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Search Results: 1 - 10 of 3941 matches for " Geraldo Barroso;Klumb "
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Chromosome 17 abnormalities and mutation of the TP53 gene: correlation between cytogenetics, flow cytometry and molecular analysis in three cases of chronic myeloid leukemia
Otero, Luize;Cavalcanti Júnior, Geraldo Barroso;Klumb, Claudete Esteves;Scheiner, Marcos Antonio Mauricio;Magluta, Eliane Pereira Sim?es;Fernandez, Teresa de Souza;Silva, Maria Luiza Macedo;Pires, Virgínia;Andrade, Gabriela Vasconcelos;Maia, Raquel Ciuvalschi;Tabak, Daniel;
Genetics and Molecular Biology , 2005, DOI: 10.1590/S1415-47572005000100007
Abstract: chronic myeloid leukemia (cml) have been described. this chromosomal region contains the tumor suppressor gene tp53 that may be an important factor in the evolution of this disease. in this study, we used flow cytometry and western blotting to assess p53 protein expression and single stranded conformational polymorphism to examine tp53 gene alterations in three patients with cml who showed alterations in 17p. only the case with del(17)(p11) had p53 expression positive by flow cytometry and an abnormal migration pattern by sscp analysis. the importance of the correlation between the results obtained with these techniques, as well as the clinical course of the patients, are discussed.
Crise da escola ou na escola? Uma análise da crise de sentido dos sistemas públicos de escolariza??o obrigatória
Barroso,Geraldo;
Revista Portuguesa de Educa??o , 2008,
Abstract: this study discusses the meaning that are ascribed to the crisis of public (state) schools of compulsory attendance in the educational critical literature published since the last decades of the 20th century, both in brazil and portugal. it lists the optimistc expectations that impelled the massification of schooling after the second world war and compares them with the impasses that the public systems of education are confronting, at the beginning of the 21o century, and which are largely due to the unfulfilled promises of modernity. it also deals with the impact of the changes of globalised cultures and economies, multicultural societies, accelerated information, and nation-states deflated of their historical functions in the configuration of that crisis; it deals as well with the different estrategies that have been designed, both in brazil and in portugal, in order to overcome this crisis.
Crise da escola ou na escola? Uma análise da crise de sentido dos sistemas públicos de escolariza o obrigatória
Geraldo Barroso
Revista Portuguesa de Educa??o , 2008,
Abstract: This study discusses the meaning that are ascribed to the crisis of public (state) schools of compulsory attendance in the educational critical literature published since the last decades of the 20th century, both in Brazil and Portugal. It lists the optimistc expectations that impelled the massification of schooling after the Second World War and compares them with the impasses that the public systems of education are confronting, at the beginning of the 21o century, and which are largely due to the unfulfilled promises of modernity. It also deals with the impact of the changes of globalised cultures and economies, multicultural societies, accelerated information, and Nation-States deflated of their historical functions in the configuration of that crisis; it deals as well with the different estrategies that have been designed, both in Brazil and in Portugal, in order to overcome this crisis.
Avalia??o dos métodos de detec??o das altera??es do gene e proteína P53 nas neoplasias linfóides
Klumb, Claudete E.;Cavalcanti Júnior, Geraldo B.;
Revista Brasileira de Hematologia e Hemoterapia , 2002, DOI: 10.1590/S1516-84842002000200008
Abstract: the p53 protein plays a central role in cellular responses, including cycle arrest and cell death in response to dna damage. dysfunction of this protein can induce abnormal cell growth, increased cell survival, and drug resistance. the p53 tumor suppressor gene is altered in many types of human cancer including hematological malignancies. most of the p53 biologically significant mutations impair the ability of protein to act as a transcriptional regulator. unlike functional p53, which is rapidly degraded after its synthesis, mutated forms tend to accumulate in the cells, thus becoming detectable by immunohistochemistry. its has been reported that mutations of p53 gene occur with a frequency of approximately 12.5% in lymphoid malignancies. however, aggressive non-hodgkin's lymphomas (nhl), especially burkitt's lymphoma, show higher frequencies. most p53 gene mutations in nhl are missense mutations, stabilising the functionally defective protein, but wild-type form of p53 protein also has a high p53 expression detected by immunohistochemistry indicating a discrepancy between gene mutation and protein detection. the aim of this work is to perform a comprehensive review of the methods used to identify gene alterations and p53 protein expression in lymphoid neoplasias in order to investigate its involvement in these neoplasias.
Avalia o dos métodos de detec o das altera es do gene e proteína P53 nas neoplasias linfóides
Klumb Claudete E.,Cavalcanti Júnior Geraldo B.
Revista Brasileira de Hematologia e Hemoterapia , 2002,
Abstract: A proteína p53 desempenha um papel central na resposta celular que inclui a parada do ciclo celular permitindo o reparo do dano no DNA, ou indu o da morte celular. A perda da fun o dessa proteína pode levar à prolifera o celular desordenada, aumento da sobrevida da célula e resistência às drogas quimioterápicas. O gene supressor de tumor p53 é alterado em diversas neoplasias, entre as quais se incluem as neoplasias hematológicas. Estas altera es s o, em sua maioria, muta es que levam à perda da capacidade da proteína p53 de regular a transcri o de diversos genes envolvidos em importantes processos da célula. Ao contrário da proteína selvagem, cuja degrada o ocorre rapidamente depois da síntese, as formas mutadas da proteína têm a meia vida aumentada e se acumulam dentro da célula possibilitando a detec o por imunohistoquímica. As muta es do gene p53 ocorrem com uma freqüência em torno de 12.5% nas neoplasias hematológicas, no entanto, em alguns tipos de linfomas n o Hodgkin (LNH), particularmente, nos linfomas de Burkitt, freqüências superiores têm sido observadas. A maior parte das muta es do gene p53 s o muta es do tipo missense e ocasionam perda da fun o e estabiliza o da proteína. Entretanto, alta express o da proteína selvagem também tem sido detectada por imunohistoquímica, o que indica uma discrepancia entre muta es do gene e detec o da proteína. O objetivo deste trabalho é realizar uma revis o dos métodos usados para identificar as altera es do gene e da proteína p53 com ênfase nas neoplasias linfóides, visando determinar o seu envolvimento nessas neoplasias.
Freqüência de síndrome metabólica em pacientes com nefrite lúpica
Cunha, Bernardo Matos da;Klumb, Evandro Mendes;Moura, Jaqueline Quintanilha;Santos, Amanda;Pinheiro, Geraldo da Rocha Castelar;Albuquerque, Elisa M. N.;Levy, Roger Abramino;
Revista Brasileira de Reumatologia , 2008, DOI: 10.1590/S0482-50042008000500003
Abstract: introduction: patients with systemic lupus erythematosus (sle) have n increased morbidity due to cardiovascular diseases (cvd). metabolic syndrome (ms) is a complex syndrome composed by a cluster of cardiovascular risk factors. objectives: study the prevalence of ms in a cohort of brazilian patients with lupus nephritis in a university hospital; evaluate its impact in disease outcome, and the frequency of each specific risk factor. methods: 46 patients with lupus nephritis were studied and defined as having or not ms in accordance with the national cholesterol education program - adult treatment panel iii (ncep-atp iii) criteria. results: ms was present in 30.4% of patients. there was significant association between ms presence and low levels of creatinine clearance and high levels of blood creatinine (p < 0.04 and p < 0.008, respectively). the class of lupus nephritis, the disease duration, cumulative dose of prednisone, 24-hour urine protein and systemic lupus international collaborating clinics (slicc) score were not significantly associated with ms. conclusion: in our cohort of patients with lupus nephritis there was a high prevalence of ms, comparable to international data. the only factors associated with ms in that population were the ones that define chronic renal damage.
Análise de demanda para o tratamento estético de pacientes na Regi o Tocantina (Brasil)
Ana Lúcia Barrêto Gomes,Dany Geraldo Kramer Cavalcanti e Silva,Geraldo Barroso Cavalcanti Júnior,Aurean de Paula Carvalho
Ciência & Desenvolvimento , 2010,
Abstract:
Growth of bare root Pinus taeda, L. seedlings cultivated under five densities in nursery
Carneiro, José Geraldo de Araújo;Barroso, Deborah Guerra;Soares, Luis Maurício da Silva;
Scientia Agricola , 2007, DOI: 10.1590/S0103-90162007000100004
Abstract: seedlings compete for nutrients, water and light. the available area for each seedling affects their behavior related to requirements for these resources. this experiment evaluated the influence of five plant densities on the growth of bare root pinus taeda, l. seedlings in a nursery after outplanting. the analyzed characteristics were: height (h), root collar diameter (d), h/d ratio, and dry matter weight. higher densities stimulated h growth and the lowest densities increased d average and dry matter weight and lowered the h/d ratio. seedlings were distributed by h, d and h/d classes. higher densities had a larger number of seedlings in larger h classes. larger numbers of seedlings with larger d and lower h/d ratios were found in lower densities. ten months after outplanting the seedlings grown in lower densities had higher survival percentages and growth. some saplings of standardized heights were uprooted with the objective of studying their root systems. the lowest densities stimulated higher numbers of first and second order roots as well as fresh and dry matter weights of thin roots with mycorrhizae presence. in both parts of the experiment, the density of 278 seedlings m-2 yielded equivalent averages as compared to the lowest densities.
Crescimento de mudas de Anadenanthera macrocarpa (Benth) Brenan (angico -vermelho) em substrato fertilizado e inoculado com rizóbio
Chaves, Luciana de Lima Brand?o;Carneiro, José Geraldo de Araújo;Barroso, Deborah Guerra;
Revista árvore , 2006, DOI: 10.1590/S0100-67622006000600006
Abstract: seedlings of anadenanthera macrocarpa (red angico) were grown in 18 x 15 cm black polyethylene bags. the growth medium was sieved and mixed with residues of sugarcane bagasse + decomposed filter cake (3:2, v:v) the objective was the evaluation of the fertilization and inoculation with rhizobium on the quality of the seedlings. two experiments were carried out. in each one, separately, ammonium sulfate and ammonium nitrate were added, in three different doses. in both experiments, a specific rhizobium species was also inoculated together with the seeds. a completely randomized design with three replicates was used. at 180 days after sowing, the seedlings were evaluated for height (h), root collar diameter (d), h/d ratio, shoot and root dry matter weights, leaf area and root regeneration potential. it was concluded that inoculation with rhizobium was sufficient to stimulate growth of "red-angico" seedlings in this substrate. the tested fertilizers were not efficient for the stimulation of seedling growth.
Substrato de cavas de extra o de argila enriquecido com subprodutos agroindustriais e urbanos para produ o de mudas de sesbania
Coutinho Marcos Pellegrini,Carneiro José Geraldo de Araújo,Barroso Deborah Guerra,Rodrigues Luciana Aparecida
Revista árvore , 2006,
Abstract: O trabalho teve como objetivo avaliar o crescimento, em casa de vegeta o, de mudas de Sesbania virgata (Cav.) Pers., produzidas em substrato de cavas de extra o de argila e adubadas com subprodutos organicos. As mudas foram cultivadas em vasos de 5 L, adicionando-se ao substrato "ferkal", composto de lixo urbano e torta de filtro, em diferentes doses (40, 80, 120 e 160 g dm-3), e comparadas com o controle (sem aduba o). O experimento foi conduzido em delineamento inteiramente casualizado, com cinco repeti es, constituídas de uma planta. Aos quatro meses após a semeadura, foram feitas avalia es de altura, diametro do colo, matéria seca da parte aérea e de raízes laterais. Também foram determinados comprimento, área superficial das raízes laterais, coloniza o micorrízica e teores foliares de N, P e K. O substrato sem aduba o originou mudas com maiores dimens es de altura, diametro do colo e matéria seca da parte aérea. Contudo, n o houve diferen as com rela o à matéria seca, comprimento e área superficial das raízes e coloniza o micorrízica, entre os tratamentos. Constatou-se tendência de crescimento dos valores das características morfológicas da parte aérea das mudas, à medida que as doses foram aumentadas. Os teores foliares de N, P e K das mudas que n o receberam adi o dos subprodutos foram menores em rela o às mudas adubadas. Os resultados evidenciaram que o uso de sesbania para revegeta o de cavas de extra o de argila n o implica gastos adicionais com fertilizantes organicos. Entretanto, a adi o dos subprodutos estudados pode favorecer a forma o de serapilheira mais rica em nutrientes.
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