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Search Results: 1 - 10 of 191186 matches for " Gnanasekaran D "
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In vitro studies on anti asthmatic, analgesic and anti convulsant activities of the medicinal plant Bryonia laciniosa.Linn
Jayarama Reddy,Gnanasekaran D.,Vijay D.,Ranganathan T.V.
International Journal of Drug Discovery , 2010,
Abstract: The study was carried out to ascertain anti asthmatic, analgesic and anti convulsant activities ofthe medicinal plant Bryonia Laciniosa. The anti asthmatic activity was estimated by mesenteric mast cellcount by Atopic allergy method. Eddy's hot plate and Analgesiometer tests were used to assess theanalgesic activity of Bryonia Laciniosa. Anticonvulsant activity was evaluated by Maximum electroshockinducedseizure test. The results indicated that 70% alcoholic extract of Bryonia laciniosa increased theantiasmatic activity, analgestic activity and also anticonvulsant activity.
Studies on hepatoprotective activity of traditional ayurvedic formulation ‘Vidakana Choornam’ against carbon tetrachloride induced hepatotoxicity in albino rat
Jayarama Reddy, Gnanasekaran D, Ranganathan TV and Vijay D
International Journal of Pharmaceuticals Analysis , 2010,
Abstract: The study was carried out to ascertain the hepatoprotective activity of traditional ayurvedicformulation ‘Vidakana Choornam’ against carbon tetrachloride induced hepatotoxicity in albino rat. Effect ofcarbon tetrachloride and herbal products on liver weights was studied. Bilirubin level in serum, SerumGlutamate Pyruvate Transaminase (GPT) level in serum, Serum Glutamate Oxaloacetate Transaminase(GOT) level in serum and ALP level in serum were estimated in both control treatment. Histopathologicalstudies were also carried out. It was found that there was an increase in liver weight during carbontetrachloride treatment which may be due to accumulation of fat. The results of Vidakana Choornam’treatment against carbon tetrachloride induced hepatotoxicity revealed that there was considerablereduction in Bilirubin level in serum, Serum Glutamate Pyruvate Transaminase (GPT) level in serum, SerumGlutamate Oxaloacetate Transaminase (GOT) level in serum and ALP level in serum. The hepatoprotectiveactivity of this simple formulation was found to be as effective as Liv – 52, infact the activity on decreasingthe serum bilirubin level was much higher when compared to Liv – 52
In vitro hepatoprotective activity of Siddha medicinal plant Indigofera tinctoria
D. Gnanasekaran,C. Umamaheswara Reddy,B. Jaiprakash,N. Narayanan
International Journal of Pharmacy and Biomedical Sciences , 2012,
Abstract: Liver plays a major role in detoxification. Any injury to it or impairment of its function may lead to many implications on one’s health. Management of liver diseases is still a challenge to modern medicine. The allopathic medicine has little to offer for the alleviation of hepatic ailments whereas the most important representatives are of phytoconstituents. The work presented in this paper is on plant mentioned as Kayakarpam plants in published as well as unpublished palm leaf literatures. The study was aimed to evaluation of the hepatoprotective activity of the whole plant Indigofera tinctoria on the Chang cell line (normal human liver cells). The ethanolic extract was tested for its inhibitory effect on chang cell Line. The percentage viability of the cell line was carried out. The cytotoxicity of Indigofera tinctoria on normal human liver cell was evaluated by the SRB asasy [Sulphorhodamine B asssay] and MTT assay [(3-(4,5 dimethylthiazole –2 yl)-2,5 diphenyl tetrazolium bromide) assay]. The principle involved is the cleavage of tetrazolium salt MTT into a blue coloured derivative by living cells which contains mitochondrial enzyme succinate dehydrogenase However, the information available on the pharmacological activity of the plant is very limited. Hence, it was proposed to carry out a preliminary in vitro analysis of the hepato protective activity of the plant, which gave promising results.
3. Adaptogenic activity of a Siddha medicinal plant: Sida cordata
D. Gnanasekaran,C. Umamaheswara Reddy,B. Jaiprakash,N. Narayanan
International Journal of Pharmaceutical and Biomedical Research (IJPBR) , 2012,
Abstract: The present study was carried out to investigate mechanism of adaptogenic activity of a siddha medicinal plant, Sida cordata (whole plant). Forced swimming test (FST) is a screening model for antidepressants / adaptogens. Two swimming sessions were conducted: a 15min pre-test followed 24h later by a 6min test. The total duration of immobility behaviour was recorded during the second 6min test. Mouse was judged immobile, when it remained floating in water, in an upright position making only small movements to keep the head above water. The experimental animals were euthanized and their brains were removed immediately, and the prefrontal cortexes (PFC) were dissected out on ice for biochemical analysis. LD50 of the test drug was found to be greater than 2000mg/kg body weight. The animals treated with total extract (100mg/kg) and (200mg/kg) showed significant decrease in the immobility period with simultaneous increase in anti oxidant markers as well as adrenaline and serotonin levels. In conclusion, the above study indicates positive adaptogenic activity of the extract Sida cordata (whole plant), by forced swim test and resultant biochemical studies.
Evaluating Application Architecture, Quantitatively
V. Gnanasekaran
Advances in Computer Science : an International Journal , 2013,
Abstract: This article describes how quantitative treatment can be applied to an application’s architecture-evaluation process and shows how a quantitative output with intuitive reports will provide more clarity than a qualitative output on the quality of an application architecture.“You cannot control what you cannot measure.”—BILL HEWITT
Trace Level Gas Sensing Characteristics of Nano-Crystalline Silver Decamolybdate  [PDF]
Sunasira Misra, Venkataraman Jayaraman, Thiagarajan Gnanasekaran
Soft Nanoscience Letters (SNL) , 2013, DOI: 10.4236/snl.2013.34A011
Abstract: A soft-chemical method has been developed for the synthesis of nano-crystalline powders of silver decamolybdate. Gas sensing characteristics of this composition both in porous pellet and thin film configurations were investigated. The compound Ag6Mo10O33 was found to sense selectively ammonia at 503 K. Above 503 K it has significant cross sensitivity to petroleum gas (PG). Spin coated thin films exhibited selective sensing towards PG.
6. Hepatoprotective activity of Coccinia indica leaves extract
B. Shyam Kumar,D. Gnanasekaran,V. Jaishree,K.P. Channabasavaraj
International Journal of Pharmaceutical and Biomedical Research (IJPBR) , 2010,
Abstract: The leaves of Coccinia indica (Family: Cucurbitaceae) are sweet, acrid, cooling, and astringent to the bowels, cures kapha and pitta. It is cultivated in Africa and Asia particularly in India used as a vegetable. A diethyl ether extract of the leaves was studied for hepatoprotective activity against carbon tetrachloride induced liver toxicity in rats. The results shownhepatoprotective activity of Coccinia indica leave extract at dose 400 mg/kg body weight was comparable with standard treatment 125 mg/kg body weight of silymarin, a known hepatoprotective drug. These data also supplement for histopathological study of rat liver section.
A Multi-Hop Dynamic Path-Selection (MHDP) Algorithm for the Augmented Lifetime of Wireless Sensor Networks  [PDF]
Perumal Kalyanasundaram, Thangavel Gnanasekaran
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.710285
Abstract: In Wireless Sensor Networks (WSN), the lifetime of sensors is the crucial issue. Numerous schemes are proposed to augment the life time of sensors based on the wide range of parameters. In majority of the cases, the center of attraction will be the nodes’ lifetime enhancement and routing. In the scenario of cluster based WSN, multi-hop mode of communication reduces the communication cast by increasing average delay and also increases the routing overhead. In this proposed scheme, two ideas are introduced to overcome the delay and routing overhead. To achieve the higher degree in the lifetime of the nodes, the residual energy (remaining energy) of the nodes for multi-hop node choice is taken into consideration first. Then the modification in the routing protocol is evolved (Multi-Hop Dynamic Path-Selection Algorithm—MHDP). A dynamic path updating is initiated in frequent interval based on nodes residual energy to avoid the data loss due to path extrication and also to avoid the early dying of nodes due to elevation of data forwarding. The proposed method improves network’s lifetime significantly. The diminution in the average delay and increment in the lifetime of network are also accomplished. The MHDP offers 50% delay lesser than clustering. The average residual energy is 20% higher than clustering and 10% higher than multi-hop clustering. The proposed method improves network lifetime by 40% than clustering and 30% than multi-hop clustering which is considerably much better than the preceding methods.
Analysis of Water and Hydrogen Bond Dynamics at the Surface of an Antifreeze Protein
Yao Xu,Ramachandran Gnanasekaran,David M. Leitner
Journal of Atomic, Molecular, and Optical Physics , 2012, DOI: 10.1155/2012/125071
Abstract: We examine dynamics of water molecules and hydrogen bonds at the water-protein interface of the wild-type antifreeze protein from spruce budworm Choristoneura fumiferana and a mutant that is not antifreeze active by all-atom molecular dynamics simulations. Water dynamics in the hydration layer around the protein is analyzed by calculation of velocity autocorrelation functions and their power spectra, and hydrogen bond time correlation functions are calculated for hydrogen bonds between water molecules and the protein. Both water and hydrogen bond dynamics from subpicosecond to hundred picosecond time scales are sensitive to location on the protein surface and appear correlated with protein function. In particular, hydrogen bond lifetimes are longest for water molecules hydrogen bonded to the ice-binding plane of the wild type, whereas hydrogen bond lifetimes between water and protein atoms on all three planes are similar for the mutant.
CONCURRENT ENGINEERING MODEL (CEM) ANALYSIS ON LOGISTICS DESIGN PARAMETERS – A CASE STUDY
J.S. Gnanasekaran,S. Shanmugasundaram
South African Journal of Industrial Engineering , 2012,
Abstract: ENGLISH ABSTRACT: Logistics engineering can be divided into internal or in-plant logistics and external manufacturing logistics. Internal (in-plant) logistics include material handling, warehousing, and storage systems, while external manufacturing logistics include transportation. Both must be integrated to minimise costs at a competitive level of service. For example, plant layout and production planning must consider internal logistics. The design decisions are made in the early phases of product design, and development will have a significant effect over future manufacturing and logistical activities. In this paper, a methodology is developed and presented to minimise the design cycle time of any manufacturing firm, including their suppliers, and to maximise the whole system’s effectiveness. AFRIKAANSE OPSOMMING: Logistieke ingenieurswese kan verdeel word in interne of binne-aanleg logistiek en eksterne vervaardigingslogistiek. Interne (binne-aanleg) logistiek behels materiaalhantering, berging en voorraadhoudingsisteme, terwyl eksterne vervaardigingslogistiek vervoer insluit. Die fasette moet geintegreer wees om koste te minimiseer by ‘n mededingende diensvlak. So byvoorbeeld moet die uitleg van ‘n aanleg en produksiebeplanning interne logistiek in aanmerking neem. Die ontwerpbesluite word geneem in die beginstadium van die produkontwerp en ontwikkeling sal ‘n betekenisvolle invloed hê op toekomstige vervaardigings- en logistieke aktiwiteite. In hierdie artikel word ‘n metodologie ontwikkel en aangebied om die ontwerpsiklustyd van enige vervaardigingsonderneming te minimiseer met inagneming van die leweransiers om sodoende die totale sisteem se effektiwiteit te maksimiseer.
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