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Search Results: 1 - 10 of 5492 matches for " Giuseppe Battaglia "
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Effect of interactions on the cellular uptake of nanoparticles
Abhishek Chaudhuri,Giuseppe Battaglia,Ramin Golestanian
Physics , 2011, DOI: 10.1088/1478-3975/8/4/046002
Abstract: We present a simple two-state model to understand the size-dependent endocytosis of nanoparticles. Using this model, we elucidate the relevant energy terms required to understand the size-dependent uptake mechanism and verify it by correctly predicting the behavior at large and small particle sizes. In the absence of interactions between the nanoparticles we observe an asymmetric distribution of sizes with maximum uptake at intermediate sizes and a minimum size cut-off below which there can be no endocytosis. Including the effect of interactions in our model has remarkable effects on the uptake characteristics. Attractive interactions shift the minimum size cut-off and increase the optimal uptake while repulsive interactions make the distribution more symmetric lowering the optimal uptake.
Optimization by Quantum Annealing: Lessons from hard 3-SAT cases
Demian Battaglia,Giuseppe Santoro,Erio Tosatti
Physics , 2005, DOI: 10.1103/PhysRevE.71.066707
Abstract: The Path Integral Monte Carlo simulated Quantum Annealing algorithm is applied to the optimization of a large hard instance of the Random 3-SAT Problem (N=10000). The dynamical behavior of the quantum and the classical annealing are compared, showing important qualitative differences in the way of exploring the complex energy landscape of the combinatorial optimization problem. At variance with the results obtained for the Ising spin glass and for the Traveling Salesman Problem, in the present case the linear-schedule Quantum Annealing performance is definitely worse than Classical Annealing. Nevertheless, a quantum cooling protocol based on field-cycling and able to outperform standard classical simulated annealing over short time scales is introduced.
Workplace conflicts and psychological work-related injuries: our experience in Italy
Giuseppe Taino, Andrea Battaglia, Marcello Imbriani
Journal of Health and Social Sciences , 3, DOI: 10.19204/2016/wrkp3
Abstract: In Europe, all countries regularly recognise mental disorders as workplace accidents (mainly post-traumatic stress disorders). However, there has been little emphasis on this emerging issue in Italy. Our discussion focuses on a recent case report regarding an employee who was affected by an acute anxiety disorder after a common workplace conflict with a coworker. Given that prolonged and unresolved relationship conflicts may result in more extreme forms of conflict known as workplace bullying, relationship conflicts should be minimised or prevented as early as possible. These conflicts can also lead to acute stress disorders, particularly in workers who are at-risk for stress disorders. To prevent psychological work-related injuries, occupational stakeholders should use assessments for work-related stress as a framework for addressing all organisational risk factors that are related to workplace relationships and conflict.
Cognitive Impairment Affects Physical Recovery of Patients with Heart Failure Undergoing Intensive Cardiac Rehabilitation
Giuseppe Caminiti,Francesca Ranghi,Sara De Benedetti,Daniela Battaglia
Rehabilitation Research and Practice , 2012, DOI: 10.1155/2012/218928
Neonatal diabetes mellitus due to pancreatic agenesis and pervasive developmental disorder
Alessandro Giannattasio, Maria Pintaudi, Maria Mancardi, Francesca Battaglia, Edvige Veneselli, Renata Lorini, Giuseppe d'Annunzio
Italian Journal of Pediatrics , 2009, DOI: 10.1186/1824-7288-35-23
Abstract: Dear Editor,Recent studies suggested a link between type 1 diabetes mellitus and pervasive developmental disorder (PDD) and hypothesized a common autoimmune pathogenesis or shared genetic factors [1]. Confirmation of an association between PDD and type 1 diabetes mellitus is still lacking. On the contrary permanent neonatal diabetes mellitus (PNDM) due to pancreas agenesis is an extremely rare condition, associated with intra-uterine growth retardation (IUGR), cardiac defects, gall bladder or cerebellum agenesis [2]. No association with psychiatric symptoms has been described up to now. We describe a patient with association of PNDM due to pancreatic agenesis, mild mental retardation and PDD. The patient, a boy who is currently aged 6, is the first child of healthy unrelated parents (father from Italy and mother from Spain). He was born at 35 weeks of gestation, with severe IUGR (weight 1620 g, <3rd percentile and length 45 cm, <3rd percentile) [3]. In the first day of life he developed hyperglycemia: neonatal diabetes was diagnosed and treated with insulin, initially intravenously and then subcutaneously. Atrial septal defect was discovered, in absence of other dysmorphic features. Pancreas agenesis was detected by ultrasound, and then confirmed by magnetic resonance imaging (MRI). Pancreatic exocrine insufficiency was treated with enzymes. Glycemic control was characterized during the first two years of life by fluctuations despite strict dietary regimen and frequent variation of insulin dosages. When 3 month-old the child presented a severe episode of hypoglicemia (plasma glucose 30 mg%); intramuscular glucagon was administrated and no neurological damage was evident at subsequent neuroimaging studies. Karyotype was normal and search for Fragile-X Syndrome was negative, as well as genetic testing for the most common forms of neonatal diabetes [4]. Brain MRI and neurophysiologic evaluations (auditory brainstem evoked potential, nerve conduction velocities and elec
Observations of Embryonic Changes in Middle and Late Stages of the Greater Wax Moth, Galleria mellonella (Lepidoptera: Pyralidae)  [PDF]
Muhamad Abidalla, Donatella Battaglia
Advances in Entomology (AE) , 2018, DOI: 10.4236/ae.2018.63015
Abstract: The embryogenesis of lepidopteran insects has morphogenetic events accompanying the blastokinesis movements (anatrepsis and katatrepsis) in early and late stages, respectively. Katatrepsis is related to embryonic movement with yolk mass and regression of amnioserosa folds in the second half of the development cycle. The whole mount method and differential interference contrast microscopy (DIC) were used for analysing the embryonic developmental changes. Those changes in the middle and late embryonic periods were described and divided into eight stages: 1) Completion of segmentation and differentiation of cephalic and thoracic appendages (32 - 40 hours post-oviposition h. PO); 2) Expanded growth of cephalo-gnathal and abdominal parts (41 - 60 h. PO); 3) Completion of thoracic appendages and appearance of pleuropodia, katatrepsis (60 - 70 h. PO); 4) Pre-revolution morphogenetic movement of the cephalo-gnathal region (71 - 80 h. PO); 5) revolution of the embryo (81 - 100 h. PO); 6) Beginning of dorsal closure (101 - 115 h. PO); 7) completion of dorsal closure (116 - 120 h. PO); and 8) full-grown embryo just before hatching (121 - 144 h. PO).
Biological monitoring of asphalt workers by urinary 1-hydroxypyrene: comparison between outdoor and indoor paving
Battaglia Andrea,Battaglia Alberto
Prevention and Research : International Open Access Journal of Prevention and Research in Medicine , 2012, DOI: 10.7362/2240-2594.020.2012
Abstract: Introduction: This study investigates urinary excretion of 1-hydroxypyrene (1-OHP) in 108 asphalt workers, who carried out daily activities adhering scrupulously to the preventive and protective policies laid down by "Regione Lombardia". Objectives: We want to evaluate the sensitivity of the assay of urinary hydroxypyrene as a descriptor of exposure to polycyclic aromatic hydrocarbons and evaluate the contribution of smoking on urinary 1-OHP. Methods: Values found after two days of asphalt working and values after two days of inactivity were compared. Readings were also compared between smokers and non-smokers, and between outdoor and indoor paving. Results: Differences of urinary 1-OHP values measured in the same workers after 2 days of inactivity, and values after two days spent in asphalting were not statistically significant, while a significant association between the two readings emerged in case of indoor asphalting. No significant differences between smokers and non-smokers were found. Conclusions: Urinary 1-OHP is a biomarker that better correlates with exposure to fumes of bitumen, but only when exposure is high, as it happens during indoor asphalting; in cases of low exposure, increase in the urinary excretion of the marker can not be statistically significant. Cigarette smoking, known for interfering with this indicator of exposure, could limit specificity, but did not significantly contribute in tests done in absence of occupational exposure.
Enhanced Fluorescence Imaging of Live Cells by Effective Cytosolic Delivery of Probes
Marzia Massignani,Irene Canton,Tao Sun,Vanessa Hearnden,Sheila MacNeil,Adam Blanazs,Steven P. Armes,Andrew Lewis,Giuseppe Battaglia
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010459
Abstract: Microscopic techniques enable real-space imaging of complex biological events and processes. They have become an essential tool to confirm and complement hypotheses made by biomedical scientists and also allow the re-examination of existing models, hence influencing future investigations. Particularly imaging live cells is crucial for an improved understanding of dynamic biological processes, however hitherto live cell imaging has been limited by the necessity to introduce probes within a cell without altering its physiological and structural integrity. We demonstrate herein that this hurdle can be overcome by effective cytosolic delivery.
Protein supplementation in strength and conditioning adepts: knowledge, dietary behavior and practice in Palermo, Italy
Antonino Bianco, Caterina Mammina, Antonio Paoli, Marianna Bellafiore, Giuseppe Battaglia, Giovanni Caramazza, Antonio Palma, Monèm Jemni
Journal of the International Society of Sports Nutrition , 2011, DOI: 10.1186/1550-2783-8-25
Abstract: The purpose of this study was to examine the use of protein supplementation, alone or in association with other supplements, and dietary behavior amongst regular fitness center attendees in Palermo, Italy.Resistance training information have been collected from 800 regular fitness center attendees for the initial analysis. A specific questionnaire was generated for the experimentation. Data were collected using a face-to-face interview method. Supplement users were then compared to the non users and analyzed using a one-way ANOVA, Kruskall-Wallis, chi-square test or exact test of Fisher when appropriate.30.1% of the respondents use dietary supplements during their training as a believe it is the "way to gain muscles and strength". Whey protein shakes (50.0%) mixed with creatine and amino-acids (48.3%) were the most frequent choices amongst the users. A majority of the subjects (34.0%) appeared to rely on their gym instructors' advice for their intake; a lower proportion (13.0%) consulted physicians, while none of them consulted nutritionists. A high consumption of milk has been noticed in both users (67,7%) and non-users (52,8%); supplement non-users consumed significantly more snacks and bakery products than users per week (P < 0.001), while users consumed significantly more protein-rich foods (P < 0.01) with a particular preference for meat (48.0%).A considerable number of regular strength training adepts consume protein supplements mixed with other products (mainly creatine and amino-acids). Limited numbers consult "dietary specialists" and rely mainly on their instructors. We emphasize on the importance of the dissemination of scientifically based information about supplementation in this environment and the promotion of updated educational programs for the instructors.Nutrition is traditionally perceived as a crucial component of physical fitness and performance. In the last few decades, the increasing understanding of human nutrition and its effects on the met
Upper limb artery segmental occlusions due to chronic use of ergotamine combined with itraconazole, treated by thrombolysis
Edoardo Cervi, Stefano Bonardelli, Giuseppe Battaglia, Federico Gheza, Roberto Maffeis, Franco Nodari, Roberto Maroldi, Stefano M Giulini
Thrombosis Journal , 2011, DOI: 10.1186/1477-9560-9-13
Abstract: A woman of 62 years presented with a severe pain left forearm appeared 10 days ago, with a worsening trend. The same symptoms appeared after 5 days also in the right forearm. Physical examination showed the right arm slightly hypothermic, with radial reduced pulse in presence of reduced sensitivity. The left arm was frankly hypothermic, pulse less on radial and with an ulnar humeral reduced pulse, associated to a decreased sensitivity and motility.Clinical history shows a chronic headache for which the patient took a daily basis for years Cafergot suppository (equivalent to 3.2 mg of ergotamine).From about ten days had begun therapy with itraconazole for vaginal candidiasis. The Color-Doppler ultrasound shown arterial thrombosis of the upper limbs (humeral and radial bilateral), with minimal residual flow to the right and no signal on the humeral and radial left artery.Angiography revealed progressive reduction in size of the axillary artery and right humeral artery stenosis with right segmental occlusions and multiple hypertrophic collateral circulations at the elbow joint. At the level of the right forearm was recognizable only the radial artery, decreased in size. Does not recognize the ulnar, interosseous artery was thin. To the left showed progressive reduction in size of the distal subclavian and humeral artery, determined by multiple segmental steno-occlusion with collateral vessels serving only a thin hypotrophic interosseous artery.Arteriographic findings were compatible with systemic drug-induced disease. The immediate implementation of thrombolysis, continued for 26 hours, with heparin in continuous intravenous infusion and subsequent anticoagulant therapy allowed the gradual disappearance of the symptoms with the reappearance of peripheral pulses.Angiography showed regression of vasospasm and the resumption of flow in distal vessels. The patient had regained sensitivity and motility in the upper limbs and bilaterally radial and ulnar were present.A 62 ye
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