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Search Results: 1 - 10 of 149932 matches for " H. Mizutani "
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IL-1 Receptor Type II Production Is Upregulated by IL-4 and IL-13, and Downregulated by IFN-γ in Mouse Gingival Epithelial Cells  [PDF]
Y. Kamiya, Y. Ishihara, H. Kamei, Y. Ozawa, H. Mizutani, K. Kubo, H. Maeda, T. Noguchi
Modern Research in Inflammation (MRI) , 2014, DOI: 10.4236/mri.2014.32005

Background and Objective: Interleukin-1 (IL-1) binds to 2 distinct and separate receptors, types I and II (IL-1RI and IL-1RII, respectively). The binding of IL-1 to IL-1RI induces cellular signaling and biological effects, whereas binding to IL-1RII does not induce cellular signaling and indirectly inhibits IL-1 biological activities such as that of the decoy receptor. Recently, Suzukiet al.reported that soluble IL-1RII (sIL-1RII) was detected in gingival crevicular fluid from a periodontitis patient. However, it remains unclear which cells produce sIL-1RII detected in periodontal tissues. We examined the localization of IL-1RII producing cells in gingival tissues as well as related production control mechanisms. Material and Methods: IL-1RII mRNA expression in gingival epithelial cells (GE1) was performed by real-time PCR analysis, while the amount of sIL-1RII production in supernatant from GE1 cells was examined by dot-blot analysis. Involvement of the phosphorylation of STAT6 in the signaling pathway was determined by western blot analysis. Statistical analysis was performed with Student’st-test. Results: Culturing with IL-4 and IL-13 significantly increased IL-1RII mRNA to levels 10.5-and 8.89-fold, respectively, above that of the control (p< 0.01), while addition of interferon-γ (IFN-γ) significantly suppressed IL-1RII mRNA by 0.22-fold as compared to the control (p< 0.05). Soluble IL-1RII in the supernatant of cultured GE1 cells was increased by IL-4 and IL-13, and decreased by IFN-γ, while western blotting determines the suppression of IL-1RII production by IFN-γ. Without the addition of IL-4 or IL-13 with or without

Issues Related to Accounting Education for NFPs in the U.S.  [PDF]
Fuminobu Mizutani
Open Journal of Accounting (OJAcct) , 2016, DOI: 10.4236/ojacct.2016.51001
Abstract: There have been no efforts to organize existing works about accounting education for NFPs. This paper is an article reviewing existing works published in the 21st century. There is a sufficient volume of cases to use the case method. Some of the existing works were about active learning (mainly service learning). Some existing works can be used to improve lectures. Some existing works can help faculty members to design their curriculums. However, some issues still remain and these issues should be resolved in the future. As a whole, the problem of existing works is lack of sufficient concerns about other academic areas. Some of future works are hoped to be more interdisciplinary.
Prediction markers for respiratory distress syndrome: evaluation of the stable microbubble test, surfactant protein-A and hepatocyte growth factor levels in amniotic fluid.
Kumazawa K,Hiramatsu Y,Masuyama H,Mizutani Y
Acta Medica Okayama , 2003,
Abstract: Surfactant treatment in infants with respiratory distress syndrome (RDS) has decreased neonatal mortality. With the advent of this therapy, it has become important to predict accurately the fetal lung maturity of a fetus before delivery. We evaluated the stable microbubble test (SMT), surfactant protein-A (SP-A) and hepatocyte growth factor (HGF) in amniotic fluid as predicting markers for RDS. Of 55 amniotic fluid samples obtained by amniocentesis from women less than 37 weeks pregnant, the SMT values were as follows: sensitivity 76.5%, specificity 84.2%, positive predictive value 68.4%, negative predictive value 88.9% and overall accuracy 81.8%. For SP-A, the values were 88.2%, 65.8%, 53.6%, 92.6% and 72.7%, respectively. If we used both SMT and SP-A, we could diagnose with 100% accuracy that a case with measurements of SMT > or = 2 and SP-A > or = 420 ng/ml would not complicate with RDS (24/24). However, the RDS diagnostic accuracy of HGF does not equal to those of SMT and SP-A levels. We concluded that the rapidity, simplicity and reliability of SMT was very useful during 24-36 weeks of gestation as a bedside procedure to predict fetuses likely to develop RDS. We also noted the additive effect of SP-A in improving the accuracy of lung maturity diagnosis.
Metal-nonmetal transition in LixCoO2 thin film and thermopower enhancement at high Li concentration
Y. Ishida,A. Mizutani,K. Sugiura,H. Ohta,K. Koumoto
Physics , 2010, DOI: 10.1103/PhysRevB.82.075325
Abstract: We investigate the transport properties of LixCoO2 thin films whose resistivities are nearly an order of magnitude lower than those of the bulk polycrystals. A metal-nonmetal transition occurs at ~0.8 in a biphasic domain, and the Seebeck coefficient (S) is drastically increased at ~140 K (= T*) with increasing the Li concentration to show a peak of magnitude ~120 \muV/K in the S-T curve of x = 0.87. We show that T* corresponds to a crossover temperature in the conduction, most likely reflecting the correlation-induced temperature dependence in the low-energy excitations.
Off-shell effects in the electromagnetic production of strangeness
T. Mizutani,C. Fayard,G. -H. Lamot,B. Saghai
Physics , 1997, DOI: 10.1103/PhysRevC.58.75
Abstract: Previous approaches to the photo- and electro-production of strangeness off the proton, based upon effective hadronic Lagrangians, are extended here to incorporate the so called off-shell effects inherent to the fermions with spin >= 3/2. A formalism for intermediate-state, spin 3/2, nucleonic and hyperonic resonances is presented and applied to the processes $\gamma + p ---> K^{+} + \Lambda$, for $E_{\gamma}^{lab}$ <= 2.5 GeV, $e + p ---> e' + K^+ + \Lambda$, as well as the branching ratio for the crossed channel reaction $K^- + p ---> \gamma + \Lambda$, with stopped kaons. The sensitivity, from moderate to significant, of various observables to such effects are discussed.
Two dimensionality in quasi one-dimensional cobalt oxides
J. Sugiyama,H. Nozaki,J. H. Brewer,E. J. Ansaldo,T. Takami,H. Ikuta,U. Mizutani
Physics , 2005, DOI: 10.1103/PhysRevB.72.064418
Abstract: By means of muon spin rotation and relaxation ($\mu^+$SR) techniques, we have investigated the magnetism of quasi one-dimensional (1D) cobalt oxides $AE_{n+2}$Co$_{n+1}$O$_{3n+3}$ ($AE$=Ca, Sr and Ba, $n$=1, 2, 3, 5 and $\infty$), in which the 1D CoO$_3$ chain is surrounded by six equally spaced chains forming a triangular lattice in the $ab$-plane, using polycrystalline samples, from room temperature down to 1.8 K. For the compounds with $n$=1 - 5, transverse field $\mu^+$SR experiments showed the existence of a magnetic transition below $\sim$100 K. The onset temperature of the transition ($T_{\rm c}^{\rm on}$) was found to decrease with $n$; from 100 K for $n$=1 to 60 K for $n$=5. A damped muon spin oscillation was observed only in the sample with $n$=1 (Ca$_3$Co$_2$O$_6$), whereas only a fast relaxation obtained even at 1.8 K in the other three samples. In combination with the results of susceptibility measurements, this indicates that a two-dimensional short-range antiferromagnetic (AF) order appears below $T_{\rm c}^{\rm on}$ for all compounds with $n$=1 - 5; but quasi-static long-range AF order formed only in Ca$_3$Co$_2$O$_6$, below 25 K. For BaCoO$_3$ ($n$=$\infty$), as $T$ decreased from 300 K, 1D ferromagnetic (F) order appeared below 53 K, and a sharp 2D AF transition occurred at 15 K.
Toxicity of Xanthene Food Dyes by Inhibition of Human Drug-Metabolizing Enzymes in a Noncompetitive Manner
Takaharu Mizutani
Journal of Environmental and Public Health , 2009, DOI: 10.1155/2009/953952
Abstract: The synthetic food dyes studied were rose bengal (RB), phroxine (PL), amaranth, erythrosine B (ET), allura red, new coccine, acid red (AR), tartrazine, sunset yellow FCF, brilliant blue FCF, and indigo carmine. First, data confirmed that these dyes were not substrates for CYP2A6, UGT1A6, and UGT2B7. ET inhibited UGT1A6 (glucuronidation of p-nitrophenol) and UGT2B7 (glucuronidation of androsterone). We showed the inhibitory effect of xanthene dye on human UGT1A6 activity. Basic ET, PL, and RB in those food dyes strongly inhibited UGT1A6 activity, with IC50 values = 0.05, 0.04, and 0.015 mM, respectively. Meanwhile, AR of an acidic xanthene food dye showed no inhibition. Next, we studied the inhibition of CYP3A4 of a major phase I drug-metabolizing enzyme and P-glycoprotein of a major transporter by synthetic food dyes. Human CYP3A4 and P-glycoprotein were also inhibited by basic xanthene food dyes. The IC50 values of these dyes to inhibit CYP3A4 and P-glycoprotein were the same as the inhibition level of UGT1A6 by three halogenated xanthene food dyes (ET, PL, and RB) described above, except AR, like the results with UGT1A6 and UGT2B7. We also confirmed the noninhibition of CYP3A4 and P-gp by other synthetic food dyes. Part of this inhibition depended upon the reaction of 1O2 originating on xanthene dyes by light irradiation, because inhibition was prevented by 1O2 quenchers. We studied the influence of superoxide dismutase and catalase on this inhibition by dyes and we found prevention of inhibition by superoxide dismutase but not catalase. This result suggests that superoxide anions, originating on dyes by light irradiation, must attack drug-metabolizing enzymes. It is possible that red cosmetics containing phloxine, erythrosine, or rose bengal react with proteins on skin under lighting and may lead to rough skin.
Effective Lagrangian Study of $γp \to K^+ Λ$ (spin 3/2 resonances and their off-shell effects)
T. Mizutani
Physics , 1998,
Abstract: The purpose of the present discussion is to supplement the talk, by B.~Saghai at this workshop, on the study of the electromagnetic production of strangeness on the nucleon based upon effective Lagrangian methods. Here we focus on the proper treatment of the spin 3/2 resonances and their associated effects due to the spin 1/2 component of the corresponding fields when they are {\it off the mass shell}.
Strichartz estimates for Schr?dinger equations with variable coefficients and potentials at most linear at spatial infinity
Haruya Mizutani
Mathematics , 2011,
Abstract: In the present paper we consider Schr\"odinger equations with variable coefficients and potentials, where the principal part is a long-range perturbation of the flat Laplacian and potentials have at most linear growth at spatial infinity. We then prove local-in-time Strichartz estimates, outside a large compact set centered at origin, expect for the endpoint. Moreover we also prove global-in-space Strichartz estimates under the non-trapping condition on the Hamilton flow generated by the kinetic energy.
Strichartz estimates for Schr?dinger equations with variable coefficients and unbounded potentials II. Superquadratic potentials
Haruya Mizutani
Mathematics , 2012,
Abstract: In this paper we prove local-in-time Strichartz estimates with loss of derivatives for Schr\"odinger equations with variable coefficients and potentials, under the conditions that the geodesic flow is nontrapping and potentials grow polynomially at infinity. This is a generalization to the case with variable coefficients and improvement of the result by Yajima-Zhang. The proof is based on microlocal techniques including the semiclassical parametrix for a time scale depending on a spatial localization and the Littlewood-Paley type decomposition with respect to both of space and frequency.
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