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Search Results: 1 - 10 of 42856 matches for " HUANG Zebing "
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某医院感染病区2011—2015年临床分离病原菌及其耐药性
Distribution and antimicrobial resistance of clinically isolated bacteria from department of infectious diseases of a hospital in 2011-2015

李军,刘清霞,黄泽炳,黄燕,周蓉蓉
LI Jun
, LIU Qingxia, HUANG Zebing, HUANG Yan, ZHOU Rongrong

- , 2016, DOI: 10.3969/j.issn.1671-9638.2016.07.007
Abstract: 目的了解湘雅医院感染病区患者临床分离病原菌分布及其耐药性。方法回顾性分析该院2011—2015年感染病区患者临床分离病原菌的构成及药敏结果。结果5年间共分离病原菌560株,其中革兰阳性菌247株(44.1%),革兰阴性菌313株(55.9%)。耐甲氧西林凝固酶阴性葡萄球菌和金黄色葡萄球菌分别占69.8%(81/116)和24.3%(9/37)。肠球菌对万古霉素、利奈唑胺、磷霉素有较高的敏感性(敏感率>81%)。肠杆菌科细菌对碳青霉烯类仍高度敏感(88.9%~100.0%),对阿米卡星、头孢哌酮/舒巴坦及哌拉西林/他唑巴坦的敏感性较高(敏感率>84%)。分离的多重耐药菌主要为鲍曼不动杆菌,耐亚胺培南鲍曼不动杆菌检出率从2011年的50.0%上升至2015年的77.8%,对亚胺培南的耐药率为64.9%。结论感染病区临床分离病原菌以革兰阴性菌为主,多重耐药菌检出率呈上升趋势;应根据病原菌的分布及其耐药性,合理选择抗菌药物
妊娠急性脂肪肝患者肺部感染的危险因素
Risk factors for pulmonary infection in patients with acute fatty liver of pregnancy

黄泽炳, 陈君, 漆敏,李宁, 黄燕
HUANG Zebing
, CHEN Jun, QI Min, LI Ning, HUANG Yan

- , 2018, DOI: 10.3969/j.issn.1671-9638.2018.08.008
Abstract: 目的探讨妊娠急性脂肪肝(AFLP)患者并发肺部感染的相关危险因素。方法回顾性分析2015年1月—2017年12月某三甲医院的AFLP患者的临床资料,发生肺部感染者为感染组,未发生肺部感染者为对照组,对年龄、发病孕周、发病至分娩时间、分娩方式、总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血肌酐(Scr)、凝血酶原时间(PT)等进行单因素分析。结果共收集到28例AFLP患者,排除不符合纳入标准的10例患者,最终纳入18例AFLP患者,其中肺部感染组10例,对照组8例。单因素分析结果示,感染组患者血清TBIL、PT高于对照组(P<0.05),感染组患者ALT、AST水平低于对照组(P<0.05)。结论肝功能是影响AFLP患者并发肺部感染的关键因素,积极改善肝功能是防控AFLP并发肺部感染的关键
Identification of Two Novel HLA-A?0201-Restricted CTL Epitopes Derived from MAGE-A4
Zheng-Cai Jia,Bing Ni,Ze-Min Huang,Yi Tian,Jun Tang,Jing-Xue Wang,Xiao-Lan Fu,Yu-Zhang Wu
Clinical and Developmental Immunology , 2010, DOI: 10.1155/2010/567594
Abstract: MAGE-A antigens belong to cancer/testis (CT) antigens that are expressed in tumors but not in normal tissues except testis and placenta. MAGE-A antigens and their epitope peptides have been used in tumor immunotherapy trials. MAGE-A4 antigen is extensively expressed in various histological types of tumors, so it represents an attractive target for tumor immunotherapy. In this study, we predicted HLA-A∗0201-restricted cytotoxic T lymphocyte (CTL) epitopes of MAGE-A4, followed by peptide/HLA-A∗0201 affinity and complex stability assays. Of selected four peptides (designated P1, P2, P3, and P4), P1 (MAGE-A4286-294, KVLEHVVRV) and P3 (MAGE-A4272-280, FLWGPRALA) could elicit peptide-specific CTLs both in vitro from HLA-A∗0201-positive PBMCs and in HLA-A∗0201/Kb transgenic mice. And the induced CTLs could lyse target cells in an HLA-A∗0201-restricted fashion, demonstrating that the two peptides are HLA-A∗0201-restricted CTL epitopes and could serve as targets for therapeutic antitumoral vaccination.
Method of tracking human body for the self-timer system in the digital camera
一种用于数码相机自拍系统的人体检测方法

HUANG Ze-bing,ZHAO Qun-fei,YU Zai-guang,
黄泽兵
,赵群飞,喻再光

计算机应用 , 2006,
Abstract: Based on designing an intelligent self-timer system for the Digital Camera, a simple and effective approach was given to detect and locate the human body based on the still background. The background model was built based on the difference between real-timer image and reference image, in terms of which foreground objects were segmented. Then shadows were removed according to the contained angle of color vector. Finally threshold of the projection was used to extract and locate the human body. This algorithm can meet the object-tracking requirements of self-timer with low computation and good adaotability.
Identification of Two Novel HLA-A?0201-Restricted CTL Epitopes Derived from MAGE-A4
Zheng-Cai Jia,Bing Ni,Ze-Min Huang,Yi Tian,Jun Tang,Jing-Xue Wang,Xiao-Lan Fu,Yu-Zhang Wu
Journal of Immunology Research , 2010, DOI: 10.1155/2010/567594
Abstract: MAGE-A antigens belong to cancer/testis (CT) antigens that are expressed in tumors but not in normal tissues except testis and placenta. MAGE-A antigens and their epitope peptides have been used in tumor immunotherapy trials. MAGE-A4 antigen is extensively expressed in various histological types of tumors, so it represents an attractive target for tumor immunotherapy. In this study, we predicted HLA-A?0201-restricted cytotoxic T lymphocyte (CTL) epitopes of MAGE-A4, followed by peptide/HLA-A?0201 affinity and complex stability assays. Of selected four peptides (designated P1, P2, P3, and P4), P1 (MAGE-A4286-294, KVLEHVVRV) and P3 (MAGE-A4272-280, FLWGPRALA) could elicit peptide-specific CTLs both in vitro from HLA-A?0201-positive PBMCs and in HLA-A?0201/Kb transgenic mice. And the induced CTLs could lyse target cells in an HLA-A?0201-restricted fashion, demonstrating that the two peptides are HLA-A?0201-restricted CTL epitopes and could serve as targets for therapeutic antitumoral vaccination. 1. Introduction The melanoma antigen genes family A (MAGE-A) consists of 12 closely related genes (MAGE-A1 to A12) located in the q28 region of chromosome X [1, 2]. MAGE-A-encoded antigens (MAGE-A) belong to cancer/testis (CT) antigens. These antigens are expressed in various histological types of carcinomas, but not in normal tissues with the exception of testis and placenta [3–8]. Although testis expresses MAGE-A antigens and placenta also expresses some of them [9], testis and placenta do not express MHC class I molecules and therefore cannot be attacked by cytotoxic T lymphocytes (CTLs) specific for these antigens. Thus, MAGE-A antigens are appealing targets for antitumor immunotherapy. A number of clinical trials of therapeutic vaccination have been performed, based on these antigens and their epitope peptides. In some clinical trials executed with short peptides, tumor regressions have been observed in a minority of patients [10–12]. Of the MAGE-A family, MAGE-A4 is one of genes that are abundantly expressed by many tumors of different histological types, such as urothelial carcinoma, bladder cancer, lung cancer, ovarian neoplasm, esophageal squamous cell carcinoma, and oral squamous cell carcinoma [4, 13–17]. Up to now, at least four variants have been found for this gene. The four variants encode the same protein referred to MAGE-A4. MAGE-A4 is found to interact with the liver oncoprotein gankyrin and suppress the tumorigenic activity of gankyrin [18]. Its carboxyl-terminal fragment of 107 amino acids induces p53-dependent and p53-independent apoptosis in
HMGB1抗体对刀豆蛋白A引起小鼠肝损伤的保护作用
Protective role of high mobility group box1 protein antibody in ConAinduced liver injury in mice

黄泽炳,黄燕,周蓉蓉,陈若蝉,易盼盼,李宁,范学工
HUANG Zebing
, HUANG Yan, ZHOU Rongrong, CHEN Ruochan, YI Panpan, LI Ning, FA

- , 2015, DOI: 10.3969/j.issn.1671-9638.2015.12.001
Abstract: 目的研究高迁移率族蛋白1(HMGB1)抗体对刀豆蛋白A(ConA)引起小鼠肝损伤的保护作用。方法将健康无污染雄性Balb/c小鼠分成空白对照组(注射生理盐水)、模型组(注射ConA)和实验组(注射ConA+HMGB1抗体),3组小鼠注射药物6 h后摘眼球取血,所获血液离心后取血清检测谷丙转氨酶(ALT)和HMGB1,留取肝脏组织进行HE染色、Tunel、免疫荧光等检测。结果实验组小鼠肝组织病理炎症反应轻于模型组。小鼠血清中ALT、HMGB1:空白对照组分别为(52.00±8.34)U/L、(7.54±0.53)ng/mL,模型组分别为(5 551.50±1 445.74)U/L、(18.06±1.65)ng/mL,实验组分别为(1 977.40±654.89)U/L、(10.77±0.71)ng/mL;肝组织中HMGB1 mRNA、HMGB1表达量(相对值):空白对照组分别为1.886±0.253、0.086±0.028,模型组分别为4.718±0.341、0.268±0.043,实验组分别为3.005±0.331、0.116±0.008;实验组小鼠血清中ALT、HMGB1,以及肝组织中HMGB1 mRNA、HMGB1表达量均低于模型组(均P<0.001)。肝组织细胞凋亡、肝细胞内HMGB1迁移(标准化):空白对照组均为1±0,模型组分别为4.67±0.33、4.50±0.22,实验组分别为2.67±0.21、2.33±0.21;实验组小鼠肝组织细胞凋亡、肝细胞内HMGB1迁移均低于模型组(均P<0.001)。结论HMGB1抗体能改善肝组织的病理损伤,可以保护ConA引起的小鼠肝损伤
Particular Candida albicans Strains in the Digestive Tract of Dyspeptic Patients, Identified by Multilocus Sequence Typing
Yan-Bing Gong, Jian-Ling Zheng, Bo Jin, De-Xiang Zhuo, Zhu-Qing Huang, He Qi, Wei Zhang, Wei Duan, Ji-Ting Fu, Chui-Jie Wang, Ze-Bin Mao
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035311
Abstract: Background Candida albicans is a human commensal that is also responsible for chronic gastritis and peptic ulcerous disease. Little is known about the genetic profiles of the C. albicans strains in the digestive tract of dyspeptic patients. The aim of this study was to evaluate the prevalence, diversity, and genetic profiles among C. albicans isolates recovered from natural colonization of the digestive tract in the dyspeptic patients. Methods and Findings Oral swab samples (n = 111) and gastric mucosa samples (n = 102) were obtained from a group of patients who presented dyspeptic symptoms or ulcer complaints. Oral swab samples (n = 162) were also obtained from healthy volunteers. C. albicans isolates were characterized and analyzed by multilocus sequence typing. The prevalence of Candida spp. in the oral samples was not significantly different between the dyspeptic group and the healthy group (36.0%, 40/111 vs. 29.6%, 48/162; P > 0.05). However, there were significant differences between the groups in the distribution of species isolated and the genotypes of the C. albicans isolates. C. albicans was isolated from 97.8% of the Candida-positive subjects in the dyspeptic group, but from only 56.3% in the healthy group (P < 0.001). DST1593 was the dominant C. albicans genotype from the digestive tract of the dyspeptic group (60%, 27/45), but not the healthy group (14.8%, 4/27) (P < 0.001). Conclusions Our data suggest a possible link between particular C. albicans strain genotypes and the host microenvironment. Positivity for particular C. albicans genotypes could signify susceptibility to dyspepsia.
Protective Role of α2HS-Glycoprotein in HBV-Associated Liver Failure
Xia-Hong Dai,Pan Zhang,Mei-Fang Xiao,Rong-Rong Zhou,Bao-Xin Zhang,Guan-Sheng Hu,Ze-Bing Huang,Xue-Gong Fan
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12063846
Abstract: n this study, levels of plasma α2-Heremans-Schmid glycoprotein, serum tumor necrosis factor-α, serum liver function parameters and short-term mortality were measured in 100 hepatitis B patients. Release of interleukin-6 and tumor necrosis factor-α from the lipopolysaccharide-stimulated peripheral blood mononuclear cells in the presence/absence of spermine and α2-Heremans-Schmid glycoprotein were analyzed by enzyme-linked immunosorbent assay to determine the significance and potential mechanism of α2-Heremans-Schmid glycoprotein in hepatitis B virus-associated liver damage. Results showed that serum α2-Heremans-Schmid glycoprotein levels in acute-on-chronic liver failure patients were significantly lower than that in chronic hepatitis B patients or healthy controls (p < 0.05). A negative dependence between serum human α2-Heremans-Schmid glycoprotein and tumor necrosis factor-α levels was observed. Interleukin-6 and tumor necrosis factor-α levels in the lipopolysaccharide-induced peripheral blood mononuclear cell supernates were significantly reduced by spermine and/or α2-Heremans-Schmid glycoprotein. The latter two proteins jointly inhibited cytokine release. These observations suggest that plasma α2-Heremans-Schmid glycoprotein is an independent marker of liver damage and a prognostic indicator of hepatitis B virus chronicity. It may reduce liver inflammation by partially inhibiting release of inflammatory factors from activated peripheral blood mononuclear cells.
Effect of Bi and Mo Doping on Magnetic and Sintered Characteristics of MgCuZn Ferrite
Bi-Mo复合掺杂对MgCuZn铁氧体烧结特性和磁性能的影响

DENG Lian-Wen,FENG Ze-Kun,HUANG Xiao-Zhong,ZHOU Ke-Xing,YANG Bing-Chu,
邓联文
,冯则坤,黄小忠,周克省,杨兵初

无机材料学报 , 2008,
Abstract: 为改善MgCuZn铁氧体的低温烧结特性并提高其软磁性能,采用传统氧化物法制备MgCuZn铁氧体材料,研究了Bi-Mo复合掺杂对其烧结特性和软磁性能的影响.结果表明:复合掺杂Bi2O3和MoO3适量时(分别为0.6w%和0.1wt%),在较低的烧结温度(1020°C)就能获得较高的烧结密度(≥4.75g/cm3),起始磁导率可达1240,且具有较高的品质因数(100kHz 下为33.8).通过主成分优选、有效的掺杂技术及工艺条件可以提高MgCuZn铁氧体的综合性能,使其可应用于多层片式电感中.
Study on the regional economic disparity in Jiangsu Province in view of culture
江苏省区域经济差异的文化研究

MENG Zhao-yi,QU Ai-xue,CHE Bing-qing,HUANG Ze-hu,LIU Yan,
孟召宜
,渠爱雪,车冰清,黄泽虎,刘燕

地理研究 , 2010,
Abstract: According to dialect as a main index and county as a unit, Jiangsu province is divided into Chuhan cultural region, Wu cultural region and Jianghuai cultural region.Furthermore the three cultural regions are divided into seven cultural sub-regions. Then on the basis of cultural division, the spatial pattern and evolution trend of economic disparities among cultural regions and cultural sub-regions from 1952 to 2008 are studied by taking per capita GDP as a measure index, and taking Gini coefficient, one-stage Theil decomposition and two-stage nested Theil decomposition as measure methods. Results show that overall economic disparities of Jiangsu cultural regions increase slowly with fluctuations. In terms of the level of cultural region, economic disparities of inter-cultural region increase with fluctuations and has become the main component of the overall economic disparities. At the level of cultural sub-region, inter- and intra-economic disparities of cultural sub-regions are both decreasing continuously with fluctuation, and the former is the most important contributor to the economic disparities of intra-cultural region. As for evolution process, the change of economic disparities at different levels can all be divided into repeated fluctuation and non-equilibrium increase stages with the year 1978 as a divide line. The formation of the economic disparities among the cultural regions and sub-cultural regions is related with disparities of the regional culture and traditions in Jiangsu province. From the level of the three major cultural regions, it can be found that Wu culture, with open mind and practicality as its core spirit, can breed, select and innovate the "Sunan model" and form the dynamic power and cultural connotation to the leading economic development of southern Jiangsu. The Chuhan-culture, based on the traditional farming culture, which has closed, conservative and lagged characteristics, leads to slow modernization process of northern Jiangsu. The analyses show that different regional cultures of Jiangsu Province breed different mental models, social capital and informal institutions. As a result, different internal and external cultural powers leads to economic disparities.
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