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Search Results: 1 - 10 of 658 matches for " Gemma Molinaro "
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Lack or Inhibition of Dopaminergic Stimulation Induces a Development Increase of Striatal Tyrosine Hydroxylase-Positive Interneurons
Carla Letizia Busceti, Domenico Bucci, Gemma Molinaro, Paola Di Pietro, Luca Zangrandi, Roberto Gradini, Rosario Moratalla, Giuseppe Battaglia, Valeria Bruno, Ferdinando Nicoletti, Francesco Fornai
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044025
Abstract: We examined the role of endogenous dopamine (DA) in regulating the number of intrinsic tyrosine hydroxylase-positive (TH+) striatal neurons using mice at postnatal day (PND) 4 to 8, a period that corresponds to the developmental peak in the number of these neurons. We adopted the strategy of depleting endogenous DA by a 2-day treatment with α-methyl-p-tyrosine (αMpT, 150 mg/kg, i.p.). This treatment markedly increased the number of striatal TH+ neurons, assessed by stereological counting, and the increase was highly correlated to the extent of DA loss. Interestingly, TH+ neurons were found closer to the clusters of DA fibers after DA depletion, indicating that the concentration gradient of extracellular DA critically regulates the distribution of striatal TH+ neurons. A single i.p. injection of the D1 receptor antagonist, SCH23390 (0.1 mg/kg), the D2/D3 receptor antagonist, raclopride (0.1 mg/kg), or the D4 receptor antagonist, L-745,870 (5 mg/kg) in mice at PND4 also increased the number of TH+ neurons after 4 days. Treatment with the D1-like receptor agonist SKF38393 (10 mg/kg) or with the D2-like receptor agonist, quinpirole (1 mg/kg) did not change the number of TH+ neurons. At least the effects of SCH23390 were prevented by a combined treatment with SKF38393. Immunohistochemical analysis indicated that striatal TH+ neurons expressed D2 and D4 receptors, but not D1 receptors. Moreover, treatment with the α4β2 receptor antagonist dihydro-β-erythroidine (DHβE) (3.2 mg/kg) also increased the number of TH+ neurons. The evidence that DHβE mimicked the action of SCH23390 in increasing the number of TH+ neurons supports the hypothesis that activation of D1 receptors controls the number of striatal TH+ neurons by enhancing the release of acetylcholine. These data demonstrate for the first time that endogenous DA negatively regulates the number of striatal TH+ neurons by direct and indirect mechanisms mediated by multiple DA receptor subtypes.
Radiation Therapy in a Case of Orbital Lymphoma
Molinaro MA
Online Journal of Health & Allied Sciences , 2008,
Abstract: Introduction: Orbital lymphoma is a rare presentation of extranodal non-Hodgkin's lymphoma, accounting for less than 1% of the total. The role of radiotherapy in its management is well-established. This is a report of a case of orbital lymphoma Materials and Methods: Clinical records and pathologic material of a patient woman of 62 age treated with local radiotherapy for localized orbital lymphoma. Treatment consisted of 36 Gy in 1.8-Gy fractions of irradiation using 6-MV photons with complex treatment planning for retrobulbar lesions. Median follow-up was 18 months Results: Local control was 100%. Cataracts was not observed in 8 of the treated eyes.Conclusion: In this case, localized orbital MALT lymphoma was well controlled with radiotherapy.
CILEA a “TheServerSideJavaSymposiumEurope”, Barcellona, 21-23 Giugno 2006
Chiara Molinaro
Bollettino del CILEA , 2006, DOI: 10.1472/bc.v102i0.1269
Abstract: CILEA partecipa al primo incontro europeo della comunità di utilizzatori di Java. CILEA takes part to the first European symposium of the Java Community.
Il Portale della Moda Italiana per il Fashion Institute of Milan
Chiara Molinaro
Bollettino del CILEA , 2009, DOI: 10.1472/bc.v0i112.1437
Abstract: CILEA è coinvolto nel Flagship Project Fashion Institute of Milan, patrocinato dal Comune di Milano, per la realizzazione del Portale della Moda Italiana. Le idee e i progetti dei diversi partner e istituzioni sono stati presentati durante il workshop “Milano & Moda”, organizzato dalla Fondazione IULM, con la partecipazione del sindaco Letizia Moratti. CILEA is involved in the Flagship Project Fashion Institute of Milan, sponsored by Comune di Milano, and our aim is to realize the web portal about Italian Fashion. Ideas and projects of the various actors were proposed during the workshop “Milano & Moda”, organized by Fondazione IULM, with special guest Mayoress Letizia Moratti.
Magnetic Theory and Applications in the Naples Bay (Southern Tyrrhenian Sea, Italy): Magnetic Anomaly Fields and Relationships with Morpho-Structural Lineaments  [PDF]
Gemma Aiello, Ennio Marsella
World Journal of Condensed Matter Physics (WJCMP) , 2016, DOI: 10.4236/wjcmp.2016.63020
Abstract: Magnetic theory and application to a complex volcanic area located in Southern Italy are here discussed showing the example of the Gulf of Naples, located at Southern Italy Tyrrhenian margin. A magnetic anomaly map of the Gulf of Naples has been constructed aimed at highlighting new knowledge on geophysics and volcanology of this area of the Eastern Tyrrhenian margin, characterized by a complex geophysical setting, strongly depending on sea bottom topography. The theoretical aspects of marine magnetometry and multibeam bathymetry have been discussed. Magnetic data processing included the correction of the data for the diurnal variation, the correction of the data for the offset and the leveling of the data as a function of the correction at the cross-points of the navigation lines. Multibeam and single-beam bathymetric data processing has been considered. Magnetic anomaly fields in the Naples Bay have been discussed through a detailed geological interpretation and correlated with main morpho-structural features recognized through morpho- bathymetric interpretation. Details of magnetic anomalies have been selected, represented and correlated with significant seismic profiles, recorded on the same navigation lines of magnetometry. They include the continental shelf offshore the Somma-Vesuvius volcanic complex, the outer shelf of the Gulf of Pozzuoli offshore the Phlegrean Fields volcanic complex, the relict volcanic banks of Pentapalummo, Nisida and Miseno, the Gaia volcanic bank on the Naples slope, the western slope of the Dohrn canyon, the Magnaghi canyon’s head and the magnetic anomalies among the Ischia and Procida islands.
Activation of mGlu3 Receptors Stimulates the Production of GDNF in Striatal Neurons
Giuseppe Battaglia, Gemma Molinaro, Barbara Riozzi, Marianna Storto, Carla L. Busceti, Paola Spinsanti, Domenico Bucci, Valentina Di Liberto, Giuseppina Mudò, Corrado Corti, Mauro Corsi, Ferdinando Nicoletti, Natale Belluardo, Valeria Bruno
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0006591
Abstract: Metabotropic glutamate (mGlu) receptors have been considered potential targets for the therapy of experimental parkinsonism. One hypothetical advantage associated with the use of mGlu receptor ligands is the lack of the adverse effects typically induced by ionotropic glutamate receptor antagonists, such as sedation, ataxia, and severe learning impairment. Low doses of the mGlu2/3 metabotropic glutamate receptor agonist, LY379268 (0.25–3 mg/kg, i.p.) increased glial cell line-derived neurotrophic factor (GDNF) mRNA and protein levels in the mouse brain, as assessed by in situ hybridization, real-time PCR, immunoblotting, and immunohistochemistry. This increase was prominent in the striatum, but was also observed in the cerebral cortex. GDNF mRNA levels peaked at 3 h and declined afterwards, whereas GDNF protein levels progressively increased from 24 to 72 h following LY379268 injection. The action of LY379268 was abrogated by the mGlu2/3 receptor antagonist, LY341495 (1 mg/kg, i.p.), and was lost in mGlu3 receptor knockout mice, but not in mGlu2 receptor knockout mice. In pure cultures of striatal neurons, the increase in GDNF induced by LY379268 required the activation of the mitogen-activated protein kinase and phosphatidylinositol-3-kinase pathways, as shown by the use of specific inhibitors of the two pathways. Both in vivo and in vitro studies led to the conclusion that neurons were the only source of GDNF in response to mGlu3 receptor activation. Remarkably, acute or repeated injections of LY379268 at doses that enhanced striatal GDNF levels (0.25 or 3 mg/kg, i.p.) were highly protective against nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyri?dinein mice, as assessed by stereological counting of tyrosine hydroxylase-positive neurons in the pars compacta of the substantia nigra. We speculate that selective mGlu3 receptor agonists or enhancers are potential candidates as neuroprotective agents in Parkinson's disease, and their use might circumvent the limitations associated with the administration of exogenous GDNF.
Induction of the Wnt Antagonist Dickkopf-1 Is Involved in Stress-Induced Hippocampal Damage
Francesco Matrisciano,Carla L. Busceti,Domenico Bucci,Rosamaria Orlando,Alessandra Caruso,Gemma Molinaro,Irene Cappuccio,Barbara Riozzi,Roberto Gradini,Marta Motolese,Filippo Caraci,Agata Copani,Sergio Scaccianoce,Daniela Melchiorri,Valeria Bruno,Giuseppe Battaglia,Ferdinando Nicoletti
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016447
Abstract: The identification of mechanisms that mediate stress-induced hippocampal damage may shed new light into the pathophysiology of depressive disorders and provide new targets for therapeutic intervention. We focused on the secreted glycoprotein Dickkopf-1 (Dkk-1), an inhibitor of the canonical Wnt pathway, involved in neurodegeneration. Mice exposed to mild restraint stress showed increased hippocampal levels of Dkk-1 and reduced expression of β-catenin, an intracellular protein positively regulated by the canonical Wnt signalling pathway. In adrenalectomized mice, Dkk-1 was induced by corticosterone injection, but not by exposure to stress. Corticosterone also induced Dkk-1 in mouse organotypic hippocampal cultures and primary cultures of hippocampal neurons and, at least in the latter model, the action of corticosterone was reversed by the type-2 glucocorticoid receptor antagonist mifepristone. To examine whether induction of Dkk-1 was causally related to stress-induced hippocampal damage, we used doubleridge mice, which are characterized by a defective induction of Dkk-1. As compared to control mice, doubleridge mice showed a paradoxical increase in basal hippocampal Dkk-1 levels, but no Dkk-1 induction in response to stress. In contrast, stress reduced Dkk-1 levels in doubleridge mice. In control mice, chronic stress induced a reduction in hippocampal volume associated with neuronal loss and dendritic atrophy in the CA1 region, and a reduced neurogenesis in the dentate gyrus. Doubleridge mice were resistant to the detrimental effect of chronic stress and, instead, responded to stress with increases in dendritic arborisation and neurogenesis. Thus, the outcome of chronic stress was tightly related to changes in Dkk-1 expression in the hippocampus. These data indicate that induction of Dkk-1 is causally related to stress-induced hippocampal damage and provide the first evidence that Dkk-1 expression is regulated by corticosteroids in the central nervous system. Drugs that rescue the canonical Wnt pathway may attenuate hippocampal damage in major depression and other stress-related disorders.
Wanessa Carneiro Molinaro Ferreira
Revista da SJRJ , 2010,
Abstract: Este trabalho analisa as recentes mudan as no Código de Processo Penal, especialmente no que toca à adequa o ao sistema acusatório e o novo rito do procedimento comum ordinário. As altera es promovidas s o importantes para a atualiza o da lei processual penal, de forma a se implementarem os princípios constitucionais.
How the Experts Algorithm Can Help Solve LPs Online
Anupam Gupta,Marco Molinaro
Mathematics , 2014,
Abstract: We consider the problem of solving packing/covering LPs online, when the columns of the constraint matrix are presented in random order. This problem has received much attention and the main focus is to figure out how large the right-hand sides of the LPs have to be (compared to the entries on the left-hand side of the constraints) to allow $(1+\epsilon)$-approximations online. It is known that the right-hand sides have to be $\Omega(\epsilon^{-2} \log m)$ times the left-hand sides, where $m$ is the number of constraints. In this paper we give a primal-dual algorithm that achieve this bound for mixed packing/covering LPs. Our algorithms construct dual solutions using a regret-minimizing online learning algorithm in a black-box fashion, and use them to construct primal solutions. The adversarial guarantee that holds for the constructed duals helps us to take care of most of the correlations that arise in the algorithm; the remaining correlations are handled via martingale concentration and maximal inequalities. These ideas lead to conceptually simple and modular algorithms, which we hope will be useful in other contexts.
The Query-commit Problem
Marco Molinaro,R. Ravi
Computer Science , 2011,
Abstract: In the query-commit problem we are given a graph where edges have distinct probabilities of existing. It is possible to query the edges of the graph, and if the queried edge exists then its endpoints are irrevocably matched. The goal is to find a querying strategy which maximizes the expected size of the matching obtained. This stochastic matching setup is motivated by applications in kidney exchanges and online dating. In this paper we address the query-commit problem from both theoretical and experimental perspectives. First, we show that a simple class of edges can be queried without compromising the optimality of the strategy. This property is then used to obtain in polynomial time an optimal querying strategy when the input graph is sparse. Next we turn our attentions to the kidney exchange application, focusing on instances modeled over real data from existing exchange programs. We prove that, as the number of nodes grows, almost every instance admits a strategy which matches almost all nodes. This result supports the intuition that more exchanges are possible on a larger pool of patient/donors and gives theoretical justification for unifying the existing exchange programs. Finally, we evaluate experimentally different querying strategies over kidney exchange instances. We show that even very simple heuristics perform fairly well, being within 1.5% of an optimal clairvoyant strategy, that knows in advance the edges in the graph. In such a time-sensitive application, this result motivates the use of committing strategies.
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