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Search Results: 1 - 10 of 37061 matches for " Haidong Yan "
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A Target Tracking Algorithm Based on Improved Camshift and UKF  [PDF]
Zouguo Yan, Weiguo Liang, Haidong lv
Journal of Software Engineering and Applications (JSEA) , 2014, DOI: 10.4236/jsea.2014.713094
Abstract: A tracking algorithm based on improved Camshift and UKF is proposed in this paper to deal with the problems which exist in traditional Camshift algorithm, such as artificial orientation and tracking failure under color interference as well as object’s changed illumination occlusion. Meanwhile, in order to solve the sheltered problem, the UKF is combined with improved Camshift algorithm to predict the position of the target effectively. Experiment results show that the proposed algorithm can avoid the interference of the background color and solve the sheltered problem of the object, so that achieving a precise and timely tracking of moving objects. Also it has better robustness to color noises and occlusion when the object’s scale changes and deformation occurs.
Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy
Jinhua Tang,Haidong Yan,Shougang Zhuang
International Journal of Nephrology , 2012, DOI: 10.1155/2012/608397
Abstract: Obesity-related glomerulopathy is an increasing cause of end-stage renal disease. Obesity has been considered a state of chronic low-grade systemic inflammation and chronic oxidative stress. Augmented inflammation in adipose and kidney tissues promotes the progression of kidney damage in obesity. Adipose tissue, which is accumulated in obesity, is a key endocrine organ that produces multiple biologically active molecules, including leptin, adiponectin, resistin, that affect inflammation, and subsequent deregulation of cell function in renal glomeruli that leads to pathological changes. Oxidative stress is also associated with obesity-related renal diseases and may trigger the initiation or progression of renal damage in obesity. In this paper, we focus on inflammation and oxidative stress in the progression of obesity-related glomerulopathy and possible interventions to prevent kidney injury in obesity. 1. Introduction Obesity has become a heavy public health problem in the United States, with a prevalence among adults increasing to 32% from 13% between the 1960s and 2004 [1]. Currently, 66% of adults and 16% of children and adolescents are overweight or obese [1]. Although obesity has long been recognized as an independent risk factor for cardiovascular diseases and diabetes mellitus, newer research points to obesity as an important risk factor for chronic kidney diseases (CKDs) [2–4]. In 1974, Weisinger et al. [5] firstly reported that massive obese patients developed nephrotic-range proteinuria. Subsequent studies confirmed that obesity could induce renal injury, namely, obesity-related glomerulopathy (ORG) [6–8]. A large-scale clinicopathologic study including 6818 renal biopsies from 1986 to 2000 revealed a progressive increase in biopsy incidence of ORG from 0.2% in 1986–1990 to 2.0% in 1996–2000 [8]. The tenfold increase in incidence of ORG over 15 years suggests a newly emerging epidemic [8]. The clinical characteristics of subjects with ORG typically manifest with nephrotic or subnephrotic proteinuria, accompanied by renal insufficiency [8–10]. Histologically, ORG presents as focal segmental glomerulosclerosis (FSGS) and glomerular hypertrophy or glomerular hypertrophy alone and relatively decreased podocyte density and number and mild foot process fusion [8, 11, 12]. Clinically, it is distinguished from idiopathic FSGS (I-FSGS) by its lower incidence of nephrotic syndrome, more benign course, and slower progression of proteinuria and renal failure [8, 11]. ORG is an increasing cause of end-stage renal disease (ESRD). The pathophysiology of ORG
Corrections to ¢ € Multitarget Identification and Localization Using Bistatic MIMO Radar Systems ¢ €
Haidong Yan,Jun Li,Guisheng Liao
EURASIP Journal on Advances in Signal Processing , 2008, DOI: 10.1155/2008/973932
Multitarget Identification and Localization Using Bistatic MIMO Radar Systems
Haidong Yan,Jun Li,Guisheng Liao
EURASIP Journal on Advances in Signal Processing , 2007, DOI: 10.1155/2008/283483
Abstract: A scheme for multitarget identification and localization using bistatic MIMO radar systems is proposed. Multitarget can be distinguished by Capon method, as well as the targets angles with respect to transmitter and receiver can be synthesized using the received signals. Thus, the locations of the multiple targets are obtained and spatial synchronization problem in traditional bistatic radars is avoided. The maximum number of targets that can be uniquely identified by proposed method is also analyzed. It is indicated that the product of the numbers of receive and transmit elements minus-one targets can be identified by exploiting the fluctuating of the radar cross section (RCS) of the targets. Cramer-Rao bounds (CRB) are derived to obtain more insights of this scheme. Simulation results demonstrate the performances of the proposed method using Swerling II target model in various scenarios.
A mathematical model of T cell response predicts synergistic treatment combination in cancer immunotherapy
Haidong Dong,Yiyi Yan,Roxana S. Dronca,Svetomir N. Markovic
Quantitative Biology , 2015,
Abstract: T cell responses are regulated by multiple signals including costimulation and immune checkpoints along with antigen stimulation. Recently clinical trials demonstrated that blockade of immune checkpoint signals led to dramatic clinic responses in a fraction of cancer patients. To improve the therapeutic efficacy of regimens aimed to enhance T cell responses to cancers, a predictable mathematical model is needed for designing efficient therapy. Here we provide a mathematical model to predict the net outcome of a T cell response by integrating both positive and negative signals in addition to antigen stimulation. A digital range of adjustment of each signal is formulated in our model for prediction of a final T cell response. Our model provides a rationale for synergistic treatment combination aimed to defuse resistance and maximize T cell responses against cancers.
High mobility group box 1 protein (HMGB1) as an immune-modulating factor for polarization of human T lymphocytes
Lifeng Huang,Yongming Yao,Haidong Meng,Xiaodong Zhao,Ning Dong,Yan Yu,
Lifeng Huang
,Yongming Yao,Haidong Meng,Xiaodong Zhao,Ning Dong,Yan Yu

老年心脏病学杂志(英文版) , 2008,
Abstract: Objective This study was performed to investigate the effect of high mobility group box-1 protein (HMGB 1) on immune function of human T lymphocytes in vitro and explore its potential role in cell-mediated immune dysfunction.Methods Fresh blood was obtained from healthy adult volunteers and peripheral blood mononuclear cells (PBMCs) were isolated,then rhHMGB 1 was added to PBMCs.Four-color flow cytometric (FCM) analysis was used for the measurement of intracellular cytokine including interleukin Results (1) Different stimulating time and dosage of rhHMGB 1 did not alter the number of IFN-a positive cells (Th 1).rhHMGB 1 stimulation provoked a dose-dependent and time-dependent increase in Th2 subset and decrease in ratio of Th 1 to Th2.(2) Compared with the untreated cells,when the cells were coincubated with rhHMGB 1 (10-100ng/ml) for 12 hrs,protein release of IL-2 and sIL-2R were significantly up-regulated.At 48 hrs,in contrast,protein production was relatively lower in cells after exposure to 100-1000 ng/ml rhHMGBI.Conclusions These findings demonstrated that HMGB1 has a dual influence on immune functions of human T lymphocytes.
Identification of Candidate Reference Genes in Perennial Ryegrass for Quantitative RT-PCR under Various Abiotic Stress Conditions
Linkai Huang, Haidong Yan, Xiaomei Jiang, Guohua Yin, Xinquan Zhang, Xiao Qi, Yu Zhang, Yanhong Yan, Xiao Ma, Yan Peng
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093724
Abstract: Background Quantitative real-time reverse-transcriptase PCR (qRT-PCR) is an important technique for analyzing differences in gene expression due to its sensitivity, accuracy and specificity. However, the stability of the expression of reference genes is necessary to ensure accurate qRT-PCR assessment of expression in genes of interest. Perennial ryegrass (Lolium perenne L.) is important forage and turf grass species in temperate regions, but the expression stability of its reference genes under various stresses has not been well-studied. Methodology/Principal Findings In this study, 11 candidate reference genes were evaluated for use as controls in qRT-PCR to quantify gene expression in perennial ryegrass under drought, high salinity, heat, waterlogging, and ABA (abscisic acid) treatments. Four approaches – Delta CT, geNorm, BestKeeper and Normfinder were used to determine the stability of expression in these reference genes. The results are consistent with the idea that the best reference genes depend on the stress treatment under investigation. Eukaryotic initiation factor 4 alpha (eIF4A), Transcription elongation factor 1 (TEF1) and Tat binding protein-1 (TBP-1) were the three most stably expressed genes under drought stress and were also the three best genes for studying salt stress. eIF4A, TBP-1, and Ubiquitin-conjugating enzyme (E2) were the most suitable reference genes to study heat stress, while eIF4A, TEF1, and E2 were the three best reference genes for studying the effects of ABA. Finally, Ubiquitin (UBQ), TEF1, and eIF4A were the three best reference genes for waterlogging treatments. Conclusions/Significance These results will be helpful in choosing the best reference genes for use in studies related to various abiotic stresses in perennial ryegrass. The stability of expression in these reference genes will enable better normalization and quantification of the transcript levels for studies of gene expression in such studies.
Attenuation of Cigarette Smoke-Induced Airway Mucus Production by Hydrogen-Rich Saline in Rats
Yunye Ning, Yan Shang, Haidong Huang, Jingxi Zhang, Yuchao Dong, Wujian Xu, Qiang Li
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083429
Abstract: Background Over-production of mucus is an important pathophysiological feature in chronic airway disease such as chronic obstructive pulmonary disease (COPD) and asthma. Cigarette smoking (CS) is the leading cause of COPD. Oxidative stress plays a key role in CS-induced airway abnormal mucus production. Hydrogen protected cells and tissues against oxidative damage by scavenging hydroxyl radicals. In the present study we investigated the effect of hydrogen on CS-induced mucus production in rats. Methods Male Sprague-Dawley rats were divided into four groups: sham control, CS group, hydrogen-rich saline pretreatment group and hydrogen-rich saline control group. Lung morphology and tissue biochemical changes were determined by immunohistochemistry, Alcian Blue/periodic acid-Schiff staining, TUNEL, western blot and realtime RT-PCR. Results Hydrogen-rich saline pretreatment attenuated CS-induced mucus accumulation in the bronchiolar lumen, goblet cell hyperplasia, muc5ac over-expression and abnormal cell apoptosis in the airway epithelium as well as malondialdehyde increase in the BALF. The phosphorylation of EGFR at Tyr1068 and Nrf2 up-regulation expression in the rat lungs challenged by CS exposure were also abrogated by hydrogen-rich saline. Conclusion Hydrogen-rich saline pretreatment ameliorated CS-induced airway mucus production and airway epithelium damage in rats. The protective role of hydrogen on CS-exposed rat lungs was achieved at least partly by its free radical scavenging ability. This is the first report to demonstrate that intraperitoneal administration of hydrogen-rich saline protected rat airways against CS damage and it could be promising in treating abnormal airway mucus production in COPD.
Structural and magnetic phase transitions in EuTi1-xNbxO3
Ling Li,James Morris,Michael Koehler,Zhiling Dun,Haidong Zhou,Jiaqiang Yan,David Mandrus,Veerle Keppens
Physics , 2015, DOI: 10.1103/PhysRevB.92.024109
Abstract: We investigate the structural and magnetic phase transitions in EuTi1-xNbxO3 with synchrotron powder X-ray diffraction (XRD), resonant ultrasound spectroscopy (RUS), and magnetization measurements. Upon Nb-doping, the Pm-3m to I4/mcm structural transition shifts to higher temperatures and the room temperature lattice parameter increases while the magnitude of the octahedral tilting decreases. In addition, Nb substitution for Ti destabilizes the antiferromagnetic ground state of the parent compound and long range ferromagnetic order is observed in the samples containing more than 10% Nb. The structural transition in pure and doped compounds is marked by a step-like softening of the elastic moduli in a narrow temperature interval near TS, which resembles that of SrTiO3 and can be adequately modeled using the Landau free energy model employing the same coupling between strain and octahedral tilting order parameter as previously used to model SrTiO3.
Yields and elliptic flow of d(dbar) and He3(He3bar) in Au+Au collisions at sqrt(sNN)= 200 GeV
Haidong Liu
Physics , 2007, DOI: 10.1088/0954-3899/34/8/S162
Abstract: We present the transverse momentum spectra at mid-rapidity for $d$, $\bar{d}$ ($1
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