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Search Results: 1 - 10 of 298211 matches for " Glen J. Pearson "
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Non-Immunosuppressant Medication Use in Heart Transplant Patients: A Guide for Pharmacists  [PDF]
Gregory Egan, Glen J. Pearson
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.510107
Abstract: For heart transplant patients, there are a number of non-immunosuppressant medications that are routinely prescribed to mitigate the side-effects of immunosuppression, treat the related complications, and improve long-term survival. This review focuses on the medications used to prevent and manage cardiac allograft vasculopathy (CAV), hypertension, dyslipidemia and osteoporosis. The rationale and evidence supporting their use are summarized and the immunosuppressant drugs are only discussed briefly, as they relate to each of these medical issues. Pharmacy practitioners are likely to encounter patients post-cardiac transplant in a variety of clinical settings; therefore, a concise appreciation of the principles for the long-term medical management of these patients is important when providing collaborative care.
Evaluation of the Management of Hyperlipidemia and Hypertension in an Outpatient Cardiac Transplant Clinic  [PDF]
Jane J. Xu, Ilene Burton, Wayne J. Tymchak, Glen J. Pearson
Pharmacology & Pharmacy (PP) , 2016, DOI: 10.4236/pp.2016.71010
Abstract: Background: Allograft coronary artery disease (ACAD) is a common cause of morbidity and mortality post-orthotopic heart transplantation (OHT). ACAD progression may be reduced by modifying cardiovascular risk factors, such as hyperlipidemia and hypertension. We sought to evaluate the management of hyperlipidemia and hypertension among OHT recipients followed in an outpatient cardiac transplant clinic. Objective: The primary objective was to assess the proportion of OHT patients achieving both the recommended LDL target of <2.0 mmol/L and BP targets of <140/90 mmHg (or <130/80 mmHg for diabetics) in an outpatient cardiac transplant clinic. Methods: A cross-sectional retrospective analysis of the medical records of all adult OHT recipients actively followed in our outpatient cardiac transplant between January-March 2009. Results: Of the 193 patients included, both the low-density lipoprotein (LDL) cholesterol and blood pressure (BP) targets were achieved in 111 (57.5%) patients. The LDL target alone was achieved by 140 (72.5%) patients and the BP target alone by 153 (79.3%) patients. Statins were prescribed in 183 (94.8%) patients with a mean LDL of 1.81 mmol/L (±0.55). Angiotensin converting enzyme-inhibitors [ACE-I] (or angiotensin receptor blockers [ARB]) were prescribed in 154 (79.8%) patients, diltiazem in 101 (52.3%) patients, and both in 85 (44.0%) patients, with a mean BP of 124.2/77.8 mmHg (±13.6/8.2). Adverse reactions related to statins, ACE-inhibitors or diltiazem were uncommon and rarely resulted in drug discontinuation. Conclusions: Guideline recommended that LDL and BP targets are achievable in a significant proportion of OHT recipients. The high utilization rates of statins for dyslipidemia and ACE-I (or ARB) and diltiazem for BP were consistent with guideline recommendations for the prevention of ACAD. Despite concerns regarding the potential for pharmacokinetic drug interactions in OHT patients, the reported rates of any drug intolerance to these medications were low in our population.
Maintenance of improved lipid levels following attendance at a cardiovascular risk reduction clinic: a 10-year experience
Glen J Pearson,Kari L Olson,Nicole E Panich,Sumit R Majumdar
Vascular Health and Risk Management , 2008,
Abstract: Glen J Pearson1,5, Kari L Olson6, Nicole E Panich1, Sumit R Majumdar2,5, Ross T Tsuyuki1,4, Dawna M Gilchrist2,5, Ali Damani4, Gordon A Francis3,5The MILLARR Study (Maintenance of Improved Lipid Levels Following Attendance at a Cardiovascular Risk Reduction Clinic) 1Department of Medicine, Divisions of Cardiology; 2General Internal Medicine; 3Endocrinology and Metabolism; Faculty of Pharmacy and Pharmaceutical Sciences; 4University of Alberta, Edmonton, Alberta, Canada; 5Cardiovascular Risk Reduction Clinic (CRRC), University of Alberta Hospital, Edmonton, Alberta, Canada; 6University of Colorado Health Sciences Center, Denver, Colorado, USA; 7Family Medicine (Private Practice), Calgary, Alberta, CanadaBackground: Specialty cardiovascular risk reduction clinics (CRRC) increase the proportion of patients attaining recommended lipid targets; however, it is not known if the benefits are sustained after discharge. We evaluated the impact of a CRRC on lipid levels and assessed the long-term effect of a CRRC in maintaining improved lipid levels following discharge.Methods: The medical records of consecutive dyslipidemic patients discharged >6 months from a tertiary hospital CRRC from January 1991 to January 2001 were retrospectively reviewed. The primary outcome was the change in patients’ lipid levels between the final CRRC visit and the most recent primary care follow-up. A worst-case analysis was conducted to evaluate the potential impact of the patients in whom the follow-up lipid profiles post-discharge from the CRRC were not obtained.Results: Within the CRRC (median follow-up = 1.28 years in 1064 patients), we observed statistically significant improvements in all lipid parameters. In the 411 patients for whom post-discharge lipid profiles were available (median follow-up = 2.41 years), there were no significant differences observed in low-density lipoprotein-cholesterol, total cholesterol (TC), or triglycerides since CRRC discharge; however, there were small improvements in high-density lipoprotein-cholesterol (HDL-C) and TC:HDL ratio (p < 0.05 for both). The unadjusted worst-case analysis (653 patients with no follow-up lipid profiles) demonstrated statistically significant worsening of all lipid parameters between CRRC discharge and the most recent follow-up. However, when the change in lipid parameters between the baseline and the most recent follow-up was assessed in this analysis, the changes in all lipid parameters were significantly improved (p < 0.05).Conclusions: This study demonstrates that a CRRC can improve lipid levels and suggests that th
Fluctuation of Corrected Serum Calcium Levels Following Partial and Total Thyroidectomy  [PDF]
Vikas Malik, Glen J. Watson, Chu Q. Phua, Prad Murthy
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.24069
Abstract: Objectives: To identify any fluctuation of corrected serum calcium levels and to determine the presence of sub-clinical hypocalcaemia following partial and total thyroidectomy with preservation of at least two parathyroid glands. Design: A prospective study. Setting: Tertiary Head & Neck referral unit. Patients: Eighty five patients undergoing partial or total thyroidectomy with or without laryngectomy from April 2003 to April 2009 were included in the study. Corrected serum calcium levels (CCSL) were noted preoperatively and postoperatively on day 1, day 7 and 6 months. Results: Forty six patients underwent hemi-thyroidectomy (HT), 29 underwent total thyroidectomy (TT) and 10 underwent total thyroidectomy with laryngectomy (TTL). Nine (19.56%) patients in the HT group, 6 (24.14%) in the TT group and 3 (30.0%) in the TTL group developed hypocalcaemia postoperatively which was most significant on 1st postoperative day. This improved by 7th postoperative day in each group when the change in calcium levels became statistically insignificant. Six patients (3 patients had HT, 2 had TT and 1 had TTL) developed sub-clinical mild hypocalcaemia which was persistent at 6 months follow-up. Conclusion: The most significant changes in corrected serum calcium levels occur within first 24 hours after thyroid surgery. Thereafter most patients return to normocalcaemia within a seven-day period. Despite preservation of parathyroid glands there is a subgroup of patients who develop sub-clinical hypocalcaemia which persists even at six months but does not require treatment.
Büyük Britanya ve rlanda Kütüphanelerinde ark Yazma Eserleri Koleksiyonlar
J. D. Pearson
Türk Kütüphanecili?i , 1955,
Abstract:
Primitive tensors and convergence of an iterative process for the eigenvalues of a primitive tensor
K. J. Pearson
Mathematics , 2010,
Abstract: An algorithm for finding the eigenvalue of a nonnegative irreducible tensor was recently proposed by Michael Ng, Liqun Qi, and Guanglu Zhou in {\it Finding the largest eigenvalue of a nonnegative tensor}. However, the authors did not prove the proposed algorithm converges. In this paper, primitive tensors are defined and the algorithm is shown to converge for primitive tensors.
Lattice Boltzmann modeling for tracer test analysis in a fractured Gneiss aquifer  [PDF]
Ramadan Abdelaziz, Andrew J. Pearson, Broder J. Merkel
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.53050
Abstract:

Fractured Gneiss aquifers present a challenge to hydrogeologists because of their geological complexity. Interpretation methods which can be applied to porous media cannot be applied to fractured Gneiss aquifers because flow and transport occur in fractures, joints, and conduits. In contrast, the rock matrix contribution to groundwater flow is not very important in Gneiss aquifers. Sodium chloride was injected into groundwater flow under steady state condition as tracer to determine transport parameters which are needed for transport modeling. QTRACER2 was used to evaluate the tracer test data. Lattice Boltzmann method was applied to simulate flow and tracer transport through a fracture zone in Gneiss. Experimental tracer data and the numerical solution by lattice Boltzmann method are compared. In general, the results indicate that a 2D Lattice Boltzmann model is able to simulate solute transport in fractured gneiss aquifer at field scale level.

8th International Conference: Primary Therapy of Early Breast Cancer, St Gallen, Switzerland, March 12–15 2003
Hilary Glen, Robert J Jones
Breast Cancer Research , 2003, DOI: 10.1186/bcr611
Abstract: The tone of the 3-day meeting was set by Umberto Veronesi (European Institute of Oncology, Milan, Italy) at the opening session. The ongoing aim of primary therapy in early breast cancer is moving from the concept of 'maximum tolerated treatment' to that of 'minimum necessary treatment'. Toward this goal, the St Gallen consensus continues to strive to define a group of patients with exceptionally good prognosis who require minimal primary therapy, and much of the conference was concerned with how to improve this definition, as well as how best to treat the groups at higher risk for subsequent relapse. Throughout the meeting a recurrent theme was the distinction between prognostic information (which defines a level of risk) and predictive information (which predicts response to a particular therapy).The St Gallen 2003 consensus statement is still being written and will be published in the summer (in the Journal of Clinical Oncology), and therefore we will not discuss its likely content, but we review some of the key issues discussed at the plenary and poster sessions.Daniel F Hayes (University of Michigan, Ann Arbor, USA) introduced the concept of positive predictive power as a means of assessing the validity of a predictive marker. Martine Piccart (Jules Bordet Institute, Brussels, Belgium) summarized promising new markers that may have prognostic and predictive value in the management of early breast cancer. These included uPA/Pal-1, cyclin E and cDNA microarrays, but all of these require further evaluation in prospective trials. Stephen Braun (Universit?tsklinikum, Innsbruck, Austria) presented data suggesting that immunocytological demonstration of bone marrow micrometastases has independent prognostic value, and prospective evaluation of this technique aimed at ascertaining its predictive value is being planned.The results of a large trial comparing the adjuvant use of anastrazole and tamoxifen in combination have been discussed elsewhere [1], but many speakers
Inclusion and online learning opportunities: designing for accessibility
Elaine J. Pearson,Tony Koppi
Research in Learning Technology , 2002, DOI: 10.3402/rlt.v10i2.11398
Abstract: Higher education institutions worldwide are adopting flexible learning methods and online technologies which increase the potential for widening the learning community to include people for whom participation may previously have been difficult or impossible. The development of courseware that is accessible, flexible and informative can benefit not only people with special needs, but such courseware provides a better educational experience for all students.
Eigenvalues of the adjacency tensor on products of hypergraphs
K. J. Pearson,Tan Zhang
International Journal of Contemporary Mathematical Sciences , 2013,
Abstract: We consider the generalized notions of Cartesian and tensor productson m-uniform hypergraphs. The adjacency tensor is analogousto the adjacency matrix and two different notions of eigenvalues of theadjacency tensor on the products of hypergraphs are studied. The eigenvaluesand E-eigenvalues of the adjacency tensor of the Cartesian andtensor products of two hypergraphs in relation to the E-eigenvalues andeigenvalues of the adjacency tensor of the factors are considered.
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