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Search Results: 1 - 10 of 5095 matches for " Giuseppe Ristagno "
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Increased susceptibility to cardiovascular effects of dihydrocapcaicin in resuscitated rats. Cardiovascular effects of dihydrocapsaicin
Keld Fosgerau, Giuseppe Ristagno, Magdalena Jayatissa, Mads Axelsen, Jacob W Gotfredsen, Uno J Weber, Lars K?ber, Christian Torp-Pedersen, Charlotte Videbaek
BMC Cardiovascular Disorders , 2010, DOI: 10.1186/1471-2261-10-39
Abstract: Here we tested the hypothesis that the cardiovascular system in healthy rats and rats resuscitated from a cardiac arrest may be differentially affected by a transient receptor potential vanilloid type 1 agonist, by continuous intravenous infusion of dihydrocapsaicin (DHC).Compared to baseline, infusion of DHC caused an initial increase in mean arterial blood pressure in both healthy and resuscitated rats of 25% and 10%, respectively. Also, we observed an initial response of tachycardia in both healthy and resuscitated rats of 30% and 20%, respectively. Then, at high levels of DHC infusion (> 2.0 mg/kg/hr) we observed two single episodes of transient bradycardia and hypotension in 33% of the healthy rats, which was consistent with a TRPV1 agonist induced Bezold-Jarisch reflex. In contrast, in resuscitated rats we observed multiple episodes of bradycardia/hypotension in 100% of the rats and at a dose of DHC of 0.65 mg/kg/hr. Notably, this DHC effect could be completely blocked in the resuscitated rats by pre-treatment with atropine, a muscarinic acetylcholine antagonist.Our results indicate that the susceptibility of the rats towards TRPV1 agonist induced Bezold-Jarisch reflex is increased in those resuscitated from cardiac arrest compared to the healthy situation.The transient receptor potential vanilloid type 1 (TRPV1) is a member of the mammalian transient receptor potential family of ion channels [1] and was cloned in 1997 [2]. TRPV1 is a non-selective cation channel with a preference for calcium, which can be directly activated by noxious heat (> 43°C), extracellular acidification, as well as a large heterogeneous group of natural compounds such as dihydrocapsaicin (DHC) from chili pepper [3,4]. The TRPV1 receptor is widely expressed in the human body [5,6] particularly in "port-of-entry" tissues, the central nervous system (CNS), and in the peripheral nervous system in primary small to medium diameter sensory neurons such as dorsal root, trigeminal, and nodose g
Supercritical Fluid Adsorption of Domperidone on Silica Aerogel  [PDF]
Giuseppe Caputo
Advances in Chemical Engineering and Science (ACES) , 2013, DOI: 10.4236/aces.2013.33024
Abstract:

Silica aerogel (SA) was loaded with domperidone to demonstrate the potentiality of adsorption processes based on the usage of supercritical carbon dioxide to treat poorly water-soluble drugs, forming new kinds of drug delivery systems. The effects of pressure, temperature and solution concentration on loaded SA were studied. Adsorption isotherms were measured at 35and 45 and fitted with Langmuir model. Release kinetics of the adsorbed drug were also evaluated by in vitro dissolution tests. Results showed that domperidone can be uniformly dispersed into the aerogel and that the release rate of domperidone from the composite, constituted by drug and silica aerogel, is much faster than that of the crystalline drug. The proposed adsorption method is suitable for the production of domperidone fast release tablets.

Modeling and simulation in tissue biomechanics: Modern tools to face an ancient challenge  [PDF]
Giuseppe Vairo
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.612A001
Abstract:

This is the editorial for the specail issue on Modeling and Simulation in Tissue Biomechanics published in Journal of Biomedical Science and Engineering


Archimedes’ Psammites and the Tradition of Italic Thought of Science  [PDF]
Giuseppe Boscarino
Advances in Historical Studies (AHS) , 2015, DOI: 10.4236/ahs.2015.41002
Abstract: It is intended to confute the opinion of a Platonic Archimedes, through the study of the fundamental theses of his Sandreckoner (Psammites) and of its particular logical-linguistic aspects, but especially of an Aristotelic Archimedes, as Delsedine (1970) maintains in his article “L’infini numérique dans l’Arénaire d’Archimède”. He writes: The Sandreckonerrépond à la nécessitè d’adapter la notation numérique à l’idée de l’infinité potentielle de l’ensamble des nombres naturales”1. First, it is focused on the general aspects of the work, which highlight its Enlightenment and Py-thagorean—Democritean character, then it is passed to the analysis of its particular linguistic and logical aspects and of its fundamental theses, translated into symbolic form, in which it is still giving prominence to its Pythagorean-Democritean or Italic character (Boscarino, 1999, 2010, 2011, 2012).
Archimedes’ to Eratosthenes in the Palimpsest and Archimedes in Heron’s Metrikon  [PDF]
Giuseppe Boscarino
Advances in Historical Studies (AHS) , 2015, DOI: 10.4236/ahs.2015.45025
Abstract: It is argued that even with some new readings made by the publication of the Letter to Eratosthenes in the Archimedes Palimpsest, with the wonderful discovery of his so-called “mechanical method” (a certain way of theorizing in mathematical things by means of mechanical entities) at the beginning of the twentieth century, some important historical-philological and philosophicalepistemological issues still remain, which have already discussed in part in my writings. We produce some important testimonies taken from Metrikon by Heron of Alexandria in favour of our translations and interpretations of Archimedes’ lexicon, not without placing under investigation at the same time the personality and the importance of Hero in the history of philosophical, scientific and technological Greek-Hellenistic thought in line with Archimedes and the tradition of Italic thought of science (The quotations of the Greek texts of Archimedes, Heron and Pappus are my translations).
Endogenous Ranking in the Two-Sector Urn-Ball Matching Process  [PDF]
Giuseppe Rose
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.83024
Abstract: This paper contributes to the debate concerning micro-foundations of matching functions in frictional labor markets. The focus is on a particular matching regime, i.e., the so-called urn-ball process. It is shown that in a twosector economy, even in the presence of heterogeneous workers, the assumption of applicants-ranking may be misleading. Instead, the choice concerning the adoption of either ranking or no-ranking behavior is endogenous and it is affected by both the tightness of the two sectors and the composition of the labor force in terms of skills. Moreover it is proved that exogenous shocks may change the form of the matching function. This result casts additional doubts on the assumption of exogenous matching function often made in empirical works aimed at assessing the effectiveness of policy measures.
Evidences for Varying Speed of Light with Time  [PDF]
Giuseppe Pipino
Journal of High Energy Physics, Gravitation and Cosmology (JHEPGC) , 2019, DOI: 10.4236/jhepgc.2019.52022
Abstract: Aims: The paper explores the hypothesis that the speed of light c is decreasing over time at rate (dc/dt)=-H? c, H being the Hubble constant. This hypothesis differs from the so-called tired light, in which the velocity c is supposed to vary during the journey of photons in the empty space for some frictional mechanism. In the hypothesis of the author the speed c, during this journey, is assumed constant. In this way the problems of the tired hypothesis are overcome. Methods: The paper links the variation dc/dt with the Hubble constant and infers a value of dc/dt from the difference between the value of the variation of the Earth-Moon distance measured by the Lunar Laser Ranging Experiment and the tidal effect. Results: Under the hypothesis c time varying, we explain: 1) The cosmological redshift. 2) The anomalous acceleration ap ≈ -8 × 10-10 m?sec-2, measured for some spacecrafts. 3) The high redshift of supernovae Ia, which seems to evidence an acceleration of the expansion of the universe. 4) The peripheral motion of stars in galaxies around their rotational centre. 5) The dilation of the light curves observed for supernovae Ia.
The Role of Hyperinsulenemia as a Risk Factor for Pancreatic Cancer  [PDF]
Giuseppe Preziosi, Jude A. Oben, Giuseppe Fusai
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.410175
Abstract:

Background: Pancreatic cancer is associated with a very severe prognosis and identification of risk factors is essential. Diabetes and obesity are both established risk factors, and they both cause hyperinsulenemia. With this review we wished to appraise the evidence of a role of high insulin levels in causing pancreatic cancer. Methods: We searched PubMed, Embase, Cochrane Library and Medline, and all evidence on potential pathophysiology of hyperinsulenemia and pancreatic cancer was included. Metaand pooled-analysis on epidemiological evidence are reported, and individual studies were as appropriate for specific topics (role of therapies, central adiposity and role of physical exercise). Conclusion: Hyperinsulenemia, and possibly hyperestrogenism secondary to a metabolic syndrome, are important elements in the pathogenesis of pancreatic cancer. Modification of certain life-style factors (exercise and weight loss) appears to modify the risk of pancreatic malignancy.

Entangled States and Observables in Open Quantum Relativity  [PDF]
Salvatore Capozziello, Giuseppe Basini
Journal of Modern Physics (JMP) , 2010, DOI: 10.4236/jmp.2010.15041
Abstract: In the framework of the so called Open Quantum Relativity, we investigate a quantum universe, starting from a minimal set of variables defining the given quantum state. Entanglement between quantum states is the way to link different regions of the universe, even if (apparently) causally disconnected. As a consequence, the concept of causality results recovered and enlarged. Besides, the observed CDM model emerges from this picture, giving the possibility to realize a statistical and quantum interpretation of the cosmological constant. In particular, the novelty consists in the fact that the presently observed universe could be the result of several entanglement phenomena giving rise to a certain amount of entropy directly related to the value of cosmological constant.
Social Representations of Medically Assisted Fecundation a Study on the Discursive Construction of “Media Texts”  [PDF]
Amelia Manuti, Giuseppe Mininni
Psychology (PSYCH) , 2010, DOI: 10.4236/psych.2010.15043
Abstract: The present contribution moves from the theory of social representations (Moscovici, 1961) and focuses attention on the importance of social communication within negotiation processes of shared meanings. Actually, discursive psychology (Potter, & Wetherell, 1987; Billig, 1991) has showed that social representation have a narrative nature since they organize the cognitive schemata that people use to give sense to the world (Lazlo, 1997). In such a frame a crucial role is played by mass media, which do contribute to construct and convey the figurative nucleus of each representation (Mininni, 2004). By adopting this discursive perspective, the present contribution aims at investigating the social debate about assisted fecundation which in Italy has accompanied the campaign for the abrogation of Law 40. The corpus of data is made up of a sample of 46 media-texts collected within the weeks before the referendum. The data have been investigated by adopting diatextual analysis (Mininni, 1992; 2003; 2005).
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