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Search Results: 1 - 10 of 146473 matches for " Ganesh B. Patil "
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In Silico Mining of EST-SSRs in Jatropha curcas L. towards Assessing Genetic Polymorphism and Marker Development for Selection of High Oil Yielding Clones  [PDF]
Neeraj Jain, Ganesh B. Patil, Poonam Bhargava, Rajani S. Nadgauda
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.511167
Abstract:



In recent years, Jatropha curcas L. has gained popularity as a potential biodiesel plant. The varying oil content, reported between accessions belonging to different agroclimatic zones, has necessitated the assessment of the existing genetic variability to generate reliable molecular markers for selection of high oil yielding variety. EST derived SSR markers are more useful than genomic markers as they represent the transcriptome, thus, directly linked to functional genes. The present report describes the in silico mining of the microsatellites (SSRs) using J. curcas ESTs from various tissues viz. embryo, root, leaf and seed available in the public domain of NCBI. A total of 13,513 ESTs were downloaded. From these ESTs, 7552 unigenes were obtained and 395 SSRs were generated from 377 SSR-ESTs. These EST-SSRs can be used as potential microsatellite markers for diversity analysis, MAS etc. Since the Jatropha genes carrying SSRs have been identified in this study, thus, EST-SSRs directly linked to genes will be useful for developing trait linked markers.



The Design of Circular Microstrip Patch Antenna by Using Quasi-Newton Algorithm of ANN  [PDF]
Abhilasha Mishra, Ganesh B. Janvale, Bhausaheb Vyankatrao Pawar, Pradeep Mitharam Patil
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2010, DOI: 10.4236/jemaa.2010.27058
Abstract: The paper presents the Quasi Newton model of Artificial Neural Network for design of circular microstrip antenna (MSA). In this model, a closed form expression is used for accurate determination of the resonant frequency of circular microstrip patch antenna. The calculated resonant frequency results are in good agreement with the experimental results reported elsewhere. The results show better agreement with the trained and tested data of ANN models. The results are verified by the experimental results to produce accurate ANN models. This presents ANN model practically as an alternative method to the detailed electromagnetic design of circular microstrip antenna.
Design and Development of Novel Dual-Compartment Capsule for Improved Gastroretention
Ganesh B. Patil,Saurabh S. Singh,Ketan P. Ramani,Vivekanand K. Chatap
ISRN Pharmaceutics , 2013, DOI: 10.1155/2013/752471
Abstract:
Design and Development of Novel Dual-Compartment Capsule for Improved Gastroretention
Ganesh B. Patil,Saurabh S. Singh,Ketan P. Ramani,Vivekanand K. Chatap,Prashant K. Deshmukh
ISRN Pharmaceutics , 2013, DOI: 10.1155/2013/752471
Abstract: The aim of the proposed research work was to develop a novel dual-compartment capsule (NDCC) with polymeric disc for gastroretentive dosage form, which will ultimately result in better solubility and bioavailability of Ofloxacin. Floating ring caps were formulated by using different natural polymers, separating ring band and swellable polymer located at the bottom of capsule. Formulated ring caps were assessed for coating thickness, In vitro buoyancy, In vitro drug release, release kinetics and stability studies. Coating attained by the capsule shell was found to be 0.0643?mm. Depending on nature of natural polymer used, most of the formulations showed buoyancy for more than 9 hrs. Developed formulation demonstrated considerably higher drug release up to 9 hrs. The developed formulation depicted the drug release according to Korsmeyer-Peppas model. There was not any significant change in performance characteristics of developed ring caps after subjecting them to stability studies. The present study suggests that the use of NDCC for oral delivery of Ofloxacin could be an alternative to improve its systemic availability which could be regulated by the floating approach. The designed dosage system can have futuristic applications over payloads which require stomach-specific delivery. 1. Introduction Although tremendous advances have been made in drug delivery, considering costs and patient compliance, the oral route still remains the preferred route of administration for therapeutic agents. The environment of gastrointestinal tract significantly varies from stomach to large intestine (Table 1) [1]. This variation could serve a promising platform for the site-specific drug delivery of therapeutics. Table 1: Salient features of GI tract. The presence of a dosage form in the upper part of the gastrointestinal tract is important especially for drugs that are degraded or metabolized in the intestine or for drugs with local activity in the stomach [2, 3]. Likewise Singh and Kim [4] suggested that floating drug delivery is of particular interest for drugs which (a) have local action in the stomach, (b) are primarily absorbed in the stomach, (c) have poor solubility at an alkaline pH, (d) have a narrow window of absorption, and (e) are unstable in the intestinal or colonic environment. Gastrointestinal retention depends on many factors such as density and size of the dosage form, the fasting or fed condition of the patient, and the nature of the meal as well as posture [5–7]. Several gastroretentive formulation approaches such as high density [8], swelling [9],
Study on Temperature Gradients and Protein Enrichment by Aspergillus oryzae in Solid-State Fermentation on Packed Bed Bioreactor Using Jowar (Sorghum) Straw as Substrate  [PDF]
Ganesh A. Bathe, Vilas S. Patil, Ashish S. Chaurasia
Journal of Sustainable Bioenergy Systems (JSBS) , 2012, DOI: 10.4236/jsbs.2012.23005
Abstract: The packed bed solid state bioreactor designated as PBSSB is constructed in the present study. The experiments are carried out in packed bed bioreactor with jowar straw and inoculated with Aspergillus oryzae. Temperature gradient has been measured at different axial positions. It is found that the organisms grew rapidly during the period from 20 to 30 h during which heat generation is more. These results are in agreement with other researchers. The fermented jowar straw shows threefold increase in protein content. This can be utilized as high value nutritional feed to animals.
Application of Potent Actinomycete Strains for Bio-Degradation of Domestic Agro-Waste by Composting and Treatment of Pulp-Paper Mill Effluent  [PDF]
Lalita Limaye, Rajesh Patil, Prafull Ranadive, Ganesh Kamath
Advances in Microbiology (AiM) , 2017, DOI: 10.4236/aim.2017.71008
Abstract: Actinomycetes are known to produce an extensive range of bioactive compounds as well as variety of enzymes having multiple biotechnological applications. They are an important source of lignocellulose hydrolyzing enzymes and constitute considerable proportion of the soil or aquatic micro-flora responsible for degradation of biomass in natural environment. Presently, most of the commercially exploited lignocellulases and commercial biodegradation processes rely mostly on fungal or bacterial micro-organisms. Actinomycetes are relatively less explored for biodegradation processes that utilize lignocellulases for solid agro-waste management and waste water treatment. There is also a need to search and explore novel actinomycete strains for various biodegradation applications. This study involved examining the possibility of using only potent actinomycetes strains for the composting process by creating the consortium of such strains that could produce thermo-tolerant and alkali-tolerant key enzymes necessary for the degradation of cellulose, hemi-cellulose and lignin. The newly developed actinomycete consortium was tested for the composting activity and the composting process was optimized. The analysis of the composted material generated under ideal condition, demonstrated desirable physical and chemical characteristics. Paper pulp effluent poses a hazard to waterways due to toxicity. The toxicity of this mill effluent can be attributed to a compound called lignin and its chlorinated derivatives that are let out during the treatment of lignocellulosic constituents. Current study also involves the use of a strain of actinomycete having ability to produce enzyme laccase, which is active under alkaline condition for the treatment of paper pulp effluent. Enzyme laccase is known for its ability to attack phenolic components of lignin and common hazardous component of effluent, polycyclic aromatic hydrocarbons (PAH). Aerobic treatment of effluent by actinomycete strain indicated 21% reduction in COD at pH 7.5 after 14 days under optimum condition. This strain was identified as Streptomyces rochei based on molecular fingerprinting and was reported to be the producer of laccase probably for the first time. LCMS analysis of the treated effluent sample showed the presence of degradation compounds forming after 7 and 14 days of treatment. These compounds showed the degradation of lignin components and other phenolic, non-phenolic components of the effluent by intra molecular re-arrangement, oxidation and ring opening reactions. Overall, potent thermo-tolerant and
BioPP: a tool for web-publication of biological networks
Ganesh A Viswanathan, German Nudelman, Sonali Patil, Stuart C Sealfon
BMC Bioinformatics , 2007, DOI: 10.1186/1471-2105-8-168
Abstract: BioPP suite is a web-based application that allows pathway knowledgebases stored in CD-SBML to be web published with an easily navigated user interface. The BioPP suite consists of four interrelated elements: a pathway publisher, an upload web-interface, a pathway repository for user-deposited knowledgebases and a pathway navigator. Users have the option to convert their CD-SBML files to HTML for restricted use or to allow their knowledgebase to be web-accessible to the scientific community. All entities in all knowledgebases in the repository are linked to public database entries as well as to a newly created public wiki which provides a discussion forum.BioPP tools and the public repository facilitate sharing of pathway knowledgebases and interactive curation for research teams and scientific communities. BioPP suite is accessible at http://tsb.mssm.edu/pathwayPublisher/broadcast/ webciteUnderstanding cellular function requires detailed cell-type specific insight into the structure and operation of the molecular networks formed by a cell's genes and proteins [1]. The communication among cellular components is governed by logical and signal transfer processes [2]. These interactions are typically represented as a directed wiring diagram showing aspects of signaling, metabolic and gene pathway connections [3,4]. Cellular pathway maps provide insight into network topology and capture the relationship of the nodes, and into the underlying biological responses. Due to the complexity of these networks, there is increasing impetus to create utility-based software tools to construct, visualize, and analyze pathways [5].Biological network curation involves the construction, verification and refinement of an annotated pathway map. Maps may be generic or cell-type specific. Accurate assembly of an annotated pathway map is a difficult, slow, iterative and labor-intensive project (Fig 1). Curators use various databases and text-mining tools to identify relevant citations or da
Effect of some physical parameters and crospovidone on directly compressed frusemide tablets
Chaulang Ganesh,Patil Kundan,Ghodke Dhananjay,Yeole Pramod
Asian Journal of Pharmaceutics , 2008,
Abstract: The aim of this study was to evaluate the effect of increasing crospovidone (superdisintegrant) load on the characteristics of fast-disintegrating tablets for the potential use of the drug for its therapeutic effect. Five tablet formulations, F 0 , F 1 , F 3 , F 7 , and F 10 containing 0%, 1%, 3%, 7%, and 10% (w/w) of crospovidone, respectively, frusemide and microcrystalline cellulose (PH102), were prepared by direct compression, at a different compression forces. Tablet weight variation, content uniformity, crushing strength, disintegration time, wetting time, and in vitro release were measured for each formulation at each compression force. A linear increase in compression force resulted in an exponential increase in hardness for all formulations, a linear increase in disintegration and wetting times was observed for the formulations F 0 , F 1 , F 3 with the increase in compression force. The tablet formulation F 7 indicated, there was no effect of compression force on disintegration and wetting time. The in vitro release of the drug was increased with increase in concentration of crospovidone irrespective the compression force. However, storage under high humidity conditions caused the softening of the tablets containing the high amount of crospovidone, leading to softening of tablets. Fast disintegration of the tablets within 1-2 min is prerequisite for improving the dissolution of frusemide, attributed to increase in speed at which maximum surface area of sparingly soluble drug is exposed to the dissolution medium. However, tablet containing high amount of crospovidone must be protected from the atmospheric moisture because storage of these tablets at high humidity led to softening and losing the tablet characteristics.
Pulsatile drug delivery system
Belgamwar Veena,Gaikwad Madhuri,Patil Ganesh,Surana Sanjay
Asian Journal of Pharmaceutics , 2008,
Abstract: Pulsatile drug delivery system is the most interesting time- and site-specific system. This system is designed for chronopharmacotherapy which is based on circadian rhythm. The principle rationale for the use of pulsatile release is for the drugs where a constant drug release, i.e., a zero-order release is not desired. Pulsatile drug delivery system is defined as the rapid and transient release of certain amount of molecules within a short time period immediately after a predetermined off-release period, i.e., lag time. Various systems like capsular systems, osmotic systems, pulsatile system based on the use of soluble or erodible polymer coating, use of rupturable membranes and pulsatile system based on membrane permeability are summarized in this article. These systems are beneficial for the drugs having chronopharmacological behavior where night time dosing is required and for the drugs having high first-pass effect and having specific site of absorption in gastrointestinal tract.
Synthesis, Characterization, and Antibacterial Studies of Mixed Ligand Dioxouranium Complexes with 8-Hydroxyquinoline and Some Amino Acids
Sunil S. Patil,Ganesh A. Thakur,Manzoor M. Shaikh
ISRN Pharmaceutics , 2011, DOI: 10.5402/2011/168539
Abstract:
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