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Search Results: 1 - 10 of 1303 matches for " Georgios Decavalas "
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ErbB Receptors and ErbB Targeted Therapies in Endometrial Cancer  [PDF]
Georgios Androutsopoulos, Georgios Michail, Georgios Adonakis, Georgios Decavalas
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.56055

The Epidermal Growth Factor system is present in human organs and plays an important role in cell proliferation, differentiation and apoptosis during embryogenesis and postnatal development. It has four receptors (EGFR, ErbB-2, ErbB-3 and ErbB-4) and numerous ligands. Dysregulation of the Epidermal Growth Factor signaling network is implicated in the pathogenesis of various disorders. Especially in cancer, the Epidermal Growth Factor system becomes hyperactivated with various mechanisms (ligand overproduction, receptor overproduction, constitutive receptor activation). EGFR overexpression may have a dual role in endometrial cancer. It seems that in type I endometrial cancer, EGFR overexpression did not affect disease progression. However in type II endometrial cancer, EGFR overexpression associated with high grade disease and adverse clinical outcome. Moreover ΕrbB-2 overexpression especially in type II endometrial cancer, is an indicator of a highly aggressive disease with poor overall survival. The potential role of ErbB receptors (especially EGFR and ErbB-2) as targets for cancer therapy has been investigated for over 20 years. There are 2 major classes of ErbB targeted therapies: anti-ErbB monoclonal antibodies (MoAbs) and ErbB-specific tyrosine kinase inhibitors (TKIs). ErbB targeted therapies have still shown modest effect in unselected endometrial cancer patients. However, they may be clinically active as adjuvant therapy in well-defined subgroups of type II endometrial cancer patients with EGFR and ErbB-2 overexpression.

Systemic Sclerosis and Multiple Cancers of the Female Genital Tract: Prolonged Survival following Current Treatment Strategies
Georgios Androutsopoulos,Georgios Adonakis,Athanasios Tsamandas,Andreas Andonopoulos,Georgios Decavalas
Case Reports in Rheumatology , 2011, DOI: 10.1155/2011/392068
Abstract: Background. Systemic sclerosis is a rare, chronic, multisystem, and autoimmune disease. There is an overall increased risk of malignancy in patients with systemic sclerosis. However, multiple cancers of the female genital tract in patients with SSc are a very rare event. Our aim is to present a case of SSc and multiple cancers of the female genital tract, with prolonged survival following current treatment strategies. Case. The patient, a 43-year-old nulliparous premenopausal Greek woman suffering from systemic sclerosis, presented with a history of abdominal pain and abnormal uterine bleeding. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, total omentectomy, appendectomy, and pelvic lymph node dissection. The histopathology revealed synchronous primary cancers of the endometrium and left ovary. The final diagnosis was stage Ib endometrial cancer endometrioid type and stage IIIc ovarian cancer endometrioid type. She underwent postoperative adjuvant chemotherapy and remains well without evidence of disease 89 months after initial surgery. Conclusion. Although our patient was diagnosed at advanced stage disease, prolonged survival may be related with radical surgery and postoperative adjuvant chemotherapy according to current treatment strategies.
Vaginal Primary Malignant Melanoma: A Rare and Aggressive Tumor
Georgios Androutsopoulos,Emmanouil Terzakis,Georgia Ioannidou,Athanasios Tsamandas,Georgios Decavalas
Case Reports in Obstetrics and Gynecology , 2013, DOI: 10.1155/2013/137908
Abstract: Vaginal primary malignant melanoma is a rare and very aggressive tumor. It most commonly occurs in postmenopausal women, with a mean age of 57 years. Our patient is an 80-year-old, postmenopausal Greek woman presented with a complaint of abnormal vaginal bleeding. On gynecologic examination there was a pigmented, raised, ulcerated, and irregular lesion ?cm in the upper third of anterior vaginal wall. She underwent a wide local excision of the lesion. The histopathology revealed vaginal primary malignant melanoma with ulceration and no clear surgical margins. She denied any additional surgical interventions and underwent to postoperative adjuvant radiotherapy. Follow up 5 months after initial diagnosis revealed no evidence of local recurrence or distant metastasis. The prognosis of vaginal primary malignant melanoma is very poor despite treatment modality, because most of the cases are diagnosed at advanced stage. Particularly patients with no clear surgical margins and tumor size >3?cm needed postoperative adjuvant radiotherapy. 1. Introduction Vaginal primary malignant melanoma (VPMM) is a rare and very aggressive tumor [1, 2]. It accounts for 0.3–0.8% of all malignant melanomas, 2–5% of female genital tract melanomas, and less than 3% of all vaginal malignancies [1–3]. About 250 cases have been reported in the English literature [1, 2]. The estimated incidence of VPMM is 0.026/100,000 women per year [2, 3]. It most commonly occurs in postmenopausal women, with a mean age of 57 years [4–6]. There are no significant differences in VPMM incidence, between various racial or ethnic groups [3, 7]. The precise etiology of VPMM is relative unknown [8]. It is thought that VPMM arises from melanocytes present in the vaginal epithelium [8, 9]. However, it is obvious that ultraviolet radiation is not the causal factor in VPMM [7]. Our aim is to present a case of VPMM that underwent a wide local excision and postoperative adjuvant radiotherapy. 2. Case Presentation The patient, an 80-year-old, gravida 3, para 2 postmenopausal Greek woman, presented to the Department of Obstetrics and Gynecology of the University of Patras Medical School with a complaint of abnormal vaginal bleeding. Her medical history included hypertension and diabetes mellitus. She had menopause at the age of 50. Her surgical history was unremarkable. Her family history revealed no evidence of cancer among the first-degree relatives. On gynecologic examination there was a pigmented, raised, ulcerated, and irregular lesion ?cm in the upper third of anterior vaginal wall. There were no palpable
Necrotizing Fasciitis Complicating Pregnancy: A Case Report and Literature Review
Marinos Nikolaou,Petros Zampakis,Vasiliki Vervita,Konstantinos Almaloglou,Georgios Adonakis,Markos Marangos,Georgios Decavalas
Case Reports in Obstetrics and Gynecology , 2014, DOI: 10.1155/2014/505410
Abstract: Necrotizing fasciitis is a rare, life-threatening surgical infection in pregnancy with high rates of morbidity and mortality. A 15-year-old primigravid woman, at 28?weeks of gestation with no significant previous medical history, was admitted to our hospital complaining of severe left lower extremity pain and high fever the last 72?hours. During clinical examination, she had a swollen, erythematous and tender to palpation inflamed skin over the medial aspect of the upper thigh without any evidence of injury. Incision drainage was performed immediately and she received broad spectrum antibiotics. During initial laboratory examinations, diabetes mellitus was diagnosed. There was no clinical improvement over the following days. Magnetic resonance imaging (MRI) revealed subcutaneous tissue inflammation and edema of infected tissues confirming the disease entity. Multidisciplinary therapy with immediate aggressive surgical debridement of necrotic tissues, multiple antibiotics, and intensive care monitoring was performed successfully. The patient’s postoperative course was uncomplicated and skin defect was closed with split thickness skin grafting. Our case emphasized the potential immunosuppressive role of pregnancy state in conjunction with diabetes mellitus in the development of severe necrotizing soft tissue infections. 1. Introduction Necrotizing fasciitis (NF) is a rare life-threatening invasive soft tissue infection which is characterized by widespread necrosis of subcutaneous tissue, superficial fascia, and other adjacent tissue [1]. It is a surgical emergency with reported overall high mortality rate among patients with NF up to 76% [2]. It primarily involves the subcutaneous tissue and rapidly extends along superficial fascia planes [3]. Management of NF is based on early, aggressive surgical debridement of necrotic tissues, broad spectrum antibiotics, and intensive supportive care [3, 4]. Numerous aerobic and anaerobic pathogens are synergistically implicated in the pathogenesis of disease [1, 5]. NF occurs mainly in patients with predisposing factors such as diabetes mellitus, obesity, peripheral vascular disease, and immune system impairment or following a variety of injuries and surgical procedures which result in skin integrity interruption and rarely from hematogenous spread [2, 5]. Pregnancy is responsible for an immunosuppressive state, which may contribute to the development of severe necrotic soft tissue infections [6, 7]. Previous studies have showed that NF in pregnancy is rare and usually is characterized by acute onset and rapid
Liquid Column Deformation and Particle Size Distribution in Gas Atomization  [PDF]
Georgios S. E. Antipas
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.22012
Abstract: A water-gas flow injected by a close coupled atomizer was studied via High Speed Photography and Phase Doppler Anemometry. The formation of a wave disturbance on the surface of the water column was confirmed. The flow converged within an area approximately 3 mm in diameter, independent of atomization conditions. The particle size distribution across the spray suggested a trend of decreasing particle sizes and particle velocities with increasing distance from the spray axis of symmetry.
Ore Microscopy and Microanalysis of the Nickeliferous Iron Ores from Komnina Vermion Area (N.W. Greece)  [PDF]
Georgios Alevizos, Eftychia Repouskou
Geomaterials (GM) , 2011, DOI: 10.4236/gm.2011.12008
Abstract: Nickel laterites are considerable sources of nickel. To be successfully exploited it is important to know the mineralogical and microstructural characteristics of the ore. Besides, the identification of the mineralogical components as well as the fabric description, can lead to the interpretation of the mechanism of deposit genesis. The aim of the present study is the microscopic and microanalytical investigation of the Fe-Ni ores from Komnina Vermion area (N.W. Greece). The mineralogical composition of the ore is mainly hematite, quartz, chromite and chlorite, while in minor quantities goethite, nickeliferous chlorite, serpentine, talc and calcite are also present. The ore structure is allotriomorphic inequigranular and the texture is oolitic-pisolitic. According to microscopic examination the deposit can be registered as a secondary pseudo-autochthonous.
The Transmission Channels between Financial Sector and Real Economy in Light of the Current Financial Crisis a Critical Survey of the Literature  [PDF]
Georgios L. Vousinas
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.44028

The present study undertakes a critical review of the research around the major issue of the transmission channels between financial sector and real economy. The aim of the study is to shed light on the interaction between the financial system and the economy, in the shadow of the current crisis. The literature documents the importance of these channels in the determination of economic activity and therefore, real economy as a whole. The study highlights the emergence of the liquidity channel as a key factor of the transmission of bank credit shocks to real economy and underlines the existing “regulation gaps”. The paper concludes that the financial sector plays an even more crucial role these days and drastic measures along with intense supervision must be undertaken so as to work properly and serve the economic world.

Eurasian Economic Community: Towards Integration. Economic Challenges and Geostrategic Aspects  [PDF]
Georgios L. Vousinas
Modern Economy (ME) , 2014, DOI: 10.4236/me.2014.59088

The present study deals with Eurasian Economic Community (EurAsEC), a relatively new entity that appeared in the post-Soviet region, which tries to join the neighboring countries into a strong and structured union. The paper presents the integration steps that have been taken so far and examines the economic challenges faced as well as the geostrategic aspects. A comparison with the benchmark of the surrounding area, the European Union, is also undertaken in order to investigate both the similarities and differences among them and show if they could co-exist in the years to come. The main purpose of this study is to examine the reasons for the union’s formation, shed light on its economic prospects and highlight the newly established geostrategic conditions in such a crucial territory of the world.

Trends in Central Bank Transparency  [PDF]
Georgios Oikonomou, Eleftherios Spyromitros
Theoretical Economics Letters (TEL) , 2017, DOI: 10.4236/tel.2017.77142
Abstract: In this paper we have updated Central Bank Transparency Index from 2011 to 2016, following the methodology of Eijffinger and Geraats (2006) [1]. Then, we break down the index’s aspects and we analyze which are more likely to be changed through time. This, in respect to the annual data we have collected, makes clearer how the recent financial crisis has affected the Central Banks’ transparency trend and offers interesting insights for monetary policy transmission. Also, we divided the countries into developed, emerging and frontiers, as there is difference in their indexes changes, probably related to their economic and financial development.
Strong Electric Field in 2D Graphene: The Integer Quantum Hall Regime from a Different (Many-Body) Perspective  [PDF]
Georgios Konstantinou, Konstantinos Moulopoulos
Advances in Materials Physics and Chemistry (AMPC) , 2018, DOI: 10.4236/ampc.2018.81003
Abstract: We investigate the emerging consequences of an applied strong in-plane electric field on a macroscopically large graphene sheet subjected to a perpendicular magnetic field, by determining in exact analytical form various many-body thermodynamic properties and the Hall coefficient. The results suggest exotic possibilities that necessitate very careful experimental investigation. In this alternate form of Quantum Hall Effect, non-linear phenomena related to the global magnetization, energy and Hall conductivity (the latter depending on the strengths of magnetic B- and electric E-fields) emerge without using perturbation methods, to all orders of E-field and B-field strengths. Interestingly enough, when the value of the electric field is sufficiently strong, fractional quantization also emerges, whose topological stability has to be verified.
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