13C NMR and FTIR. Thermal properties and dissolubility of PBBIBBO were also investigated. These results showed that PBBIBBO exhibited good thermal stability.
Capacity-Optimized Access Scheduling Control for Heterogeneous MANETs with MIMO Links  [PDF]
Haixia Cui, Wanmei Feng
Communications and Network (CN) , 2017, DOI: 10.4236/cn.2017.92009
Abstract: Multiple-input and multiple-output (MIMO) technique can significantly improve transmission reliability and bandwidth efficiency in wireless networks. However, many upper layer aspects of MIMO links, especially in mobile networks with heterogeneous antennas and strong interference environments, need further investigation. In this paper, we study its impact on medium access and network capacity. Since MIMO links can enhance physical layer capacity and co-channel interference suppression that affects network access scheduling directly, we develop a capacity-optimized access scheduling control (COASC) scheme for mobile ad hoc networks (MANETs) with MIMO links. We formulate the distributed scheduling taking the key of optimization into design to improve the network capacity and transmission reliability. Simulation results are presented to show the effectiveness of the proposed scheme.
Comprehensive transcriptome analysis reveals novel genes involved in cardiac glycoside biosynthesis and mlncRNAs associated with secondary metabolism and stress response in Digitalis purpurea
Bin Wu, Ying Li, Haixia Yan, Yimian Ma, Hongmei Luo, Lichai Yuan, Shilin Chen, Shanfa Lu
BMC Genomics , 2012, DOI: 10.1186/1471-2164-13-15
Abstract: Through high-throughput 454 sequencing and subsequent assembly, we obtained 23532 genes, of which 15626 encode conserved proteins. We determined 140 unigenes to be candidates involved in cardiac glycoside biosynthesis. It could be grouped into 30 families, of which 29 were identified for the first time in D. purpurea. We identified 2660 mRNA-like npcRNA (mlncRNA) candidates, an emerging class of regulators, using a computational mlncRNA identification pipeline and 13 microRNA-producing unigenes based on sequence conservation and hairpin structure-forming capability. Twenty five protein-coding unigenes were predicted to be targets of these microRNAs. Among the mlncRNA candidates, only 320 could be grouped into 140 families with at least two members in a family. The majority of D. purpurea mlncRNAs were species-specific and many of them showed tissue-specific expression and responded to cold and dehydration stresses. We identified 417 protein-coding genes with regions significantly homologous or complementary to 375 mlncRNAs. It includes five genes involved in secondary metabolism. A positive correlation was found in gene expression between protein-coding genes and the homologous mlncRNAs in response to cold and dehydration stresses, while the correlation was negative when protein-coding genes and mlncRNAs were complementary to each other.Through comprehensive transcriptome analysis, we not only identified 29 novel gene families potentially involved in the biosynthesis of cardiac glycosides but also characterized a large number of mlncRNAs. Our results suggest the importance of mlncRNAs in secondary metabolism and stress response in D. purpurea.Digitalis purpurea L. (common foxglove, purple foxglove or lady's glove) is an herbaceous biennial flowering plant species. It is native to Europe and has been widely introduced into other parts of the world. Now, this plant becomes naturalized in many countries, such as China, Canada, USA, and New Zealand [1]. D. purpurea is k
Relationship between structure and function ofJWA in the modulation of cell differentiation
Xia Wei,Zhou Jianwei,Cao Haixia,Zou Changping,Wang Chengya,Shen Qun,Lu Hua
Chinese Science Bulletin , 2001, DOI: 10.1007/BF02901133
Abstract: To elucidate the structure characteristic, regulation of expression and the potential function ofJWA— a novel retinoic acid responsible and cytoskeleton associate gene, a ratJWA homologue gene and a 621-bpJWA promoter fragment were cloned and analyzed. Using reverse transcription-polymerase chain reaction (RT-PCR),JWA mRNA expression in NIH3T3, K562 and human primary acute promyelocytic leukaemia (APL) cells have been investigated after treatment with all trans retinoic acid (ATRA), N-4-hydroxyphenyl-retinamide (4HPR), arsenic trioxide (As2O3), Phorbol-12-myristate-13-acetate (TPA) and dimethyl sulfoxide (DMSO). The results showed that there is a complete TPA responsive element (TRE) existed in the promoter ofJWA at 437 to 443 bp; ratJWA homologue gene showed that there are four nucleotides different from humanJWA within coding region. After treatment with TPA, an uneven pattern ofJWA transcription existed in different cell lines, suggesting that even TPA induces cell differentiation in different cell lines, and it may be referred to different signal pathways. In ATRA pretreated APL cells, all the above chemicals induce cellular differentiation and down regulateJWA transcriptionin vitro. This suggests that pretreatment of ATRA on APL cells seems a precondition for turning onJWA involved signal pathway.
Role of JWA in acute promyelocytic leukemia cell differentiation and apoptosis triggered by retinoic acid, 12-tetradecanoylphorbol-13-acetate and arsenic trioxide
Haixia Cao,Wei Xia,Qun Shen,Hua Lu,Jian Ye,Aiping Li,Changping Zou,Jianwei Zhou
Chinese Science Bulletin , 2002, DOI: 10.1360/02tb9188
Abstract: JWA, a cytoskeleton associated gene, was primarily found to be regulated by all trans-retinoic acid (ATRA), 13 cis-retinoic acid (13 cis-RA) and 12-tetradecanoylphorbol-13-acetate (TPA). Our previous data showed that JWA might be involved in both cellular differentiation and apoptosis induced by several chemicals. In this study, we addressed the possible mechanism of JWA in the regulation of cell differentiation and apoptosis in NB4, a human acute promyelocytic leukemia cell line. CD11b/CD33 expression and cell cycle were analyzed for detecting of cell differentiation and apoptosis. Both reverse-transcription polymerase chain reaction (RT-PCR) and Western blot assays were used for understanding the expressions of JWA. The results showed that under the indicated concentrations ATRA (10 6 mol/L) and AS2O3 (10 6 mol/L) induced cell differentiation and apoptosis separately; while both 4HPR (10 6 mol/L) and TPA (10 7 mol/L) showed dual-directional effects on NB4 cells, they not only trigger cells’ differentiation but also induce cells apoptosis at the same time. All chemicals up-regulated JWA expression whatever they trigger cells either differentiation or apoptosis; however, it seems that the chemicals have no effect on PML/RARα in the treated NB4 cells. Anti-sense JWA oligonucleotide could partially block the ability of TPA in inducing cell differentiation and apoptosis via direct signal pathway. Interestingly, a high molecular weight JWA protein (JWAF) was identified only in de novo primary APL cells and it was also responsible for ATRA treatment. It raises questions of whether the JWAF is a novel APL specific marker and, how it was involved in the known mechanism of APL.
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