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Influence of the Occlusal Alteration in the Mandible Morphology of the Gerbil
Dias,Fernando José; Oliveira,Richard Honorato de; Issa,Jo?o Paulo Mardegan; Regalo,Simone Cecílio Hallak; Souza,Valéria O. Pagnano de; Catirse,Alma Blásida C. E. B; Iyomasa,Mamie Mizusaki;
International Journal of Morphology , 2010, DOI: 10.4067/S0717-95022010000400027
Abstract: considering the biomechanical aspects, many facts need to be understood on the mandible, to know which effects unilateral occlusal changes may cause on the stomatognathic system. the aim of this study was to analyze the malocclusion by unilateral teeth extraction on the mandible morphology in gerbil. we used 10 gerbils meriones unguiculatus, young male, weighing around 50-60g, divided into two groups (n=5), an experimental group and control, which evaluated the two hemi-mandibles, with a total of 20 samples which were measured by digital pachymeter. the measures were taken: (1) length and (2) width of the mandible condyle and (3) body height in the region of mandibular 1st molar. data from these measurements were analyzed using anova and mann-whitney test. the results of this study showed a statistically significant difference in the three measures between experimental and control groups. the width of the mandible head (condyle) showed statistical difference between the ipsilateral and contralateral sides to teeth extraction. it was concluded that the mastication modification by unilateral teeth extraction caused an imbalance, promoting not only a modification in the craniofacial growth pattern, but also a harmful effect on the stomatognathic system of the gerbil used as an experimental model in this study.
MORPHOLOGIC STUDY OF THE MASSETER MUSCLE OF GERBIL (Meriones unguiculatus)
Oliveira,J. J.; Iyomasa,M. M.; Mizusaki,C. I.; Lopes,R . A.; Watanabe,I.; De Oliveira,A. M.; Olave,E.;
Revista chilena de anatomía , 2000, DOI: 10.4067/S0716-98682000000200011
Abstract: the injury of the masticatory muscles related with craniomandibulars disorders are common in clinical aspects. therefore, morphologic date of these muscles are important to understand the stomatognatic system. the purpose of this paper is to show the morphology of the masseter muscle of gerbil meriones unguiculatus using the macroscopic and scanning electron microscopy. for macroscopic observation, were used 5 animals. the animals were perfused with 10% formol solution. they were dissections to observe and to photography. after then, the muscles were removed and immersed in formalin solution for a few days. the specimens were processed by the conventional histologic technique and embbeded in paraffin. seried sections with 6 μm thickness were stainned with h. e. and analysed and photographed in jenamed photomicroscope. our results showed that the masseter muscle presents 5 bundles which mix itself in middle portion, and some spindles were fusionned by the external capsule of themselves, as a giant spindles.
Photoperiodic Control of Testis Activity in the Mongolian Gerbil (Meriones unguiculatus)
B.Gunduz,A. Karakas
Journal of Medical Sciences , 2001,
Abstract: The purpose of research work was to examine the effects of different photoperiods (24L:0D; 14L:10D; 8L:16D and OL:24D) on testes and accessory sex organs in mature male Mongolian gerbils (Meriones unguiculatus). 14L born and raised animals with functional testes were held under four different photoperiods for ten weeks. Testicular size were measured every week for ten weeks. At sacrifice, testes of 14L animals were large and showed full spermatogenesis and possessed tall columnar epithelial cells and secretion in the lumen of seminal vesicles. Transfer to 24L, 8L, or 0L resulted in a decrease in testes size; the seminal vesicles had an epithelium with low columnar or cuboidal cells and contained a reduced amount of secretion in lumen. The histological appearances of testes were similar in 24L, 8L and 0L. Therefore, very long and short photoperiods have a strong effect on reproductive system in this species.
PERCOBAAN ENTEROMEGALI PADA MENCIT DAN GERBIL (MERIONES UNGUICULATUS) DISEBABKAN SULFAS ATROPIN DAN CHLORPROMAZINE HCL
Iwan T. Budiarso,Roedyanto Tjokrosapoetro,Frans Sukardi,Irma Hassan
Bulletin of Health Research , 2012,
Abstract: Seventy nine mice and 18 gerbils were used in this experiment. The Chlorpromazine Group con-sisted of 39 mice and 12 gerbils. Each animal was injected with Chlorpromazine HQ 50 mg per kilogram body weight. Injections were administered twice a week for a period of 10 weeks. Clinical signs were only found in mice. Abdominal distention was transient in few animals and persisted in few others until the experiment was terminated. Few animals, without signs of meteorismus, developed priapismus and semenal discharge. The gut weight expressed in percentage of the total body weight of the enteromegalic mice was above 13 %, whereas that of the control animals varied between 6.3 % and 12.4 %. One gerbil developed segmental hydrosalpinx. Forty mice and 6 gerbils in the Sulfas Atropin Group were treated similarly as those of the Chlor-promazine Group, but injected with Atropini Sulfas daily at the rate of 0.330 mg to 0.660 mgper kilo-gram body weight for 14 or 20 days. Abdominal distention and/or enteromegaly did not occur at the termination of the experiment.
Effect of L-Deprenyl on the Putrescine Level and Neuronal Damage after Transient Global Cerebral Ischemia in Gerbils  [PDF]
Hyung Lee, Yeun-Kyung Chu, Joon-Ho Shon, Kyung-Hee Chun, Jee-In Kim, Seong-Ryong Lee
International Journal of Organic Chemistry (IJOC) , 2017, DOI: 10.4236/ijoc.2017.72014
Abstract: L-Deprenyl is selective and irreversible monoamine oxidase B inhibitor, known to have neuroprotective properties. Putrescine, one of polyamine, is thought to be important in the neuronal cell damage associated with various type of excitatory neurotoxicity. We examined the effects of L-deprenyl on the changes in putrescine level and neuronal damage after transient global ischemia in ger-bils. Male Mongolian gerbils weighing 65 - 75 g were used in the experiment. Global ischemia was induced by occlusion of common carotid arteries for 3 min to observe neuronal injury in hippocampal pyramidal cells. L-Deprenyl group was given 10 mg/kg of L-deprenyl intraperitoneally immediately after, 3 h and 6 h after global ischemia. Treated animals were processed in parallel with ischemic animals receiving saline as a vehicle and with sham- operated controls. Hippocampal putrescine level was increased by global ischemia and inhibited by L-deprenyl treatment. In histological findings, counts of viable neurons were made in the pyramidal cell layer of the hippocampal CA1 area 3 days after ischemic insult. The number of viable neurons in the pyramidal cell layer of CA1 area was significantly increased in animals treated with L-deprenyl compared to vehicle-treated ischemic animals (p < 0.05). In terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick endlabeling (TUNEL) assay, semiquantitative analysis of dark-brown neuronal cells was made in the hippocampal CA1 area. There was also a significant difference in the degree of TUNEL staining in the hippocampal CA1 area between vehi-cle-treated and L-deprenyl-treated animals (p < 0.05). These data show L-deprenyl is effective as a prophylactic treatment for neuronal injury when it is administrated before ischemia but a further study need to know the effects of administration of L-deprenyl after ischemia and at given times after reper-fusion.
MORPHOLOGIC STUDY OF THE MASSETER MUSCLE OF GERBIL (Meriones unguiculatus) ESTUDIO MORFOLóGICO DEL MúSCULO MASETERO DEL GERBIL (Meriones unguiculatus)
J. J. Oliveira,M. M. Iyomasa,C. I. Mizusaki,R . A. Lopes
Revista chilena de anatomía , 2000,
Abstract: The injury of the masticatory muscles related with craniomandibulars disorders are common in clinical aspects. Therefore, morphologic date of these muscles are important to understand the stomatognatic system. The purpose of this paper is to show the morphology of the masseter muscle of gerbil Meriones unguiculatus using the macroscopic and scanning electron microscopy. For macroscopic observation, were used 5 animals. The animals were perfused with 10% formol solution. They were dissections to observe and to photography. After then, the muscles were removed and immersed in formalin solution for a few days. The specimens were processed by the conventional histologic technique and embbeded in paraffin. Seried sections with 6 μm thickness were stainned with H. E. and analysed and photographed in JENAMED photomicroscope. Our results showed that the masseter muscle presents 5 bundles which mix itself in middle portion, and some spindles were fusionned by the external capsule of themselves, as a giant spindles. El da o de los músculos masticadores relacionados con desórdenes cráneomandibulares son aspectos comunes en la clínica. Es importante contar con datos morfológicos de estos músculos en el sistema estomatognático. El propósito de este trabajo es mostrar la morfología del músculo masetero del gerbil Meriones unguiculatus, desde el nivel macroscópico hasta el de microscopía electrónica. En la observación macroscópica fueron utilizados 5 animales que fueron perfundidos con solución de formalina al 10%. Las disecciones fueron fotografiadas. Posteriormente, los músculos fueron removidos e sumergidos en la solución de formalina, por unos pocos días. Las muestras fueron procesadas a través de técnicas histológicas convencionales y sumergidas en parafina. Cortes seriados de 6 μm fueron te idos con H. E. analizados y fotografiados con un fotomicroscopio JENAMED. Nuestros resultados mostraron que el músculo masetero presentaba 5 fascículos, los cuales se mezclaban en la porción media, y algunos husos estaban fusionados con la cápsula externa de ellos mismos, pareciendo husos gigantes
Clinical and Histochemical Alterations of the Periodontal Ligament in Gerbils after Malocclusion Induced
Naves,Leandro Moura Leite; Issa,Jo?o Paulo Mardegan; Pitol,Dimitrius Leonardo; Fukada,Sandra Yasuyo; di Matteo,Miguel ángel Sala; Iyomasa,Mamie Mizusaki;
International Journal of Morphology , 2007, DOI: 10.4067/S0717-95022007000400036
Abstract: the aim of this article is to show the clinical and histochemical alterations of the first periodontal ligament, on the right side, after upper molars teeth extraction on the left side in gerbils. after two months, the periodontal ligaments were removed and processed for histochemical analysis. the data showed that trap reaction was able to evidence the osteoclastic activity in the hyperfunction hemimandible, right side, explaining the functional changes in the periodontal ligament after teeth extraction, and a little gingival recession and radicular exposure of teeth without function was observed at inferior molars of the left side
Comportamiento de la infección experimental por aislamientos colombianos de Giardia duodenalis en el modelo animal del gerbo ( Meriones unguiculatus)
Arévalo,Adriana; Duque,Sofía; Nicholls,Rubén Santiago;
Biomédica , 2005,
Abstract: introduction. natural and experimental giardia infections have been reported from bovines, equines, goats, canines, felines and rodents such as mice, rats and gerbils. the latter have provided successful animal models for giardia duodenalis and giardia muris experimental infections. objective. the gerbil model was used to establish the pattern of infection of colombian giardia human isolates. materials and methods. giardia cysts were obtained from stool specimens of symptomatic giardiasis patients by means of sucrose-percoll gradients. animal inoculation was performed by gastric intubation and injection with 5x103 giardia cysts. the course of infection was established by counting cysts every day and trophozoites weekly throughout a period of 30 days. results. the pattern of cyst excretion was found to be intermittent. cysts were released during the second and third weeks of infection but not during the first or fourth weeks. the mean minimal number of cysts released per 2-hr collection period was 79 and the mean maximum number was 17,943. colonization of the small intestine by trophozoites was observed with a mean number ranging from 15,000 to 6,577,778 trophozoites/ml. discussion and conclusions. gerbils inoculated with g. duodenalis isolates obtained from geographical areas outside colombia resolved the infection between 86 and 114 days after infection, whereas gerbils infected with colombian g. duodenalis isolates resolved the infection at 30 days. the gerbil proved to be a good animal model for experimental infection with colombian isolates of g. duodenalis. experimental giardia infection of gerbils permit a sufficient yield of cysts and trophozoites to be used as antigens for the immunization of other animals and to obtain giardia antibodies that could be used for giardia antigen detection assays in stool specimens.
Contribution of animal models to the research of the causes of diabetes
Eleazar Shafrir
World Journal of Diabetes , 2010,
Abstract: In most publications, animal models of diabetes have mainly been investigated for their multiple etiologies as well as for changes leading to diabetes and their genetic derivation. Aspects which seem important and need a special research endeavor are the mechanism of the causes of diabetes and the lapse into complications in different species, their molecular basis and possible arrest and prevention. A concise list and and short discussion of the intensively studied rodents is presented of spontaneous or nutritional background causing Type 2 diabetes but omitting diabetes evoked by transgenic manipulations or gene knockout techniques.
Tyrosinase (Tyr) Gene Mutation in Albino Mongolian Gerbil (Meriones unguiculatus)  [PDF]
Takao Ukaji, Masahiro A. Iwasa, Osamu Kai
Open Journal of Animal Sciences (OJAS) , 2016, DOI: 10.4236/ojas.2016.64031
Abstract:
Tyrosinase is encoded by the Tyr (c or albino) locus and is the key enzyme in pigment biosynthesis. Loss of function of this enzyme caused by gene mutation results in albinism. Most cases of albinism are caused by missense mutations of tyrosinase. Albino mutations in Tyr have been identified in various animals, including human, mouse, rat, rabbit, cattle, cat, and ferret, but not in gerbil. We created two new gerbil strains: MON/Num/a (inbred agouti phenotype) and MON/Num/c (albino phenotype). Here, we report that four nucleotide substitutions in the Tyr gene caused two missense mutations in amino acids in the albino gerbil: a G-to-A mutation at position 204 in exon 1 caused R77H, and A-to-G at position 1392 and G-to-T at position 1393 in exon 5 caused Q473R. The substitution at position 1408 in exon 5 was silent. These missense mutations are conserved in all albino phenotypes we tested. Therefore, we suggest that these mutations are responsible for albinism in gerbil.
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