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Search Results: 1 - 10 of 3147 matches for " Gonzalo Rincon "
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Quantum phase transition between orbital-selective Mott states in Hund's metals
Julian Rincon,Adriana Moreo,Gonzalo Alvarez,Elbio Dagotto
Physics , 2014, DOI: 10.1103/PhysRevB.90.241105
Abstract: We report a quantum phase transition between orbital-selective Mott states, with different localized orbitals, in a Hund's metals model. Using the density matrix renormalization group, the phase diagram is constructed varying the electronic density and Hubbard $U$, at robust Hund's coupling. We demonstrate that this transition is preempted by charge fluctuations and the emergence of free spinless fermions, as opposed to the magnetically-driven Mott transition. The Luttinger correlation exponent is shown to have a universal value in the strong-coupling phase, whereas it is interaction dependent at intermediate couplings. At weak coupling we find a second transition from a normal metal to the intermediate-coupling phase.
Exotic magnetic order in the orbital-selective Mott regime of multiorbital systems
Julian Rincon,Adriana Moreo,Gonzalo Alvarez,Elbio Dagotto
Physics , 2014, DOI: 10.1103/PhysRevLett.112.106405
Abstract: The orbital-selective Mott phase (OSMP) of multiorbital Hubbard models has been extensively analyzed before using static and dynamical mean-field approximations. In parallel, the properties of Block states (antiferromagnetically coupled ferromagnetic spin clusters) in Fe-based superconductors have also been much discussed. The present effort uses numerically exact techniques in one-dimensional systems to report the observation of Block states within the OSMP regime, connecting two seemingly independent areas of research, and providing analogies with the physics of Double-Exchange models.
Transcriptional profiling of bovine milk using RNA sequencing
Saumya Wickramasinghe, Gonzalo Rincon, Alma Islas-Trejo, Juan F Medrano
BMC Genomics , 2012, DOI: 10.1186/1471-2164-13-45
Abstract: A total of 16,892 genes were expressed in transition lactation, 19,094 genes were expressed in peak lactation and 18,070 genes were expressed in late lactation. Regardless of the lactation stage approximately 9,000 genes showed ubiquitous expression. Genes encoding caseins, whey proteins and enzymes in lactose synthesis pathway showed higher expression in early lactation. The majority of genes in the fat metabolism pathway had high expression in transition and peak lactation milk. Most of the genes encoding for endogenous proteases and enzymes in ubiquitin-proteasome pathway showed higher expression along the course of lactation.This is the first study to describe the comprehensive bovine milk transcriptome in Holstein cows. The results revealed that 69% of NCBI Btau 4.0 annotated genes are expressed in bovine milk somatic cells. Most of the genes were ubiquitously expressed in all three stages of lactation. However, a fraction of the milk transcriptome has genes devoted to specific functions unique to the lactation stage. This indicates the ability of milk somatic cells to adapt to different molecular functions according to the biological need of the animal. This study provides a valuable insight into the biology of lactation in the cow, as well as many avenues for future research on the bovine lactome.Milk is a unique biological fluid consumed by mammalian infants. It contains many macro- and micro-nutrients that are essential for the growth and development of the newborn [1,2]. In addition, a diverse cocktail of bioactive factors, such as antibodies, oligosaccharides and nucleotides in milk, play immune, pre-biotic and protective functions in the infant gut [1,3,4].Cow milk has an important role in human nutrition because cow milk-based infant formula is the most available substitute for human breast milk and cow milk is consumed beyond infancy in human populations around the world. However, there are significant differences between the physicochemical properties
Transcriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing
Saumya Wickramasinghe,Serenus Hua,Gonzalo Rincon,Alma Islas-Trejo,J. Bruce German,Carlito B. Lebrilla,Juan F. Medrano
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018895
Abstract: This study examines the genes coding for enzymes involved in bovine milk oligosaccharide metabolism by comparing the oligosaccharide profiles with the expressions of glycosylation-related genes. Fresh milk samples (n = 32) were collected from four Holstein and Jersey cows at days 1, 15, 90 and 250 of lactation and free milk oligosaccharide profiles were analyzed. RNA was extracted from milk somatic cells at days 15 and 250 of lactation (n = 12) and gene expression analysis was conducted by RNA-Sequencing. A list was created of 121 glycosylation-related genes involved in oligosaccharide metabolism pathways in bovine by analyzing the oligosaccharide profiles and performing an extensive literature search. No significant differences were observed in either oligosaccharide profiles or expressions of glycosylation-related genes between Holstein and Jersey cows. The highest concentrations of free oligosaccharides were observed in the colostrum samples and a sharp decrease was observed in the concentration of free oligosaccharides on day 15, followed by progressive decrease on days 90 and 250. Ninety-two glycosylation-related genes were expressed in milk somatic cells. Most of these genes exhibited higher expression in day 250 samples indicating increases in net glycosylation-related metabolism in spite of decreases in free milk oligosaccharides in late lactation milk. Even though fucosylated free oligosaccharides were not identified, gene expression indicated the likely presence of fucosylated oligosaccharides in bovine milk. Fucosidase genes were expressed in milk and a possible explanation for not detecting fucosylated free oligosaccharides is the degradation of large fucosylated free oligosaccharides by the fucosidases. Detailed characterization of enzymes encoded by the 92 glycosylation-related genes identified in this study will provide the basic knowledge for metabolic network analysis of oligosaccharides in mammalian milk. These candidate genes will guide the design of a targeted breeding strategy to optimize the content of beneficial oligosaccharides in bovine milk.
Special issue on Interleukin-6 (IL-6)
Mercedes Rincon
International Journal of Biological Sciences , 2012,
Anisotropy, inhomogeneity and inertial range scalings in turbulent convection
Francois Rincon
Physics , 2006, DOI: 10.1017/S0022112006000917
Abstract: This paper provides a detailed study of scale-by-scale budgets in turbulent Rayleigh-B\'enard convection and aims at testing the applicability of Kolmogorov (1941) and Bolgiano (1959) theories for this flow. Particular emphasis is laid on anisotropic and inhomogeneous effects: the SO(3) decomposition of structure functions (Arad et al 1999) and a method of description of inhomogeneities proposed by Danaila et al (2001) are used to derive inhomogeneous and anisotropic generalizations of Kolmogorov and Yaglom equations applying to RB convection. The various terms in these equations are computed using data from a DNS of turbulent Boussinesq convection at $\rayleigh=10^6$ and $\prandtl=1$ with aspect ratio A=5. The analysis of the isotropic component demonstrates that the shape of the third-order velocity structure function is significantly influenced by buoyancy forcing and large-scale inhomogeneities, while the mixed third-order structure function appearing in Yaglom equation exhibits a clear scaling exponent 1 in a small range of scales. The magnitudes of the various low $\ell$ degree anisotropic components of the equations are also estimated and are shown to be comparable to their isotropic counterparts at moderate to large scales. Finally, a qualitative analysis shows that the influence of buoyancy forcing at scales smaller than the Bolgiano scale is likely to remain important up to $\rayleigh=10^9$, thus preventing Kolmogorov scalings from showing up in convective flows at lower Rayleigh numbers.
On the existence of two-dimensional nonlinear steady states in plane Couette flow
Francois Rincon
Physics , 2007, DOI: 10.1063/1.2753982
Abstract: The problem of two-dimensional steady nonlinear dynamics in plane Couette flow is revisited using homotopy from either plane Poiseuille flow or from plane Couette flow perturbed by a small symmetry-preserving identity operator. Our results show that it is not possible to obtain the nonlinear plane Couette flow solutions reported by Cherhabili and Ehrenstein [Eur. J. Mech. B/Fluids, 14, 667 (1995)] using their Poiseuille-Couette homotopy. We also demonstrate that the steady solutions obtained by Mehta and Healey [Phys. Fluids, 17, 4108 (2005)] for small symmetry-preserving perturbations are influenced by an artefact of the modified system of equations used in their paper. However, using a modified version of their model does not help to find plane Couette flow solution in the limit of vanishing symmetry-preserving perturbations either. The issue of the existence of two-dimensional nonlinear steady states in plane Couette flow remains unsettled.
Comparison of buccal and blood-derived canine DNA, either native or whole genome amplified, for array-based genome-wide association studies
Gonzalo Rincon, Katarina Tengvall, Janelle M Belanger, Laetitia Lagoutte, Juan F Medrano, Catherine André, Anne Thomas, Cynthia Lawley, Mark ST Hansen, Kerstin Lindblad-Toh, Anita M Oberbauer
BMC Research Notes , 2011, DOI: 10.1186/1756-0500-4-226
Abstract: In both buccal and blood samples, whether whole genome amplified or not, 97% of the samples had SNP call rates in excess of 80% indicating that the vast majority of the SNPs would be suitable to perform association studies regardless of the DNA source. Similarly, there were no significant differences in marker intensity measurements between buccal and blood samples for copy number variations (CNV) analysis.All DNA samples assayed, buccal or blood, native or whole genome amplified, are appropriate for use in array-based genome-wide association studies. The concordance between subsets of dogs for which both buccal and blood samples, or those samples whole genome amplified, was shown to average >99%. Thus, the two DNA sources were comparable in the generation of SNP genotypes and intensity values to estimate structural variation indicating the utility for the use of buccal cytobrush samples and the reliability of whole genome amplification for genome-wide association and CNV studies.The present study was undertaken to assess the utility of buccal cytobrush derived DNA and whole genome amplified (WGA) blood or buccal-derived DNA for use on the most recent iteration of the canine SNP GWA platform. Buccal-derived DNA has been suggested as insufficient in quantity and quality for application to the high-throughput SNP array platforms [1]. Whole blood DNA and buccal-derived DNA, as well as DNA samples (from both sources) subjected to WGA, were compared using the Illumina Infinium CanineHD Genotyping BeadChip containing 173,662 SNPs. Copy number variations (CNV), while shown to account for a significant proportion of human genetic polymorphism and have been suggested to play a role in genetic causes of disease [2], is complex and technically challenging to analyze. Specifically CNV analysis is uniquely different to GWA-SNP analysis because the data is based on the intensity measurement of the SNP. Despite the technical issues, the opportunity exists to examine this important
Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice
Charles R Farber, James Chitwood, Sang-Nam Lee, Ricardo A Verdugo, Alma Islas-Trejo, Gonzalo Rincon, Iris Lindberg, Juan F Medrano
BMC Genetics , 2008, DOI: 10.1186/1471-2156-9-34
Abstract: Through a combination of DNA microarray analysis and quantitative PCR we identified a strong expression quantitative trait locus (eQTL) regulating Scg5 expression in two mouse chromosome 2 congenic strains and three additional F2 intercrosses. More importantly, the eQTL was coincident with a body weight QTL in congenic mice and Scg5 expression was negatively correlated with body weight in two of the F2 intercrosses. Analysis of haplotype blocks and genomic sequencing of Scg5 in high (C3H/HeJ, DBA/2J, BALB/cByJ, CAST/EiJ) and low (C57BL/6J) expressing strains revealed mutations unique to C57BL/6J and possibly responsible for the difference in mRNA abundance. To evaluate the functional consequence of Scg5 overexpression we measured the pituitary levels of 7B2 protein and PCSK2 activity and found both to be increased. In spite of this increase, the level of pituitary α-MSH, a PCSK2 processing product, was unaltered.Together, these data support a role for Scg5 in the modulation of body weight.Body weight, as with all complex traits, is partially regulated by the coordinate action of individual genes. One common approach for dissecting the genetics of growth is the mapping of quantitative trait loci (QTL). In the last decade numerous human and mouse growth QTL have been identified [1]; however, while this progress is important, few if any of the loci have been unequivocally resolved to the effects of a single quantitative trait gene (QTG).Several studies involving many different mouse inbred strains have demonstrated an enrichment of growth and obesity QTL on chromosome 2 [2,3]. In our laboratory, we have developed a number of genomic resources with the goal of discerning the molecular basis of chromosome 2 QTL segregating between the C57BL/6J (B6), C57BL/6J-hg/hg (HG) and CAST/EiJ (CAST) strains [4,5]. These include two congenic strains, B6.CAST-(D2Mit329-D2Mit457)N(6) (B62D) and HG.CAST-(D2Mit329-D2Mit457)N(6) (HG2D), constructed by introgressing an identical congenic
Pulmonary Complications in Patients with Severe Brain Injury
Kiwon Lee,Fred Rincon
Critical Care Research and Practice , 2012, DOI: 10.1155/2012/207247
Abstract: Pulmonary complications are prevalent in the critically ill neurological population. Respiratory failure, pneumonia, acute lung injury and the acute respiratory distress syndrome (ALI/ARDS), pulmonary edema, pulmonary contusions and pneumo/hemothorax, and pulmonary embolism are frequently encountered in the setting of severe brain injury. Direct brain injury, depressed level of consciousness and inability to protect the airway, disruption of natural defense barriers, decreased mobility, and secondary neurological insults inherent to severe brain injury are the main cause of pulmonary complications in critically ill neurological patients. Prevention strategies and current and future therapies need to be implemented to avoid and treat the development of these life-threatening medical complications. 1. Introduction Pulmonary complications are very prevalent in the critically-ill neurological population. Respiratory failure, pneumonia, pleural effusions and empyema, acute lung injury and the acute respiratory distress syndrome (ALI/ARDS), pulmonary edema, and pulmonary embolism (PE) from venous thromboembolism (VTE) are frequently encountered in this patient population [1–7]. In addition, direct chest trauma and patients with traumatic brain injury (TBI) are not exempt from direct complications such as rib fractures, flail chest, lung contusions, and hemo/pneumothorax. Unfortunately, the development of these complications extends the patient’s need for care in the intensive care unit (ICU) and prevents early mobilization, and this increases the likelihood of developing secondary disability. Direct brain injury, depressed level of consciousness and inability to protect the airway, disruption of natural defense barriers, decreased mobility, and secondary physiopathologic insults inherent to severe brain injury are the main cause of pulmonary complications in critically-ill neurological patients. The goal in the ICU is to prevent, treat, and optimize hypoxemia and maintain oxygen delivery to limit secondary neurological insults. In the absence of feasible pharmacological agents to target these goals, prevention strategies to minimize pulmonary complications such as use of bedside techniques such as thoracentesis, closed thoracostomies (chest tubes), lung-protective ventilator strategies, bundles for prevention of ventilator associated pneumonias (VAP), and deep venous thrombosis (DVT) prophylaxis are the cornerstone in the prevention and management of pulmonary complications in severe brain injured patients. Finally, additional strategies to target
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