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Search Results: 1 - 10 of 9493 matches for " Gu JL "
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Efficacy of intravenous amphotericin B-polybutylcyanoacrylate nanoparticles against cryptococcal meningitis in mice
Xu N,Gu JL,Zhu YJ,Wen H
International Journal of Nanomedicine , 2011,
Abstract: Nan Xu1,2, Julin Gu3, Yuanjie Zhu3, Hai Wen3, Qiushi Ren1, Jianghan Chen31Institute for Laser Medicine and Biophotonics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China; 2Department of Dermatology, Shanghai East Hospital, Shanghai, People's Republic of China; 3Department of Dermatology, Shanghai Changzheng Hospital, Shanghai, People's Republic of ChinaAbstract: Amphotericin B deoxycholate (AmB), a classic antifungal drug, remains the initial treatment of choice for deep fungal infections, but it is not appropriate for treatment of cryptococcal meningitis due to its inability to pass through the blood–brain barrier (BBB). We examined the efficacy of amphotericin B-polybutylcyanoacrylate nanoparticles (AmB-PBCA-NPs) modified with polysorbate 80 that had a mean particle diameter less than 100 nanometers (69.0 ± 28.6 nm). AmB-PBCA-NPs were detected in the brain 30 minutes after systemic administration into BALB/c mice and had a higher concentration than systemically administered AmB liposome (AmB-L, P < 0.05); AmB was not detected in the brain. Following infection for 24 hours and then 7 days of treatment, the survival rate of mice in the AmB-PBCA-NP group (80%) was significantly higher than that of the AmB (0%) or AmB-L (60%) treatment groups. Fungal load was also lower when assessed by colony-forming unit counts obtained after plating infected brain tissue (P < 0.05). Our study indicates that AmB-PBCA-NPs with polysorbate 80 coating have the capacity to transport AmB across the BBB and is an efficient treatment against cryptococcal meningitis in a mouse model.Keywords: cryptococcal meningitis, polybutylcyanoacrylate (PBCA), nanoparticles, brain targeting
Direct methods for detecting picorna-like virus from dead and alive Triatomine insects
Rozas Dennis, GS;La Torre, JL;Muscio, OA;Guérin, DMA;
Memórias do Instituto Oswaldo Cruz , 2000, DOI: 10.1590/S0074-02762000000300006
Abstract: in this work we report four different destructive and non-destructive methods for detecting picorna-like virus particles in triatomines. the methods are based on direct observation under transmission electron microscope and they consist of four ways to prepare samples of presumable infected material. the samples are prepared processing dead or alive insect parts, or even dry or fresh insect feces. the methods can be used as analytical or preparative techniques, for quantifying virus infection and checking virus integrity as well. in this work the four methods are applied in order to detect triatoma virus (trv) particles in t. infestans colonies.
Efficacy of intravenous amphotericin B-polybutylcyanoacrylate nanoparticles against cryptococcal meningitis in mice
Xu N, Gu JL, Zhu YJ, Wen H, Ren QS, Chen JH
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S17503
Abstract: acy of intravenous amphotericin B-polybutylcyanoacrylate nanoparticles against cryptococcal meningitis in mice Original Research (3453) Total Article Views Authors: Xu N, Gu JL, Zhu YJ, Wen H, Ren QS, Chen JH Published Date April 2011 Volume 2011:6 Pages 905 - 913 DOI: http://dx.doi.org/10.2147/IJN.S17503 Nan Xu1,2, Julin Gu3, Yuanjie Zhu3, Hai Wen3, Qiushi Ren1, Jianghan Chen3 1Institute for Laser Medicine and Biophotonics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China; 2Department of Dermatology, Shanghai East Hospital, Shanghai, People's Republic of China; 3Department of Dermatology, Shanghai Changzheng Hospital, Shanghai, People's Republic of China Abstract: Amphotericin B deoxycholate (AmB), a classic antifungal drug, remains the initial treatment of choice for deep fungal infections, but it is not appropriate for treatment of cryptococcal meningitis due to its inability to pass through the blood–brain barrier (BBB). We examined the efficacy of amphotericin B-polybutylcyanoacrylate nanoparticles (AmB-PBCA-NPs) modified with polysorbate 80 that had a mean particle diameter less than 100 nanometers (69.0 ± 28.6 nm). AmB-PBCA-NPs were detected in the brain 30 minutes after systemic administration into BALB/c mice and had a higher concentration than systemically administered AmB liposome (AmB-L, P < 0.05); AmB was not detected in the brain. Following infection for 24 hours and then 7 days of treatment, the survival rate of mice in the AmB-PBCA-NP group (80%) was significantly higher than that of the AmB (0%) or AmB-L (60%) treatment groups. Fungal load was also lower when assessed by colony-forming unit counts obtained after plating infected brain tissue (P < 0.05). Our study indicates that AmB-PBCA-NPs with polysorbate 80 coating have the capacity to transport AmB across the BBB and is an efficient treatment against cryptococcal meningitis in a mouse model.
Direct methods for detecting picorna-like virus from dead and alive Triatomine insects
Rozas Dennis GS,La Torre JL,Muscio OA,Guérin DMA
Memórias do Instituto Oswaldo Cruz , 2000,
Abstract: In this work we report four different destructive and non-destructive methods for detecting picorna-like virus particles in triatomines. The methods are based on direct observation under transmission electron microscope and they consist of four ways to prepare samples of presumable infected material. The samples are prepared processing dead or alive insect parts, or even dry or fresh insect feces. The methods can be used as analytical or preparative techniques, for quantifying virus infection and checking virus integrity as well. In this work the four methods are applied in order to detect Triatoma virus (TrV) particles in T. infestans colonies.
Some considerations on selection criteria and optimization for terminal sire breeds
JL Foulley
Genetics Selection Evolution , 1976, DOI: 10.1186/1297-9686-8-1-89
Abstract:
ECM approaches to heteroskedastic mixed models with constant variance ratios
JL Foulley
Genetics Selection Evolution , 1997, DOI: 10.1186/1297-9686-29-3-297
Abstract:
Prediction of selection response for Poisson distributed traits
JL Foulley
Genetics Selection Evolution , 1993, DOI: 10.1186/1297-9686-25-3-297
Abstract:
La ense?anza de la Medicina Legal en Sevilla (1824-2006): nómina de catedráticos
Carrillo,JL.;
Cuadernos de Medicina Forense , 2005, DOI: 10.4321/S1135-76062005000400003
Abstract: the present article is a new contribution to the knowledge of the genealogy of professors who have taught forensic medicine in the various schools existing in seville from 1824 up until today.
MB ChB curriculum modernisation in South Africa – growing doctors for Africa
JL Seggie
African Journal of Health Professions Education , 2010,
Abstract:
Madagascar rosewood, illegal logging and the tropical timber trade
JL Innes
Madagascar Conservation & Development , 2010,
Abstract: Although deforestation rates in the tropics are reportedly slowing, the loss of both forest area and forest quality remains a significant issue for many countries. This is particularly true of Madagascar, where recent government instability has enabled a significant increase in the incidence of illegal logging of Dalbergia species from National Parks such as Marojejy and Masoala. The logs are exported with relative ease as export permits are being made available. While attempts have been made to improve the management of tropical forests, in 2005, the International Tropical Timber Organization considered that only 7 % of tropical production forests were being managed sustainably. Given the challenges associated with halting illegal logging at source, emphasis has shifted to the control of the trade in forest products. The Convention on the International Trade in Endangered Species provides a mechanism to restrict such trade, but the Madagascan Dalbergia species are not listed. In the USA, the recent amendments to the ‘Lacey Act’ could provide a significant disincentive to the import of illegally logged wood products, but it remains to be seen whether this Act can be enforced effectively.
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