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Search Results: 1 - 10 of 2405 matches for " Giorgio Cruccu "
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Tools for Assessing Neuropathic Pain
Giorgio Cruccu ,Andrea Truini
PLOS Medicine , 2009, DOI: 10.1371/journal.pmed.1000045
Il dolore
Prof. Giorgio Cruccu
Brainfactor , 2011,
Abstract: Il dolore è l’aspetto negativo di un sistema sensitivo indispensabile alla vita, detto sistema nocicettivo, dal latino noxa e nocēre. I bambini con difetti congeniti della trasmissione o dell’elaborazione percettiva dei segnali dolorifici (analgesia congenita) vanno incontro ad una serie di lesioni di cui non si accorgono, sempre più gravi. Crescendo, possono riconoscere il pericolo attraverso l’educazione e l’esperienza, ma, senza l’allarme dato dal dolore, molte malattie possono evolvere senza che siano combattute per tempo, in una spirale che spesso conduce al decesso.
Topiramate modulates habituation in migraine: evidences from nociceptive responses elicited by laser evoked potentials
Laura Di Clemente, Francesca Puledda, Antonella Biasiotta, Alessandro Viganò, Edoardo Vicenzini, Andrea Truini, Giorgio Cruccu and Vittorio Di Piero
The Journal of Headache and Pain , 2013, DOI: 10.1186/1129-2377-14-25
Abstract: Our results indicate a modulating action of topiramate on cortical processing of sensorial stimuli, mainly regarding the sensory-discriminative component of pain, elaborated by SII, without a significant effect on the affective dimension of pain, in which the ACC has an important role.
Hyperalgesic activity of kisspeptin in mice
Simona Spampinato, Angela Trabucco, Antonella Biasiotta, Francesca Biagioni, Giorgio Cruccu, Agata Copani, William H Colledge, Maria Sortino, Ferdinando Nicoletti, Santina Chiechio
Molecular Pain , 2011, DOI: 10.1186/1744-8069-7-90
Abstract: Immunofluorescent staining in the mouse skin showed the presence of GPR54 receptors in PGP9.5-positive sensory fibers. Intraplantar injection of kisspeptin (1 or 3 nmol/5 μl) induced a small nocifensive response in naive mice, and lowered thermal pain threshold in the hot plate test. Both intraplantar and intrathecal (0.5 or 1 nmol/3 μl) injection of kisspeptin caused hyperalgesia in the first and second phases of the formalin test, whereas the GPR54 antagonist, p234 (0.1 or 1 nmol), caused a robust analgesia. Intraplantar injection of kisspeptin combined with formalin enhanced TRPV1 phosphorylation at Ser800 at the injection site, and increased ERK1/2 phosphorylation in the ipsilateral dorsal horn as compared to naive mice and mice treated with formalin alone.These data demonstrate for the first time that kisspeptin regulates pain sensitivity in rodents and suggest that peripheral GPR54 receptors could be targeted by novel drugs in the treatment of inflammatory pain.Kisspeptin is a 54-amino acid peptide originally discovered for its activity as metastasis-suppressor [1]. It is encoded by the Kiss1 gene as a 145-amino acid precursor protein and cleaved to a 54-amino acid protein as well as into shorter products (kisspeptin-10,-13,-14) known to play a critical role in the neuroendocrine regulation of reproduction [2-5].In the brain, kisspeptin is localized not only in areas involved in gonadotropin secretion, but also in other regions such as the amygdala, hippocampus, and the periacqueductal gray [6,7].Its action is mediated by a 7-TM receptor named GPR54, also known as KISS1R, which is coupled to polyphosphoinositide hydrolysis via a Gq/11 GTP binding protein [2,8].Loss-of-function mutations of GPR54 cause a non-Kallman variant of hypogonadotropic/hypogonadism in humans (i.e. hypogonadotropic/hypogonadism without anosmia) [2,9]. Interestingly, the expression of kisspeptin and GPR54 is not restricted to the hypothalamus. Relatively high levels of kisspeptin and GPR5
Using of Particle Swarm for Performance Optimization of Helicopter Rotor Blades  [PDF]
Giorgio Guglieri
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.330197
Abstract: As part of a research activity at Politecnico di Torino, aiming to develop multi-disciplinary design procedures implementing nature inspired meta-heuristic algorithms, a performance design optimization procedure for helicopter rotors has been developed and tested. The procedure optimizes the aerodynamic performance of blades by selecting the point of taper initiation, the root chord, the taper ratio, and the maximum twist which minimize horsepower for different flight regimes. Satisfactory aerodynamic performance is defined by the requirements which must hold for any flight condition: the required power must be minimized, both the section drag divergence Mach number on the advancing side of the rotor disc and the maximum section lift coefficient on the retreating side of the rotor disc must be avoided and, even more important, the rotor must be trimmed. The procedure uses a comprehensive mathematical model to estimate the trim states of the helicopter and the optimization algorithm consists of a repulsive particle swarm optimization program. A comparison with an evolutionary micro-genetic algorithm is also presented.
A Note on the Guignard Constraint Qualification and the Guignard Regularity Condition in Vector Optimization  [PDF]
Giorgio Giorgi
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.44101

Some remarks are made on the use of the Abadie constraint qualification, the Guignard constraint qualifications and the Guignard regularity condition in obtaining weak and strong Kuhn-Tucker type optimality conditions in differentiable vector optimization problems.

Simulation of Atmospheric Wave-Fronts with Turbulence Intermittency  [PDF]
Giorgio Sedmak
International Journal of Astronomy and Astrophysics (IJAA) , 2014, DOI: 10.4236/ijaa.2014.41014
Abstract: A new extendable method for the simulation of atmospheric wave-fronts with turbulence intermittency is reported. The purpose is to generate simulations consistent with the distributions observed for the turbulence parameters and the seeing, not available with standard methods. The intermittency is included by entering log-normal distributed arrays for the Fried parameter and the spatial coherence outer scale length into an extended form of the phase spectrum. The method is tested on large samples of simulated long-exposure point-source images. The tests show the agreement of the simulations with literature data. The simulations show that the intermittency affects negligibly the long-term median image size but breaks the symmetry of the wave-front phase spectrum, scatters the phase structure function and changes the image profile.
A Simple Way to Prove the Characterization of Differentiable Quasiconvex Functions  [PDF]
Giorgio Giorgi
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.58114

We give a short and easy proof of the characterization of differentiable quasiconvex functions.

Central Bank Communication, Ambiguity and Market Interest Rates: A Case Study  [PDF]
Carlo Di Giorgio, Enzo Rossi
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.33039
Abstract: We asked a representative sample of European banks to judge messages released by ECB members (from February 1999 to February 2000) in terms of their ambiguity. In this paper, we use our survey to derive a definition of ambiguity and to evaluate ECB communication. A Structural Vector Autoregression model is estimated and the results show that ambiguous messages were able to affect agents’ expectations for a limited period after a speech by ECB members; moreover, they show that ambiguity had temporary effects also on volatility and moved rates away from the policy rate.
Before the Emergence of Homo sapiens: Overview on the Early-to-Middle Pleistocene Fossil Record (with a Proposal about Homo heidelbergensis at the subspecific level)
Giorgio Manzi
International Journal of Evolutionary Biology , 2011, DOI: 10.4061/2011/582678
Abstract: The origin of H. sapiens has deep roots, which include two crucial nodes: (1) the emergence and diffusion of the last common ancestor of later Homo (in the Early Pleistocene) and (2) the tempo and mode of the appearance of distinct evolutionary lineages (in the Middle Pleistocene). The window between 1,000 and 500 thousand years before present appears of crucial importance, including the generation of a new and more encephalised kind of humanity, referred to by many authors as H. heidelbergensis. This species greatly diversified during the Middle Pleistocene up to the formation of new variants (i.e., incipient species) that, eventually, led to the allopatric speciation of H. neanderthalensis and H. sapiens. The special case furnished by the calvarium found near Ceprano (Italy), dated to 430–385?ka, offers the opportunity to investigate this matter from an original perspective. It is proposed to separate the hypodigm of a single, widespread, and polymorphic human taxon of the Middle Pleistocene into distinct subspecies (i.e., incipient species). The ancestral one should be H. heidelbergensis, including specimens such as Ceprano and the mandible from Mauer. 1. Introduction The origin of anatomically and genetically modern humans (H. sapiens) from a small population of “archaic” Homo is an event reasonably well set in sub–Saharan Africa around 200 thousand years before present (or ka) [1–3]. Nevertheless, this event has deep roots in the Middle Pleistocene, primarily at the time of the divergence between the evolutionary lineage of our own species and that of the Neanderthals—between approximately 800 and or 520?ka, according to Briggs and coworkers [4] (compare [5]), or between 538 and 315?ka, according to Endicott and colleagues [6]—and even earlier, in the late Early Pleistocene, when the common ancestor of both H. sapiens and H. neanderthalensis emerged and began to spread geographically. This paper aims at investigating such a new frontier for paleoanthropology. It will focus on topology, chronology, tempo, and mode of the main evolutionary nodes before the appearance of H. sapiens. When considering all the available data, we are confronted with a comprehensive scenario about the deep roots of our species. At the same time, it becomes possible to approach the issue from regional and/or local perspectives [7]. The special case study provided by a well-known fossil specimen from Italy—that is, the calvarium from Ceprano (for a review, see [8])—may help to see the remote origins of H. sapiens from an interesting and helpful perspective. 2. Old and New
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