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Search Results: 1 - 10 of 301557 matches for " Gregory J Zablocki "
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Visionary genomics
J Petrash, Philip A Ruzycki, Gregory J Zablocki
Human Genomics , 2011, DOI: 10.1186/1479-7364-5-6-519
Abstract: We have come a very long way since the days of John Dalton and his 1794 paper on the origins of colour blindness, a condition he shared with his brother [1]. Investigators from the vision research community have worked out the major pathways of how visual information is received, processed and transmitted to the brain, and how specialised tissues such as the cornea and lens work together to focus light on the retina and filter out harmful ultraviolet light. Molecular pathways responsible for the expression and accumulation of crystallins, the specialised proteins that make up 35 per cent of the wet weight of the ocular lens, have been discovered and studied in great detail. Genes for virtually all components of the phototransduction cascade have been identified and studied to define a host of molecular defects associated with anomalous perception of the visual world.Now that we have a comprehensive understanding of the genes responsible for the organisation and functional integration of the visual system, it is reasonable to consider the challenges posed by major heritable vision diseases that either are not treatable or for which current therapies cannot meet the global burden of disease. We can ponder whether the emergence of next-generation genome technologies will lead us closer to discovering new therapeutic strategies and achieving improved care of patients with vision disorders. Two major blinding conditions, age-related macular degeneration (AMD) and glaucoma, can serve as useful examples to highlight how far we have come, and how far we have yet to go, in our understanding of genetic influence on disease pathogenesis.AMD is the leading cause of blindness in people aged over 60 years in North America. Many commonalities have been associated with the complex manifestation of AMD, including accumulation of excess oxidised lipoproteins in the form of drusen; atrophy of the retinal pigment epithelium; formation of new blood vessels in the choroid; and environmen
The Value of Beauty in Theory Pursuit: Kuhn, Duhem, and Decision Theory  [PDF]
Gregory J. Morgan
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.31003
Abstract:

Should judgments of beauty play a guiding role in theoretical science even if beauty is not a sign of truth? In this paper I argue that they should in certain cases. If we analyze the rationality of theoretical pursuit using decision theory, a theory’s beauty can influence the utilities of the various options confronting the researcher. After considering the views of Pierre Duhem and Thomas Kuhn on aesthetics in science, I suggest that because we value freedom of inquiry we rightly allow scientists some choice in how they value aesthetic properties of theories and thus some freedom to use beauty to guide their research program.

Circumcision of Infants and Children: Short-Term Trauma and Long-Term Psychosexual Harm  [PDF]
Gregory J. Boyle
Advances in Sexual Medicine (ASM) , 2015, DOI: 10.4236/asm.2015.52004
Abstract: Non-therapeutic infant male circumcision is a permanent surgical alteration to the penis that may cause significant physical, sexual and psychological harm. Physical harms include unintended adverse effects of the surgery itself (e.g., complications such as bleeding, infection, excessive removal of foreskin leaving insufficient shaft skin to accommodate erections, etc.), as well as the inherent loss of healthy, functional tissue. Sexual harms that necessarily follow from circumcision include the loss of all sensation in the foreskin itself, and the loss of all sexual functions that involve the physical manipulation of the foreskin. Additional sexual harms that may follow circumcision include reduced sexual sensation in the remaining penile structures, difficulty with masturbation, increased chafing in both the circumcised man and his sexual partner, as well as reduced overall psychosexual/psychological tension relief and subjective satisfaction. Psychological harms include short-term trauma as well as the potential for long-term emotional disturbances, including sadness, frustration, distress, and anger—akin to post-traumatic stress disorder (PTSD). In this paper, the extent and severity of these various harms are considered and it is argued that they are more serious and more widespread than is commonly believed.
Does Male Circumcision Adversely Affect Sexual Sensation, Function, or Satisfaction? Critical Comment on Morris and Krieger (2013)  [PDF]
Gregory J. Boyle
Advances in Sexual Medicine (ASM) , 2015, DOI: 10.4236/asm.2015.52002
Abstract: Morris and Krieger (2013) have argued that male circumcision does not impact adversely on sexual sensation, satisfaction, and/or function. In the present paper, it is argued that such a view is untenable. By selectively citing Morris’ own non-peer-reviewed letters and opinion pieces purporting to show flaws in studies reporting evidence of negative effects of circumcision, and by failing adequately to account for replies to these letters by the authors of the original research (and others), Morris and Krieger give an incomplete and misleading account of the available literature. Consequently, Morris and Krieger reach an implausible conclusion that is inconsistent with what is known about the anatomy and functions of the penile foreskin, and the likely effects of its surgical removal.
Bound States and Superconductivity in Dense Fermi Systems
Blaschke, D.;Zablocki, D.
High Energy Physics - Phenomenology , 2008, DOI: 10.1134/S1063779608070071
Abstract: A quantum field theoretical approach to the thermodynamics of dense Fermi systems is developed for the description of the formation and dissolution of quantum condensates and bound states in dependence of temperature and density. As a model system we study the chiral and superconducting phase transitions in two-flavor quark matter within the NJL model and their interrelation with the formation of quark-antiquark and diquark bound states. The phase diagram of quark matter is evaluated as a function of the diquark coupling strength and a coexistence region of chiral symmetry breaking and color superconductivity is obtained at very strong coupling. The crossover between Bose-Einstein condensation (BEC) of diquark bound states and condensation of diquark resonances (Cooper pairs) in the continuum (BCS) is discussed as a Mott effect. This effect consists in the transition of bound states into the continuum of scattering states under the influence of compression and heating. We explain the physics of the Mott transition with special emphasis on role of the Pauli principle for the case of the pion in quark matter.
Bound States and Superconductivity in Dense Fermi Systems
D. Blaschke,D. Zablocki
Physics , 2008, DOI: 10.1134/S1063779608070071
Abstract: A quantum field theoretical approach to the thermodynamics of dense Fermi systems is developed for the description of the formation and dissolution of quantum condensates and bound states in dependence of temperature and density. As a model system we study the chiral and superconducting phase transitions in two-flavor quark matter within the NJL model and their interrelation with the formation of quark-antiquark and diquark bound states. The phase diagram of quark matter is evaluated as a function of the diquark coupling strength and a coexistence region of chiral symmetry breaking and color superconductivity is obtained at very strong coupling. The crossover between Bose-Einstein condensation (BEC) of diquark bound states and condensation of diquark resonances (Cooper pairs) in the continuum (BCS) is discussed as a Mott effect. This effect consists in the transition of bound states into the continuum of scattering states under the influence of compression and heating. We explain the physics of the Mott transition with special emphasis on role of the Pauli principle for the case of the pion in quark matter.
Quantum Condensates in Nuclear Matter: Problems
G. Ropke,D. Zablocki
Physics , 2010, DOI: 10.1134/S1063779609020014
Abstract: In connection with the contribution "Quantum Condensates in Nuclear Matter" some problems are given to become more familiar with the techniques of many-particle physics.
Non-Immunosuppressant Medication Use in Heart Transplant Patients: A Guide for Pharmacists  [PDF]
Gregory Egan, Glen J. Pearson
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.510107
Abstract: For heart transplant patients, there are a number of non-immunosuppressant medications that are routinely prescribed to mitigate the side-effects of immunosuppression, treat the related complications, and improve long-term survival. This review focuses on the medications used to prevent and manage cardiac allograft vasculopathy (CAV), hypertension, dyslipidemia and osteoporosis. The rationale and evidence supporting their use are summarized and the immunosuppressant drugs are only discussed briefly, as they relate to each of these medical issues. Pharmacy practitioners are likely to encounter patients post-cardiac transplant in a variety of clinical settings; therefore, a concise appreciation of the principles for the long-term medical management of these patients is important when providing collaborative care.
NARCCAP Model Skill and Bias for the Southeast United States  [PDF]
Erik D. Kabela, Gregory J. Carbone
American Journal of Climate Change (AJCC) , 2015, DOI: 10.4236/ajcc.2015.41009
Abstract: This paper investigates dynamically downscaled regional climate model (RCM) output from the North American Regional Climate Change Assessment Program (NARCCAP) for two sub-regions of the Southeast United States. A suite of four statistical measures were used to assess model skill and biases were presented in hindcasting daily minimum and maximum temperature and mean precipitation during a historical reference period, 1970-1999. Most models demonstrated high skill for temperature during the historical period. Two outliers included two RCMs run using the Geophysical Fluids Dynamics Lab (GFDL) model as their lateral boundary conditions; these models suffered from a cold maximum temperature bias. Improvement with GFDL-based projections of maximum temperature was noted from May through November when they ran with observed seasurface conditions (GFDL-timeslice), particularly for the east sub-region. Precipitation skill proved mixed-relatively high when measured using a probability density function overlap measurement or the index of agreement, but relatively low when measured with root-mean square error or mean absolute error, because several models overestimated the frequency of extreme precipitation events.
Non Small-Cell Lung Cancer Metastatic to the Mitral Valve: Case Report and Review of the Literature  [PDF]
Daniel J. Axelson, Natalie P. Kreitzer, Gregory J. Fermann
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.37094
Abstract:

In 2008, 1.6 million new cases of lung cancer were diagnosed worldwide, representing 13% of all cancer cases for the year, and in 2010, 19% of cancer deaths were attributed to lung cancer. Though lung cancer frequently metastasizes to the adrenal glands, bone, brain, liver, and other lung, it infrequently metastasizes to the heart. Here, we report a case of lung cancer metastatic to the mitral valve.

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