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Search Results: 1 - 10 of 2674 matches for " Guy Froyen "
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Ubiquitin Ligase HUWE1 Regulates Axon Branching through the Wnt/β-Catenin Pathway in a Drosophila Model for Intellectual Disability
Joke Vandewalle, Marion Langen, Marlen Zschaetzsch, Bonnie Nijhof, Jamie M. Kramer, Hilde Brems, Marijke Bauters, Elsa Lauwers, Mohammed Srahna, Peter Marynen, Patrik Verstreken, Annette Schenck, Bassem A. Hassan, Guy Froyen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081791
Abstract: We recently reported that duplication of the E3 ubiquitin ligase HUWE1 results in intellectual disability (ID) in male patients. However, the underlying molecular mechanism remains unknown. We used Drosophila melanogaster as a model to investigate the effect of increased HUWE1 levels on the developing nervous system. Similar to the observed levels in patients we overexpressed the HUWE1 mRNA about 2-fold in the fly. The development of the mushroom body and neuromuscular junctions were not altered, and basal neurotransmission was unaffected. These data are in agreement with normal learning and memory in the courtship conditioning paradigm. However, a disturbed branching phenotype at the axon terminals of the dorsal cluster neurons (DCN) was detected. Interestingly, overexpression of HUWE1 was found to decrease the protein levels of dishevelled (dsh) by 50%. As dsh as well as Fz2 mutant flies showed the same disturbed DCN branching phenotype, and the constitutive active homolog of β-catenin, armadillo, could partially rescue this phenotype, our data strongly suggest that increased dosage of HUWE1 compromises the Wnt/β-catenin pathway possibly by enhancing the degradation of dsh.
Orogenesis: Cause of Sedimentary Formations  [PDF]
Guy Guy Berthault
Open Journal of Geology (OJG) , 2013, DOI: 10.4236/ojg.2013.32B005

Experiments on stratification discussed here have revealed the mechanical nature of lamination as well as the role of turbulent current as agent of stratification. They challenge Steno’s principle that superposed strata are successive sedimentary layers. They show that relative chronology should not be referred to as “stages” but as “sequences” of series. The rock formation studied by Lalomov shows that the duration of sedimentation could be considerably shorter than indicated by the Geological Time Scale. The latter scale corresponds to large marine transgressions and regressions that can result from the shift of polar axis following such major orogeneses as the Caledonian, Hercynian and Alpine.

On Bifurcation from Infinity and Multipoint Boundary Value Problems  [PDF]
Guy Degla
Advances in Pure Mathematics (APM) , 2014, DOI: 10.4236/apm.2014.44018

We generalize a result on bifurcation from infinity of high order ordinary differential equations with multi-point boundary conditions. Our abstract setting represents a variant of Nonlinear Krein-Ruthman theorems. Furthermore, an analysis of this abstract setting raises an open question motivated by some misunderstanding and inconclusive proofs about the simplicity of principal eigenvalues in some articles in the literature.

A Remark on the Uniform Convergence of Some Sequences of Functions  [PDF]
Guy Degla
Advances in Pure Mathematics (APM) , 2015, DOI: 10.4236/apm.2015.59048
Abstract: We stress a basic criterion that shows in a simple way how a sequence of real-valued functions can converge uniformly when it is more or less evident that the sequence converges uniformly away from a finite number of points of the closure of its domain. For functions of a real variable, unlike in most classical textbooks our criterion avoids the search of extrema (by differential calculus) of their general term.
The Case for the Recognition of Krav-Maga as Part of the Intangible Cultural Heritage of Israel  [PDF]
Guy Mor
Open Journal of Social Sciences (JSS) , 2019, DOI: 10.4236/jss.2019.74023
Abstract: Krav-Maga (“contact combat”) has attracted increasing attention, both in Israel and abroad, as a civilian combat discipline, a martial art and an effective self-defense system used by the Israel Defense Forces (IDF). This paper explores the interactions between the development of Krav-Maga and the history, culture and heritage of the Jewish population of Israel. Using qualitative research methods, it is demonstrated that the evolution of Krav-Maga is intertwined with ideological changes and historical events that affected the Jewish people in the late 19th and early 20th centuries, and with the cultural history and identity of Jewish immigrants to Israel in the mid 20th century. We argue that Krav-Maga meets the criteria set out in UNESCO’s definition of intangible cultural heritage and that it should be included in the Representative List of the Intangible Cultural Heritage of Israel.
Fabrication and tribological properties of Al reinforced with carbon fibers
Estrems Amestoy, Manuel,Faura Mateu, Félix,Froyen, Ludo
Revista de Metalurgia , 2000,
Abstract: The present work studies the manufacturing process of Al reinforced with Carbon Fibres (CF) by "Squeeze Casting", establishing the variables for obtaining an acceptable product with little Al4C3 at the interface. Friction and wear tests are performed and the necessary conditions for the formation of a tribofilm are established. The tests show an increasing resistance to abrasion due to their own wear mechanism. Certain design criteria for those components subjected to friction are recommended in order to maximise the mechanical performance of the tribological system. Este trabajo estudia el proceso de fabricación de composites Al reforzado con fibras de carbono mediante la técnica ''Squeeze Casting'', estableciendo las variables para obtener un producto aceptable que tenga poca cantidad de Al4C3 en la interfase. Se han realizado ensayos de fricción y desgaste y se han establecido las condiciones necesarias para la formación de la tribocapa. Se muestra la alta capacidad de resistencia a la abrasión de las piezas producidas debido a su propio mecanismo de desgaste y se recomiendan ciertos criterios de dise o para componentes mecánicos con el fin de optimizar las prestaciones mecánicas en un sistema tribológico.
Universal Design Patterns for stoma care away-from-home
Hubert Froyen,Evelien Verdonck,Dirk De Meester,Ann Heylighen
Australasian Medical Journal , 2009,
Abstract: Accommodating the real diversity of user populations,including those with physical and / or mental impairments and functional limitations, requires a large amount of designinformation in connection with human dis-abilities(limitations and possibilities). In order to collect andorganise this information for designers and decision makers, Universal Design Patterns (UD Patterns) offer descriptive information about, on the one hand, CONFLICTS between users and built environments, and on the other hand,empirically evident design RESOLUTIONS. Directcollaboration with users / experts was tested in thedevelopment of a specific UD Pattern for a (Semi-) ambulant accessible toilet for personal care, with specific emphasis onstoma-care in public facilities. The paper illustrates howpeople with ostomies and care-givers communicate with researchers, and how relevant design information is extracted and structured. On a more general level, results show how environment-related dimensions of human functioning differ from medical aspects, and how direct involvement of end-users enriches the content of design information.
Documenting handicap situations and eliminations through Universal Design patterns
Hubert Froyen,Evelien Verdonck,Dirk De Meester,Ann Heylighen
Australasian Medical Journal , 2009,
Abstract: According to contemporary academic and social insights,human functional limitations and handicaps are not exclusively the result of the physical and / or mental characteristics of the individual (medical model), but theycan just as well be a consequence of a maladjustment of the social and physical environment (conflict / social model).This radical reversal of focus from person to environment,or in other words, from the assessment that the person isimpeded to the insight that the physical and socialenvironment is an impediment, has far-reaching consequences for the designing of human-made environments.The recent Universal Design paradigm extends beyond accommodating ‘modal’ users and aims to include the realdiversity of user populations, including those with physical and / or mental impairments and functional limitations. To achieve this, a large amount of design information in connection with human dis-abilities (limitations andpossibilities) is required.Together with prescriptive laws and regulations, designers need descriptive information about; on the one hand,CONFLICTS between users and built environments, and onthe other hand, empirically evident design RESOLUTIONS. In response to this need, the paper advances the development of specific Universal Design Patterns (UD Patterns) in order to collect and organise this information for decision makers and for designers.
Point-charge electrostatics in disordered alloys
C. Wolverton,Alex Zunger,S. Froyen,S. H. Wei
Physics , 1996, DOI: 10.1103/PhysRevB.54.7843
Abstract: A simple analytic model of point-ion electrostatics has been previously proposed in which the magnitude of the net charge q_i on each atom in an ordered or random alloy depends linearly on the number N_i^(1) of unlike neighbors in its first coordination shell. Point charges extracted from recent large supercell (256-432 atom) local density approximation (LDA) calculations of Cu-Zn random alloys now enable an assessment of the physical validity and accuracy of the simple model. We find that this model accurately describes (i) the trends in q_i vs. N_i^(1), particularly for fcc alloys, (ii) the magnitudes of total electrostatic energies in random alloys, (iii) the relationships between constant-occupation-averaged charges and Coulomb shifts (i.e., the average over all sites occupied by either $A$ or $B$ atoms) in the random alloy, and (iv) the linear relation between the site charge q_i and the constant- charge-averaged Coulomb shift (i.e., the average over all sites with the same charge) for fcc alloys. However, for bcc alloys the fluctuations predicted by the model in the q_i vs. V_i relation exceed those found in the LDA supercell calculations. We find that (a) the fluctuations present in the model have a vanishing contribution to the electrostatic energy. (b) Generalizing the model to include a dependence of the charge on the atoms in the first three (two) shells in bcc (fcc) - rather than the first shell only - removes the fluctuations, in complete agreement with the LDA data. We also demonstrate an efficient way to extract charge transfer parameters of the generalized model from LDA calculations on small unit cells.
Evaluation of Innovative Teaching Approaches: The Moderating Effect of Student Prior Experience  [PDF]
Bruce Byrne, Richard Guy
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.326113
Abstract: The success of creative or innovative teaching approaches is often measured by student perceptual ratings of the learning environment or by academic outcomes. This paper examines student perceptions of a novel human physiology laboratory format and the effect of prior experience on these perceptions. The same undergraduate human physiology course, taught at second year level, was taken by students who had previously completed a semester of human physiology (‘continuing’ students) and by those taking it for the first time (‘new’ students). The “continuing” students were significantly more positive about the novel format compared to the previous format. The class as a whole (‘continuing’ plus “new”) also gave a strong positive rating of the novel format. However a comparison between the ‘continuing’ and the “new’ students showed that the latter were significantly more positive in their perception of the laboratory in all areas apart from active participation. A correlational analysis indicated strong inter-rater links for the ‘continuing’ students but weak or non-significant inter-rater correlations for the ‘new’ students. The study suggests that, given the diversity of student backgrounds and prior experience in a given class, that perceptual ratings of the learning environment alone may not provide enough support for the effectiveness of novel teaching interventions.
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