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Search Results: 1 - 10 of 3439 matches for " Gastric mucosal lesion "
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Protective effect of fermented papaya preparation on stress-induced acute gastric mucosal lesion  [PDF]
Shinki Murakami, Fusako Takayama, Toru Egashira, Mitsuko Imao, Akitane Mori
Journal of Biophysical Chemistry (JBPC) , 2012, DOI: 10.4236/jbpc.2012.34038
Abstract: Stress ulceration is single or multiple mucosal defects with/without bleeding from the gastric mucosa during the physiologic stress. Oxidative stress (OS) is a key pathogenic factor in psychogenic stress-induced acute gastric mucosal lesion (AGML). Fermented papaya preparation (FPP) is reported to have oxygen radical scavenging activity and is effective in OS-related diseases. Here, we investigated the protective effects and the mechanism of action of FPP on stress-induced AGML in rats, induced by water immersion restraint stress (WIRS). Exposure of rats to 6-hour WIRS resulted in the appearance of splinter hemorrhages and mucosal lesions in the stomach. WIRS induced significant increase in lipid peroxidation and decrease in superoxide dismutase-like activity in both the plasma and gastric mucosa. WIRS also significantly increased myeloperoxidase activity together with Nuclear factor-kappaB (NF-kB) activation in gastric mucosa. FPP reduced all the above changes. The results suggest that oral administration of FPP provides protection against WIRS-induced acute gastric mucosal lesions through its anti-oxidative and anti-inflammatory properties.
Journal of Research in Medical Sciences , 2002,
Abstract: Introduction. Gastric ulcer is a multifactorial disease, which its pathophysioligy has not been clear yet. The aim of this study was to obtain the prophylactic effects of EDTA on Aspirin induced gastric mucosal lesions. Methods. In fasted male rats the effect of a single oral dose of the EDTA was evaluated in the following test systems: combination of 1 ml EDTA 1.5% + 300 mg/kg aspirin and 1 ml EDTA 1.5%, 2.5%, 5% and 7.5% 30 minutes before 300 mg/kg aspirin. Then the gastric mucosal lesions were assessed microscopically and marcroscopically. Results. EDTA at different doses reduced macroscopic and microscpic gastric mucosal lesion induced by aspirin. Discussion. Combination therapy of EDTA and aspirin has distinct advantages regard to both low gastrointestinal toxicity and restored therapeutic activity.
Effect of early propranolol administration on portal hypertensive gastropathy in cirrhotic rats
Savas Rafailidis, Charalampos Demertzidis, Konstantinos Ballas, Michail Alatsakis, Nikolaos Symeonidis, Theodoros Pavlidis, Kyriakos Psarras, Valentini Tzioufa-Asimakopoulou, Athanassios Sakadamis
World Journal of Gastroenterology , 2009,
Abstract: AIM: To investigate any protective effect of early propranolol administration in the development of portal hypertensive gastropathy in cirrhotic rats.METHODS: For the development of liver cirrhosis and portal hypertensive gastropathy, 60 rats underwent ligation of the left adrenal vein and complete devascularization of the left renal vein, followed by phenobarbital and carbon tetrachloride (CCl4) administration. After two weeks of CCl4 administration, the rats were randomly separated into two groups. In group A, propranolol was continuously administered intragastrically throughout the study, whereas in group B normal saline (placebo) was administered instead. Hemodynamic studies and vascular morphometric analysis of gastric sections were performed after complete induction of cirrhosis.RESULTS: Vascular morphometric studies showed higher numbers of vessels in all mucosal layers in the control group. Statistical analysis revealed a significantly higher total vascular surface in the control group compared to the propranolol group, but with no statistically significant difference between the mean vascular surfaces between the groups. Our study clearly shows that the increased mucosal blood flow is manifested by a marked increase of vessel count.CONCLUSION: Early propranolol’s administration in portal hypertensive cirrhotic rats seems to prevent intense gastric vascular congestion that characterizes portal hypertensive gastropathy.
Inhibitory Effects of Dan Shen Extract F on Ethanol-Induced Gastric Mucosal Lesion and Gastric Mucosal Blood Vessels Impairment and Its Effects on Lipid Peroxidation in Rats

GaoMingqi,Lin Geng,Li Hequan,Nie Huo,Liu Shoulan,

世界科学技术-中医药现代化 , 2008,
Abstract: 目的:观察丹参提取物F(DSE-F)对乙醇诱导的大鼠胃粘膜损伤及其微血管损伤的抑制作用及对脂质过氧化物的影响.方法:160-200g Wistar系雄性大鼠随机分为空白对照,对照及丹参提取物F组,实验前24hr禁食不禁水,经胃管向胃内分别灌注生理盐水、无水乙醇、及DSE-F(1mL/100g),0.5hr后处死动物.测定了胃粘膜损伤、胃粘膜微血管的损伤、胃粘膜超氧化物歧化酶(SOD)活性和谷胱甘肽过氧化物酶(GSH-Px)活性及丙二醛(MDA)含量.结果:1)对照组及DSE-F组的大鼠胃粘膜损伤面积(%)分别为7.57±0.50,2.53±0.22;光镜下Ⅲ级损伤(%)分别为51.88±11.20,20.67±5.05;两组差异均有统计学意义(P<0.01),DSE-F对乙醇致胃粘膜损伤具有抑制作用.2)对照组及DSE-F组的胃粘膜伊文斯蓝EB含量(ng/g湿重)分别为12.46±0.70,8.05±1.86;单星蓝MB染色面积(%)分别为4.54±0.83,0.90±0.10;两组差异均有统计学意义(P<0.05),DSE-F可减轻乙醇致胃粘膜微血管的损伤作用.3)与空白对照组的大鼠胃粘膜的SOD(Nu/mg pro)和GSH-Px(u)的活性分别为7.68±0.68(Nu/mg pro),52.67±21.32(u)相比,对照(无水乙醇)组的SOD及GSH-Px的活性为3.18±0.59(Nu/mg pro),31.52±14.65(u),均显著降低(P<0.01).DSE-F组的SOD及GSH-Px的活性为6.11±0.54(Nu/mg pro),49.31±15.82(u)均显著高于对照组(P<0.01).而空白对照组的MDA含量(nmol/mg pro)为0.90±0.05,对照组及DSE-F组的MDA含量则分别为1.38±0.19,0.92±0.06.结论:丹参提取物F具有对乙醇致大鼠胃粘膜损伤及胃粘膜微血管损伤的抑制作用,该作用与其促进胃粘膜SOD及GSH-Px的活性及抑制MDA的作用相关.
- , 2017, DOI: 10.16781/j.0258-879x.2017.12.1590
Abstract: 目的 探讨内镜黏膜下剥离术(ESD)治疗胃黏膜浅表病变的临床安全性和效果,并对ESD治疗出现并发症的相关因素及处理进行分析。方法 回顾性分析116例胃黏膜浅表病变行ESD治疗患者的临床病例资料,观察ESD的治疗情况和效果,分析术中及术后出现并发症的相关因素及处理情况。结果 116例胃黏膜浅表病变全部完成ESD治疗,一次性整块切除率为99.1%(115/116),组织学完全治愈性切除率为95.7%(111/116),肿瘤平均最大径为(25.0±11.6) mm,平均手术时间(56.6±20.5) min;术中急性少量出血发生率为3.4%(4/116),无急性大量出血发生,延迟性出血发生率为0.9%(1/116);5例出血病例均应用电凝止血和止血夹联合内镜下止血成功;术中穿孔发生率为2.6%(3/116),3例穿孔病例在术中应用钛夹夹闭,穿孔患者无气腹发生,均保守治疗成功。ESD术后2个月时复查,创面溃疡愈合率为100%,术后平均随访(20.3±5.1)个月。术中出血和穿孔发生的危险因素为胃角(χ2=7.937,P=0.01)及术后病理结果为早期胃癌(χ2=9.145,P=0.005)。结论 ESD是一种安全有效的胃黏膜浅表病变微创治疗方法,手术操作成功率高;强调ESD术中和术后应注意预防性止血。强调早期术中发现穿孔,大多能完成内镜下穿孔的有效闭合。
Objective To investigate the clinical safety and efficacy of endoscopic submucosal dissection (ESD) in the treatment of superficial lesions of gastric mucosa, and to analyze the related factors and management of complications of ESD treatment. Methods We retrospectively analyzed the clinical data of 116 patients with superficial lesions of gastric mucosa undergoing ESD, evaluated the efficacy of ESD, observed the appearance and treatment of complications of ESD, and analyzed the factors influencing intraoperative and postoperative complications. Results The ESD was successfully completed in all cases, with the en bloc resection rate being 99.1% (115/116) and the complete cure rate being 95.7% (111/116). The average tumor size was (25.0±11.6) mm, and the average operation time was (56.6±20.5) min. The incidence rates of acute slight bleeding during operation and delayed bleeding were 3.4% (4/116) and 0.9% (1/116), respectively, without acute hemorrhage; 5 cases of bleeding were successfully treated by coagulation hemostasis and hemoclip. Perforation occured in 3 cases (2.6%) and was closed by hemoclip during operation; all cases of perforation had no pneumoperitoneum and were treated successfully by conservative method. Review at 2 months after ESD showed that the ulcer healing rate was 100%. The average follow-up time was (20.3±5.1) months. Gastric angle (χ2=7.937, P=0.01) and the postoperative pathological results as early carcinoma (χ2=9.145, P=0.005) were risk factors influencing the intraoperative bleeding and perforation complications. Conclusion ESD is a safe and effective minimally invasive treatment, and has high operation success rate. The prevention of bleeding should be emphasized during and after ESD operation. Perforation complications also should be discovered during the early stage of operation, which can contribute to complete effective closure of perforation under endoscope in most cases
Effect of education of primary health care workers on HIV-related oral lesions in Nairobi East district
Lucina N. Koyio,Wil JM J.M. van der Sanden,Andre van der Ven,Nico Creugers
Journal of Public Health Research , 2012, DOI: 10.4081/jphr.2012.e20
Abstract: Background. An estimated 90% of HIV-infected people are likely to develop oral lesions in the course of HIV infection. Oro-pharyngeal candidiasis (OPC), an early marker for HIV-infection, can be diagnosed during an oral examination (OE). Primary healthcare (PHC) providers in Kenya are neither trained nor sufficiently equipped to perform this simple, cheap and non-invasive examination. The PHC system in Kenya offers an opportunity to integrate early recognition and management of oral lesions into general health care. This study aims to estimate the effect of a multifaceted intervention for PHC providers in training them to perform an OE. Specifically, our primary objective is to establish whether the intervention is effective in increasing: i) the frequency of early detection of HIV-related oral lesions; and ii) referral rates for HIV-testing. Design and methods. The study has been designed in two parts: a retrospective clinical data record study and a prospective cohort study with pre-post control group design, carried out in 2 administrative divisions in Nairobi East district. The intervention group will receive one day of training on recognition of HIV-related oral lesions and other common oral conditions. Reminder sessions will be held at individual health facilities. Routine tally sheets will be used to record all patients with HIV-related oral lesions, dental caries and periodontal disease. A convenience sample of all the PHC in a division will be used. It will not be possible to blind investigators or assessors. Expected impact of the study for Public Health. Early recognition and treatment of HIV infection influences long-term survival rates and will reduce healthcare expenditure.
Protection by Liquorice in Alcohol Induced Gastric Mucosa Damage
A.E. Ligha,H.B. Fawehinmi
Pakistan Journal of Nutrition , 2009,
Abstract: Gastric diseases are widespread among the inhabitants of many countries and alcohol consumption is a known precipitating factor. This study investigates the protective effect of Liquorice, an indigenous plant in tropical and sub-tropical areas and belongs to the Fabaceae family on 80% alcohol- induce gastric mucosa lesions and morphological changes in rats. The rats were divided into five groups of five rats per group. Gastric damage was induced with 80% alcohol. The treated group received the crude extract of 200 mg/kg.oral prior to alcohol gastric mucosa damage induction. Histological studies, ulcer index, Alkaline Phosphotase (ALP), lipid peroxidation product (TBARS) which is an index of lipid peroxidation were studied. Liquorice pre-treatment showed protection against alcohol mucosa damage; a significant reduction in the ulcer index of 1.94 ±0.05 against 5.24 ±0.07 of positive control. The ALP and TBARS were also significantly reduced. The results suggest that Liquorice seed extracts have significant mucosal protective and antioxidative effects on the gastric mucosa in rats.
Effects of Anethum chryseum Leaves Extracts on Gastric Irritation
Ali M. Bahrami,Valadi Ali
International Journal of Pharmacology , 2010,
Abstract: As a folk remedy, Anethum chryseum leaves is used for some gastrointestinal ailments. We aimed to evaluate aqueous and ethanolic extracts of anti-ulcer and acute toxicity effects of the Anethum chryseum in mice. Gastric mucosal lesions were induced by oral administration of HCl (1 N) and absolute ethanol in mice. The acidity and total acid content of gastric juice were measured in pylorus-ligated mice. LD50 values of the aqueous and ethanolic extracts were 3.04 g kg-1 i.p., (1.5, 6.16) and 6.98 g kg-1, i.p., (5.69, 8.56), respectively. The efficacy of high dose of extracts (p.o.) was similar to sucralfate. The acidity and total acid content were reduced by the orally or intraperitoneally administration of the extracts. The results suggest that A. chryseum leaves extracts have significant mucosal protective and antisecretory effects of the gastric mucosa in mice.
Risk factors for bleeding from stress ulcer in severely injured and critically ill persons
?ija?ki A.D.,Popovi? N.M.,Karamarkovi? A.R.,Stefanovi? B.D.
Acta Chirurgica Iugoslavica , 2007, DOI: 10.2298/aci0701077s
Abstract: Bleeding stress ulcus is a mucosal stress induced lesion which appears as a result of mucosal damage in severely injured and critically ill persons. Prophylaxis treatment has dramatically reduced the incidence of bleeding in Intensive care units. We conducted a prospective study for the five years period. Of 954 patients (196 with acute necrotizing pancreatitis and 758 with severe injuries), 84 (8.5%) has clinically important bleeding. About 80% of these patients had more than one independent risk for acute bleeding from gastrointestinal tract. Prophylaxis treatment reduced bleeding in 90% risk patients (according Zinner score). Despite of prophylaxis, 13 patients required surgery. Overall mortality was 29 (34%) of 84 patients, including seven of 13 who required surgery. Sepsis and respiratory failure were identified as strong risk factors for bleeding in our group. The choice of the best prophylactic agens still remains the question.
Fluconazole induced herpes labialis-like lesions in an adult male
Nisha Afonso,Pawan Rane,Amit Dang,Padmanabh V. Rataboli
Australasian Medical Journal , 2009,
Abstract: Fluconazole is a bistriazole commonly prescribed for thetreatment of various fungal infections caused by yeasts and dermatophytes. However, there have been several reports of rare Adverse Drug Reactions (ADRs) like Fixed Dose Eruption (FDE), Toxic Epidermal Necrolysis and Stevens Johnson Syndrome following oral administration of fluconazole. We report a rare case of fluconazole induced oral mucosal lesions, mimicking herpes labialis, in a 34 year old male patient receiving oral fluconazole for the treatment of allergic fungal sinusitis.
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