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Search Results: 1 - 10 of 19435 matches for " Hae-Ryong Song "
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Skeletal age in idiopathic short stature: An analytical study by the TW3 method, Greulich and Pyle method
Kim Hak,Song Hae-Ryong,Shyam Ashok,Heon Song
Indian Journal of Orthopaedics , 2010,
Abstract: Background: The skeletal age in short stature and in various other growth abnormalities is well documented. We lack the study pertaining to the analysis of the skeletal age in idiopathic short stature or analyzing the difference in skeletal age delay or advancement between the familial short stature (FSS) and non-familial short stature (non-FSS) groups, hence this study. Present retrospective study is designed to study the variation in patterns of skeletal age in ISS. Materials and Methods: One hundred and eighty six patients, 95 males and 91 females of idiopathic short stature were examined to assess the skeletal age deviation in relation to chronological age. The radiographs of the left hand and wrist were done. The skeletal age was assessed using Tanner and Whitehouse (TW3) method and Greulich and Pyle (GP) atlas. The patients were divided into two groups based on the parental heights. Group A (Familial Short Stature; FSS) with 100 patients (55 males, 45 females) included patients whose at least one parent was short and Group B (non-Familial Short Stature; non-FSS) with 86 patients (40 males, 46 females), included patients whose parental height was normal. The carpal scores, RUS (Radius, Ulna and Short bone) scores and GP age were determined and the respective delay or advances were calculated. Results: The skeletal age in Group A was delayed relative to chronological age by a mean of 1.9 years in males and 2.3 years in females (P< 0.05) by RUS method, mean of 2.7 years in males and 2.6 years in females by Carpal score (P< 0.05), 2.2 years in males and 2.7 years in females by GP atlas age (P< 0.05). The skeletal age in Group B was advanced by a mean of 0.9 years in males and 1.4 years in females (P< 0.05) by RUS method, mean of 0.4 years in males and 0.35 years in females by Carpal score (P< 0.05), mean of 1.1 years in males and 0.2 years in females by GP atlas method (P< 0.05). The Pearson′s coefficient of correlation (P< .001) demonstrated good agreement association between all three scores. Conclusions: There is definite age delay in both males and females in the FSS group while the bone maturation is accelerated in the non-FSS group. Both RUS and GP show good correlation amongst both the genders in both the groups and there is good inter observer correlation for both the methods. We can hypothesize that while treatment protocols to accelerate bone age will be beneficial in the FSS group, these should be avoided in the non-FSS group. Our study also indicates that there definitely exists a difference in normal growth curves in both these groups and
Treatment of neuromuscular scoliosis with posterior-only pedicle screw fixation
Hitesh N Modi, Seung-Woo Suh, Hae-Ryong Song, Harry M Fernandez, Jae-Hyuk Yang
Journal of Orthopaedic Surgery and Research , 2008, DOI: 10.1186/1749-799x-3-23
Abstract: Between 2003 and 2006, 26 consecutive patients (7 cerebral palsy, 10 Duchenne muscular dystrophy, 5 spinal muscular atrophy and 4 others) with neuromuscular scoliosis underwent posterior pedicle screw fixation for the deformity. Preoperative, immediate postoperative and final follow-up Cobb's angle and pelvic obliquity were analyzed on radiographs. The average age of the patients was 17.5 years (range, 8–44 years) and the average follow-up was 25 months (18–52 months).Average Cobb's angle was 78.53° before surgery, 30.70° after surgery (60.9% correction), and 33.06° at final follow-up (57.9% correction) showing significant correction (p < 0.0001). There were 9 patients with curves more than 90° showed an average pre-operative, post operative and final follow up Cobb's angle 105.67°, 52.33° (50.47% correction) and 53.33° (49.53% correction) respectively and 17 patients with curve less than 90° showed average per operative, post operative and final follow up Cobb's angle 64.18, 19.24(70% correction) and 21.41(66.64 correction); which suggests statistically no significant difference in both groups (p = 0.1284). 7 patients underwent Posterior vertebral column resection due to the presence of a rigid curve. The average spinal-pelvic obliquity was 16.27° before surgery, 8.96° after surgery, and 9.27° at final follow-up exhibited significant correction (p < 0.0001). There was 1 poliomyelitis patient who had power grade 3 in lower limbs pre-operatively, developed grade 2 power post-operatively and gradually improved to the pre-operative stage. There was 1 case of deep wound infection and no case of pseud-arthrosis, instrument failures or mortality.Results indicate that in patients with neuromuscular scoliosis, acceptable amounts of curve correction can be achieved and maintained with posterior-only pedicle screw instrumentation without anterior release procedure.The prevalence of severe spinal deformity in patients with neuromuscular disorders is estimated between 50% and 8
Differential wedging of vertebral body and intervertebral disc in thoracic and lumbar spine in adolescent idiopathic scoliosis – A cross sectional study in 150 patients
Hitesh N Modi, Seung Suh, Hae-Ryong Song, Jae-Hyuk Yang, Hak-Jun Kim, Chetna H Modi
Scoliosis , 2008, DOI: 10.1186/1748-7161-3-11
Abstract: This cross sectional study in 150 patients of adolescent idiopathic scoliosis was done to evaluate vertebral body and disc wedging in scoliosis and to compare the extent of differential wedging of body and disc, in thoracic and lumbar area. We measured wedging of vertebral bodies and discs, along with two adjacent vertebrae and disc, above and below the apex and evaluated them according to severity of curve (curve < 30° and curve > 30°) to find the relationship of vertebral body or disc wedging with scoliosis in thoracic and lumbar spine. We also compared the wedging and rotations of vertebrae.In both thoracic and lumbar curves, we found that greater the degree of scoliosis, greater the wedging in both disc and body and the degree of wedging was more at apex supporting the theory of growth retardation in stress concentration area. However, the degree of wedging in vertebral body is more than the disc in thoracic spine while the wedging was more in disc than body in lumbar spine. On comparing the wedging with the rotation, we did not find any significant relationship suggesting that it has no relation with rotation.From our study, we can conclude that wedging in disc and body are increasing with progression on scoliosis and maximum at apex; however there is differential wedging of body and disc, in thoracic and lumbar area, that is vertebral body wedging is more profound in thoracic area while disc wedging is more profound in lumbar area which possibly form 'vicious cycle' by asymmetric loading to spine for the progression of curve.Scoliosis is a three-dimensional deformity involving coronal, sagittal and axial angulations. Extent of the disease progress, decision to change the treatment strategy and efficacy of the treatment are mainly dependent on the severity in coronal plane angle, commonly known as Cobb's angle as a primary interest. In idiopathic scoliosis, factors responsible for the progression of curve are still unclear and authors have their own point of vi
Repression of FLOWERING LOCUS T Chromatin by Functionally Redundant Histone H3 Lysine 4 Demethylases in Arabidopsis
Ju-Hee Jeong,Hae-Ryong Song,Jong-Hyun Ko,Young-Min Jeong,Young Eun Kwon,Jae Hong Seol,Richard M. Amasino,Bosl Noh,Yoo-Sun Noh
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008033
Abstract: FLOWERING LOCUS T (FT) plays a key role as a mobile floral induction signal that initiates the floral transition. Therefore, precise control of FT expression is critical for the reproductive success of flowering plants. Coexistence of bivalent histone H3 lysine 27 trimethylation (H3K27me3) and H3K4me3 marks at the FT locus and the role of H3K27me3 as a strong FT repression mechanism in Arabidopsis have been reported. However, the role of an active mark, H3K4me3, in FT regulation has not been addressed, nor have the components affecting this mark been identified. Mutations in Arabidopsis thaliana Jumonji4 (AtJmj4) and EARLY FLOWERING6 (ELF6), two Arabidopsis genes encoding Jumonji (Jmj) family proteins, caused FT-dependent, additive early flowering correlated with increased expression of FT mRNA and increased H3K4me3 levels within FT chromatin. Purified recombinant AtJmj4 protein possesses specific demethylase activity for mono-, di-, and trimethylated H3K4. Tagged AtJmj4 and ELF6 proteins associate directly with the FT transcription initiation region, a region where the H3K4me3 levels were increased most significantly in the mutants. Thus, our study demonstrates the roles of AtJmj4 and ELF6 as H3K4 demethylases directly repressing FT chromatin and preventing precocious flowering in Arabidopsis.
Compound C Prevents the Unfolded Protein Response during Glucose Deprivation through a Mechanism Independent of AMPK and BMP Signaling
Sakae Saito, Aki Furuno, Junko Sakurai, Hae-Ryong Park, Kazuo Shin-ya, Akihiro Tomida
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045845
Abstract: Inhibiting the unfolded protein response (UPR) can be a therapeutic approach, especially for targeting the tumor microenvironment. Here, we show that compound C (also known as dorsomorphin), a small-molecule inhibitor of AMP-activated protein kinase (AMPK) and bone morphogenetic protein (BMP) signaling, inhibit the UPR-induced transcription program depending on the glucose deprivation conditions. We found that compound C prevented UPR marker glucose-regulated protein 78 (GRP78) accumulation and exerted enhanced cytotoxicity during glucose deprivation. Gene expression profiling, together with biochemical analysis, revealed that compound C had a unique mode of action to suppress the transcriptional activation of UPR-targeted genes, as compared with the classic UPR inhibitors versipelostatin and biguanides. Surprisingly, the UPR-inhibiting activity of compound C was not associated with either AMPK or BMP signaling inhibition. We further found that combination treatments of compound C and the classic UPR inhibitors resulted in synergistic cell death with UPR suppression during glucose deprivation. Our findings demonstrate that compound C could be a unique tool for developing a UPR-targeted antitumor therapy.
Design of Highly Sensitive C2H5OH Sensors Using Self-Assembled ZnO Nanostructures
Kang-Min Kim,Hae-Ryong Kim,Kwon-Il Choi,Hyo-Joong Kim,Jong-Heun Lee
Sensors , 2011, DOI: 10.3390/s111009685
Abstract: Various ZnO nanostructures such as porous nanorods and two hierarchical structures consisting of porous nanosheets or crystalline nanorods were prepared by the reaction of mixtures of oleic-acid-dissolved ethanol solutions and aqueous dissolved Zn-precursor solutions in the presence of NaOH. All three ZnO nanostructures showed sensitive and selective detection of C2H5OH. In particular, ultra-high responses (Ra/Rg =?~1,200, Ra: resistance in air, Rg: resistance in gas) to 100 ppm C2H5OH was attained using porous nanorods and hierarchical structures assembled from porous nanosheets, which is one of the highest values reported in the literature. The gas response and linearity of gas sensors were discussed in relation to the size, surface area, and porosity of the nanostructures.
Selective Detection of NO2 Using Cr-Doped CuO Nanorods
Kang-Min Kim,Hyun-Mook Jeong,Hae-Ryong Kim,Kwon-Il Choi,Hyo-Joong Kim,Jong-Heun Lee
Sensors , 2012, DOI: 10.3390/s120608013
Abstract: CuO nanosheets, Cr-doped CuO nanosheets, and Cr-doped CuO nanorods were prepared by heating a slurry containing Cu-hydroxide/Cr-hydroxide. Their responses to 100 ppm NO2, C2H5OH, NH3, trimethylamine, C3H8, and CO were measured. For 2.2 at% Cr-doped CuO nanorods, the response (Ra/Rg, Ra: resistance in air, Rg: resistance in gas) to 100 ppm NO2 was 134.2 at 250 °C, which was significantly higher than that of pure CuO nano-sheets (Ra/Rg = 7.5) and 0.76 at% Cr-doped CuO nanosheets (Ra/Rg = 19.9). In addition, the sensitivity for NO2 was also markedly enhanced by Cr doping. Highly sensitive and selective detection of NO2 in 2.2 at% Cr-doped CuO nanorods is explained in relation to Cr-doping induced changes in donor density, morphology, and catalytic effects.
Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion
Yeon Ja Choi, Yun Jung Park, Ji Young Park, Hyoung Oh Jeong, Dae Hyun Kim, Young Mi Ha, Ji Min Kim, Yu Min Song, Hyoung-Sam Heo, Byung Pal Yu, Pusoon Chun, Hyung Ryong Moon, Hae Young Chung
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0043418
Abstract: Autophagy is a major degradative process responsible for the disposal of cytoplasmic proteins and dysfunctional organelles via the lysosomal pathway. During the autophagic process, cells form double-membraned vesicles called autophagosomes that sequester disposable materials in the cytoplasm and finally fuse with lysosomes. In the present study, we investigated the inhibition of autophagy by a synthesized compound, MHY1485, in a culture system by using Ac2F rat hepatocytes. Autophagic flux was measured to evaluate the autophagic activity. Autophagosomes were visualized in Ac2F cells transfected with AdGFP-LC3 by live-cell confocal microscopy. In addition, activity of mTOR, a major regulatory protein of autophagy, was assessed by western blot and docking simulation using AutoDock 4.2. In the result, treatment with MHY1485 suppressed the basal autophagic flux, and this inhibitory effect was clearly confirmed in cells under starvation, a strong physiological inducer of autophagy. The levels of p62 and beclin-1 did not show significant change after treatment with MHY1485. Decreased co-localization of autophagosomes and lysosomes in confocal microscopic images revealed the inhibitory effect of MHY1485 on lysosomal fusion during starvation-induced autophagy. These effects of MHY1485 led to the accumulation of LC3II and enlargement of the autophagosomes in a dose- and time- dependent manner. Furthermore, MHY1485 induced mTOR activation and correspondingly showed a higher docking score than PP242, a well-known ATP-competitive mTOR inhibitor, in docking simulation. In conclusion, MHY1485 has an inhibitory effect on the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes. MHY1485 also induces mTOR activity, providing a possibility for another regulatory mechanism of autophagy by the MHY compound. The significance of this study is the finding of a novel inhibitor of autophagy with an mTOR activating effect.
Journal of Plant Development , 2009,
Abstract: Aquatic plants (hydrophytic plants or hydrophytes) are plants that have adapted to live in or on aquatic environments. Because they are living under the water require numerous special adaptations, aquatic plants can only grow in water or permanently saturated soil. Aquatic vascular plants can be ferns or angiosperms (from a variety of families, including monocots and dicots). As opposed to plants types such as mesophytes and xerophytes, hydrophytes do not have a problem in retaining water due to the abundance of water in its environment. This means the plant has less need to regulate transpiration (indeed, the regulation of transpiration would require more energy than the possible benefits incurred).The Korean vascular flora contains 217 families, 1.045 genera, 3.034 species, and 406 infraspecific taxa [CHONG-WOOK PARK, 2007].In Mokp’o region (South Korea), in 1995, was identified hydrophytes species composed by 11 orders, 22 families, 23 genera, 38 species, 9 varieties, total 48 taxa. These were composed by 22 taxa emerged plants, 15 taxa floating-leaves plants, 8 taxa submerged plants and 3 taxa free-floating plants [JEONG WOO-GYU & al., 1995].The same research collective, in 1996, in Paksil, Yundang (South Korea) swamp region was identified hydrophytes species composed by 11 orders, 22 families, 31 genera, 41 species, 10 varieties; it represents 12.1% of total plants. These is composed of 25 taxa emerged plants, 15 taxa floating-leaves plants, 9 taxa submerged plants and 3 taxa free-floating plants [JEONG WOO-GYU & al., 1996].This paper contains the classification of water plants and a brief description of some aquatic species used in Korean ancient and modern gardens in order to introduce in our country.
Limited Memory Prediction for Linear Systems with Different types of Observation
Ha-ryong Song,Vladimir Shin
Computer Science , 2010,
Abstract: This paper is concerned with distributed limited memory prediction for continuous-time linear stochastic systems with multiple sensors. A distributed fusion with the weighted sum structure is applied to the optimal local limited memory predictors. The distributed prediction algorithm represents the optimal linear fusion by weighting matrices under the minimum mean square criterion. The algorithm has the parallel structure and allows parallel processing of observations making it reliable since the rest faultless sensors can continue to the fusion estimation if some sensors occur faulty. The derivation of equations for error cross-covariances between the local predictors is the key of this paper. Example demonstrates effectiveness of the distributed limited memory predictor.
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