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Search Results: 1 - 10 of 5545 matches for " Giovanni Sozio "
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A new mutant genetic resource for tomato crop improvement by TILLING technology
Silvia Minoia, Angelo Petrozza, Olimpia D'Onofrio, Florence Piron, Giuseppina Mosca, Giovanni Sozio, Francesco Cellini, Abdelhafid Bendahmane, Filomena Carriero
BMC Research Notes , 2010, DOI: 10.1186/1756-0500-3-69
Abstract: To apply TILLING to tomato, a new mutant collection was generated in the genetic background of the processing tomato cultivar Red Setter by treating seeds with two different ethylemethane sulfonate doses (0.7% and 1%). An associated phenotype database, LycoTILL, was developed and a TILLING platform was also established. The interactive and evolving database is available online to the community for phenotypic alteration inquiries. To validate the Red Setter TILLING platform, induced point mutations were searched in 7 tomato genes with the mismatch-specific ENDO1 nuclease. In total 9.5 kb of tomato genome were screened and 66 nucleotide substitutions were identified. The overall mutation density was estimated and it resulted to be 1/322 kb and 1/574 kb for the 1% EMS and 0.7% EMS treatment respectively.The mutation density estimated in our collection and its comparison with other TILLING populations demonstrate that the Red Setter genetic resource is suitable for use in high-throughput mutation discovery. The Red Setter TILLING platform is open to the research community and is publicly available via web for requesting mutation screening services.Tomato (Solanum lycopersicum) is one of the most important vegetable plants in the world. Its fruits are end products both for the fresh market and food processing industry. Tomato presents a relatively small genome highly syntenic to others economically important Solanaceae species and was selected as a reference species for sequencing a Solanaceae genome. In addition to the availability of a number of genomic resources, including transcriptome [1-3] and metabolome [4], large collections of genetic resources are available to dissect the biochemical and the metabolic pathways in tomato [5]. Large EMS and fast neutron mutant collections, in the background of M82 tomato cultivar, have been generated and more then 3,000 phenotype alterations catalogued [6]. An EMS-induced mutation library of the miniature dwarf tomato cultivar Mi
Antiparkinson Prodrugs
Antonio Di Stefano,Piera Sozio,Laura Serafina Cerasa
Molecules , 2008, DOI: 10.3390/molecules13010046
Abstract: Parkinson`s disease (PD) is a progressive, neurodegenerative disorder whichinvolves the loss of dopaminergic neurons of the substantia nigra pars compacta. Currenttherapy is essentially symptomatic, and L-Dopa (LD), the direct precursor of dopamine(DA), is the treatment of choice in more advanced stages of the disease. Substitutiontherapy with LD is, however, associated with a number of acute problems. The peripheralconversion of LD by amino acid decarboxylase (AADC) to DA is responsible for thetypical gastrointestinal (nausea, emesis) and cardiovascular (arrhythmia, hypotension) sideeffects. To minimize the conversion to DA outside the central nervous system (CNS) LD isusually given in combination with peripheral inhibitors of AADC (carbidopa andbenserazide). In spite of that, other central nervous side effects such as dyskinesia, on-offphenomenon and end-of-dose deterioration still remain. The main factors responsible forthe poor bioavailability and the wide range of inter- and intra-patient variations of plasmalevels are the drug’s physical-chemical properties: low water and lipid solubility, resultingin unfavourable partition, and the high susceptibility to chemical and enzymaticdegradation. In order to improve the bioavailability, the prodrug approach appeared to bethe most promising and some LD prodrugs have been prepared in an effort to solve theseproblems. We report here a review of progress in antiparkinson prodrugs, focusing onchemical structures mainly related to LD, DA and dopaminergic agonists.
Transdermal donepezil on the treatment of Alzheimer's disease
Sozio P, Cerasa LS, Marinelli L, Di Stefano A
Neuropsychiatric Disease and Treatment , 2012, DOI: http://dx.doi.org/10.2147/NDT.S16089
Abstract: ansdermal donepezil on the treatment of Alzheimer's disease Review (3042) Total Article Views Authors: Sozio P, Cerasa LS, Marinelli L, Di Stefano A Published Date August 2012 Volume 2012:8 Pages 361 - 368 DOI: http://dx.doi.org/10.2147/NDT.S16089 Received: 18 June 2012 Accepted: 27 July 2012 Published: 20 August 2012 Piera Sozio, Laura S Cerasa, Lisa Marinelli, Antonio Di Stefano Department of Pharmacy, University of "G. d'Annunzio," Vai dei Vestini, Chieti, Italy Abstract: Alzheimer's disease (AD) is the most common type of senile dementia, characterized by cognitive deficits related to degeneration of cholinergic neurons. The first anti-Alzheimer drugs approved by the Food and Drug Administration were the cholinesterase inhibitors (ChEIs), which are capable of improving cholinergic neurotransmission by inhibiting acetylcholinesterase. The most common ChEIs used to treat cognitive symptoms in mild to moderate AD are rivastigmine, galantamine, and donepezil. In particular, the lattermost drug has been widely used to treat AD patients worldwide because it is significantly less hepatotoxic and better tolerated than its predecessor, tetrahydroaminoacridine. It also demonstrates high selectivity towards acetylcholinesterase inhibition and has a long duration of action. The formulations available for donepezil are immediate release (5 or 10 mg), sustained release (23 mg), and orally disintegrating (5 or 10 mg) tablets, all of which are intended for oral-route administration. Since the oral donepezil therapy is associated with adverse events in the gastrointestinal system and in plasma fluctuations, an alternative route of administration, such as the transdermal one, has been recently attempted. The goal of this paper is to provide a critical overview of AD therapy with donepezil, focusing particularly on the advantages of the transdermal over the oral route of administration.
Coopera o Estratégica, Redes de Coopera o e Desenvolvimento Regional: o caso Unijuí/Sedai
Enise Barth Teixeira,Marlise Sozio Vitcel,Marlise Costa Beber
Desenvolvimento em Quest?o , 2007,
Abstract: The strategic cooperation has assumed important and growing role in contemporary organizations as a result of the great competitiveness and globalization. Fidene, mantenedora Unijuí, as an institution of higher education, community character has sought stock able to meet with their social function, through partnerships with society and with governments. This study aims to present an analysis of the relationship of cooperation between universities, business and government which is a strategy of cooperation between institutions, through programs aimed to extend the classification of micro, small and medium enterprises. The research classifies himself as exploratory and descriptive in a qualitative approach. The technical procedures employed were bibliographic searches and document. The results confirm that the performance of Fidene/Unijuí, especially in programs for technical and managerial support for micro, small and medium enterprises, is collaborating with the development of the region. It follows that the institution, the precedence for continuous interaction with their community, consolidates into a university community, with the mission and purpose of contributing to sustainable regional development.
Prevalence and predictors of solid or hematological malignancies in a monocentric cohort of HIV patients from central Italy
E Mazzotta,A Agostinone,F Sozio,T Ursini
Journal of the International AIDS Society , 2012, DOI: 10.7448/ias.15.6.18084
Abstract: Introduction: HIV-infected patients have a higher risk of developing cancer than the general population. Kaposi's sarcoma (KS), non-Hodgkin's lymphoma (NHL), primary CNS lymphoma (PCL) and invasive cervical cancers are considered AIDS-defining. An increased incidence in recent years, however, has been reported also for other malignancies after the introduction of HAART. Methods: We performed a case-control study to characterize all HIV-infected patients with both AIDS and non-AIDS-defining neoplasms observed among all consecutive patients followed at the Infectious Diseases Unit of Pescara General Hospital, since 1991 through 2012. All cases were matched with equinumerous controls without neoplasia homogeneous for age, sex and AIDS diagnosis. Results: Out of 626 patients consecutively assisted since 1991, 57 cases of malignancy (9.1%) were observed. Of these, 45 (79.0%) occurred in males; mean age was 43.6±9.3 years; 49 (86.0%) patients were diagnosed with AIDS. Tumors observed were: NHL, 17 (29.8%); SK, 13 (22.8%); HCC, 5 (8.8%); CPL, 6 (10.5%); Hodgkin's lymphoma, 4 (7.0%); solid tumors, 12 (21.1%), including 1 AIDS-defining tumor (anal cancer). Among these, 37 (66.1%) patients died; of them 14 (37.8%) had non-AIDS cancers. Cases were well matched with the 55 controls for sex (p=0.9), age (p=0.6) and AIDS diagnosis (p=0.6). In comparison with controls, CD4 nadirs were not different (153±151 in controls vs 136±154 cells/mmc), while CD4 at tumor diagnosis were very different between controls (463±283 cells/mmc) and cases (226±209 cells/mmc, p<0.0001). Among patients with malignancies, those who died had a non-significant reduction in CD4 counts (p=0.14); seemingly irrelevant were smoking status (p=0.9), working ability (p=0.4), HCV coinfection (p=0.4). Surprisingly, in patients co-infected with HBV, including HBsAg negative, antibody-positive subjects, tumors were significantly more frequent (60.7% vs. 38.8%, p=0.009). Conclusion: Factors potentially relevant for carcinogenesis in the prolonged survival patients of the HAART era may include HBV coinfection in spite of the lack of active biochemical activity (HbsAg negative) in the majority of coinfected patients. The potential relevance of this finding deserves prompt assessment in a larger multicentric cohort.
A MultiFactorial Risk Score to weigh toxicities and co-morbidities relative to costs of antiretrovirals in a cohort of HIV-infected patients
M Tontodonati,F Sozio,F Vadini,E Polilli
Journal of the International AIDS Society , 2012, DOI: 10.7448/ias.15.6.18387
Abstract: Purpose of the study: Considering costs of antiretrovirals (ARVs) for HIV patients is increasingly needed. A simple and comprehensive tool weighing comorbidities and ARV-related toxicities could be useful to judge the appropriateness of use of more expensive drugs. We conceived a MultiFactorial Risk Score (MFRS) to evaluate the appropriateness of ARVs prescription relative to their costs. Methods: HIV patients were consecutively enrolled in 2010-2011. We considered socio-demographic characteristics, HIV history, cardiovascular risk factors, low energy fractures, bone density. Psychological factors were assessed by BDI, DS14 and TAS-20. The MFRS was calculated as the sum of the following: age (<30y 1 point; 1 point increase every 5y, 10 for≥70); AIDS diagnosis (5); CD4 nadir (5 if <100; 1 point less every 100 CD4 increase); ART line (0 first, up to 5 for≥6 lines); lipodistrophy (5); HCV coinfection (7); education (1 degree, 2 secondary, 3 primary); alcohol (3) and drug abuse (5); working activity (3 if unemployed); hypertension (3); cholesterol≥200 mg/dl (3); diabetes (3); Framingham score (7 if>7%); creatinine (0 if <1 mg/dl, 1 if<1.2; 2 if<1.5>1.2, 5 if<2> 1.5, 7 if≥2); bone fractures (7); bone status at DEXA (0 normal, 3 osteopenic, 5 osteoporotic); cancer (5); depression (3 if BDI>17); other psychiatric illness (5). Annual costs of individual ART regimens were calculated. MFRS was correlated in univariate and multivariate models with all variables. All statistical analyses were carried out using Stata 10.1. Summary of results: We enrolled 241 HIV patients, 74.3% males, aged 44.5±9.9y; 19 patients (7.8%) were untreated, 74.8% of treated had undetectable HIV RNA. Mean Nadir CD4 counts were 218±168, 38.5% of patients had an AIDS diagnosis. Mean individual ARV annual cost was 10,976±5,360. Mean MFRS was 28.5±13.9 (4–64). MFRS was significantly higher (p<0.001) in patients with older age, longer duration of HIV infection, lower CD4 nadirs, AIDS diagnosis, lipodistrophy, HCV, smoking, lower education, alcohol/drug abuse, hypertension, carotid plaques, higher Framingham score, diabetes, bone fractures or disorders, depression, alexithymia, and higher ARV costs. In multivariate models, ARV costs were significantly higher in patients with older age, previous AIDS diagnosis, lower CD4 nadir and higher MFRS. Conclusions: MFRS may be a simple and reliable tool to match patients’ complexity and ARV costs, deserving further validation on larger samples.
Retrospective evaluation of late presentation and retention in care in a monocentric cohort of HIV-patients in 2006–2011
T Ursini,E Polilli,F Sozio,E Mazzotta
Journal of the International AIDS Society , 2012, DOI: 10.7448/ias.15.6.18301
Abstract: Almost 1/3 of HIV-infected individuals enter health care late in the course of infection, worsening their prognosis and costs of care. According to the recent European consensus definitions, late presenters are persons presenting with CD4 counts <350/μL, and presenters with advanced HIV disease have CD4 < 200/μL or an AIDS-event. These latter, in particular, are at high risk of further opportunistic infections or death despite of HAART. We included all patients newly diagnosed with HIV infection at the Infectious Diseases Unit of Pescara from 2006 to present, registered for at least one day of observation. The duration of follow up was plotted for all enrolled patients up to 31/12/2011. Demographic, clinical, virological and immunological data, lines of therapy and outcome of HAART were collected for each patient. We included 140 consecutive patients, 18.6% in 2006, 17.9% in 2011; 76.4% were male, while the average age was 39.3±10.2y. AIDS diagnosis at presentation was for 39.7% (50% in 2006, 41.7% in 2011); 52.7% had advanced HIV disease (CD4 <200/μL, 53.8% in 2006, 70.8% in 2011), 67.2 % were late presenters (CD4 <350/μL, 73.1% in 2006, 79.2% in 2011). The average CD4 counts at enrollment were 313.8±294.1 in 2006, 361.3±263.1 in 2007, 281.8±295.5 in 2008, 238.4±201.6 in 2009, 394.1±183.9 in 2010, 225.7±245.2 in 2011. Eight per cent of patients were HCV coinfected. Heterosexual exposure occurred in 54% of patients, homosexual in 36%; drug addiction in 7.5%. Among enrollees, 71.4% were Italian, 18.6% from sub-Saharan Africa, 5.7% from South America and 4.2% from Eastern Europe. With a median follow up of 2.5 years, 105 patients (75%) were still being treated as of November 30th, 2011; among these 104 (99.1%) were in virological suppression. Among the 35 patients no longer followed, 15 (11.4%) died during the first 6 months of treatment, 20 (14.3%) were lost in the first 6 months of follow-up. All 15 deaths occurred in patients enrolled with CD4 <200/μL. After initiation of HAART only 1 patient (0.7%) switched for virological failure, 19 (13.6%) for toxicity or simplification. The proportion of late presenters at our center is high (67.2%) in the absence of appropriate local screening measures. Early mortality after diagnosis is similarly high, concentrated in patients with late presentation. Retention in care after 6 months and virological success of treated patients appear very promising, much more than recently reported in North America.
Social content matching in MapReduce
Gianmarco De Francisci Morales,Aristides Gionis,Mauro Sozio
Computer Science , 2011,
Abstract: Matching problems are ubiquitous. They occur in economic markets, labor markets, internet advertising, and elsewhere. In this paper we focus on an application of matching for social media. Our goal is to distribute content from information suppliers to information consumers. We seek to maximize the overall relevance of the matched content from suppliers to consumers while regulating the overall activity, e.g., ensuring that no consumer is overwhelmed with data and that all suppliers have chances to deliver their content. We propose two matching algorithms, GreedyMR and StackMR, geared for the MapReduce paradigm. Both algorithms have provable approximation guarantees, and in practice they produce high-quality solutions. While both algorithms scale extremely well, we can show that StackMR requires only a poly-logarithmic number of MapReduce steps, making it an attractive option for applications with very large datasets. We experimentally show the trade-offs between quality and efficiency of our solutions on two large datasets coming from real-world social-media web sites.
Scalable Facility Location for Massive Graphs on Pregel-like Systems
Kiran Garimella,Gianmarco De Francisci Morales,Aristides Gionis,Mauro Sozio
Computer Science , 2015,
Abstract: We propose a new scalable algorithm for facility location. Facility location is a classic problem, where the goal is to select a subset of facilities to open, from a set of candidate facilities F , in order to serve a set of clients C. The objective is to minimize the total cost of opening facilities plus the cost of serving each client from the facility it is assigned to. In this work, we are interested in the graph setting, where the cost of serving a client from a facility is represented by the shortest-path distance on the graph. This setting allows to model natural problems arising in the Web and in social media applications. It also allows to leverage the inherent sparsity of such graphs, as the input is much smaller than the full pairwise distances between all vertices. To obtain truly scalable performance, we design a parallel algorithm that operates on clusters of shared-nothing machines. In particular, we target modern Pregel-like architectures, and we implement our algorithm on Apache Giraph. Our solution makes use of a recent result to build sketches for massive graphs, and of a fast parallel algorithm to find maximal independent sets, as building blocks. In so doing, we show how these problems can be solved on a Pregel-like architecture, and we investigate the properties of these algorithms. Extensive experimental results show that our algorithm scales gracefully to graphs with billions of edges, while obtaining values of the objective function that are competitive with a state-of-the-art sequential algorithm.
Polluting Productions and Sustainable Economic Growth: A Local Stability Analysis  [PDF]
Giovanni Bella
Journal of Service Science and Management (JSSM) , 2009, DOI: 10.4236/jssm.2009.21007
Abstract: The aim of this paper is to analyze the link between natural capital and economic growth, in a Romer-type economy characterized by dirty emissions in the production process, and to examine the conditions under which a sustainable growth, which implies a decreasing level of dirty emissions, might be both feasible and optimal. This work is close to Aghion-Howitt (1998) with some more general specifications, in particular regarding the structure of preferences and the technological sector. We also deeply study the transitional dynamics of this economy towards the steady state, and conclude that a determinate saddle path sustainable equilibrium can be reached even in presence of a long run positive level of polluting emissions, thanks to a growing level of new home-made inventories, without whom some indetermi-nacy problems are likely to emerge.
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