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Search Results: 1 - 10 of 705 matches for " Gemma Wallis "
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Discriminators of mouse bladder response to intravesical Bacillus Calmette-Guerin (BCG)
Marcia R Saban, Cindy Simpson, Carole Davis, Gemma Wallis, Nicholas Knowlton, Mark Frank, Michael Centola, Randle M Gallucci, Ricardo Saban
BMC Immunology , 2007, DOI: 10.1186/1471-2172-8-6
Abstract: C57BL/6 female mice received four weekly instillations of BCG, LPS, or TNF-α. Morphometric analyses were conducted in bladders isolated from all groups and urine was collected for multiplex analysis of 18 cytokines. In addition, chromatin immune precipitation combined with real-time polymerase chain reaction assay (CHIP/Q-PCR) was used to test whether intravesical BCG would alter bladder cytokine gene expression.Acute BCG instillation induced edema which was progressively replaced by an inflammatory infiltrate, composed primarily of neutrophils, in response to weekly administrations. Our morphological analysis suggests that these polymorphonuclear neutrophils are of prime importance for the bladder responses to BCG. Overall, the inflammation induced by BCG was higher than LPS or TNF-α treatment but the major difference observed was the unique granuloma formation in response to BCG. Among the cytokines measured, this study highlighted the importance of IL-1β, IL-2, IL-3, IL-4, IL-6, IL-10, IL-17, GM-CSF, KC, and Rantes as discriminators between generalized inflammation and BCG-specific inflammatory responses. CHIP/Q-PCR indicates that acute BCG instillation induced an up-regulation of IL-17A, IL-17B, and IL-17RA, whereas chronic BCG induced IL-17B, IL-17RA, and IL-17RB.To the best of our knowledge, the present work is the first to report that BCG induces an increase in the IL-17 family genes. In addition, BCG induces a unique type of persisting bladder inflammation different from TNF-α, LPS, and, most likely, other classical pro-inflammatory stimuli.Intravesical Bacillus Calmette-Guerin (BCG) has been presented as a promising option for treatment of interstitial cystitis [1]. However, intravesical BCG is best known as the most effective agent for the treatment of high-grade superficial bladder cancer [2-4]. In this context, BCG is used to reduce both the recurrence rate of bladder tumor and to diminish the risk of its progression [2,3]. As an adjunct to transurethral
Digital mammography in the United Kingdom: the reality
M Wallis
Breast Cancer Research , 2006, DOI: 10.1186/bcr1418
Abstract: To date, all the equipment has been technically satisfactory and produces good image quality at an acceptable dose. Several units have been shown to work on mobile vans. Translating this into safe and affordable screening has been less successful.No full-field digital mammography machine will work at its best without patient archiving and communications systems and a radiology information system. Integration into the current Information Technology structures has been hampered by parallel development and implementation work on the national Information Technology programme and a national reluctance to spend local money on short-term fixes.The current differences in cost will not be offset by savings in film and film-handling processes, so improvements in throughput (i.e. shorter appointments and/or longer days) are required, and this has not been fully addressed.
Field Assisted Glass Sealing
George Wallis
Active and Passive Electronic Components , 1975, DOI: 10.1155/apec.2.45
Professional accountability of doctors in New Zealand
Wallis K
Journal of Primary Health Care , 2013,
Constructing Banach ideals using upper $\ell_p$-estimates
Ben Wallis
Mathematics , 2014,
Abstract: Using upper $\ell_p$-estimates for normalized weakly null sequence images, we describe a new family of operator ideals $\mathcal{WD}_{\ell_p}^{(\infty,\xi)}$ with parameters $1\leq p\leq\infty$ and $1\leq\xi\leq\omega_1$. These classes contain the completely continuous operators, and are distinct for all choices $1\leq p\leq\infty$ and, when $p\neq 1$, for all choices $\xi\neq\omega_1$. For the case $\xi=1$, there exists an ideal norm $\|\cdot\|_{(p,1)}$ on the class $\mathcal{WD}_{\ell_p}^{(\infty,1)}$ under which it forms a Banach ideal.
Closed ideals in $\mathcal{L}(X)$ and $\mathcal{L}(X^*)$ when $X$ contains certain copies of $\ell_p$ and $c_0$
Ben Wallis
Mathematics , 2015,
Abstract: Suppose $X$ is a real or complexified Banach space containing a complemented copy of $\ell_p$, $p\in(1,2)$, and a copy (not necessarily complemented) of either $\ell_q$, $q\in(p,\infty)$, or $c_0$. Then $\mathcal{L}(X)$ and $\mathcal{L}(X^*)$ each admit continuum many closed ideals. If in addition $q\geq p'$, $\frac{1}{p}+\frac{1}{p'}=1$, then the closed ideals of $\mathcal{L}(X)$ and $\mathcal{L}(X^*)$ each fail to be linearly ordered. We obtain additional results in the special cases of $\mathcal{L}(\ell_1\oplus\ell_q)$ and $\mathcal{L}(\ell_p\oplus c_0)$, $1
Magnetic Theory and Applications in the Naples Bay (Southern Tyrrhenian Sea, Italy): Magnetic Anomaly Fields and Relationships with Morpho-Structural Lineaments  [PDF]
Gemma Aiello, Ennio Marsella
World Journal of Condensed Matter Physics (WJCMP) , 2016, DOI: 10.4236/wjcmp.2016.63020
Abstract: Magnetic theory and application to a complex volcanic area located in Southern Italy are here discussed showing the example of the Gulf of Naples, located at Southern Italy Tyrrhenian margin. A magnetic anomaly map of the Gulf of Naples has been constructed aimed at highlighting new knowledge on geophysics and volcanology of this area of the Eastern Tyrrhenian margin, characterized by a complex geophysical setting, strongly depending on sea bottom topography. The theoretical aspects of marine magnetometry and multibeam bathymetry have been discussed. Magnetic data processing included the correction of the data for the diurnal variation, the correction of the data for the offset and the leveling of the data as a function of the correction at the cross-points of the navigation lines. Multibeam and single-beam bathymetric data processing has been considered. Magnetic anomaly fields in the Naples Bay have been discussed through a detailed geological interpretation and correlated with main morpho-structural features recognized through morpho- bathymetric interpretation. Details of magnetic anomalies have been selected, represented and correlated with significant seismic profiles, recorded on the same navigation lines of magnetometry. They include the continental shelf offshore the Somma-Vesuvius volcanic complex, the outer shelf of the Gulf of Pozzuoli offshore the Phlegrean Fields volcanic complex, the relict volcanic banks of Pentapalummo, Nisida and Miseno, the Gaia volcanic bank on the Naples slope, the western slope of the Dohrn canyon, the Magnaghi canyon’s head and the magnetic anomalies among the Ischia and Procida islands.
Production, purification and characterization of two recombinant DNA-derived N-terminal ovine growth hormone variants: oGH3 and oGH5
AJ Sami, OC Wallis, M Wallis
African Journal of Biotechnology , 2008,
Abstract: Two recombinant DNA-derived variants of ovine growth hormone were produced, purified, characterized and compared with the authentic pituitary derived GH. The variants oGH3 and oGH5 were isolated by differential centrifugation method and were purified after refolding by ion-exchange chromatography and gel filtration. Both the proteins showed single band on SDS-PAGE and had molecular weight and iso-electric point closer to authentic pituitary GH. The variants oGH3 and oGH5 were compared with the authentic pituitary derived GH in radio immuno assays, radio receptor assays and binding with the monoclonal antibodies OA 11 and OA12.
Building the Clinical Bridge: An Australian Success
Marianne Wallis,Wendy Chaboyer
Nursing Research and Practice , 2012, DOI: 10.1155/2012/579072
Abstract: Nursing effectiveness science includes primary, secondary, and translational, clinically focused research activities which aim to improve patient or client outcomes. It is imperative, for the successful conduct of a program of nursing effectiveness science, that a clinical bridge is established between academic and healthcare service facilities. An Australian example of the development of a robust clinical bridge through the use of jointly funded positions at the professorial level is outlined. In addition, an analysis of the practical application of Lewin’s model of change management and the contribution of both servant and transformational leadership styles to the bridge building process is provided. 1. Introduction In Australia, a relatively popular strategy, aimed at improving collaboration between clinicians and research focused academics, has been the appointment of a Professor of Nursing and/or Midwifery into a Clinical Chair position, jointly funded by a university and a health service or hospital (a joint Clinical Chair). There has been much commentary, especially in Australia, about the development of such positions [1–4]. What is not so clear from this commentary is what elements surrounding this strategy lead to successful collaborative partnerships and the development of a clinical bridge to enable nursing effectiveness science. By nursing effectiveness science we mean primary, secondary, and translational, clinically focused research activities which aim to improve patient or client outcomes. Activities involved in nursing effectiveness science include systematic reviews and meta-analyses of previously conducted research studies, exploratory, correlational, and experimental clinical research studies, and translational research studies aimed at changing clinical practice. In this paper we outline the antecedents that shaped one university-health service collaboration and the change management strategies which helped construct the clinical bridge. We also explore how different types of leadership facilitated the achievement of outcomes, and finally we comment on future directions for nursing effectiveness science. 2. The Context Joint Clinical Chair positions in nursing emerged, in Australia, in the late 1980s. By 1996 there were 20 joint Clinical Chairs in Australia [5] and currently there are many more. Generally, these positions are appointed at the level of Professor although some have been appointed at the level of Associate Professor. There is also a distinction between “generic” joint Clinical Chairs (i.e., Professor of Nursing,
Attitudes and perceptions of Australian pharmacy students towards Complementary and Alternative Medicine – a pilot study
Evelin Tiralongo, Marianne Wallis
BMC Complementary and Alternative Medicine , 2008, DOI: 10.1186/1472-6882-8-2
Abstract: The study aimed to describe the attitudes, perceptions and beliefs of second, third and fourth year pharmacy students towards complementary and alternative medicine (CAM) and to explore factors that might affect attitudes such as learning, preceptors and placements.Pharmacy students from a University in South East Queensland, Australia participated in the study. The study consisted of a cross-sectional survey (n = 110) and semi-structured interviews (n = 9).The overall response rate for the survey was 75%, namely 50% (36/72) for second year, 77.3% (34/44) for third year and 97.6% (40/41) for fourth year students. Overall, 95.5% of pharmacy students believe that pharmacists should be able to advise patients about CAM and most (93.7%) have used CAM prior to course enrolment. Students' attitudes to CAM are influenced by the use of CAM by family, friends and self, CAM training, lecturers and to a lesser degree by preceptors. The majority of pharmacy students (89.2%) perceive education about CAM as a core and integral part of their professional degree and favour it over an additional postgraduate degree. However, they see a greater need for education in complementary medicines (such as herbal medicines, vitamins and minerals) than for education in complementary therapies (such as acupuncture, meditation and bio-magnetism). Knowledge and educational input rationalised rather than marginalised students' attitudes towards CAM.Pharmacy students perceive education about CAM as a core and integral part of their professional degree. Students' attitudes towards CAM can be influenced by learning, lecturers, preceptors and practice experience. The content and focus of CAM education has to be further investigated and tailored to meet the professional needs of our future health professionals.Surveys of medical and pharmacy students report that the majority of students welcome the inclusion of CAM education in the medical [1-4] and pharmacy curricula [5,6]. However, most of the studi
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