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Search Results: 1 - 10 of 5509 matches for " Giuseppe Giannini "
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HE4 in the Differential Diagnosis of a Pelvic Mass: A Case Report
Emanuela Anastasi,Teresa Granato,Anna Coppa,Lucia Manganaro,Giuseppe Giannini,Sara Comploj,Luigi Frati,Cecilia Midulla
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12010627
Abstract: Neoplasms of the ovary present an increasing challenge to the physician. Neoplastic ovarian cysts can resemble endometriomas in ultrasound imaging and need to be carefully considered in the differential diagnosis. We report the case of a woman with a strong family history of hereditary breast and ovarian cancer, who presented with a pelvic mass. The young girl refused oncogenetic counseling and genetic testing, even though she had a 50% a priori probability of being a BRCA1 mutation carrier. Pelvic magnetic resonance imaging (MRI) and a comparative analysis of the serum concentration of HE-4 and CA125 biomarkers provided accuracy and sensitivity in the diagnosis of a benign ovarian pathology. Based on this experience, we propose that the sensitivity of a screening program based on a HE4 and CA125 assay and MRI in high risk patients with mutations in the BRCA1 and BRCA2 genes may be considered a useful pre-operative tool for the differential diagnosis of pelvic?masses.
A Comparative Analysis of the Photo-Protective Effects of Soy Isoflavones in Their Aglycone and Glucoside Forms
Barbara Iovine,Maria Luigia Iannella,Franco Gasparri,Valentina Giannini,Giuseppe Monfrecola,Maria Assunta Bevilacqua
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms131216444
Abstract: Isoflavones exist in nature predominantly as glucosides such as daidzin or genistin and are rarely found in their corresponding aglycone forms daidzein and genistein. The metabolism and absorption of isoflavones ingested with food is well documented, but little is known about their use as topical photo-protective agents. The aim of this study was to investigate in a comparative analysis the photo-protective effects of isoflavones in both their aglycone and glucoside forms. In human skin fibroblasts irradiated with 60 mJ/cm 2 ultraviolet B (UVB), we measured the expression levels of COX-2 and Gadd45, which are involved in inflammation and DNA repair, respectively. We also determined the cellular response to UVB-induced DNA damage using the comet assay. Our findings suggest that both the isoflavone glucosides at a specific concentration and combination with an aglycone mixture exerted an anti-inflammatory and photo-protective effect that prevented 41% and 71% of UVB-induced DNA damage, respectively. The advantages of using either isoflavone glucosides or an aglycone mixture in applications in the field of dermatology will depend on their properties and their different potential uses.
1989–1999. Ten years of low-invasive techniques for the treatment of lumbar disk herniation: a critical review of 80 monitored cases
Giuseppe Calvosa,Valerio Maria Monaco,Enrico Bonicoli,Cesare Faldini,Sandro Giannini,Alessandro Faldini
Journal of Orthopaedics and Traumatology , 2001, DOI: 10.1007/PL00012208
Abstract: Low invasive techniques for the treatment of lumbar disk herniation are still a subject of debate and interest in the field of vertebral surgery. We present a critical review of 80 cases of percutaneous nucleotomy performed from 1989 to 1999 at the First Orthopaedic Clinic in Pisa. The analysis of the results confirms the usefulness of this method for lumbar disk hernias in young patients who precisely meet the indications for surgery. Furthermore, automised percutaneous nucleotomy did not provoke collapses in the intervertebral space or instability in the functional units following the emptying of the nucleus. Post-operative magnetic resonance imaging revealed, in all cases, the creation of a discal scar.
Galectin-3 Impairment of MYCN-Dependent Apoptosis-Sensitive Phenotype Is Antagonized by Nutlin-3 in Neuroblastoma Cells
Veronica Veschi, Marialaura Petroni, Beatrice Cardinali, Carlo Dominici, Isabella Screpanti, Luigi Frati, Armando Bartolazzi, Alberto Gulino, Giuseppe Giannini
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049139
Abstract: MYCN amplification occurs in about 20–25% of human neuroblastomas and characterizes the majority of the high-risk cases, which display less than 50% prolonged survival rate despite intense multimodal treatment. Somehow paradoxically, MYCN also sensitizes neuroblastoma cells to apoptosis, understanding the molecular mechanisms of which might be relevant for the therapy of MYCN amplified neuroblastoma. We recently reported that the apoptosis-sensitive phenotype induced by MYCN is linked to stabilization of p53 and its proapoptotic kinase HIPK2. In MYCN primed neuroblastoma cells, further activation of both HIPK2 and p53 by Nutlin-3 leads to massive apoptosis in vitro and to tumor shrinkage and impairment of metastasis in xenograft models. Here we report that Galectin-3 impairs MYCN-primed and HIPK2-p53-dependent apoptosis in neuroblastoma cells. Galectin-3 is broadly expressed in human neuroblastoma cell lines and tumors and is repressed by MYCN to induce the apoptosis-sensitive phenotype. Despite its reduced levels, Galectin-3 can still exert residual antiapoptotic effects in MYCN amplified neuroblastoma cells, possibly due to its specific subcellular localization. Importantly, Nutlin-3 represses Galectin-3 expression, and this is required for its potent cell killing effect on MYCN amplified cell lines. Our data further characterize the apoptosis-sensitive phenotype induced by MYCN, expand our understanding of the activity of MDM2-p53 antagonists and highlight Galectin-3 as a potential biomarker for the tailored p53 reactivation therapy in patients with high-risk neuroblastomas.
El lugar propio de la utopía
Atenea (Concepción) , 2005, DOI: 10.4067/S0718-04622005000100002
Abstract: utopia is not ?mortal? since it is a subjective expression of an ideology. and ideologies don?t die: they only change, become oppositional, succeed each other, become ?ideologized? (in the sense of absolutizing the value they propose). an example that can be prudently recognized today: the nationalist ideology with its absolutizing of the value of the ?patria?
Book Review: Nicola Russo Filosofia ed ecologia. Idee sulla scienza e sulla prassi ecologiche Guida Editore, Napoli 2000
Gianluca Giannini
S&F_scienzaefilosofia.it , 2009,
IN-E-vocazioni della fine (o della cinemetafisica)
Gianluca Giannini
S&F_scienzaefilosofia.it , 2012,
Abstract: Is it somehow necessary for the human being to be? Is there something that reveals the need of the human being (and for the human being) to continue to be? Through the intersection between philosophy and cinema, and the age-old problem of “The End of the World”, this paper tries to develop an hypothesis involving the deconstruction of this question and, finally, of the inner reasons that support any answers based on traditional Metaphysics.
Ecophysiology, biology and genetics of poplar: state of research in Italy
Raffaello Giannini
Forest@ , 2007,
Abstract: A workshop on the state of art of research, biology and genetics in Popolar in Italy, has been held in Sesto Fiorentino (Firenze) on 25 th of may, 2007. The rationale and the aims of the meeting along with a short descriptions of the communications given are reported.
Towards a sovereign bankruptcy procedure and greater restraint in IMF crisis lending. An interim assessmen
Curzio Giannini
PSL Quarterly Review , 2003,
Abstract: The paper reviews the area of the international financial architecture relating tosovereign crisis resolution. It is argued that shifting part of the burden of crisisresolution onto creditors may encourage debtor countries to take early action to counter an unsustainable debt path. Collective action clauses, the sovereign debt restructuring mechanism, and ceilings on IMF loans, are all necessary components of a new and better crisis resolution framework.
Verso una procedura fallimentare per il debito sovrano e maggiore disciplina nei finanziamenti del Fondo Monetario Internazionale. Una valutazione di mezza via
Curzio Giannini
Moneta e Credito , 2003,
Abstract: The paper reviews the area of the international financial architecture relating to sovereign crisis resolution. It is argued that shifting part of the burden of crisis resolution onto creditors may encourage debtor countries to take early action to counter an unsustainable debt path. Collective action clauses, the sovereign debt restructuring mechanism, and ceilings on IMF loans, are all necessary components of a new and better crisis resolution framework.
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