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Search Results: 1 - 10 of 521 matches for " Georgiev OB "
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The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis
Cherneva RV,Georgiev OB,Petrova DS,Trifonova NL
International Journal of COPD , 2012,
Abstract: Radostina V Cherneva,1 Ognian B Georgiev,1 Daniela S Petrova,1 Nedka L Trifonova,2 Maria Stamenova,2 Vesela I Ivanova,3 Veselin I Vlasov31Clinic of Internal Medicine, Division of Pulmonology, University Hospital Alexandrovska, Sofia, Bulgaria; 2Department of Biology, 3Department of Pathology, Medical University of Sofia, Sofia, BulgariaBackground: αB-crystallin (HspB5) is a chaperone whose role as a marker of innate immunity activation as well as its therapeutic potential have recently been investigated in several inflammatory diseases: multiple sclerosis, myocardial ischemia, and Guillain–Barré syndrome.Aim: The aim of this study is to determine the role of αB-crystallin in chronic obstructive pulmonary disease (COPD) pathogenesis and inflammation.Materials: Plasma levels of αB-crystallin were studied in 163 patients: 52 healthy non-COPD smokers; 20 COPD smokers in Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages I–II; 43 COPD smokers in GOLD stages III-IV. Forty-eight patients were diagnosed with acute inflammatory respiratory disease. The plasma levels of αB-crystallin antibodies were determined by an enzyme-linked immunosorbent assay (Calbiochem), and were confirmed with Western blotting. Tissue expression of the protein was compared in three different groups of patients: COPD smokers, COPD nonsmokers, and in patients with age-related emphysema.Results: The mean level of anti-αB-crystallin antibodies in non-COPD smokers was 0.291nm. In COPD smokers it was 0.352 nm and, in patients with inflammatory lung diseases, 0.433 nm. in patients with inflammatory lung diseases. There was a statistically significant difference between COPD smokers and healthy non-COPD smokers (P = 0.010). The same could be observed comparing the group of patients with acute inflammation and non-COPD healthy smokers (P = 0.007). There was no statistically significant difference between patients with mild/moderate inflammation and those with severe COPD. Tissue detection of the protein showed that it was significantly overexpressed in COPD smokers in comparison to COPD nonsmokers and was only slightly expressed in patients with age-related emphysema.Conclusion: αB-crystallin is increased in patients with inflammatory lung diseases. Though unspecific, it could be used in a panel of markers discerning COPD smokers from healthy nonsmokers. As αB-crystallin is a regulator of innate immunity and a therapeutic anti-inflammatory agent, its exact role in COPD pathogenesis and therapy should be explored further.Keywords: COPD, HspB5, chaperonopathology, pathogenesis
The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis
Cherneva RV, Georgiev OB, Petrova DS, Trifonova NL, Stamenova M, Ivanova V, Vlasov VI
International Journal of Chronic Obstructive Pulmonary Disease , 2012, DOI: http://dx.doi.org/10.2147/COPD.S34929
Abstract: ole of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis Original Research (1222) Total Article Views Authors: Cherneva RV, Georgiev OB, Petrova DS, Trifonova NL, Stamenova M, Ivanova V, Vlasov VI Published Date October 2012 Volume 2012:7 Pages 633 - 640 DOI: http://dx.doi.org/10.2147/COPD.S34929 Received: 11 June 2012 Accepted: 02 August 2012 Published: 04 October 2012 Radostina V Cherneva,1 Ognian B Georgiev,1 Daniela S Petrova,1 Nedka L Trifonova,2 Maria Stamenova,2 Vesela I Ivanova,3 Veselin I Vlasov3 1Clinic of Internal Medicine, Division of Pulmonology, University Hospital Alexandrovska, Sofia, Bulgaria; 2Department of Biology, 3Department of Pathology, Medical University of Sofia, Sofia, Bulgaria Background: αB-crystallin (HspB5) is a chaperone whose role as a marker of innate immunity activation as well as its therapeutic potential have recently been investigated in several inflammatory diseases: multiple sclerosis, myocardial ischemia, and Guillain–Barré syndrome. Aim: The aim of this study is to determine the role of αB-crystallin in chronic obstructive pulmonary disease (COPD) pathogenesis and inflammation. Materials: Plasma levels of αB-crystallin were studied in 163 patients: 52 healthy non-COPD smokers; 20 COPD smokers in Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages I–II; 43 COPD smokers in GOLD stages III-IV. Forty-eight patients were diagnosed with acute inflammatory respiratory disease. The plasma levels of αB-crystallin antibodies were determined by an enzyme-linked immunosorbent assay (Calbiochem), and were confirmed with Western blotting. Tissue expression of the protein was compared in three different groups of patients: COPD smokers, COPD nonsmokers, and in patients with age-related emphysema. Results: The mean level of anti-αB-crystallin antibodies in non-COPD smokers was 0.291nm. In COPD smokers it was 0.352 nm and, in patients with inflammatory lung diseases, 0.433 nm. in patients with inflammatory lung diseases. There was a statistically significant difference between COPD smokers and healthy non-COPD smokers (P = 0.010). The same could be observed comparing the group of patients with acute inflammation and non-COPD healthy smokers (P = 0.007). There was no statistically significant difference between patients with mild/moderate inflammation and those with severe COPD. Tissue detection of the protein showed that it was significantly overexpressed in COPD smokers in comparison to COPD nonsmokers and was only slightly expressed in patients with age-related emphysema. Conclusion: αB-crystallin is increased in patients with inflammatory lung diseases. Though unspecific, it could be used in a panel of markers discerning COPD smokers from healthy nonsmokers. As αB-crystallin is a regulator of innate immunity and a therapeutic anti-inflammatory agent, its exact role in COPD pathogenesis and therapy should be explored further.
Causality of Phase of Wave Function or Can Copenhagen Interpretation of Quantum Mechanics Be Considered Complete?  [PDF]
Ivan Georgiev Koprinkov
Journal of Modern Physics (JMP) , 2016, DOI: 10.4236/jmp.2016.74039
Abstract: Theoretical and experimental evidences of a causal relation of the phase of the wave function and physical reality are presented. The Copenhagen interpretation of quantum mechanics, which gives physical meaning to the amplitude of the wave function only, cannot be considered complete on that ground. A new dynamics-statistical interpretation of quantum mechanics is proposed.
Culture and the Challenges of Development in Africa: Towards A Hybridization of Traditional and Modern Values
OB Akpomuvie
African Research Review , 2010,
Abstract: Development is a multi-dimensional process involving changes in structures, altitudes and institutions as well as the acceleration of economic growth, reduction of inequality and eradication of absolute poverty. However, the paper argues that the cultural dimension is a long-neglected aspect of development; the challenge, therefore, lies in fostering a synergistic development between science and technology and cultural values. What is essential is how to take culture into account both scientifically (methods and data) and practically. Because people do not commit themselves to a development undertaking unless that undertaking corresponds to their deeply felt needs, people should be able to derive the means and motivation for their development; the paper further stressed. This paper recommends a renaissance of applied cultural studies through the consolidation and generation of knowledge about (1) how cultural diversity affects what people do and want; (2) how cultural factor interact with other variables in the “production” of development, good or bad; and (3) how culture itself is affected by various kinds of development and other factors.
Poverty, Access to Health Care Services and Human Capital Development in Nigeria
OB Akpomuvie
African Research Review , 2010,
Abstract: The paper is aimed at examining the poverty profile of Nigeria and its consequences on access to health care services and human capital development in the country. It is a startling paradox that about two – thirds of Nigerians are poor despite living in a country with vast potential wealth. Apart from looking at the theoretical milieu, the paper also examined the nature and dimensions of poverty in Nigeria. The paper which employed secondary methods of data collection revealed that the achievement of even the modest goal of stopping the traumatic march of poverty has so far eluded Nigeria. It further revealed that health is a major component of a nation’s socio-economic development because it is essential for a virile labour force for the creation and maintenance of its wealth. The paper however, recommended comprehensive health sector reform, aimed at strengthening the national health system and enhancing the delivery of effective and affordable health services.
Museums and Development in Africa
OB Akpomuvie
African Research Review , 2010,
Abstract: The theme of this paper is centred on museums as veritable tools fornational unity and development in Africa. It argued ratherdispassionately that after several decades of economic development inAfrica, it is clear that cultural parameters and processes are as important aseconomic aspects of the evolution of African societies. Besides appraising the objectives of museums in Nigeria, it also critically looked at museums and scientific/ technological development in Africa. The paper which reliedoverwhelmingly on secondary methods of data collection, revealed thatmuseums are avenues through which the cultural and natural resources ofa nation as well as its people's abilities and attitudes, in the presence of this institution, can be mobilized to achieve the desired development goals. It however, recommended that African peoples should utilize the resourcesand methods of science and technology critically and intelligently, if they areto overcome their backwardness in these areas.
Mapping research areas and collaboration in the College of Human Sciences, University of South Africa
OB Onyancha
Inkanyiso: Journal of Humanities and Social Sciences , 2010,
Abstract: This paper examines the research output of the College of Human Sciences (CHS) at the University of South Africa (UNISA) with a view to determining the subjects or topics of research focus as well as the pattern and extent of research collaboration within the college. Using informetric approaches and more specifically the content analysis, the study employs various analytical technologies including UCINET for Windows, Microsoft Excel, Pajek, TI and TextStat to analyse data that was extracted from the University’s institutional research management system (IRMA). Results indicate that the research focus of the college is largely on HIV/AIDS; the most productive department was Christian Spirituality; the actual research output of the college is below the expected output; research is largely conducted singly as opposed to collaborative research; and that external research collaboration is common. Conclusions and recommendations for further research are provided.
Proverbial Space and the Dialectics of Place and Displacement in Sade Adeniran’s Imagine This
OB Jegede
African Research Review , 2012,
Abstract: Literary scholarship on proverb usage in Nigerian literary discourse had focused mostly on canonized writers and the nature, structure, form and context of proverbs in literature. Little work has been done on Sade Adeniran, her novel and the effect of place and displacement on proverb usage. This study is concerned with Adeniran‘s use of proverbs in her debut novel titled Imagine This. The novel, which won the Best First Book award for Commonwealth Writers‘ Prize (Africa Region) in 2008, has not received much critical attention because of the relative newness of the writer and the novel. The current paper examines Adeniran‘s attempt at creating a large proverbial space through her conscious use and structural arrangement of proverb in language. It foregrounds the dialectic of place and displacement, and location and dislocation as a crucible for her identity formation and major factor in appreciating her proverbs in the novel. Postcolonial theory served as the theoretical framework for the paper. Through the reading of the cultural features, Adeniran‘s techniques of writing which demonstrate her use of proverbs were purposively selected and subjected to content analysis in order to discuss the dynamics of language change in the novel. Proverbs are graphically enacted and foregrounded and Yoruba and English overlap in Imagine This. Through an examination of the implication of location and dislocation on proverb usage in the novel, the novel reveals an abundant usage of techniques of postcolonial writings such as code-mixing, pidginisation, use of proverbs, untranslated words and other language variants through which Adeniran creates a cultural space for herself. Geographical place and displacement as a feature of postcolonial writing imposes a gap that produces linguistic displacement. Therefore proverbs and other language variance and identity as in their literary contexts are areas of postcolonial study that require further research.
An overview of stress in medical practice
OB Familoni
African Health Sciences , 2008,
Abstract: Stress can be generally defined as undue, inappropriate or exaggerated response to a situation. Whereas anxiety about a situation could be positive, stress is always negative with attending adverse psychological and physiological changes leading to decreased productivity, disease and sometimes death African Health Science Vol. 8 (1) 2008: pp. 6-7
Kangaroo Mother Care: Using Appropriate Technology for the Care of Premature and Low Birth Weight Infants - A review
OB Ibe
Nigerian Journal of Paediatrics , 2003,
Abstract: Kangaroo mother care (KMC) was developed in 1978 in Colombia by the duo of Rey and Martinez in order to cope with the overcrowding, recurrent nosocomial infections and scarcity of resources in hospitals caring for low birth weight (LBW) infants. Currently, this method of care consists of three components: (a) Kangaroo position (skin-to-skin contact between a mother's bare breast and her nearly naked infant – except for a diaper, and woollen cap) which provides adequate warmth for the infant; (b) Kangaroo nutrition (exclusive or nearly exclusive breastfeeding) and (c) Kangaroo discharge policies (early discharge in Kangaroo position irrespective of weight or gestational age) with strict follow-up. In some settings, a fourth component namely, Kangaroo support, has been introduced. This describes the physical and emotional support given to mothers and their families when KMC is practised. Numerous studies both in developed and developing countries exist that highlight the practice of KMC in diverse settings, its benefits and limitations. KMC offers an appropriate technology for developing countries as well as the benefits of safety, in terms of physiologic response. In addition, the practice of KMC increases the prevalence and duration of breastfeeding, reduces hospital readmissions with shorter periods of hospitalisation. There is also reduced mortality among these patients. The previous recommendation was that KMC should be practised for preterm/LBW infants who are already stabilised, but there is now data to suggest that KMC itself helps stabilise preterm infants within the first six hours of life. This paper reviews the components, benefits, limitations and possibility of the practice of KMC in Nigeria. Nigerian Journal of Paediatrics 30(3) 2003:71-77
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