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Search Results: 1 - 10 of 640 matches for " Giuseppina Campisi "
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Obesity and craniofacial variables in subjects with obstructive sleep apnea syndrome: comparisons of cephalometric values
Antonino M Cuccia, Giuseppina Campisi, Rosangela Cannavale, Giuseppe Colella
Head & Face Medicine , 2007, DOI: 10.1186/1746-160x-3-41
Abstract: After a careful analysis of the literature from 1990 to 2006, 5 papers with similar procedural criteria were selected. Inclusion criteria were: recruitment of Caucasian patients with an apnea-hypopnea index (AHI) >10 as grouped in non-obese (Body Mass Index – [BMI] < 30) vs. obese (BMI ≥ 30).A low position of the hyoid bone was present in both groups. In non-obese patients, an increased value of the ANB angle and a reduced dimension of the cranial base (S-N) were found to be the most common finding, whereas major skeletal divergence (ANS-PNS ^Go-Me) was evident among obese patients. No strict association was found between OSAS and length of the soft palate.In both non-obese and obese OSAS patients, skeletal changes were often evident; with special emphasis of intermaxillary divergence in obese patients. Unexpectedly, in obese OSAS patients, alterations of oropharyngeal soft tissue were not always present and did not prevail.Obstructive Sleep Apnea Syndrome (OSAS) is an obstructive-type respiratory disorder of sleep, associated with excessive drowsiness during the day or with at least two of the following symptoms: sudden awakening with a sensation of suffocation, not sufficiently refreshing sleep, and tiredness during the day and problems in the cognitive sphere. Apnea can be defined as an interruption of breathing during sleep, with persistence of thoracic and/or abdominal movements associated with a decrease in oxygen tension and a consequent desaturation of oxygen of the arterial hemoglobin [1].The term hypopnoea means a decrease of >50% in airflow, with a persistence of the thoracic and/or abdominal movements. Hypopnea may also be defined as a reduction of breathing width (but >50%) associated to a reduction of oxygen saturation (SaO2) >3% or to an awakening.According to the international standards, each of those respiratory events must last not less than 10 seconds and not more than 3 minutes. The frequency of apnea and hypopnea per hour of sleep is called "ind
The Production of the Oral Mucosa of Antiendomysial and Anti—Tissue-Transglutaminase Antibodies in Patients with Celiac Disease: A Review
Domenico Compilato,Giuseppina Campisi,Luca Pastore,Antonio Carroccio
The Scientific World Journal , 2010, DOI: 10.1100/tsw.2010.228
Abstract:
Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from an Italian central region
Maurizio Procaccini, Giuseppina Campisi, Pantaleo Bufo, Domenico Compilato, Claudia Massaccesi, Carlo Catassi, Lorenzo Muzio
Head & Face Medicine , 2007, DOI: 10.1186/1746-160x-3-25
Abstract: Fifty patients with CD and fifty healthy subjects (age range: 3–25 years), matched for age, gender and geographical area, were evaluated by a single trained examiner. Diagnosis of oral diseases was based on typical medical history and clinical features. Histopathological analysis was performed when needed. Adequate univariate statistical analysis was performed.Enamel hypoplasia was observed in 26% cases vs 16% in controls (p > 0.2; OR = 1.8446; 95% CI = 0.6886: 4.9414). Frequency of RAS in the CD group was significantly higher (36% vs 12%; p = 0.0091; OR = 4.125; 95% CI = 1.4725: 11.552) in CD group than that in controls (36% vs 12%). Four cases of atrophic glossitis and 1 of dermatitis herpetiformis were found in CD patients vs 1 and none, respectively, among controls.The prevalence of enamel hypoplasia was not higher in the study population than in the control group. RAS was significantly more frequent in patients with CD.Celiac disease (CD), also known as celiac sprue or gluten-sensitive entheropathy, can be defined as a chronic inflammatory intestinal disease characterised by nutrient malabsorption and improvement after the withdrawal of gluten (found in wheat, barley) from the diet. Prevalence of CD ranges from 1:85 to 1:300 have been reported for CD in Western countries [1-6]. In addition to the classical gastrointestinal presentation (diarrhoea, abdominal distension, vomiting, weight loss and pallor) CD can cause minimal intestinal damage and weak or absent systemic symptomatology (also known as "silent form"). In these patients the lack of symptoms can persist for a long time, while the biopsy of the bowel shows the typical atrophy of intestinal mucosa [7]. It is also well recognized the association of CD with several complications, as lymphomas, autoimmune and degenerative nervous system diseases [8-10].The oral cavity, a part of gastrointestinal system [11], can also be affected by several abnormalities in patients with CD. As the mouth is very easy to exa
P-cadherin expression and survival rate in oral squamous cell carcinoma:an immunohistochemical study
Lorenzo Lo Muzio, Giuseppina Campisi, Antonio Farina, Corrado Rubini, Giuseppe Pannone, Rosario Serpico, Gregorio Laino, Alfredo De Lillo, Francesco Carinci
BMC Cancer , 2005, DOI: 10.1186/1471-2407-5-63
Abstract: In a retrospective study, a cohort of 67 OSCC patients was investigated for P-cad expression and its cellular localization by immunohistochemistry; some respective healthy margins of resection were similarly investigated as standard controls. After grouping for P-cad expression, OSCCs were statistically analyzed for the variables age, gender, histological grading (G), TNM, Staging, and overall survival rate. Univariate and multivariate analyses were performed.37 cases (55.2%) of OSCC showed membranous/cytoplasmic positivity for P-cad, whereas 30 (44.8 %) were negative. Although with some differences in membranous vs cytoplasmic localization of P-cad in OSCC with different G, no statistical association was found between P-cad expression and any variables considered at baseline. In terms of prognostic significance, P-cad non expression was found to have an independent association with poorer overall survival rate than P-cad expressing group (P = 0.056); moreover, among P-cad +ve patients the best prognosis was for those OSCC with membranous (P < 0.0001) than those with cytoplasmic P-cad expression.On the basis of these results, it is possible to suggest P-cad as an early marker of poor prognosis. The abnormal or lack of P-cad expression could constitute an hallmark of aggressive biological behavior in OSCCInvasive OSCC, in spite of improved therapeutic procedures, actually show a generally poor prognosis since its local aggressiveness and metastases. In particular, the incidence of lymph node metastases has been found to be significantly associated with several factors; among these, not only macroscopic parameters, such as clinical stage, localization and thickness of primary tumours [1-10], but also microscopic-molecular parameters from differentiation of tumoral cells up to their skill for adherence [11-14]. Recently, many investigations have been performed in this latter direction, until to know that intercellular adhesiveness is mediated by a family of glycoprotei
Changes in pharyngeal aerobic microflora in oral breathers after palatal rapid expansion
Angela Cazzolla, Giuseppina Campisi, Grazia Lacaita, Marco Cuccia, Antonio Ripa, Nunzio Testa, Domenico Ciavarella, Lorenzo Lo Muzio
BMC Oral Health , 2006, DOI: 10.1186/1472-6831-6-2
Abstract: In an open clinical trial, we studied 50 oral breathers, aged 8 to 14 years and suffering from both maxillary constriction and posterior cross-bite. At baseline, patients were examined by a single otorhinolaryngologist (ENT), confirming nasal obstruction in all subjects by posterior rhino-manometric test. Patients were evaluated three times by oropharyngeal swabs:1) at baseline (T = 0); 2) after palatal spreading out (T = 1); and 3) at the end of RPE treatment (T = 2). With regard to the microbiological aspect, the most common and potentially pathogenic oral microrganisms (i.e. Streptococcus pyogenes, Diplococcus pneumoniae, Staphylococcus aureus, Haemophilus spp, Branhamella catarrhalis, Klebsiella pneumoniae, Candida albicans) were specifically detected in proper culture plates, isolated colonies were identified by means of biochemical tests and counted by calibrated loop. The data were analyzed by means of the following tests: Chi-square test, Fisher's exact test and Wilcoxon's test.After the use of RME there was a statistically significant decrease of Staphylococcus aureus stock at CFU/mLat T1(P = 0.0005; Z = -3,455 by Wilcoxon Rank test) and T2 (P < 0.0001; Z = -4,512 by Wilcoxon Rank test) vs T0. No significant changes were found for the other examined microrganisms.Our data suggest that RPE therapy in oral breathers may strongly reduce the pathogenic aerobic and facultatively anaerobic microflora in the oral pharynx after a normalization of the upper airways function, and may reduce the risk of respiratory infections.Aerobic and facultative anaerobic bacteria are prevalent among the bacterial populations of the human body, particularly on mucous membrane surfaces. In the oral cavity these bacteria are found on the tooth surface (above all in subgingival plaque), in the saliva, on the tongue surface and in the tonsillar crypts. [1]Genera commonly found in the oral cavity are Actinomyces, Arachnia, Bacteroides, Bifidobacterium, Eubacterium, Fusobacterium, Lacto
Pathophysiology of age-related diseases
Giuseppina Campisi, Martina Chiappelli, Massimo De Martinis, Vito Franco, Lia Ginaldi, Rosario Guiglia, Federico Licastro, Domenico Lio
Immunity & Ageing , 2009, DOI: 10.1186/1742-4933-6-12
Abstract: A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy on 7-8 April 2009. Three lectures from that Symposium by G. Campisi, L. Ginaldi and F. Licastro are here summarized. Elderly patients constitute a very heterogeneous group with a wide range of cultural, social and educational backgrounds. A worldwide phenomenon of the increasing number of elderly people has been recognized, with older people comprising a larger proportion of the population. This demographic phenomenon is related to an increase in chronic and at times debilitating diseases, associated with advancing age and an exponential growth in health costs. In some cases, a modification to life-style can reduce the so-called 'indirect' and 'intangible' costs of diseases in terms of public health. Thus, a better understanding of the pathophysiology of age-related diseases is urgently required to improve our understanding of maintaining good health in the elderly and to program possible therapeutic intervention.The demographic changes described above could have a dramatic impact on mucosal and dental health: the elderly are at greater risk of oral diseases since gains in longevity result in more medically compromising conditions or systemic diseases, together with several oral-related manifestations.Ageing affects oral tissues in addition to other parts of the human body, and oral health (the health of the mouth, teeth and associated structures, and their functional activity) is an integral component of general health. Indeed, oral diseases can have a profound impact on general health, as documented by the World Health Organization, whilst problems relating to general health can, and frequently do, manifest themselves in the mouth [1]. This relationship has been extensively treated in the literature, by scientific societies and Journals dedicated to this area of specialisation [2-4].The most common oral conditions in the elderly are: dental caries, gingivitis
Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and positively associated with HPV16 E7 oncoprotein
Vito Rodolico, Walter Arancio, Marco C Amato, Francesco Aragona, Francesco Cappello, Olga Di Fede, Giuseppe Pannone, Giuseppina Campisi
Infectious Agents and Cancer , 2011, DOI: 10.1186/1750-9378-6-18
Abstract: We studied tumor specimens from 62 OSCC; a higher prevalence of tumors in TNM stage II and also in pT2 class between OSCC infected positive HPV16 DNA than non-infected ones was observed. HIF-1α positivity was detected throughout the analysed fields, not associated with areas of necrosis and also observed in cells immediately adjacent to blood vessels. A significant increase in mean values of the HIF-1α labeling indexes was observed for pT1-T2, as well for stage I-II, in the infected positive HPV16 DNA tumors than non-infected ones. HIF-1α and HPV16 E7 labeling indexes showed a significantly positive correlation which suggested a positive association between HPV16 E7 and HIF-1α expression.In our specimens HIF-1α immunoreactivity hints for an O2-independent regulatory mechanism in infected positive HPV16 DNA tumors, especially for pT1-T2 and stage I-II tumors, suggesting a very early involvement in the development of HPV-induced OSCC. HIF-1α and HPV16 E7 labeling indexes suggest also a positive association between the two proteins in infected positive HPV16 DNA OSCC.Nowadays there is increasing evidence for the role of high risk (HR) Human PapillomaVirus (HPV) in the pathogenesis of Oral Squamous Cell Carcinoma (OSCC) [1-7], till to consider HPV positive (HPV+) OSCC as a distinct clinicopathological entity with a different outcome in comparison with HPV negative (HPV-) OSCC [2,6,8-11]. The HR types HPV16, 18, 31 and others, are frequently found in cervical cancers and have been found to be risk factors also for OSCC, independently from alcohol and tobacco use [2,12-16]. HPV16, the most common HR HPV type detected in biopsies from women with cervical squamous cell carcinoma (55%) [17,18], was also the most common type detected in OSCC (16%), accounted for 68.2% of all HPV+ OSCC [19,20].The E6 and E7 oncogenes from HR HPVs are responsible for maintaining differentiating cells active in cell cycling and are able to transform both cervical and upper aero-digestive tract e
Update on gingival overgrowth by cyclosporine A in renal transplants
Ciavarella,Domenico; Guiglia,Rosario; Campisi,Giuseppina; Cosola,Michele Di; Liberto,Chiara Di; Sabatucci,Antonio; Escudero,Nayra; Bascones,Antonio; Lo Muzio,Lorenzo;
Medicina Oral, Patología Oral y Cirugía Bucal (Internet) , 2007,
Abstract: severe gingival overgrowth is one of the most frequent side effects in renal transplant patients associated with assumption of cyclosporine a. several associations with age, sex, dosage, duration of therapy or interval since transplantation have been hypothesized. the introduction of alternative immunosuppressant drugs have been suggested to permit better long-term transplant outcomes and a decrease in incidence of gingival overgrowth. the aim of the present paper is to summarize current knowledge regarding aetiology, pathogenesis and management of gingival overgrowth induced by cyclosporine a.
Archivio Disobedience. Intervista con Marco Scotini
Giusi Campisi
lo Squaderno , 2009,
Abstract: Marco Scotini, come curatore del progetto in progress Archivio Disobedience, che cosa significa disobbedienza oggi e come si declina nell’esperienza artistica? Marco Scotini: Per fortuna viviamo in tempi di profonda trasformazione sociale ma anche di radicale trasformazione culturale, nonostante la continua minaccia da parte del capitalismo attuale di riterritorilizzare il potere e il controllo nelle maglie del politico che, come ben sappiamo, è invece finito. è una mossa strategica che, nel migliore dei casi, ci riporta a vecchi antagonismi e a forme dell’ ”impegno” totalmente superate. La “disobbedienza”, al contrario, è la conditio sine qua non dell’agire politico contemporaneo proprio perché crea nuove alleanze, nuove coordinate e nuovi contesti d’azione.
CELLULAR SENESCENCE, AGING AND CANCER
Judith Campisi
The Scientific World Journal , 2001, DOI: 10.1100/tsw.2001.106
Abstract:
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