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Search Results: 1 - 10 of 291 matches for " Gianluigi Condorelli "
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Complex Systems Theory: Some Considerations for Sociology  [PDF]
Rosalia Condorelli
Open Journal of Applied Sciences (OJAppS) , 2016, DOI: 10.4236/ojapps.2016.67044
Abstract: This essay presents a reflection on the main implications of Complexity Theory for science in general, redefining and dispelling myths of traditional science, and Sociology in particular, suggesting a redefinition of Parsons’ classic concept of Social System, articulated around the property of self-maintenance of order rather than on its possible discontinuity and instability. It argues that Complexity Theory has established the limits of Classic Science, leading to a more realistic awareness of working and evolution mechanisms of Natural and Social Systems and showing the limits of our capacity to predict and control events. Dissipative structures have shown the creative role of time. Instability, emergence, surprise, unpredictability are the rule rather than the exception when systems move away from equilibrium (entropy), even if these processes are generated from a system’s deterministic working mechanisms. Therefore, we have come to realize how constructive the contribution of Complexity is, in regards to the long lasting problem of the relationship between order and disorder. Today, the terms of this relationship have been re-specified in its new configuration of inter-relationship link, according to a unicum which finds its synthesis in self-organization and deterministic chaos concepts. From this perspective, as Prigogine suggested, studies on Complex Systems are heading toward a historical, biological conception of Physics, and a new alliance between natural systems and living, social systems. Non-linearity, far from equilibrium self-organization, emergence and surprise meet at all levels, as this paper attempts to highlight. In Sociology, insights of Complexity Theory have contributed to a new way of thinking about social systems, by re-addressing some fundamental issues starting to social system, emergence and change concepts. The current social system conception as complex dynamical systems is supported by a profitable use of non-liner models (in particular, the Logistic map) in the study of social processes.
Gender Abuse in Intimate Relationships: From Structural Coupling Theory to Emergence of Couple System  [PDF]
Rosalia Condorelli
Sociology Mind (SM) , 2017, DOI: 10.4236/sm.2017.74013
Abstract: Is love predictable in its choices? Linear Determinism, Randomness or Complexity? By applying theoretical coordinates of current sociological interpretations of intimacy and conceptual categories of New General System Theory, the paper reflects on one-factor and linear determinism implicitly underlying mate selection processes in Structural Coupling Theory and its implications for Intimate Partner Violence (IPV). Assuming personality structure as the predictor of partner choice as well as victimization risk, SCT circumscribes victimization risk just to one category of women (insecure/avoidant women coupling with ambivalent partners). We propose that adaptive complex system and non-banal machine concepts are more effective to understand the mate selection process than linear deterministic approach, which appears too mechanistic for a process that exhibits an inextricable dimension of uncertainty and unpredictability. Research results on a sample of 100 victims of IPV do not corroborate the linear one-factor determinism underlying Structural Coupling Theory neither its implications. Rather they go in the direction of Complexity.
Cultural Differentiation and Social Integration in Complex Modern Societies Reflections on Cultural Diversity Management Strategies from a Sociological Point of View  [PDF]
Rosalia Condorelli
Sociology Mind (SM) , 2018, DOI: 10.4236/sm.2018.84019
Abstract: This paper reflects on foundations of integration in our differentiated and globalized society from a sociological point of view, and links this reflection to most recent scientific acquisitions of the New Systems Theory or Complexity Science about how all systems, natural as well as social systems, work and evolve. Incorporating the sociological tradition on differentiation processes as rule of social functioning, the contemporary sociology accepted emergent, far from equilibrium (entropy), self-organization, unpredictable and surprising organizational change processes, operative closure and autopoiesis concepts, as particularly adapting concepts to represent social systems and, above all, our contemporary society characterized by an increase of complexity due to differentiation, individualization and globalization processes. In this regard, strong and permanent migratory waves, due to economic and digital globalization processes, and increasing cultural differentiation processes, have led contemporary western societies to face a serious social organizational problem: how the recognition of cultural difference and the instance of social integration can be reconciled? In this regard, the characterization of all systems as able to adapt to environmental perturbations and survive by self-organizing, balancing organization integrative constraints and emergencies, that is, far from complete differentiation, without being even minimal connection (far from equilibrium or in the edge of the chaos), can constitute a valid point of reference for sociologically reflecting, starting from here, on current integration policies of cultural differences in our complex society (pluralism, multiculturalism, interculturalism) and their implications for social integration. About it, the paper accepts the perspective of those sociological and political theories according to which, from a theoretical and empirical point of view, the sufficiency of procedural foundations seems to show serious limits as integrative constraint. Therefore, the Complexity language can justify the caution with which the normative multiculturalism—which implies it—is believed that should be considered, by anchoring it to the vision of a society conceived so as to dangerously visit that range of maximum differentiation which should be avoided, being identified as the range of ungovernability. Islamic radicalism and nationalistic rejection signs in the West show that this is no a mere theoretical possibility. How to bridge this relationality deficit that normative
Circulating MicroRNAs and Aerobic Fitness – The HUNT-Study
Anja Bye, Helge R?sj?, Stian T. Aspenes, Gianluigi Condorelli, Torbj?rn Omland, Ulrik Wisl?ff
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057496
Abstract: Aerobic fitness, measured as maximal oxygen uptake (VO2max), is a good indicator of cardiovascular health, and a strong predictor of cardiovascular mortality. Biomarkers associated with low VO2max may therefore represent potential early markers of future cardiovascular disease (CVD). The aim of this study was to assess whether circulating microRNAs (miRs) are associated with VO2max-level in healthy individuals. In a screening study, 720 miRs were measured in serum samples from healthy individuals (40–45 yrs) with high (n = 12) or low (n = 12) VO2max matched for gender, age and physical activity. Candiate miRs were validated in a second cohort of subjects with high (n = 38) or low (n = 38) VO2max. miR-210 and miR-222 were found to be higher in the low VO2max-group (p<0.05). In addition, miR-21 was increased in male participants with low VO2max (p<0.05). There were no correlations between traditional risk factors for CVD (blood pressure, cholesterol, smoking habit, or obesity) and miR-21, miR-210 and miR-222. DIANA-mirPath identified 611 potential gene-targets of miR-21, miR-210 and miR-222, and pathway analysis indicated alterations in several important signaling systems in subjects with low VO2max. Potential bias involve that blood was collected from non-fasting individuals, and that 8 performed exercise within 24 h before sampling. In conclusion, we found that miR-210, miR-21, and miR-222 were increased in healthy subjects with low VO2max. The lack of association between these three miRs, and other fitness related variables as well as traditional CVD risk factors, suggests that these miRs may have a potential as new independent biomarkers of fitness level and future CVD.
APRENDENDO A OLHAR O MUNDO ATRAVéS DE UM CALEIDOSCóPIO: ANOTA ES PARA UMA EDUCA O TRANSCULTURAL
Antonino Condorelli
Revista Espa?o do Currículo , 2010,
Abstract: O artigo examina, em primeiro lugar, as implica es cognitivas e inter-relacionais da ado o de maneiras de pensar e de interagir com o mundo diferentes das governadas pelo paradigma reducionista-disjuntivo de matriz cartesiana dominante no Ocidente e, como conseqüência primeiro da coloniza o e sucessivamente de uma mundializa o unilateral, também em boa parte do planeta. Em seguida, esbo a alguns princípios para uma possível reforma educacional em dire o a pedagogias transculturais que n o favore am apenas a manifesta o das diversas maneiras de pensar o mundo e de viver presentes na sociedade, mas reformulem os currículos e as práticas educativas à luz de estratégias polif nicas de produ o de conhecimento e de intera o com nós mesmos, com os outros e com o mundo. Por último, reconstrói algumas experiências de pedagogia transcultural praticadas pelo autor na perspectiva da ecologia integral, extraindo algumas conclus es das vivências relatadas e das reflex es desenvolvidas ao longo do trabalho.
La leyenda del mestre Riquart y de Riccardo Quartararo
Condorelli, Adele
Archivo Espa?ol de Arte , 2001,
Abstract: Extra a estrella y, sobre todo, venturosa, diría yo, la del oscuro mestre Ricart, uno de tantos pintores que trabajaban en la Valencia de la segunda mitad del siglo xv, elevado a los honores de la crónica en virtud de su presunta identificación con el célebre Riccardo Quartararo (1443-1507), el más excelente de los pintores palermitanos de su época. Todavía hoy, una buena parte de la crítica cree que Quartararo llegó a Valencia en 1472, en el séquito del cardenal Rodrigo Borja, futuro Alejandro VI, junto con el napolitano Francesco Pagano y el emiliano Paolo de San Leocadio. Puesto que, como intentaré explicar a continuación, con mi prolongado y voluntario silencio sobre el tema, me considero en parte responsable de la difusión de lo que creo un equívoco, me parece llegado el momento de relatar cómo tuvo origen la hipótesis —para muchos estudiosos convertida ya en certeza— de que Riccardo Quartararo era…
El hallazgo de los frescos de Paolo de San Leocadio en la catedral de Valencia y algunas consideraciones acerca de Francesco Pagano
Condorelli, Adele
Archivo Espa?ol de Arte , 2005,
Abstract: El extraordinario acontecimiento del hallazgo de frescos de la época del Renacimiento bajo las estructuras barrocas que revisten la bóveda de la Capilla Mayor de la Catedral de Valencia, que tuvo lugar el 20 de junio de 2004, pone de actualidad un argumento que traté el a o pasado, en Palermo, con ocasión del Convenio internacional sobre Antonello y la pintura del Quattrocento en la Europa mediterránea. El argumento de mi citada intervención versaba, entre otros temas, sobre la personalidad de Francesco Pagano, llevado a Valencia en 1472, junto con Paolo de San Leocadio, por el cardenal Rodrigo de Borja, para que pintase al fresco las paredes y la bóveda de la Capilla Mayor de la Catedral, cuyo decorado medieval había sido destruido, el 21 de mayo de 1469, por un devastador incendio...
MicroRNA-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism
Junjie Xiao, Zhi-Cheng Jing, Patrick T Ellinor, Dandan Liang, Hong Zhang, Ying Liu, Xiaoli Chen, Lei Pan, Robert Lyon, Yi Liu, Lu-Ying Peng, Xingqun Liang, Yunfu Sun, Laurentiu M Popescu, Gianluigi Condorelli, Yi-Han Chen
Journal of Translational Medicine , 2011, DOI: 10.1186/1479-5876-9-159
Abstract: Thirty-two APE patients, 32 healthy controls, and 22 non-APE patients (reported dyspnea, chest pain, or cough) were enrolled in this study. The TaqMan miRNA microarray was used to identify dysregulated miRNAs in the plasma of APE patients. The TaqMan-based miRNA quantitative real-time reverse transcription polymerase chain reactions were used to validate the dysregulated miRNAs. The receiver-operator characteristic (ROC) curve analysis was conducted to evaluate the diagnostic accuracy of the miRNA identified as the candidate biomarker.Plasma miRNA-134 (miR-134) level was significantly higher in the APE patients than in the healthy controls or non-APE patients. The ROC curve showed that plasma miR-134 was a specific diagnostic predictor of APE with an area under the curve of 0.833 (95% confidence interval, 0.737 to 0.929; P < 0.001).Our findings indicated that plasma miR-134 could be an important biomarker for the diagnosis of APE. Because of this finding, large-scale investigations are urgently needed to pave the way from basic research to clinical utilization.Acute pulmonary embolism (APE) is a common cardiovascular emergency associated with a substantial morbidity and mortality [1-3]. APE accounts for 50, 000 to 100, 000 deaths a year in the United States alone and approximately 10% of deaths in European hospitals [2,4]. The annual incidence of APE in the United States and Europe is approximately 100 cases per 100, 000 individuals [2,4]. Despite the morbidity associated with APE, the diagnosis is frequently missed due to the variable clinical presentation [5,6].Diagnostic testing for APE has been extensively studied and ranges from biomarkers, such as the D-dimer assay, to radiologic imaging, including CT angiography, venous ultrasonography, and ultimately the gold standard of pulmonary venous angiography. Although widely used as a screening tool, D-dimer assays are sensitive but not specific for detecting APE [7]. Novel biomarkers with enhanced diagnostic accurac
MicroRNA-1 Downregulation Increases Connexin 43 Displacement and Induces Ventricular Tachyarrhythmias in Rodent Hypertrophic Hearts
Antonio Curcio, Daniele Torella, Claudio Iaconetti, Eugenia Pasceri, Jolanda Sabatino, Sabato Sorrentino, Salvatore Giampà, Mariella Micieli, Alberto Polimeni, Beverley J. Henning, Angelo Leone, Daniele Catalucci, Georgina M. Ellison, Gianluigi Condorelli, Ciro Indolfi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070158
Abstract: Downregulation of the muscle-specific microRNA-1 (miR-1) mediates the induction of pathologic cardiac hypertrophy. Dysfunction of the gap junction protein connexin 43 (Cx43), an established miR-1 target, during cardiac hypertrophy leads to ventricular tachyarrhythmias (VT). However, it is still unknown whether miR-1 and Cx43 are interconnected in the pro-arrhythmic context of hypertrophy. Thus, in this study we investigated whether a reduction in the extent of cardiac hypertrophy could limit the pathological electrical remodeling of Cx43 and the onset of VT by modulating miR-1 levels. Wistar male rats underwent mechanical constriction of the ascending aorta to induce pathologic left ventricular hypertrophy (LVH) and afterwards were randomly assigned to receive 10mg/kg valsartan, VAL (LVH+VAL) delivered in the drinking water or placebo (LVH) for 12 weeks. Sham surgery was performed for control groups. Programmed ventricular stimulation reproducibly induced VT in LVH compared to LVH+VAL group. When compared to sham controls, rats from LVH group showed a significant decrease of miR-1 and an increase of Cx43 expression and its ERK1/2-dependent phosphorylation, which displaces Cx43 from the gap junction. Interestingly, VAL administration to rats with aortic banding significantly reduced cardiac hypertrophy and prevented miR-1 down-regulation and Cx43 up-regulation and phosphorylation. Gain- and loss-of-function experiments in neonatal cardiomyocytes (NCMs) in vitro confirmed that Cx43 is a direct target of miR-1. Accordingly, in vitro angiotensin II stimulation reduced miR-1 levels and increased Cx43 expression and phosphorylation compared to un-stimulated NCMs. Finally, in vivo miR-1 cardiac overexpression by an adenoviral vector intra-myocardial injection reduced Cx43 expression and phosphorylation in mice with isoproterenol-induced LVH. In conclusion, miR-1 regulates Cx43 expression and activity in hypertrophic cardiomyocytes in vitro and in vivo. Treatment of pressure overload-induced myocyte hypertrophy reduces the risk of life-threatening VT by normalizing miR-1 expression levels with the consequent stabilization of Cx43 expression and activity within the gap junction.
The Universe at Lattice-Fields  [PDF]
Giovanni Guido, Gianluigi Filippelli
Journal of High Energy Physics, Gravitation and Cosmology (JHEPGC) , 2017, DOI: 10.4236/jhepgc.2017.34060
Abstract: We formulate the idea of a Universe crossing different evolving phases \"\" where in each phase one can define a basic field at lattice structure (Uk) increasing in mass (Universe-lattice). The mass creation in Uk has a double consequence for the equivalence “mass-space”: Increasing gravity (with varying metric) and increasing space (expansion). We demonstrate that each phase is at variable metric beginning by open metric and to follow a flat metric and after closed. Then we define the lattice-field of intersection between two lattice fields of base into universe \"\" and we analyse the universe in the Nucleo-synthesis phase (intersection-lattice \"\" ) and in the that of recombination (intersection-lattice \"\" ). We show that the phase \"\" is built on the intersection of the lattices of the proton (Up) and electron (Ue) or \"\" . We show UH to be at variable metric (open in the past, flat in the present and closed in the future). Then, we explain some fundamental aspects of this universe UH: Hubble’s law by creating the mass-space in it, its age (13.82 million of Years) as time for reaching the flat metric phase and the value of critic density. In last we talk about dark universe lattice \"\", having hadronic nature, and calculating its spatial step \"\" and its density in present phase of \"\" .
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